In vivo and in vitro evidence for autocrine DCoH/HNF-1alpha transcription of albumin in the human epidermis.

abstract：:Long non-coding RNAs (lncRNAs) are thought to have various functions other than RNA silencing. We tried to evaluate the expression of lncRNAs in patients with systemic sclerosis (SSc) and determined whether lncRNAs controls collagen expression in dermal fibroblasts. lncRNA expression was determined by real-time PCR an...

journal_title：Experimental dermatology

authors： Wang Z,Jinnin M,Nakamura K,Harada M,Kudo H,Nakayama W,Inoue K,Nakashima T,Honda N,Fukushima S,Ihn H

更新日期：2016-02-01 00:00:00

abstract：:The role of angiogenesis in tumour growth and metastasis is well established. However, investigations of tumour microcirculation to date have used either biopsy material from human tumours, or animal models in vivo. We have studied the tumour microcirculation in vivo in human skin cancers using video-microscopy to exa...

journal_title：Experimental dermatology

authors： Bedlow AJ,Stanton AW,Cliff S,Mortimer PS

更新日期：1999-06-01 00:00:00

abstract：:There have been several studies on the role of the monocyte chemotactic protein-1/C-C chemokine receptor type 2 (CCR2) signalling pathway in fibrotic diseases, which identified the blockade of this pathway as a potential therapeutic target for treating fibrosis. We examined the efficacy of CCR2 antagonist (RS-504393) ...

journal_title：Experimental dermatology

authors： Ishikawa M,Yamamoto T

更新日期：2021-01-01 00:00:00

abstract：:DECORIN is a prototypical member of the small leucine-rich proteoglycan (SLRP) family that plays important roles in numerous biological processes and cellular biological pathways. We previously showed that Decorin expression was highly enhanced in mouse dorsal hair follicles (HFs) during the anagen phase and was reduc...

journal_title：Experimental dermatology

authors： Zhou L,Jing J,Wang H,Wu X,Lu Z

更新日期：2018-11-01 00:00:00

abstract：:Terence Kealey first pioneered the isolation and organ maintenance of human eccrine and sebaceous glands in the early to mid-1980. This led to subsequent methods describing the isolation and culture of human hair follicles, the human pilosebaceous unit as well as the sebaceous duct. The importance of these models in t...

journal_title：Experimental dermatology

authors： Philpott MP

更新日期：2018-05-01 00:00:00

abstract：:We aimed to evaluate the effect of small interfering RNA (siRNA) targeting CTGF on extracellular matrices (ECMs) metabolism in normal and SSc fibroblasts. Normal and SSc fibroblasts were transfected with CTGF-specific siRNAs to silence CTGF synthesis. After silencing CTGF, production of type I collagen and matrix meta...

journal_title：Experimental dermatology

authors： Ishibuchi H,Abe M,Yokoyama Y,Ishikawa O

更新日期：2010-08-01 00:00:00

abstract：:Mast cells (MCs) have been intensely investigated over the past two decades, e.g. the numbers of PubMed-listed reports on MCs have steadily increased and doubled over the past twenty years. Surprisingly, many recent findings that have fundamentally changed our understanding of MC biology and functions have yet to be s...

journal_title：Experimental dermatology

authors： Maurer M,Metz M

更新日期：2005-12-01 00:00:00

abstract：:Quercetin, glycosylated form of flavonoid compound, has potent antioxidant and anti-inflammatory properties. In this study, we have investigated the effects of quercetin on skin lesion, high-mobility group box (HMGB)1 cascade signalling and inflammation in atopic dermatitis (AD) mouse model. AD-like lesion was induced...

journal_title：Experimental dermatology

authors： Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Nomoto M,Miyashita S,Suzuki K,Nakamura M,Watanabe K

更新日期：2015-06-01 00:00:00

abstract：:Psoriasis is a chronic skin disease that affects about 1.5% of the Caucasian population and is characterized by typical macroscopic and microscopic skin alterations. Psoriatic lesions are sharply demarcated, red and slightly raised lesions with silver-whitish scales. The microscopic alterations of psoriatic plaques in...

journal_title：Experimental dermatology

authors： Sabat R,Philipp S,Höflich C,Kreutzer S,Wallace E,Asadullah K,Volk HD,Sterry W,Wolk K

更新日期：2007-10-01 00:00:00

abstract：:Chronic exposure to ultraviolet (UV) radiation alters components of the skin. We previously reported that chronic low-dose UV irradiation induced wrinkle formation but did not significantly alter dermal components of hairless mice. In the present study, we examined whether the epidermal changes by UV irradiation could...

journal_title：Experimental dermatology

authors： Kambayashi H,Odake Y,Takada K,Funasaka Y,Ichihashi M

更新日期：2003-01-01 00:00:00

abstract：:Despite recent success in melanoma therapy, most patients with metastatic disease still undergo deadly progression. We have identified a novel mechanism of multidrug resistance allowing a small subpopulation of slow-cycling melanoma cells to survive based on elevated oxidative bioenergy metabolism. In this study, we a...

journal_title：Experimental dermatology

authors： Cierlitza M,Chauvistré H,Bogeski I,Zhang X,Hauschild A,Herlyn M,Schadendorf D,Vogt T,Roesch A

更新日期：2015-02-01 00:00:00

abstract：:Keloid is a dermal proliferative disorder characterized by the excessive proliferation and migration of keratinocytes and fibroblasts. Over-activation of the serine/threonine protein kinase, mammalian target of rapamycin (mTOR), plays a pivotal role in the process. Here, we show that both mTOR complex 1 (mTORC1) and m...

journal_title：Experimental dermatology

authors： Chen J,Liu K,Liu Y,Wang X,Zhang Z

更新日期：2019-03-01 00:00:00

abstract：:Solar ultraviolet (UV) radiation has hazardous effects on human health that are, in part, associated with its immunosuppressive effects via the induction of interleukin (IL)-10 production. Although IL-10 is produced by both T helper type 2 (Th2) cells and T-regulatory type 1 (Tr1) cells, the relative contribution of e...

journal_title：Experimental dermatology

authors： Stoebner PE,Rahmoun M,Ferrand C,Meunier L,Yssel H,Pène J

更新日期：2006-08-01 00:00:00

abstract：:Seasonal variations can be found in almost any parameter of an organism's biochemistry, physiology, endocrinology, and behaviour. This phenomenon, generally called photoperiodism, results from one of the major functions of the circadian system, i.e. the translation of environmental information into rhythmic intraorgan...

journal_title：Experimental dermatology

authors： Lang R,Hintner H,Hermann A,Brandstaetter R

更新日期：2003-08-01 00:00:00

abstract：:Psoriasis is a chronic skin disease that results in red and scaly lesions. Several psoriasis susceptibility loci have been identified across the genome, of which PSORS1 on 6p21.3 is predominant. There is an ongoing debate regarding whether the HLA-C allele, Cw*0602, can be considered the major predisposing factor in t...

journal_title：Experimental dermatology

authors： Holm SJ,Carlén LM,Mallbris L,Ståhle-Bäckdahl M,O'Brien KP

更新日期：2003-08-01 00:00:00

abstract：:Itch is often regarded as unpleasant or bothersome and is accompanied by symptoms of distress and impairments in daily life. The biopsychosocial model of chronic itch describes how psychological factors can contribute to the improvement or exacerbation of chronic itch and related scratching behaviour. Recent research ...

journal_title：Experimental dermatology

authors： Evers AWM,Peerdeman KJ,van Laarhoven AIM

更新日期：2019-12-01 00:00:00

abstract：:Optical coherence tomography (OCT) is a novel non-invasive imaging technique for in vivo histologic characterization of tissues. Besides pure morphology, additional functional parameters of the tissue investigated can be evaluated at the same time, such as the refractive index and the scattering coefficient. The purpo...

journal_title：Experimental dermatology

authors： de Giorgi V,Stante M,Massi D,Mavilia L,Cappugi P,Carli P

更新日期：2005-01-01 00:00:00

abstract：:The expansive use of immunosuppressive medications in fields such as transplantational medicine and oncology, the higher frequency of invasive procedures in an ageing population and the HIV/AIDS pandemic have increased the frequency of systemic fungal infections. At the same time, increased resistance of pathogenic fu...

journal_title：Experimental dermatology

authors： Mehra T,Köberle M,Braunsdorf C,Mailänder-Sanchez D,Borelli C,Schaller M

更新日期：2012-10-01 00:00:00

abstract：:Tropisetron is a serotonin receptor (5-HT-R)-modulating agent and approved as an antiemetic for patients undergoing chemotherapy. In the gut, it acts via specific serotonin receptors, 5-HT3 -R, to elicit its beneficial effects against nausea. We investigated whether tropisetron can affect inflammatory cell responses o...

journal_title：Experimental dermatology

authors： Stegemann A,Böhm M

更新日期：2019-03-01 00:00:00

abstract：:Patients with the blistering disease, epidermolysis bullosa (EB), frequently suffer from chronic wounds that become colonized by pathogenic bacteria, such as Staphylococcus aureus. To determine S. aureus colonization rates in patients with EB, swabs were collected from the anterior nares, throats and wounds of 52 Dutc...

journal_title：Experimental dermatology

authors： van der Kooi-Pol MM,Veenstra-Kyuchukova YK,Duipmans JC,Pluister GN,Schouls LM,de Neeling AJ,Grundmann H,Jonkman MF,van Dijl JM

更新日期：2012-06-01 00:00:00

abstract：:The miRNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C-ALCL) patients were analysed with miRNA microarrays using the same control group of 12 benign inflammatory dermatoses (BID) as previously used to study the miRNA expression profile of tumor-stage mycosis fungoide...

journal_title：Experimental dermatology

authors： Benner MF,Ballabio E,van Kester MS,Saunders NJ,Vermeer MH,Willemze R,Lawrie CH,Tensen CP

更新日期：2012-08-01 00:00:00

abstract：:Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well-known corticosteroid treatments, H1 receptor (H1R) antagonists also have been used. This study observed effects of histamine H4 receptor (H4R) antagonist usage with H1R antagonist in a murine chronic...

journal_title：Experimental dermatology

authors： Matsushita A,Seike M,Okawa H,Kadawaki Y,Ohtsu H

更新日期：2012-09-01 00:00:00

abstract：:Dermal mast cells protect the skin from inflammatory effects of ultraviolet (UV) radiation and are required for UV-induced immune suppression. We sought to determine a potential mechanistic role of mast cells in reducing the sensitivity to UV radiation (i.e. phototolerance induction) through photohardening. We adminis...

journal_title：Experimental dermatology

authors： Schweintzger NA,Bambach I,Reginato E,Mayer G,Limón-Flores AY,Ullrich SE,Byrne SN,Wolf P

更新日期：2015-07-01 00:00:00

abstract：:Sangre de drago (SD) is a viscous bright red resin collected from Croton lechleri trees that grow in the South American jungle. This sap is used extensively in the native pharmacopoeia to treat skin disorders. Its effectiveness as an inhibitor of neurogenic inflammation has been recently demonstrated. To understand th...

journal_title：Experimental dermatology

authors： Pereira U,Garcia-Le Gal C,Le Gal G,Boulais N,Lebonvallet N,Dorange G,Lefeuvre L,Gougerot A,Misery L

更新日期：2010-09-01 00:00:00

abstract：:Newborn foreskin and adult skin keratinocytes (KTs) were cultured in 24-well plates using keratinocyte basal medium (KBM) either alone or supplemented with epidermal growth factor (EGF) or nerve growth factor (NGF), plus one of the following: insulin (INS), insulin-like growth factors (IGF)-1 or -2, transforming growt...

journal_title：Experimental dermatology

authors： Wilkinson DI,Theeuwes MJ,Farber EM

更新日期：1994-10-01 00:00:00

abstract：:Chimeric antigen receptor (CAR)-T cells are one of the impressive recent success stories of anti-cancer immunotherapy. Especially in haematological malignancies, this treatment strategy has shown promising results leading to the recent approval of two CAR-T cell constructs targeting CD19 in the United States and the E...

journal_title：Experimental dermatology

authors： Simon B,Uslu U

更新日期：2018-12-01 00:00:00

abstract：:Epidermolytic hyperkeratosis (EHK) is a hereditary skin disorder typified by blistering due to cytolysis. One in 100,000 individuals is affected by this autosomal-dominant disease. The onset of the disease phenotype is typically at birth. Histological and ultrastructural examination of the epidermis shows a thickened ...

journal_title：Experimental dermatology

authors： Arin MJ,Longley MA,Epstein EH Jr,Rothnagel JA,Roop DR

更新日期：2000-02-01 00:00:00

abstract：:This study was stimulated by the clinical observation of a rapid response of a chilblain lupus patient to treatment with JAK1/2-kinase inhibitor ruxolitinib. We investigated the in vivo expression of phospho-JAK2 in CLE skin samples as well as the immunomodulatory in vitro effect of ruxolitinib in cultured immortalize...

journal_title：Experimental dermatology

authors： Klaeschen AS,Wolf D,Brossart P,Bieber T,Wenzel J

更新日期：2017-08-01 00:00:00

abstract：:Patients sensitized to para-phenylenediamine (PPD) by semi-permanent tattoos increasingly develop threatening allergic reactions in response to black hair dye. The gold standard to diagnose allergic contact dermatitis is to perform epicutaneous patch tests, however, iatrogenic sensitizations and severe patch test reac...

journal_title：Experimental dermatology

authors： Kneilling M,Caroli U,Grimmel C,Fischer J,Eichner M,Wieder T,Maier FC,Röcken M,Biedermann T

更新日期：2010-05-01 00:00:00

abstract：:We have shown previously in psoriasis a very high prevalence of epidermodysplasia verruciforms-associated human papillomavirus 5 (EVHPV5) DNA and antibodies to human papillomavirus 5 (HPV5) virus-like particle (VLP) L1, and we suggested that this benign hyperproliferative disorder could be a reservoir for EVHPVs. Here...

journal_title：Experimental dermatology

authors： Majewski S,Jablonska S

更新日期：2003-12-01 00:00:00