E-FABP induces differentiation in normal human keratinocytes and modulates the differentiation process in psoriatic keratinocytes in vitro.

abstract：:There are few contradictory studies investigating the involvement of HPV in melanoma. We designed a controlled study to evaluate the HPV DNA prevalence in melanoma. One hundred patients with cutaneous malignant melanoma diagnosed between 2002 and 2006 were included. Complementary wide excision (healthy skin) was perfo...

journal_title：Experimental dermatology

authors： Ruer JB,Pépin L,Gheit T,Vidal C,Kantelip B,Tommasino M,Prétet JL,Mougin C,Aubin F

更新日期：2009-10-01 00:00:00

abstract：:Using in situ hybridization, human hair keratin basic 1 (hHb1) gene expression was investigated in human normal scalp. hHb1 transcripts were specifically detected in the cortical cells of hair shaft but neither in the outer and inner root sheaths, nor in the hair cuticle or the medulla. hHb1 expression was detected st...

journal_title：Experimental dermatology

authors： Régnier CH,Asch PH,Grosshans E,Rio MC

更新日期：1997-04-01 00:00:00

abstract：:Responses to acetylcholine (ACh) and vasoactive intestinal polypeptide (VIP) were investigated in atopic eczema (AE) patients. To elucidate the involvement of histamine to ACh-provoked vasoreactions and sensations, we applied a selective H1-antagonist (cetirizine) 3 h prior to the ACh-administration. Solutions of acet...

journal_title：Experimental dermatology

authors： Rukwied R,Heyer G

更新日期：1999-02-01 00:00:00

abstract：:Epidermolytic hyperkeratosis (EHK) is a hereditary skin disorder typified by blistering due to cytolysis. One in 100,000 individuals is affected by this autosomal-dominant disease. The onset of the disease phenotype is typically at birth. Histological and ultrastructural examination of the epidermis shows a thickened ...

journal_title：Experimental dermatology

authors： Arin MJ,Longley MA,Epstein EH Jr,Rothnagel JA,Roop DR

更新日期：2000-02-01 00:00:00

abstract：:Inter-α-trypsin inhibitors are protease inhibitors that are thought to be important regulators in various acute-phase processes. They are composed of one light chain (bikunin) and different heavy chains (ITIHs). The only function known so far of ITIHs is the covalent linkage to hyaluronan (HA). As there is virtually n...

journal_title：Experimental dermatology

authors： Huth S,Heise R,Vetter-Kauczok CS,Skazik C,Marquardt Y,Czaja K,Knüchel R,Merk HF,Dahl E,Baron JM

更新日期：2015-09-01 00:00:00

abstract：:The presence of albumin in the human epidermis has been reported more than a decade ago, but until now, it was assumed that this protein is synthesized in the liver and transported to the avascular skin. To our knowledge, transcription of albumin in the human epidermis was never considered. In this report, we present ...

journal_title：Experimental dermatology

authors： Hasse S,Kothari S,Rokos H,Kauser S,Schürer NY,Schallreuter KU

更新日期：2005-03-01 00:00:00

abstract：:Pimecrolimus (SDZ ASM981) is a non-steroid member of calcineurin inhibitors recently developed for the treatment of inflammatory skin diseases. In this study, we compared the effect of pimecrolimus and corticosteroids on the differentiation, maturation and function of murine bone marrow-derived dendritic cells (BM-DC)...

journal_title：Experimental dermatology

authors： Krummen MB,Varga G,Steinert M,Stuetz A,Luger TA,Grabbe S

更新日期：2006-01-01 00:00:00

abstract：:The generation of a robust CD8(+) cytotoxic T lymphocyte (CTL) response is a key feature of many immunotherapeutic strategies against epithelial tumors and virally infected epithelial tissue. However, surprisingly few studies have addressed whether primary epithelial cells, expressing defined endogenous antigens, are ...

journal_title：Experimental dermatology

authors： Zhou F,Frazer IH,Leggatt GR

更新日期：2009-12-01 00:00:00

abstract：:Using the indirect immunohistochemical approach, the occurrence of gamma-melanocyte stimulating hormone (gamma-MSH)-like immunoreactivity in human normal keratinocytes is described. The positive cells were observed in each layer of the epidermis (except stratum corneum) and often, at the level of the stratum spinosum,...

journal_title：Experimental dermatology

authors： Johansson O,Liu PY

更新日期：1993-10-01 00:00:00

abstract：:In mammals, the skin can form complex global and local patterns to meet diverse functional requirements in different parts of the body. To date, the fundamental principles that underlie skin patterning remain poorly understood because of the involvement of multiple interacting processes. Genes involved in the planar c...

journal_title：Experimental dermatology

authors： Chen J,Chuong CM

更新日期：2012-02-01 00:00:00

abstract：:Shprintzen-Goldberg syndrome (SGS) is a rare disorder characterized by a Marfan-like habitus, mental retardation and craniosynostosis. Cardiac abnormalities, such as aortic root dilation have also been noted as well as several skeletal abnormalities. Its nosological status is unclear as it is hard to delineate SGS fro...

journal_title：Experimental dermatology

authors： van Steensel MA,van Geel M,Parren LJ,Schrander-Stumpel CT,Marcus-Soekarman D

更新日期：2008-04-01 00:00:00

abstract：:The adoptive transfer of engineered T cells represents an important approach in immunotherapy of melanoma. However, relapse of the tumor can occur due to immune-escape mechanisms developed by the tumor cells, for example antigen loss, downregulation of the major histocompatibility complex presentation machinery and de...

journal_title：Experimental dermatology

authors： Uslu U,Schuler G,Dörrie J,Schaft N

更新日期：2016-11-01 00:00:00

abstract：:C1 inhibitor (C1INH) plays an important role in the classical pathway of the complement system. Mutations in C1INH gene cause quantitative or qualitative deficiencies in C1INH, which can lead to hereditary angioedema (HAE) type I or II. Here, we identified a novel frame-shift mutation c.1391-1445del55 (p.v464fsx556) i...

journal_title：Experimental dermatology

authors： Qu L,Wei B,Liu M,Zhang L,Xiao T,Chen HD,Zhou L,Mi QS,He C

更新日期：2012-10-01 00:00:00

abstract：:The anti-inflammatory mechanisms of adapalene, a synthetic retinoid used for the treatment of acne patients, are partially understood. They seem particularly related to the modulation of the non-specific immunity. Recent studies have shown that Toll-like receptor (TLR)-2 expression, a receptor of the innate immune sys...

journal_title：Experimental dermatology

authors： Tenaud I,Khammari A,Dreno B

更新日期：2007-06-01 00:00:00

abstract：:Canine atopic dermatitis (AD), a chronic inflammatory skin disease, shares characteristics with its human counterpart. To get insight into the role of enzymes involved in production of prostaglandin E(2) (PGE2) and leukotriene B(4) (LTB(4)), potent inflammatory mediators originating from membrane-derived arachidonic a...

journal_title：Experimental dermatology

authors： Schlotter YM,Riemers FM,Rutten VP,Knol EF,Willemse T

更新日期：2010-08-01 00:00:00

abstract：:Antibodies, specific to murine DEC205, can be used to target antigens to dendritic cells. The immunodominant domain of human type XVII collagen, hNC16A, was fused to this antibody (DEC-hNC16A) and was administered as expression plasmid by gene gun transfection with the aim of inducing tolerance to human type XVII coll...

journal_title：Experimental dermatology

authors： Ettinger M,Gratz IK,Gruber C,Hauser-Kronberger C,Johnson TS,Mahnke K,Thalhamer J,Hintner H,Peckl-Schmid D,Bauer JW

更新日期：2012-05-01 00:00:00

abstract：:We investigated the effects of a single dose of mouse interleukin-31 (IL-31) on scratching behaviour in comparison with spontaneous skin-lesion- or serotonin (5-HT)- induced scratching behaviour in NC/Nga and BALB/c mice. Intradermal (i.d.) injection of IL-31 caused a gradual increase in long-lasting scratching (LLS, ...

journal_title：Experimental dermatology

authors： Arai I,Tsuji M,Takeda H,Akiyama N,Saito S

更新日期：2013-10-01 00:00:00

abstract：:In this study, we determined the adiponectin expression in the serum and lesional skin of patients with scleroderma (SSc). Serum adiponectin concentrations were measured in 32 patients with SSc, 10 patients with SLE, 12 patients with dermatomyositis patients and 13 healthy subjects with specific enzyme-linked immunoso...

journal_title：Experimental dermatology

authors： Arakawa H,Jinnin M,Muchemwa FC,Makino T,Kajihara I,Makino K,Honda N,Sakai K,Fukushima S,Ihn H

更新日期：2011-09-01 00:00:00

abstract：:Psoriasis is now considered to be a chronic, immune-mediated and inflammatory skin disease. As the precise cause of psoriasis remains unknown, its treatment is challenging for dermatologists. Keratin 17 (K17), an intermediate filament protein, is highly expressed in psoriatic lesions, while not normally expressed in h...

journal_title：Experimental dermatology

authors： Chang T,Sun L,Wang Y,Wang D,Li W,Li C,Gao T,Liu Y,Wang G

更新日期：2011-07-01 00:00:00

abstract：:Psoriasis is a chronic inflammatory disease, and microRNAs have been reported to regulate the pathogenesis of psoriasis. Up-regulated miR-744-3p level was identified to associate with psoriasis while the precise functions of miR-744-3p in psoriasis were not well-elucidated. We first confirmed the up-regulation of miR-...

journal_title：Experimental dermatology

authors： Wang C,Zong J,Li Y,Wang X,Du W,Li L

更新日期：2019-03-01 00:00:00

abstract：:Nitric oxide (NO) is a potent intercellular mediator of melanogenesis, whereas metallothionein (MT) is an inducible intracellular antioxidant that has been reported to scavenge NO. We investigated the existence and induction of MT in melanocytes, and its inhibitory effect on NO-induced melanogenesis. The expression of...

journal_title：Experimental dermatology

authors： Sasaki M,Kizawa K,Igarashi S,Horikoshi T,Uchiwa H,Miyachi Y

更新日期：2004-08-01 00:00:00

abstract：:T cells play a major role in inflammatory skin disorders such as psoriasis vulgaris and atopic dermatitis. They are both active on the level of cell-to-cell interaction and by the secretion of pro-inflammatory mediators. CD26 is a lymphocyte membrane-associated dipeptidyl peptidase IV (DPP IV), which is able to inacti...

journal_title：Experimental dermatology

authors： Bock O,Kreiselmeyer I,Mrowietz U

更新日期：2001-12-01 00:00:00

abstract：:Hair follicle heterogeneity may be regulated by distinct dermal papillae (DP) that represent mesenchymal lineages, which can be defined by Sox2 expression. However, it was recently shown that GFP expression in the Sox2: GFP+/- mouse model occurs in the DPs of all hair follicle types, challenging the idea that hair fol...

journal_title：Experimental dermatology

authors： Salz L,Driskell RR

更新日期：2017-11-01 00:00:00

abstract：:Bullous pemphigoid (BP) and pemphigoid gestationis (PG) are acquired autoimmune subepidermal blistering diseases characterized by autoantibodies against the hemidesmosomal proteins BP180/type XVII collagen and BP230. In the vast majority of BP and PG patients, these autoantibodies bind to epitopes clustered within the...

journal_title：Experimental dermatology

authors： Sitaru C,Dähnrich C,Probst C,Komorowski L,Blöcker I,Schmidt E,Schlumberger W,Rose C,Stöcker W,Zillikens D

更新日期：2007-09-01 00:00:00

abstract：:Human dermal fibroblasts (HDFs) regulate wound-healing processes in human skin, including the regeneration of skin sensory fibres, in response to various mechanical stimuli. Because nerve growth factor (NGF) has an essential role in sensory regeneration, we evaluated the possible association of NGF with mechanical sti...

journal_title：Experimental dermatology

authors： Kim M,Shin DW,Shin H,Noh M,Shin JH

更新日期：2013-01-01 00:00:00

abstract：:Leukotrienes constitute a group of lipid mediators, which may be subdivided into two groups, with leukotriene B4 on the one hand and cysteinyl leukotrienes on the other. Although leukotrienes are abundantly expressed in skin affected by diverse chronic inflammatory diseases, including atopic dermatitis, psoriasis, pem...

journal_title：Experimental dermatology

authors： Sadik CD,Sezin T,Kim ND

更新日期：2013-11-01 00:00:00

abstract：:We have characterized a stereospecific transport mechanism for L-dopa into human epidermal Langerhans cells (LCs). It is different from any other amino acid transport system. It is highly concentrative, largely pH-independent, and independent of exogenous Na+, glucose and oxygen, and fuelled by a renewable intracellul...

journal_title：Experimental dermatology

authors： Falck B,Bendsoe N,Ronquist G

更新日期：2003-10-01 00:00:00

abstract：:Ultraviolet B (UVB) radiation induces inflammation in the skin specifically at the site of exposure. We unexpectedly found that UVB-induced inflammation was not induced in gp91phox-depleted mice. To test whether gp91phox is directly involved in UVB-induced inflammation, neutrophil- and hyaluronic acid-depleted mice we...

journal_title：Experimental dermatology

authors： Hiramoto K,Kobayashi H,Yamate Y,Ishii M,Sato EF

更新日期：2012-12-01 00:00:00

abstract：:Psychological factors are believed to play a role in the pathogenesis of alopecia areata (AA), a frequently encountered hair disorder. In our study, statistically significant elevation of psychological stress was felt by AA patients prior hair loss compared with control, which was strongly believed contributory to hai...

journal_title：Experimental dermatology

authors： Kim HS,Cho DH,Kim HJ,Lee JY,Cho BK,Park HJ

更新日期：2006-07-01 00:00:00

abstract：:An ex vivo porcine skin model was utilized to analyse the penetration of 5-aminolevulinic acid (5-ALA) contained in a nanoemulsion-based formulation BF-200 ALA (10% 5-ALA-hydrochloride) versus 16% aminolevulinate methyl ester-hydrochloride in a commercially cream (MAL cream) by fluorescence microscopy of their common ...

journal_title：Experimental dermatology

authors： Maisch T,Santarelli F,Schreml S,Babilas P,Szeimies RM

更新日期：2010-08-01 00:00:00