Vitiligo therapy: restoring immune privilege?

abstract：:Patients with the blistering disease, epidermolysis bullosa (EB), frequently suffer from chronic wounds that become colonized by pathogenic bacteria, such as Staphylococcus aureus. To determine S. aureus colonization rates in patients with EB, swabs were collected from the anterior nares, throats and wounds of 52 Dutc...

journal_title：Experimental dermatology

authors： van der Kooi-Pol MM,Veenstra-Kyuchukova YK,Duipmans JC,Pluister GN,Schouls LM,de Neeling AJ,Grundmann H,Jonkman MF,van Dijl JM

更新日期：2012-06-01 00:00:00

abstract：:Ichthyosis follicularis, alopecia and photophobia (IFAP) syndrome is an X-linked genodermatosis with congenital atrichia being the most prominent feature. Recently, we have shown that functional deficiency of MBTPS2 (membrane-bound transcription factor protease site 2) - a zinc metalloprotease essential for cholestero...

journal_title：Experimental dermatology

authors： Oeffner F,Martinez F,Schaffer J,Salhi A,Monfort S,Oltra S,Neidel U,Bornholdt D,van Bon B,König A,Happle R,Grzeschik KH

更新日期：2011-05-01 00:00:00

abstract：:Dendritic cells (DC) are key elements of the immune system. In peripheral tissues, they function as sentinels taking up and processing antigens. After migration to the draining lymph nodes, the DC either present antigenic peptides by themselves or transfer them to lymph node-resident DC. The skin is the primary interf...

journal_title：Experimental dermatology

authors： Kautz-Neu K,Meyer RG,Clausen BE,von Stebut E

更新日期：2010-08-01 00:00:00

abstract：:NC/Nga mice are known to develop scratching dermatitis akin to atopic dermatitis, under conventional (Conv), but not under the specific-pathogen-free (SPF) condition. In this study, we examined the effects of mechanical-scratching on the spontaneous scratching counts (sign of itching), in relation to the cutaneous pro...

journal_title：Experimental dermatology

authors： Takaoka A,Arai I,Sugimoto M,Futaki N,Sakurai T,Honma Y,Nakaike S

更新日期：2007-04-01 00:00:00

abstract：:Adipose tissue encircles the lower portion of anagen hair follicles and may regulate hair cycle progression. As leptin is a major adipokine, its level of expression from the dermal white adipose tissue during hair cycle progression was studied. The result shows that leptin level is differentially expressed during hair...

journal_title：Experimental dermatology

authors： Yang CC,Sheu HM,Chung PL,Chang CH,Tsai YS,Hughes MW,Tuan TL,Huang LL

更新日期：2015-01-01 00:00:00

abstract：:The high-frequency electrical conductance of tape-stripped human skin in vivo can be used to evaluate the hydration profile of Stratum corneum (SC). Tape-stripping provides access to the underlying SC layers, and the conductance of these layers (as measured by the Skicon instrument) correlates well with their water co...

journal_title：Experimental dermatology

authors： Boncheva M,de Sterke J,Caspers PJ,Puppels GJ

更新日期：2009-10-01 00:00:00

abstract：:The pathogenesis of lichen sclerosus remains unknown. However, it has been frequently associated clinically with autoimmunity. The MHC haplotype A1, B8, DR3 is associated with many autoimmune conditions and has also been associated with the uncommon allele of the tumour necrosis factor (TNF-alpha) promoter polymorphis...

journal_title：Experimental dermatology

authors： Clay FE,Cork MJ,Wilson AG,Crane AM,Lewis F,Harrington CI,Duff GW

更新日期：1996-08-01 00:00:00

abstract：:Wool fibres are hairs and the term 'wool' is usually restricted to describe the fine curly hairs that constitute the fleece produced by sheep. In a broader sense, it can be used to describe the fleeces produced by related species such as goat or yak. Research into the biology of wool growth and the structure of the wo...

journal_title：Experimental dermatology

authors： Rogers GE

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:The accuracy of diagnosis of skin cancer and especially of early malignant melanoma is most important to reduce its morbidity and mortality. Previous pilot studies using electrical impedance measurements indicate statistically significant accuracies for the detection of skin cancer. OBJECTIVES:The aim of th...

journal_title：Experimental dermatology

authors： Aberg P,Birgersson U,Elsner P,Mohr P,Ollmar S

更新日期：2011-08-01 00:00:00

abstract：:Opioids exert major effects not only in the central nervous system but also in immune responses. We investigated the effects of μ-opioid peptides, secreted by tumor cells, on anti-tumor immune responses. For this purpose, tumor growth was studied in wild-type and μ-opioid receptor-deficient (MOR-/-) mice injected with...

journal_title：Experimental dermatology

authors： Boehncke S,Hardt K,Schadendorf D,Henschler R,Boehncke WH,Duthey B

更新日期：2011-01-01 00:00:00

abstract：:For many years, the function of the sebaceous gland (SG) was underestimated and suggested by Albert M. Kligman as a remnant of human development, a 'living fossil with a past but no future'. However, the last two decades of studies and the discovery of neuro-endocrine pathways in skin have determined the importance of...

journal_title：Experimental dermatology

authors： Nejati R,Skobowiat C,Slominski AT

更新日期：2013-10-01 00:00:00

abstract：:White adipose tissue is known to be involved in numerous physiological processes such as insulin-mediated functions, lipid and glucose metabolism, vascular changes and coagulation. These processes are mainly mediated by adipokines that are secreted either from adipocytes or cells of the stromal-vascular fraction of ad...

journal_title：Experimental dermatology

authors： Gerdes S,Osadtschy S,Rostami-Yazdi M,Buhles N,Weichenthal M,Mrowietz U

更新日期：2012-01-01 00:00:00

abstract：:Activating transcription factor 3 (ATF3) expression is increased in erythema multiforme and is regulated by IFN-gamma in human keratinocytes. Experimental Dermatology 2010; 19: e310-e313. Abstract: Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP responsive element-binding protein (CREB) fami...

journal_title：Experimental dermatology

authors： Pollack BP,Sapkota B,Haun PL

更新日期：2010-08-01 00:00:00

abstract：:Bullous pemphigoid (BP) and pemphigoid gestationis (PG) are acquired autoimmune subepidermal blistering diseases characterized by autoantibodies against the hemidesmosomal proteins BP180/type XVII collagen and BP230. In the vast majority of BP and PG patients, these autoantibodies bind to epitopes clustered within the...

journal_title：Experimental dermatology

authors： Sitaru C,Dähnrich C,Probst C,Komorowski L,Blöcker I,Schmidt E,Schlumberger W,Rose C,Stöcker W,Zillikens D

更新日期：2007-09-01 00:00:00

abstract：:Dermatitis herpetiformis (DH) is a blistering skin disease characterized by cutaneous deposits of IgA and an associated, most often asymptomatic, gluten sensitive enteropathy (GSE). Gluten sensitive enteropathy is also seen in patients that do not have skin disease or cutaneous IgA deposits, but do have significant ga...

journal_title：Experimental dermatology

authors： Hall RP 3rd,Owen S,Smith A,Keough M,Bagheri B,Church P,Streilein R

更新日期：2000-08-01 00:00:00

abstract：:Glycyrrhizic acid (GA), a natural triterpene, has received attention as an agent that has protective effects against chronic diseases including ultraviolet UV-B-induced skin photodamage. However, the mechanism of its protective effect remains elusive. Here, we used an immortalized human keratinocyte cell line (HaCaT) ...

journal_title：Experimental dermatology

authors： Afnan Q,Kaiser PJ,Rafiq RA,Nazir LA,Bhushan S,Bhardwaj SC,Sandhir R,Tasduq SA

更新日期：2016-06-01 00:00:00

abstract：:Cowden syndrome (CS) is an autosomal dominant inherited disorder characterized by hamartomas in a variety of tissues including the skin, thyroid, breast, endometrium, and the brain. Individuals with CS are predisposed to development of malignancy in these organs, especially the breast and the thyroid. We describe 3 un...

journal_title：Experimental dermatology

authors： Celebi JT,Ping XL,Zhang H,Remington T,Sulica VI,Tsou HC,Peacocke M

更新日期：2000-04-01 00:00:00

abstract：:Despite recent success in melanoma therapy, most patients with metastatic disease still undergo deadly progression. We have identified a novel mechanism of multidrug resistance allowing a small subpopulation of slow-cycling melanoma cells to survive based on elevated oxidative bioenergy metabolism. In this study, we a...

journal_title：Experimental dermatology

authors： Cierlitza M,Chauvistré H,Bogeski I,Zhang X,Hauschild A,Herlyn M,Schadendorf D,Vogt T,Roesch A

更新日期：2015-02-01 00:00:00

abstract：:It is not clear whether TNF-α antagonists used in the treatment of psoriasis need to act systemically, or whether local inhibition of skin-produced TNF-α would be sufficient to silence skin inflammation. To answer this question, we conducted two multicentre, double-blinded, randomized, placebo-controlled clinical tria...

journal_title：Experimental dermatology

authors： Tsianakas A,Brunner PM,Ghoreschi K,Berger C,Loser K,Röcken M,Stingl G,Luger T,Jung T

更新日期：2016-06-01 00:00:00

abstract：:Inflammation is a crucial step in the development of allergic contact dermatitis. The primary contact with chemical allergens, called sensitization, and the secondary contact, called elicitation, result in an inflammatory response in the skin. The ability of contact allergens to induce allergic contact dermatitis corr...

journal_title：Experimental dermatology

authors： Lass C,Merfort I,Martin SF

更新日期：2010-11-01 00:00:00

abstract：:The presence of albumin in the human epidermis has been reported more than a decade ago, but until now, it was assumed that this protein is synthesized in the liver and transported to the avascular skin. To our knowledge, transcription of albumin in the human epidermis was never considered. In this report, we present ...

journal_title：Experimental dermatology

authors： Hasse S,Kothari S,Rokos H,Kauser S,Schürer NY,Schallreuter KU

更新日期：2005-03-01 00:00:00

abstract：:Pheomelanin is supposed to be the first type of melanin found in vertebrates, in contrast to the main type - eumelanin. Our study aimed at detecting pheomelanin in the skin of Hymenochirus boettgerii. We employed electron paramagnetic resonance (EPR) spectroscopy, and transmission electron microscopy (TEM), supplement...

journal_title：Experimental dermatology

authors： Wolnicka-Glubisz A,Pecio A,Podkowa D,Kolodziejczyk LM,Plonka PM

更新日期：2012-07-01 00:00:00

abstract：:The early growth response (Egr)-1 is a transcriptional factor which plays an important role in the regulation of cell growth, differentiation, cell survival and immune responses. Emerging evidences including our data demonstrate that the Egr-1 expression is up-regulated in the psoriatic skin lesions. The purpose of th...

journal_title：Experimental dermatology

authors： Jeong SH,Kim HJ,Jang Y,Ryu WI,Lee H,Kim JH,Bae HC,Choi JE,Kye YC,Son SW

更新日期：2014-12-01 00:00:00

abstract：:Exposure of the skin to ultraviolet (UV) irradiation induces photoageing through the up-regulation of matrix metalloproteinases (MMPs) and subsequent breakdown of extracellular matrices. Reactive oxygen species (ROS) and epidermal growth factor receptor (EGFR) activation play central roles in UV-induced MMP expression...

journal_title：Experimental dermatology

authors： Park M,Han J,Lee CS,Soo BH,Lim KM,Ha H

更新日期：2013-05-01 00:00:00

abstract：:Malignant melanoma is a tumor characterized by the uncontrolled proliferation of melanocytes, mainly in skin, but also in eyes. Its incidence is rising each year. To improve the diagnosis and treatment of the tumor, it is essential to develop new effective methods to early detect and characterize melanoma. Previously,...

journal_title：Experimental dermatology

authors： Godechal Q,Leveque P,Marot L,Baurain JF,Gallez B

更新日期：2012-05-01 00:00:00

abstract：:Volatile organic compounds emitted by human skin were sampled before and after acute barrier disruption of the volar forearm to investigate the significance of this approach to skin physiology research. A small wearable housing integrating a solid-phase micro-extraction fibre permitting rapid enclosed headspace sampli...

journal_title：Experimental dermatology

authors： Duffy E,Jacobs MR,Kirby B,Morrin A

更新日期：2017-10-01 00:00:00

abstract：:Reverse transcription polymerase chain reaction (qRT-PCR) has become a mainstay in many areas of skin research. To enable quantitative analysis, it is necessary to analyse expression of reference genes (RGs) for normalization of target gene expression. The selection of reliable RGs therefore has an important impact on...

journal_title：Experimental dermatology

authors： Beer L,Mlitz V,Gschwandtner M,Berger T,Narzt MS,Gruber F,Brunner PM,Tschachler E,Mildner M

更新日期：2015-10-01 00:00:00

abstract：:There have been few reports of successful long-term culture of cells established from cutaneous basal cell carcinoma (BCC) tumors. Here, we describe techniques that have enabled us to establish three long-term cultures of BCC cells isolated from BCC tumors that arose in irradiated Patched 1 (Ptch1)(+/-) mice. All thre...

journal_title：Experimental dermatology

authors： So PL,Langston AW,Daniallinia N,Hebert JL,Fujimoto MA,Khaimskiy Y,Aszterbaum M,Epstein EH Jr

更新日期：2006-09-01 00:00:00

abstract：:Reactive skin is characterized by marked sensitivity to physical (heat, cold, wind) or chemical (topically applied products) stimuli and by the impairment of the skin barrier's ability to repair itself. Several lines of evidence suggest that beyond their capacity to positively influence the composition of intestinal m...

journal_title：Experimental dermatology

authors： Guéniche A,Bastien P,Ovigne JM,Kermici M,Courchay G,Chevalier V,Breton L,Castiel-Higounenc I

更新日期：2010-08-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are thought to have various functions other than RNA silencing. We tried to evaluate the expression of lncRNAs in patients with systemic sclerosis (SSc) and determined whether lncRNAs controls collagen expression in dermal fibroblasts. lncRNA expression was determined by real-time PCR an...

journal_title：Experimental dermatology

authors： Wang Z,Jinnin M,Nakamura K,Harada M,Kudo H,Nakayama W,Inoue K,Nakashima T,Honda N,Fukushima S,Ihn H

更新日期：2016-02-01 00:00:00