Distinct genetic changes characterise multifocality and diverse histological subtypes in papillary thyroid carcinoma.

abstract：:The clinical and laboratory features of a patient with a recently recognized new variant of von Willebrand's disease are presented. The importance of this variant is that it is associated with a clinically significant bleeding diathesis but with a normal skin bleeding time, PTTK, factor VIIIc and platelet aggregation ...

journal_title：Pathology

authors： Wylie B,Gibson J,Uhr E,Kronenberg H

更新日期：1988-01-01 00:00:00

abstract：AIM:To demonstrate that Flinders Island spotted fever (FISF), a spotted fever group rickettsial infection caused by Rickettsia honei, is found not only on Flinders Island (Bass Strait), Tasmania, but elsewhere in south-east Australia. METHODS:Cases of FISF were identified by rickettsial serology, culture and the detec...

journal_title：Pathology

authors： Unsworth NB,Stenos J,McGregor AR,Dyer JR,Graves SR

更新日期：2005-06-01 00:00:00

abstract：:Cytological examination of the pleural effusion fluid obtained from a 66-yr-old Chinese lady showed numerous intra- and extracytoplasmic colourless refractile non-birefringent crystals. X-ray analysis of the crystals identified barium salts. On further inquiry, it was learnt that the fluid obtained had been placed in ...

journal_title：Pathology

authors： Chan AC,Collins RJ,Cheung TK

更新日期：1993-10-01 00:00:00

abstract：:Decreased neutrophil alkaline phosphatase (NAP) synthesis is a classical feature of Philadelphia (Ph) positive chronic phase chronic myeloid leukemia (CML). Whether this aberration is an integral leukemic property of the cell or results from mediation by other factors is unclear. During alpha-interferon (alpha-IFN) ba...

journal_title：Pathology

authors： Taylor DL,Kerwick AM,Elliott SL,Rodwell RL,Wright SJ,Marlton PV,Veleba AR,Taylor KM

更新日期：1993-10-01 00:00:00

abstract：:The main controversy about nerve sheath tumors (NSTs) has been their histogenesis. A Schwann cell origin has been proposed by many investigators for both schwannomas and neurofibromas. However Erlandson and Woodruff observed that while schwannomas appeared to be composed predominantly of Schwann cells, neurofibromas c...

journal_title：Pathology

authors： Kharbanda K,Dinda AK,Sarkar C,Karak AK,Mathur M,Roy S

更新日期：1994-01-01 00:00:00

abstract：:A patient initially treated for iron deficiency anemia was later found to have myelofibrosis. She developed increasing splenomegaly and then a mass in the right iliac fossa for which a right hemicolectomy was performed. Histopathology demonstrated extramedullary hemopoiesis in the spleen and cecum. The patient subsequ...

journal_title：Pathology

authors： Sunderland K,Barratt J,Pidcock M

更新日期：1994-01-01 00:00:00

abstract：:We counted apoptotic thymic cortical lymphocytes in semi-thin plastic sections of 266 human autopsy thymuses. The decreased patients included in the study were all aged less than 40 yrs and all died within 72 hrs of the onset of symptoms. Based on published data on animal and human material it was anticipated that ind...

journal_title：Pathology

authors： Middleton G,Reid LE,Harmon BV

更新日期：1994-04-01 00:00:00

abstract：:A 59 yr old male presented with abdominal pain and jaundice. CT scan showed a tumor in the pancreas with secondaries in the liver, peri-pancreatic lymph nodes, vertebral bone marrow and subcutaneous tissue of the neck together with a cervical lymph node. The patient died after 2 wks and autopsy revealed complete repla...

journal_title：Pathology

authors： Chetty R,Clark SP,Pitson GA

更新日期：1993-07-01 00:00:00

abstract：:An enzyme-immunoassay has been developed for rapid isotyping of murine monoclonal antibodies. This assay has several advantages over the commonly used typing methods. It does not require the presence of specific antigen. Typing plates can be prepared in advance and stored frozen. Unequivocal results can be obtained in...

journal_title：Pathology

authors： Gardner ID

更新日期：1985-01-01 00:00:00

abstract：AIM:We investigated the role of renal sympathetic innervation in the deterioration of renal haemodynamic and excretory functions during the early post-ischaemic phase of renal ischaemia/reperfusion injury. METHODS:Anaesthetised male Sprague-Dawley rats were subjected to unilateral renal ischaemia by clamping the left ...

journal_title：Pathology

authors： Salman IM,Ameer OZ,Sattar MA,Abdullah NA,Yam MF,Najim HS,Khan AH,Johns EJ

更新日期：2010-04-01 00:00:00

abstract：AIMS:CD146 is a potentially metastasis promoting cell adhesion molecule and its expression has been described in various solid tumours. We aimed to evaluate the expression of CD146 in prostate cancer by immunohistochemistry in a clinically characterised study cohort to evaluate its prognostic properties. METHODS:We ev...

journal_title：Pathology

authors： Fritzsche FR,Wassermann K,Rabien A,Schicktanz H,Dankof A,Loening SA,Dietel M,Jung K,Kristiansen G

更新日期：2008-08-01 00:00:00

abstract：:The in vitro activity of azthreonam, a novel monocyclic beta-lactam antibiotic, was investigated for Gram negative urinary pathogens by determining the susceptibilities of 105 consecutive isolates from specimens submitted to the Auckland Hospital microbiology laboratory. All were sensitive or of intermediate sensitivi...

journal_title：Pathology

authors： Lang SD,McKenzie D

更新日期：1983-04-01 00:00:00

abstract：:The first 2 exchange transfusions in Australia for Rhesus-induced erythroblastosis (hemolytic disease of the newborn) were conducted in the 9 mth period from December 1945 to August 1946. These pioneering endeavours in medical research were undertaken by 3 transfusionists who were, or had been, directors of the Red Cr...

journal_title：Pathology

authors： Pearn JH

更新日期：1994-04-01 00:00:00

abstract：AIMS:We have identified in malignant melanoma an angio-tumoural complex in which tumour cells occupy a pericytic location along the endothelium of microvessels without evidence of intravasation. This pericytic angiotropism of melanoma cells, without any sign of intravasation, suggests that melanoma cells may migrate al...

journal_title：Pathology

authors： Barnhill RL,Lugassy C

更新日期：2004-10-01 00:00:00

abstract：AIM:To compare the relative diagnostic efficacy of several different tests used to establish a diagnosis of phaeochromocytoma, in patients with a proven diagnosis of phaeochromocytoma, and in hospital patients with significant disease of other types. METHODS:We prospectively compared biochemical markers of catecholami...

journal_title：Pathology

authors： Hickman PE,Leong M,Chang J,Wilson SR,McWhinney B

更新日期：2009-02-01 00:00:00

abstract：:Ethanol in blood was assayed by 2 currently available procedures: a commercial kit enzymatic assay and a gas chromatographic procedure. Both methods were performed with commercially available materials and equipment. Results by the 2 procedures agreed well. For the 192 specimens studied, the correlation coefficient wa...

journal_title：Pathology

authors： Taylor GF,Turrill GH,Carter NG

更新日期：1984-04-01 00:00:00

abstract：:A 60 year old white male presented with atypical chest pain and exercise-induced myalgia. Physical examination revealed slight proximal limb muscle weakness and wasting. Serum creatine phosphokinase levels were persistently elevated and electromyography showed changes consistent with a mild myopathy. Light microscopic...

journal_title：Pathology

authors： Byard RW,Lach B,Preston DN

更新日期：1991-01-01 00:00:00

abstract：AIM:Performance measures for Australian laboratories reporting cervical cytology are a set of quantifiable measures relating to the profile and accuracy of reporting. This study reviews aggregate data collected over the ten years in which participation in the performance measures has been mandatory. METHODS:Laboratori...

journal_title：Pathology

authors： Shield PW,Finnimore J,Cummings M,Wright RG

更新日期：2010-12-01 00:00:00

abstract：AIM:Clostridium difficile is the major pathogen associated with nosocomial diarrhoea. We evaluated the performances of a commercially available toxin A enzyme immunoassay (EIA; Clearview C. difficile Toxin A Test), culture and tissue culture cytotoxin assay in the diagnosis of C. difficile-associated diarrhoea. METHOD...

journal_title：Pathology

authors： Anderson TL,McGregor A

更新日期：2003-06-01 00:00:00

abstract：:Renal cell carcinoma (RCC) generally has a poor prognosis because of late diagnosis and metastasis. We have previously described decreased tumour necrosis factor receptor-associated factor-1 (TRAF-1) in RCC compared with paired normal kidney in a patient cohort in Australia. In the present study, TRAF-1 expression in ...

journal_title：Pathology

authors： Rajandram R,Yap NY,Pailoor J,Razack AH,Ng KL,Ong TA,Morais C,Gobe GC

更新日期：2014-10-01 00:00:00

abstract：:Use of cellular products for therapeutic purposes has predominantly been unregulated in Australia until recently. Transplant of haemopoietic progenitor cells (HPC) for bone marrow regeneration is now a routine treatment for many disorders with an established mechanism of facility accreditation. However, other cellular...

journal_title：Pathology

authors： Trickett AE,Wall DM

更新日期：2011-10-01 00:00:00

abstract：:E-cadherin mediated intercellular adhesion is regulated by a family of cytoplasmic proteins that include alpha-, beta- and gamma-catenin and p120cas. Changes in expression of E-cadherin are believed to be an early event in melanoma development. Recent studies have also drawn attention to the over-expression of beta-ca...

journal_title：Pathology

authors： Zhang XD,Hersey P

更新日期：1999-08-01 00:00:00

abstract：:Gene targeting ('knock-out') technology is now widely used in the basic science of all disciplines of pathology and particularly auto-immune and inflammatory disease. Gene targeting is the wilful introduction of precise mutations into the genome of an animal, usually a mouse, affecting the function of a single gene or...

journal_title：Pathology

authors： Riminton DS

更新日期：2002-04-01 00:00:00

abstract：:This paper reviews the application of flow cytometric techniques to the analysis and quantitation of mixed red cell populations. Such mixtures may arise in a variety of ways, for example: through transplacental hemorrhage during pregnancy or upon delivery; through iatrogenic procedures such as blood transfusion, bone ...

journal_title：Pathology

authors： Nelson M

更新日期：1999-08-01 00:00:00

abstract：:Sera from 82 patients with acute or chronic hepatitis and 40 chronic carriers of hepatitis B were examined by ELISA and immunoblotting for reactivity with the glycolytic enzyme aldolase. The results of the ELISA tests, expressed as a percentage of a positive control, were compared to those obtained with sera from 39 p...

journal_title：Pathology

authors： Brown C,Toh BH,Pedersen JS,Clarke FM,Mackay IR,Gust I

更新日期：1987-10-01 00:00:00

abstract：:A fatal case of multiple sulfatase deficiency in a 10-year-old girl is reported. In this rare disease, which is inherited as an autosomal recessive, features of metachromatic leukodystrophy and of mucopolysaccharidoses occur together. The white matter suffers progressive destruction with sulfatides accumulating in mac...

journal_title：Pathology

authors： Kepes JJ,Berry A 3rd,Zacharias DL

更新日期：1988-07-01 00:00:00

abstract：:Tumour infiltrating lymphocytes in primary melanoma have been found to correlate with patient outcomes. A subpopulation of tumour infiltrating lymphocytes expresses the transcription factor forkhead box protein 3 (FOXP3). These are known as FOXP3+ T-regulatory cells (Tregs) and are thought to play an immune suppressiv...

journal_title：Pathology

authors： Leslie C,Bowyer SE,White A,Grieu-Iacopetta F,Trevenen M,Iacopetta B,Amanuel B,Millward M

更新日期：2015-10-01 00:00:00

abstract：:Recent updated models of the coagulation mechanism suggest that factor VII/thromboplastin complex is the main initiator or trigger of coagulation. Factor VII activation of factor IX is likely to be an important activation pathway. Inhibition of factor VII by tissue factor pathway inhibitor may have a regulatory role i...

journal_title：Pathology

authors： Wei DC,Wong RW,Robertson EP

更新日期：1997-05-01 00:00:00

abstract：:Rare tumours are a heterogeneous group of conditions that encompass benign to malignant lesions both of stromal and epithelial origin. Here some of these tumours are described, in which the authors have most familiarity. An outline of medullary carcinoma is also presented. ...

journal_title：Pathology

authors： Foschini MP,Eusebi V

更新日期：2009-01-01 00:00:00

abstract：:A 40 year old Chinese woman presented with anasarca and later developed features of POEMS syndrome. These are peripheral neuropathy (P), organomegaly (O), endocrine dysfunction (E), monoclonal gammopathy (M), and skin changes (S) which are usually associated with plasma cell dyscrasia. In our patient, monoclonal gammo...

journal_title：Pathology

authors： Leung NW,Lam CW,Pang JC

更新日期：1991-04-01 00:00:00