Sirtuin-6 deficiency exacerbates diabetes-induced impairment of wound healing.

abstract：:In the 1970s, studies of tissue architecture and cell proliferation were used to formulate a new model of epidermal homeostasis. This asserted that the tissue was maintained by long-lived, slow-cycling, self-renewing stem cells that generate a short-lived population of transit amplifying (TA) cells, which undergo term...

journal_title：Experimental dermatology

authors： Doupé DP,Jones PH

更新日期：2012-04-01 00:00:00

abstract：:Macrophages play important roles in immunity and inflammation, and in allergic, granulomatous and neoplastic diseases. Here, we present the indepth results of an ongoing study of macrophage differentiation pathways in cutaneous macrophage disorders and in vitro. Up to now, a total of 40 cases of cutaneous macrophage d...

journal_title：Experimental dermatology

authors： Kodelja V,Goerdt S

更新日期：1994-12-01 00:00:00

abstract：:Plasmatic proteasome (p-proteasome) also called circulating proteasome has recently been described as a tumor marker. We investigated the diagnostic and prognostic accuracies of p-proteasome levels in a melanoma population classified according to the American Joint Committee on Cancer staging system. Using an ELISA te...

journal_title：Experimental dermatology

authors： Henry L,Lavabre-Bertrand T,Douche T,Uttenweiler-Joseph S,Fabbro-Peray P,Monsarrat B,Martinez J,Meunier L,Stoebner PE

更新日期：2010-12-01 00:00:00

abstract：:It is not clear whether TNF-α antagonists used in the treatment of psoriasis need to act systemically, or whether local inhibition of skin-produced TNF-α would be sufficient to silence skin inflammation. To answer this question, we conducted two multicentre, double-blinded, randomized, placebo-controlled clinical tria...

journal_title：Experimental dermatology

authors： Tsianakas A,Brunner PM,Ghoreschi K,Berger C,Loser K,Röcken M,Stingl G,Luger T,Jung T

更新日期：2016-06-01 00:00:00

abstract：:Drug resistance in melanoma is commonly attributed to ineffective apoptotic pathways. Targeting apoptosis regulators is thus considered a promising approach to sensitizing melanoma to therapy. In the previous issue of Experimental Dermatology, Plötz and Eberle discuss the role that apoptosis plays in melanoma progress...

journal_title：Experimental dermatology

authors： Haass NK,Schumacher U

更新日期：2014-07-01 00:00:00

abstract：:Mast cells, eosinophils and basophils are central effector immune cells in allergic skin inflammation including atopic dermatitis (AD). Recent studies revealed that the bidirectional interaction between these three immune cell types (mast cells, eosinophils and basophils) and the nervous system is involved in the path...

journal_title：Experimental dermatology

authors： Nakashima C,Ishida Y,Kitoh A,Otsuka A,Kabashima K

更新日期：2019-12-01 00:00:00

abstract：:We investigated the effects of a single dose of mouse interleukin-31 (IL-31) on scratching behaviour in comparison with spontaneous skin-lesion- or serotonin (5-HT)- induced scratching behaviour in NC/Nga and BALB/c mice. Intradermal (i.d.) injection of IL-31 caused a gradual increase in long-lasting scratching (LLS, ...

journal_title：Experimental dermatology

authors： Arai I,Tsuji M,Takeda H,Akiyama N,Saito S

更新日期：2013-10-01 00:00:00

abstract：:Psoriasis is a chronic skin disease caused by immune disorder. The chronic skin inflammation involves inflammatory molecules that are released from T lymphocytes and keratinocytes. Therefore, developing an anti-inflammatory therapy that is suitable for long-term treatment is needed. Electrical stimulation induces biol...

journal_title：Experimental dermatology

authors： Tsurekawa Y,Morita M,Suico MA,Moriuchi M,Nakano Y,Piruzyan M,Takada M,Fukami S,Shuto T,Kai H

更新日期：2018-10-01 00:00:00

abstract：:Calcium-mediated signals play important roles in epidermal barrier formation, skin homoeostasis and wound repair. Calmodulin 4 (Calm4) is a small, Ca2+ -binding protein with strong expression in suprabasal keratinocytes. In mice, Calm4 first appears in the skin at the time of barrier formation, and its expression incr...

journal_title：Experimental dermatology

authors： Lessard JC,Kalinin A,Bible PW,Morasso MI

更新日期：2015-01-01 00:00:00

abstract：:In the area of dermatological research, the knowledge of rate and extent of substance penetration into the human skin is essential not only for evaluation of therapeutics, but also for risk assessment of chemicals and cosmetic ingredients. Recently, confocal Raman microscopy emerged as a novel analytical technique for...

journal_title：Experimental dermatology

authors： Franzen L,Anderski J,Planz V,Kostka KH,Windbergs M

更新日期：2014-12-01 00:00:00

abstract：:Malignant melanoma is a tumor characterized by the uncontrolled proliferation of melanocytes, mainly in skin, but also in eyes. Its incidence is rising each year. To improve the diagnosis and treatment of the tumor, it is essential to develop new effective methods to early detect and characterize melanoma. Previously,...

journal_title：Experimental dermatology

authors： Godechal Q,Leveque P,Marot L,Baurain JF,Gallez B

更新日期：2012-05-01 00:00:00

abstract：:Hair follicle central isthmus is surrounded by dense nerve endings and terminal Schwann cells (TSCs), forming a specialized sensory structure called lanceolate complexes. Extracellular matrix protein EGFL6 expressed from epidermis has been found closely associated with lanceolate complexes and important for proper ali...

journal_title：Experimental dermatology

authors： Wei JP,Gong Y,Zhong HB,Hua Wang T,Liao XH

更新日期：2020-04-01 00:00:00

abstract：:Ultraviolet B (UVB) radiation induces inflammation in the skin specifically at the site of exposure. We unexpectedly found that UVB-induced inflammation was not induced in gp91phox-depleted mice. To test whether gp91phox is directly involved in UVB-induced inflammation, neutrophil- and hyaluronic acid-depleted mice we...

journal_title：Experimental dermatology

authors： Hiramoto K,Kobayashi H,Yamate Y,Ishii M,Sato EF

更新日期：2012-12-01 00:00:00

abstract：:The last decade has seen a considerable improvement in the understanding of the biology of melanoma. Advances have come in the understanding of the importance of critical oncogenes and tumour suppressor genes, epigenetic phenomena, signalling pathways, drug resistance mechanisms, the pivotal role of the local immune s...

journal_title：Experimental dermatology

authors： Lorigan P,Eisen T,Hauschild A

更新日期：2008-05-01 00:00:00

abstract：:During aging, increases in the number of senescent cells are seen in various tissues. On the other hand, stem cells play crucial roles in tissue repair and homeostasis. Therefore, it is likely that stem cells give rise to new cells that replace senescent cells. However, how stem cells contribute to homeostasis in the ...

journal_title：Experimental dermatology

authors： Ohgo S,Hasegawa S,Hasebe Y,Mizutani H,Nakata S,Akamatsu H

更新日期：2015-07-01 00:00:00

abstract：:We have shown previously in psoriasis a very high prevalence of epidermodysplasia verruciforms-associated human papillomavirus 5 (EVHPV5) DNA and antibodies to human papillomavirus 5 (HPV5) virus-like particle (VLP) L1, and we suggested that this benign hyperproliferative disorder could be a reservoir for EVHPVs. Here...

journal_title：Experimental dermatology

authors： Majewski S,Jablonska S

更新日期：2003-12-01 00:00:00

abstract：:Shprintzen-Goldberg syndrome (SGS) is a rare disorder characterized by a Marfan-like habitus, mental retardation and craniosynostosis. Cardiac abnormalities, such as aortic root dilation have also been noted as well as several skeletal abnormalities. Its nosological status is unclear as it is hard to delineate SGS fro...

journal_title：Experimental dermatology

authors： van Steensel MA,van Geel M,Parren LJ,Schrander-Stumpel CT,Marcus-Soekarman D

更新日期：2008-04-01 00:00:00

abstract：:More than 40 null mutations in the filaggrin (FLG) gene are described. It is therefore possible to find two different null mutations in one individual (compound heterozygosity). It has been generally perceived that homozygous and compound heterozygous individuals were genotypically comparable; however, this has not be...

journal_title：Experimental dermatology

authors： Carlsen BC,Meldgaard M,Johansen JD,Thyssen JP,Menné T,Szecsi PB,Stender S

更新日期：2013-09-01 00:00:00

abstract：:Chronic exposure to ultraviolet (UV) radiation alters components of the skin. We previously reported that chronic low-dose UV irradiation induced wrinkle formation but did not significantly alter dermal components of hairless mice. In the present study, we examined whether the epidermal changes by UV irradiation could...

journal_title：Experimental dermatology

authors： Kambayashi H,Odake Y,Takada K,Funasaka Y,Ichihashi M

更新日期：2003-01-01 00:00:00

abstract：:Human follicle dermal papilla cells (FDPC) are a specialized population of mesenchymal cells located in the skin. They regulate hair follicle (HF) development and growth, and represent a reservoir of multipotent stem cells. Growing evidence supports the hypothesis that HF cycling is associated with vascular remodeling...

journal_title：Experimental dermatology

authors： Bassino E,Gasparri F,Giannini V,Munaron L

更新日期：2015-05-01 00:00:00

abstract：:Topical photodynamic therapy with 5-aminolevulinic acid (5-ALA) is a newly established treatment modality for epithelial skin cancer. Skin distribution of different 20% 5-ALA formulations was investigated by detection of protoporphyrin IX (PpIX) using an ex vivo porcine skin model. Fluorescence of PpIX was first detec...

journal_title：Experimental dermatology

authors： Maisch T,Worlicek C,Babilas P,Landthaler M,Szeimies RM

更新日期：2008-10-01 00:00:00

abstract：:Placental extracts have been widely used as skin lightening agents in the Japanese cosmetic market. Here, we show that placental extracts contain factors that can decrease or increase melanin synthesis by normal human melanocytes in vitro in possible association with mitochondrial respiration. When normal human melano...

journal_title：Experimental dermatology

authors： Yoshimoto S,Ohagi Y,Yoshida M,Yanagi H,Hibino S,Ichihashi M,Ando H

更新日期：2019-02-01 00:00:00

abstract：:We have previously demonstrated that serum of patients with pemphigus vulgaris induces reduction of desmoglein 3 (Dsg3) half-life in keratinocytes (FEBS Lett 2006: 580: 3276). This phenomenon seems to occur as a consequence of the progressive depletion of Dsg3 from desmosomes. Here we reported that reduction of full-l...

journal_title：Experimental dermatology

authors： Cirillo N,Campisi G,Gombos F,Perillo L,Femiano F,Lanza A

更新日期：2008-10-01 00:00:00

abstract：:5-methoxypsoralen (5-MOP) is considered an alternative to 8-methoxypsoralen (8-MOP) for photochemotherapy of psoriasis. We have compared the clinical efficacy and tolerability of 5-MOP (1.2 mg/kg)-UVA versus 8-MOP (0.6 mg/kg)-UVA therapy in 25 patients of skin type III and IV, affected by relapsing plaque-type psorias...

journal_title：Experimental dermatology

authors： Calzavara-Pinton P,Ortel B,Carlino A,Honigsmann H,De Panfilis G

更新日期：1992-07-01 00:00:00

abstract：:Interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) are 3 cytokines that play a key rôle in cutaneous homeostasis and in the immunopathogenesis of a number of dermatologic diseases. Most studies have focused on their production by keratinocytes and Langerhans ce...

journal_title：Experimental dermatology

authors： Boehm KD,Yun JK,Strohl KP,Elmets CA

更新日期：1995-12-01 00:00:00

abstract：:Ichthyosis follicularis, alopecia and photophobia (IFAP) syndrome is an X-linked genodermatosis with congenital atrichia being the most prominent feature. Recently, we have shown that functional deficiency of MBTPS2 (membrane-bound transcription factor protease site 2) - a zinc metalloprotease essential for cholestero...

journal_title：Experimental dermatology

authors： Oeffner F,Martinez F,Schaffer J,Salhi A,Monfort S,Oltra S,Neidel U,Bornholdt D,van Bon B,König A,Happle R,Grzeschik KH

更新日期：2011-05-01 00:00:00

abstract：:Wounds close by keratinocytes migrating from the edge of the wound and re-epithelializing the epidermis. It has been proposed that the major stimuli for wound closure are blood-derived growth factors, chemokines and cytokines. The small GTPase R-Ras, a known integrin activator, also regulates vascular permeability dur...

journal_title：Experimental dermatology

authors： Ketomäki T,Vähätupa M,May U,Pemmari T,Ruikka E,Hietamo J,Kaipiainen P,Barker H,Parkkila S,Uusitalo-Järvinen H,Järvinen TAH

更新日期：2019-02-01 00:00:00

abstract：:The role of T cells in the pathogenesis of psoriasis is widely acknowledged. However, key aspects of their precise function in the disease as well as the relative pathogenic contribution of T-cell subsets are still unknown. T-cell clones have been isolated from psoriatic plaques but a study of conditions affecting the...

journal_title：Experimental dermatology

authors： Kohlmann WM,Urban W,Sterry W,Foerster J

更新日期：2004-10-01 00:00:00

abstract：:The presence of albumin in the human epidermis has been reported more than a decade ago, but until now, it was assumed that this protein is synthesized in the liver and transported to the avascular skin. To our knowledge, transcription of albumin in the human epidermis was never considered. In this report, we present ...

journal_title：Experimental dermatology

authors： Hasse S,Kothari S,Rokos H,Kauser S,Schürer NY,Schallreuter KU

更新日期：2005-03-01 00:00:00

abstract：:A causative link between emotional stress and acne has long been postulated. There is mounting evidence that the molecular mechanism underlying this observation is related to the expression of receptors for several neuroendocrine mediators by the sebaceous gland. Recent and ongoing studies have indicated that human se...

journal_title：Experimental dermatology

authors： Zouboulis CC,Böhm M

更新日期：2004-01-01 00:00:00