Abstract:
:The recent upsurge in the association of congenital neurological disorders and infection by the Zika virus (ZIKV) has resulted in increased research focus on the biology of this flavivirus. Studies in animal models indicate that ZIKV can breach the placental barrier and selectively infect and deplete neuroprogenitor cells (NPCs) of the developing fetus, resulting in changes of brain structures, reminiscent of human microcephaly. In vitro and ex vivo studies using human cells and tissues showed that human NPCs and placental cells are targeted by ZIKV. Also of concern is the impact of ZIKV on human reproductive structures, with the potential to cause infertility, as the virus appears to remain in the genital tract for extended periods of time. This review discusses the putative roles of ZIKV on human reproductive complications and congenital neuropathologies.
journal_name
Pathologyjournal_title
Pathologyauthors
Gharbaran R,Somenarain Ldoi
10.1016/j.pathol.2017.07.008subject
Has Abstractpub_date
2017-12-01 00:00:00pages
707-714issue
7eissn
0031-3025issn
1465-3931pii
S0031-3025(17)30098-3journal_volume
49pub_type
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