Optimization of electron paramagnetic resonance imaging for visualization of human skin melanoma in various stages of invasion.

abstract：:Decorin is a natural transforming growth factor-β1 (TGF-β1) antagonist. Reduced decorin synthesis is associated with dermal scarring, and increased decorin expression appears to reduce scar tissue formation. To investigate the therapeutic potential of decorin for keloids, human dermal fibroblasts (HDFs) and keloid-der...

journal_title：Experimental dermatology

authors： Lee WJ,Ahn HM,Roh H,Na Y,Choi IK,Lee JH,Kim YO,Lew DH,Yun CO

更新日期：2015-08-01 00:00:00

abstract：:Curcumin (diferuloylmethane) is a polyphenol derived from turmeric (Curcuma longa), which is commonly used as a spice. Recent studies have shown that curcumin has a wide range of pharmacological activities, including anticarcinogenic, antioxidant, anti-inflammatory and antiangiogenic activities. However, the antiphoto...

journal_title：Experimental dermatology

authors： Hwang BM,Noh EM,Kim JS,Kim JM,You YO,Hwang JK,Kwon KB,Lee YR

更新日期：2013-05-01 00:00:00

abstract：:Dendritic cells (DCs) show a Janus-like functional behavior. They help us by their orchestration of numerous immune responses to defend our body against invading pathogenic micro-organisms and also induce regulatory T cells to inhibit immune reactions against autoantigens as well as diverse harmless environmental anti...

journal_title：Experimental dermatology

authors： Schäkel K

更新日期：2009-03-01 00:00:00

abstract：:There have been few reports of successful long-term culture of cells established from cutaneous basal cell carcinoma (BCC) tumors. Here, we describe techniques that have enabled us to establish three long-term cultures of BCC cells isolated from BCC tumors that arose in irradiated Patched 1 (Ptch1)(+/-) mice. All thre...

journal_title：Experimental dermatology

authors： So PL,Langston AW,Daniallinia N,Hebert JL,Fujimoto MA,Khaimskiy Y,Aszterbaum M,Epstein EH Jr

更新日期：2006-09-01 00:00:00

abstract：:Leukotrienes constitute a group of lipid mediators, which may be subdivided into two groups, with leukotriene B4 on the one hand and cysteinyl leukotrienes on the other. Although leukotrienes are abundantly expressed in skin affected by diverse chronic inflammatory diseases, including atopic dermatitis, psoriasis, pem...

journal_title：Experimental dermatology

authors： Sadik CD,Sezin T,Kim ND

更新日期：2013-11-01 00:00:00

abstract：:Rosacea is a skin inflammatory condition accompanied by cutaneous signs such as oedema, flushing, erythema, telangiectasia and pustules. Generally, rosacea is triggered by ultraviolet B (UVB) exposure. When exposed to UVB, skin epidermis thickens and produces elevated levels of pro-inflammatory cytokines, especially k...

journal_title：Experimental dermatology

authors： Son M,Park J,Oh S,Choi J,Shim M,Kang D,Byun K

更新日期：2020-05-20 00:00:00

abstract：:Pro- and anti-apoptotic members of the Bcl-2 family are fundamental in the control of apoptosis. Among them, Bax plays a key role in apoptosis induction by mediating the release of apoptogenic factors from mitochondria to the cytosol. In this report, we investigated, by immunohistofluorescence, the in vivo distributio...

journal_title：Experimental dermatology

authors： Zuliani T,Obriot H,Tual M,Lachman-Weber N,Dumas M,Formstecher P,Polakowska R,Ratinaud MH

更新日期：2008-02-01 00:00:00

abstract：:Card9 is a signalling adaptor protein in the downstream of many innate pattern recognition receptors (PRRs) and exerts a significant role in antifungal immunity. To date, Card9 deficiency has been reported to be related to increased susceptibility to many fungal infections. In this study, we established mucormycosis m...

journal_title：Experimental dermatology

authors： Sun L,Wan Z,Li R,Yu J

更新日期：2019-11-01 00:00:00

abstract：:Recent progress with innovative, experimental gene therapy approaches in animals, and recent improvements in our understanding and manipulation of stem cells, gene expression and gene delivery systems, have raised plenty of hopes in essentially all branches of clinical medicine that hitherto untreatable or poorly mana...

journal_title：Experimental dermatology

authors： Hengge UR,Taichman LB,Kaur P,Rogers G,Jensen TG,Goldsmith LA,Rees JL,Christiano AM

更新日期：1999-10-01 00:00:00

abstract：:SHARPIN is an important component of the linear ubiquitin chain assembly complex (LUBAC). Loss of function of SHARPIN results in eosinophilic inflammation in multiple organs including skin with Th2 -dominant cytokines and dysregulated development of lymphoid tissues in mice. The clinicopathological features are simila...

journal_title：Experimental dermatology

authors： Tang L,Wang J,Zhu J,Liang Y

更新日期：2018-12-01 00:00:00

abstract：:Hair follicle heterogeneity may be regulated by distinct dermal papillae (DP) that represent mesenchymal lineages, which can be defined by Sox2 expression. However, it was recently shown that GFP expression in the Sox2: GFP+/- mouse model occurs in the DPs of all hair follicle types, challenging the idea that hair fol...

journal_title：Experimental dermatology

authors： Salz L,Driskell RR

更新日期：2017-11-01 00:00:00

abstract：:Inherited skin fragility comprises disorders characterized by mechanical induced blistering and erosions within the skin and mucosal membranes as a consequence of mutations in genes encoding proteins involved in intra-epidermal or dermal-epidermal adhesion. As the molecular pathology is largely known, it is a prototyp...

journal_title：Experimental dermatology

authors： Has C,Kiritsi D

更新日期：2015-05-01 00:00:00

abstract：:Despite the lack of protective melanin and increased oxidative stress due to mM concentrations of epidermal H2O2 in vitiligo, there is no significantly increased risk for chronic actinic damage and non-melanoma skin cancer. Therefore the question arises, which protective mechanisms could be involved in the skin of the...

journal_title：Experimental dermatology

authors： Schallreuter KU,Behrens-Williams S,Khaliq TP,Picksley SM,Peters EM,Marles LK,Westerhof W,Miehe B,Fanghänel J

更新日期：2003-06-01 00:00:00

abstract：:The miRNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C-ALCL) patients were analysed with miRNA microarrays using the same control group of 12 benign inflammatory dermatoses (BID) as previously used to study the miRNA expression profile of tumor-stage mycosis fungoide...

journal_title：Experimental dermatology

authors： Benner MF,Ballabio E,van Kester MS,Saunders NJ,Vermeer MH,Willemze R,Lawrie CH,Tensen CP

更新日期：2012-08-01 00:00:00

abstract：:Pemphigus vulgaris (PV) is a regulatory T cell (Treg)-associated autoimmune disease. Treg cells maintain immunosuppression by expressing the signature transcription factor FOXP3. MicroRNAs (miRNAs) have frequently emerged as regulators in Treg-mediated immunosuppression. We previously found that miR-338-3p was overexp...

journal_title：Experimental dermatology

authors： Xu M,Liu Q,Li S,Zhang W,Huang X,Han K,Li C,Zeng K

更新日期：2020-05-09 00:00:00

abstract：:Exposure of the skin to ultraviolet (UV) irradiation induces photoageing through the up-regulation of matrix metalloproteinases (MMPs) and subsequent breakdown of extracellular matrices. Reactive oxygen species (ROS) and epidermal growth factor receptor (EGFR) activation play central roles in UV-induced MMP expression...

journal_title：Experimental dermatology

authors： Park M,Han J,Lee CS,Soo BH,Lim KM,Ha H

更新日期：2013-05-01 00:00:00

abstract：:Electrical stimulation is being used in variable skin therapeutic conditions. There have been clinical studies demonstrating the positive effect of electrical stimuli on hair regrowth. However, the underlying exact mechanism and optimal parameter settings are not clarified yet. To investigate the effects of different ...

journal_title：Experimental dermatology

authors： Sohn KM,Jeong KH,Kim JE,Park YM,Kang H

更新日期：2015-12-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) gene amplification and protein overexpression are common in several cancers. EGFR status has seldom been studied in cutaneous squamous carcinomas (SCCs), or their precursors, actinic keratoses (AKs). We evaluated the presence of EGFR genomic aberrations and EGFR protein overexpr...

journal_title：Experimental dermatology

authors： Toll A,Salgado R,Yébenes M,Martín-Ezquerra G,Gilaberte M,Baró T,Solé F,Alameda F,Espinet B,Pujol RM

更新日期：2010-02-01 00:00:00

abstract：:Mast cells (MCs) have been intensely investigated over the past two decades, e.g. the numbers of PubMed-listed reports on MCs have steadily increased and doubled over the past twenty years. Surprisingly, many recent findings that have fundamentally changed our understanding of MC biology and functions have yet to be s...

journal_title：Experimental dermatology

authors： Maurer M,Metz M

更新日期：2005-12-01 00:00:00

abstract：:The correlation between the degrees of integrity and cohesion in healthy human Stratum corneum (SC) and the properties of the SC lipid matrix could be examined non-invasively in vivo using ATR-FTIR spectroscopy and measurements of pH, conductance, and transepidermal water loss (TEWL) taken in the course of tape-stripp...

journal_title：Experimental dermatology

authors： Berthaud F,Boncheva M

更新日期：2011-03-01 00:00:00

abstract：:The therapeutic hypothesis proposed by Speeckaert and van Geel in this issue (1) is based on the dramatic effects of the new drugs targeting immune privilege checkpoints (PD1/PDL, CTLA4) in current advanced melanoma therapy as major inductors of vitiligo changes in the skin. Such striking clinical manifestations canno...

journal_title：Experimental dermatology

authors： Boniface K,Seneschal J,Taïeb A,Merched A

更新日期：2017-07-01 00:00:00

abstract：:Newborn foreskin and adult skin keratinocytes (KTs) were cultured in 24-well plates using keratinocyte basal medium (KBM) either alone or supplemented with epidermal growth factor (EGF) or nerve growth factor (NGF), plus one of the following: insulin (INS), insulin-like growth factors (IGF)-1 or -2, transforming growt...

journal_title：Experimental dermatology

authors： Wilkinson DI,Theeuwes MJ,Farber EM

更新日期：1994-10-01 00:00:00

abstract：:DECORIN is a prototypical member of the small leucine-rich proteoglycan (SLRP) family that plays important roles in numerous biological processes and cellular biological pathways. We previously showed that Decorin expression was highly enhanced in mouse dorsal hair follicles (HFs) during the anagen phase and was reduc...

journal_title：Experimental dermatology

authors： Zhou L,Jing J,Wang H,Wu X,Lu Z

更新日期：2018-11-01 00:00:00

abstract：:Claudins (Cldn) are the major components of tight junctions (TJs) sealing the paracellular cleft in tissue barriers of various organs. Zebrafish Cldnb, the homolog of mammalian Cldn4, is expressed at epithelial cell-cell contacts and is important for regulating epidermal permeability. The bacterial toxin Clostridium p...

journal_title：Experimental dermatology

authors： Zhang J,Ni C,Yang Z,Piontek A,Chen H,Wang S,Fan Y,Qin Z,Piontek J

更新日期：2015-08-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are thought to have various functions other than RNA silencing. We tried to evaluate the expression of lncRNAs in patients with systemic sclerosis (SSc) and determined whether lncRNAs controls collagen expression in dermal fibroblasts. lncRNA expression was determined by real-time PCR an...

journal_title：Experimental dermatology

authors： Wang Z,Jinnin M,Nakamura K,Harada M,Kudo H,Nakayama W,Inoue K,Nakashima T,Honda N,Fukushima S,Ihn H

更新日期：2016-02-01 00:00:00

abstract：:Subcutaneous mast cells (MCs) are vulnerable to mechanical stimulation from external environment. Thus, MCs immune function could be modulated by their mechanosensitivity. This property has been identified as the trigger mechanism of needling acupuncture, a traditional oriental therapy. Previously we have demonstrated...

journal_title：Experimental dermatology

authors： Shen D,Shen X,Schwarz W,Grygorczyk R,Wang L

更新日期：2020-05-01 00:00:00

abstract：:Nitric oxide (NO) is a potent intercellular mediator of melanogenesis, whereas metallothionein (MT) is an inducible intracellular antioxidant that has been reported to scavenge NO. We investigated the existence and induction of MT in melanocytes, and its inhibitory effect on NO-induced melanogenesis. The expression of...

journal_title：Experimental dermatology

authors： Sasaki M,Kizawa K,Igarashi S,Horikoshi T,Uchiwa H,Miyachi Y

更新日期：2004-08-01 00:00:00

abstract：:Psoriasis is a chronic skin disease caused by immune disorder. The chronic skin inflammation involves inflammatory molecules that are released from T lymphocytes and keratinocytes. Therefore, developing an anti-inflammatory therapy that is suitable for long-term treatment is needed. Electrical stimulation induces biol...

journal_title：Experimental dermatology

authors： Tsurekawa Y,Morita M,Suico MA,Moriuchi M,Nakano Y,Piruzyan M,Takada M,Fukami S,Shuto T,Kai H

更新日期：2018-10-01 00:00:00

abstract：:Ultra-violet B (UVB)-induced oxidative stress crucially perturbs the epidermal homeostasis, and the skin is endowed with protective mechanisms to take action against such damage. Here, we show the possible involvement of t-SNARE protein syntaxin3, a membrane fusion mediator of cytoplasmic vesicles, and which is releas...

journal_title：Experimental dermatology

authors： Miyazaki T,Kadono N,Konishi Y,Hagiwara N,Maekubo K,Hirai Y

更新日期：2013-12-01 00:00:00

abstract：:Epidermal fatty acid-binding protein (E-FABP) is a lipid carrier, originally discovered in human epidermis. We show that E-FABP is almost exclusively expressed in postmitotic (PM) keratinocytes, corresponding to its localization in the highest suprabasal layers, while it is barely expressed in keratinocyte stem cells ...

journal_title：Experimental dermatology

authors： Dallaglio K,Marconi A,Truzzi F,Lotti R,Palazzo E,Petrachi T,Saltari A,Coppini M,Pincelli C

更新日期：2013-04-01 00:00:00