Impairment of Th cell response in Card9 knockout mice with cutaneous mucormycosis caused by Rhizopus arrhizus.

Abstract:

:Card9 is a signalling adaptor protein in the downstream of many innate pattern recognition receptors (PRRs) and exerts a significant role in antifungal immunity. To date, Card9 deficiency has been reported to be related to increased susceptibility to many fungal infections. In this study, we established mucormycosis murine model of Rhizopus arrhizus (R. arrhizus) using wild-type (WT) mice and Card9 knockout (Card9-/- ) mice to investigate the antifungal effect of Card9 against R. arrhizus infection. Card9-/- mice were more susceptible to R. arrhizus infection than WT mice, which could be related to the impaired NF-κB pathway activation, local cytokine production and Th cell responses in Card9-/- mice.

journal_name

Exp Dermatol

journal_title

Experimental dermatology

authors

Sun L,Wan Z,Li R,Yu J

doi

10.1111/exd.14020

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

1244-1251

issue

11

eissn

0906-6705

issn

1600-0625

journal_volume

28

pub_type

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