A single sub-erythematous exposure of solar-simulated radiation on the elicitation phase of contact hypersensitivity induces IL-10-producing T-regulatory cells in human skin.

abstract：:This study demonstrates an innovative application of atomic force microscopy (AFM). The combination of high-resolution AFM technology and tape stripping is presented as a tool for the structure analysis of human stratum corneum (SC) at a nanometer scale. Topographic images with a vertical resolution of about 10 nm of ...

journal_title：Experimental dermatology

authors： Gorzelanny C,Goerge T,Schnaeker EM,Thomas K,Luger TA,Schneider SW

更新日期：2006-05-01 00:00:00

abstract：:For almost a quarter of a century, ex vivo studies of human scalp hair follicles (HFs) have permitted major advances in hair research, spanning diverse fields such as chronobiology, endocrinology, immunology, metabolism, mitochondrial biology, neurobiology, pharmacology, pigmentation and stem cell biology. Despite thi...

journal_title：Experimental dermatology

authors： Langan EA,Philpott MP,Kloepper JE,Paus R

更新日期：2015-12-01 00:00:00

abstract：:Corticotropin releasing factor, adrenocorticotropic hormone (ACTH) and alpha-melanocyte stimulating hormone either inhibit or enhance in a dose-dependent fashion an interleukin-4 (IL-4) driven human IgE synthesis in vitro. Here, we show that culture conditions strongly influence the earlier observed dose- and donor-de...

journal_title：Experimental dermatology

authors： Aebischer I,Stämpfli MR,Miescher S,Horn M,Zürcher AW,Stadler BM

更新日期：1996-02-01 00:00:00

abstract：:Despite groundbreaking new treatments such as checkpoint inhibition and targeted therapy, the overall response and survival rates are limited in patients with metastatic melanoma. Here, we hypothesize that melatonin and its metabolites could be promising boosters of the efficacy of BRAF/MEK inhibitors in patients with...

journal_title：Experimental dermatology

authors： Kleszczyński K,Böhm M

更新日期：2020-09-01 00:00:00

abstract：:Epidermal fatty acid-binding protein (E-FABP) is a lipid carrier, originally discovered in human epidermis. We show that E-FABP is almost exclusively expressed in postmitotic (PM) keratinocytes, corresponding to its localization in the highest suprabasal layers, while it is barely expressed in keratinocyte stem cells ...

journal_title：Experimental dermatology

authors： Dallaglio K,Marconi A,Truzzi F,Lotti R,Palazzo E,Petrachi T,Saltari A,Coppini M,Pincelli C

更新日期：2013-04-01 00:00:00

abstract：:Canine atopic dermatitis (AD), a chronic inflammatory skin disease, shares characteristics with its human counterpart. To get insight into the role of enzymes involved in production of prostaglandin E(2) (PGE2) and leukotriene B(4) (LTB(4)), potent inflammatory mediators originating from membrane-derived arachidonic a...

journal_title：Experimental dermatology

authors： Schlotter YM,Riemers FM,Rutten VP,Knol EF,Willemse T

更新日期：2010-08-01 00:00:00

abstract：:Despite as yet limited clinical effectiveness, dendritic cell (DC)-based immunotherapy remains a promising approach for the treatment of cancer, but requires further improvement in its immunostimulatory effectiveness. Potent anti-tumor immunity often depends on the induction of type 1 (T(H)1) immune responses. Therefo...

journal_title：Experimental dermatology

authors： Balkow S,Loser K,Krummen M,Higuchi T,Rothoeft T,Apelt J,Tuettenberg A,Weishaupt C,Beissert S,Grabbe S

更新日期：2009-01-01 00:00:00

abstract：:Chemical haptens induce a variety of allergic immune reactions by induction of hapten-specific T cells. Contact sensitizers such as the hapten trinitrochlorobenzene (TNCB) elicit an allergic response, which is confined to the area of antigen exposure. Despite this localized allergic response, we show here that the tri...

journal_title：Experimental dermatology

authors： Martin S,Delattre V,Leicht C,Weltzien HU,Simon JC

更新日期：2003-02-01 00:00:00

abstract：:Dermatitis herpetiformis (DH) is a blistering skin disease characterized by cutaneous deposits of IgA and an associated, most often asymptomatic, gluten sensitive enteropathy (GSE). Gluten sensitive enteropathy is also seen in patients that do not have skin disease or cutaneous IgA deposits, but do have significant ga...

journal_title：Experimental dermatology

authors： Hall RP 3rd,Owen S,Smith A,Keough M,Bagheri B,Church P,Streilein R

更新日期：2000-08-01 00:00:00

abstract：:Human follicle dermal papilla cells (FDPC) are a specialized population of mesenchymal cells located in the skin. They regulate hair follicle (HF) development and growth, and represent a reservoir of multipotent stem cells. Growing evidence supports the hypothesis that HF cycling is associated with vascular remodeling...

journal_title：Experimental dermatology

authors： Bassino E,Gasparri F,Giannini V,Munaron L

更新日期：2015-05-01 00:00:00

abstract：:The role of placebo and nocebo effects-that is positive or negative treatment effects that are entirely a consequence of the patient's expectations and beliefs about a treatment outcome in terms of efficacy, safety, usability or side effects-has been shown for almost all types of diseases and physiological response sy...

journal_title：Experimental dermatology

authors： Evers AW

更新日期：2017-01-01 00:00:00

abstract：:Allergen-induced emigration and maturation of dendritic cells (DC) are pivotal steps in sparking off allergic contact dermatitis. In vitro models, reflecting these steps, may provide tools for assessment of sensitizing capacities of putative contact allergens. Here, we evaluated the applicability of such models for a ...

journal_title：Experimental dermatology

authors： Rustemeyer T,Preuss M,von Blomberg BM,Das PK,Scheper RJ

更新日期：2003-10-01 00:00:00

abstract：:Current gold standard lower extremity cutaneous wound management is not always effective. Cutaneous wounds generate a "current of injury" which is directly involved in wound healing processes. Application of exogenous electrical stimulation has been hypothesised to imitate the natural electric current that occurs in c...

journal_title：Experimental dermatology

authors： Ashrafi M,Alonso-Rasgado T,Baguneid M,Bayat A

更新日期：2017-02-01 00:00:00

abstract：:For decades, an extensive debate is continued on the pathophysiology of vitiligo. Numerous hypotheses have been put forward, and many supported by well-documented arguments. Regardless of the initiating steps, most experts agree that an immune-based melanocyte destruction is responsible for the final steps leading to ...

journal_title：Experimental dermatology

authors： Speeckaert R,van Geel N

更新日期：2017-07-01 00:00:00

abstract：:Pachyonychia congenita type 1 (PC-1) is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy, focal non-epidermolytic palmoplantar keratoderma and variable features of oral leukokeratosis and follicular keratosis. Previously, we have shown that this disease can be caused by mutations...

journal_title：Experimental dermatology

authors： Smith FJ,McKenna KE,Irvine AD,Bingham EA,Coleman CM,Uitto J,McLean WH

更新日期：1999-04-01 00:00:00

abstract：:Serum levels of B-cell activating factor belonging to the tumor necrosis factor family (BAFF), a potent B-cell survival factor, are elevated in patients with systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis and systemic sclerosis (SSc). The objective of this study was to d...

journal_title：Experimental dermatology

authors： Matsushita T,Hasegawa M,Matsushita Y,Echigo T,Wayaku T,Horikawa M,Ogawa F,Takehara K,Sato S

更新日期：2007-02-01 00:00:00

abstract：:The effects of prostaglandin (PG) I1 analog, SM-10906 (SM-6) and PGE1 on extracellular matrix formation and the release of cytokines by cultured normal human dermal fibroblasts (NDF) and hypertrophic scar fibroblasts (HSF) were compared in order to evaluate the clinical efficacy of PGs in preventing scar formation. In...

journal_title：Experimental dermatology

authors： Zhou LJ,Inoue M,Ono I,Kaneko F

更新日期：1997-12-01 00:00:00

abstract：:We investigated the effects of a single dose of mouse interleukin-31 (IL-31) on scratching behaviour in comparison with spontaneous skin-lesion- or serotonin (5-HT)- induced scratching behaviour in NC/Nga and BALB/c mice. Intradermal (i.d.) injection of IL-31 caused a gradual increase in long-lasting scratching (LLS, ...

journal_title：Experimental dermatology

authors： Arai I,Tsuji M,Takeda H,Akiyama N,Saito S

更新日期：2013-10-01 00:00:00

abstract：:During aging, increases in the number of senescent cells are seen in various tissues. On the other hand, stem cells play crucial roles in tissue repair and homeostasis. Therefore, it is likely that stem cells give rise to new cells that replace senescent cells. However, how stem cells contribute to homeostasis in the ...

journal_title：Experimental dermatology

authors： Ohgo S,Hasegawa S,Hasebe Y,Mizutani H,Nakata S,Akamatsu H

更新日期：2015-07-01 00:00:00

abstract：:Opioids exert major effects not only in the central nervous system but also in immune responses. We investigated the effects of μ-opioid peptides, secreted by tumor cells, on anti-tumor immune responses. For this purpose, tumor growth was studied in wild-type and μ-opioid receptor-deficient (MOR-/-) mice injected with...

journal_title：Experimental dermatology

authors： Boehncke S,Hardt K,Schadendorf D,Henschler R,Boehncke WH,Duthey B

更新日期：2011-01-01 00:00:00

abstract：:Pemphigus vulgaris (PV) is an autoimmune bullous disease caused by immunoglobulin G (IgG) autoantibodies against desmoglein 3 (Dsg3). We have generated an active disease mouse model for PV by adoptive transfer of Dsg3(-/-) lymphocytes. In this study, we investigated the benefits and limitations of this model as a tool...

journal_title：Experimental dermatology

authors： Takae Y,Nishikawa T,Amagai M

更新日期：2009-03-01 00:00:00

abstract：:Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat gl...

journal_title：Experimental dermatology

authors： Bovell DL,MacDonald A,Meyer BA,Corbett AD,MacLaren WM,Holmes SL,Harker M

更新日期：2011-12-01 00:00:00

abstract：:Epidermal keratinocytes undergo a continuous process of terminal differentiation, which is accompanied by a dramatic change in the expression and composition of keratins. This complex and carefully orchestrated process is regulated by a large number of signal transduction events and transcriptional factors as well as ...

journal_title：Experimental dermatology

authors： Wang M,Yue Z,Paus R,Ramot Y

更新日期：2014-09-01 00:00:00

abstract：:It has been suggested that the increased rate of bacterial infection in atopic dermatitis (AD) may be caused by reduced antimicrobial protein (AMP) expression. We were interested whether common treatments in AD affect antimicrobial defense. We investigated the effects of topically applied corticosteroids betamethasone...

journal_title：Experimental dermatology

authors： Jensen JM,Ahrens K,Meingassner J,Scherer A,Bräutigam M,Stütz A,Schwarz T,Fölster-Holst R,Harder J,Gläser R,Proksch E

更新日期：2011-10-01 00:00:00

abstract：:Studies have shown that wound pH is a potentially influential factor in the healing process. Due to the flaws of traditional pH measurement approaches, wound pH measurement has not become part of current standard of care. A near-infrared pH-sensitive ratiometric film was created and characterized for measuring wound p...

journal_title：Experimental dermatology

authors： Li S,Vu H,Senkowsky J,Hu W,Tang L

更新日期：2020-01-01 00:00:00

abstract：:The expansive use of immunosuppressive medications in fields such as transplantational medicine and oncology, the higher frequency of invasive procedures in an ageing population and the HIV/AIDS pandemic have increased the frequency of systemic fungal infections. At the same time, increased resistance of pathogenic fu...

journal_title：Experimental dermatology

authors： Mehra T,Köberle M,Braunsdorf C,Mailänder-Sanchez D,Borelli C,Schaller M

更新日期：2012-10-01 00:00:00

abstract：:Skin barrier damage induces various harmful or even protective reactions in the skin, as represented by enhancement of keratinocyte cytokine production. To investigate whether acute removal of stratum corneum modulates the production of chemokines by epidermal cells, we treated ears of BALB/c and C57BL/6 mice by tape-...

journal_title：Experimental dermatology

authors： Onoue A,Kabashima K,Kobayashi M,Mori T,Tokura Y

更新日期：2009-12-01 00:00:00

abstract：:Congenital melanocytic nevi (CMN) are benign proliferations that may be associated with various consequences depending on their size. They are characterized by a specific molecular signature, namely a postzygotic somatic NRAS or BRAF mutation. We have recently reported that large CMN (lCMN), which are classically asso...

journal_title：Experimental dermatology

authors： Guégan S,Kadlub N,Picard A,Rouillé T,Charbel C,Coulomb-L'Hermine A,How-Kit A,Fraitag S,Aractingi S,Fontaine RH

更新日期：2016-10-01 00:00:00

abstract：:Neutrophil extravasation is central to inflammatory skin diseases like psoriasis and atopic dermatitis. In vivo, neutrophils have been shown to migrate through cell-to-cell junctions (paracellular pathway) or directly through the body of the endothelial cell (transcellular pathway). In vitro, however, neutrophil migra...

journal_title：Experimental dermatology

authors： Marmon S,Cammer M,Raine CS,Lisanti MP

更新日期：2009-01-01 00:00:00

abstract：:It is widely recognized that tobacco smoke causes skin pigmentation. No studies, however, have directly evaluated the mechanisms of the changes in smoker's skin pigmentation. In this study, when cultured with water-soluble tobacco smoke extract, the human epidermal melanocytes grew to a large size and produced more me...

journal_title：Experimental dermatology

authors： Nakamura M,Ueda Y,Hayashi M,Kato H,Furuhashi T,Morita A

更新日期：2013-08-01 00:00:00