Abstract:
AIMS:BRAF mutation has been shown in a large meta-analysis to be an independent prognostic marker for papillary thyroid carcinoma (PTC) with poorer survival and higher recurrence rates. METHODS:We studied prevalence of BRAF mutation in 77 patients with PTC from an Australian cohort using competitive polymerase chain reaction (C-PCR) and immunohistochemistry (IHC) with BRAF-specific antibody, VE1. Clinicopathological parameters, recurrence and mortality were analysed according to BRAF mutation status. RESULTS:Median follow-up was 84.5 months. BRAF mutation was demonstrated in 65% of cases combining both C-PCR and IHC; in 71% (37/77) of tumours >1 cm and 52% (13/25) of microcarcinomas (<1 cm). IHC was positive in 69% (49/71) and C-PCR in 53% (41/77); 87% (67/77) of our patients were treated with total thyroidectomy and 65% (50/77) also had radioactive ablation. BRAF positive tumours had a significantly higher rate of subsequent lymph node metastases (p=0.035). Significant association was found between BRAF mutation and male sex (p=0.034), but not between age >45 years at diagnosis, size of primary tumour, extrathyroidal extension, lymph node or distant metastases or clinical stage at diagnosis. CONCLUSIONS:BRAF mutation in PTC determined by IHC is associated with significantly increased risk of lymph node recurrence.
journal_name
Pathologyjournal_title
Pathologyauthors
McKelvie PA,Chan F,Yu Y,Waring P,Gresshoff I,Farrell S,Williams RAdoi
10.1097/PAT.0000000000000008subject
Has Abstractpub_date
2013-12-01 00:00:00pages
637-44issue
7eissn
0031-3025issn
1465-3931pii
S0031302516314714journal_volume
45pub_type
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