Endogenous μ-opioid peptides modulate immune response towards malignant melanoma.

abstract：:Plasmatic proteasome (p-proteasome) also called circulating proteasome has recently been described as a tumor marker. We investigated the diagnostic and prognostic accuracies of p-proteasome levels in a melanoma population classified according to the American Joint Committee on Cancer staging system. Using an ELISA te...

journal_title：Experimental dermatology

authors： Henry L,Lavabre-Bertrand T,Douche T,Uttenweiler-Joseph S,Fabbro-Peray P,Monsarrat B,Martinez J,Meunier L,Stoebner PE

更新日期：2010-12-01 00:00:00

abstract：:The role of T cells in the pathogenesis of psoriasis is widely acknowledged. However, key aspects of their precise function in the disease as well as the relative pathogenic contribution of T-cell subsets are still unknown. T-cell clones have been isolated from psoriatic plaques but a study of conditions affecting the...

journal_title：Experimental dermatology

authors： Kohlmann WM,Urban W,Sterry W,Foerster J

更新日期：2004-10-01 00:00:00

abstract：:Atopic dermatitis (AD) is related to immunoglobulin E (IgE) production, and a type-1 and type-2 helper T cell (Th1/Th2) imbalance has been hypothesized as the aetiology. While itching and scratching are important factors in the development of dermatitis, the mechanisms underlying these phenomena are poorly understood....

journal_title：Experimental dermatology

authors： Hashimoto Y,Takaoka A,Sugimoto M,Honma Y,Sakurai T,Futaki N,Arai I

更新日期：2011-10-01 00:00:00

abstract：:Curcumin (diferuloylmethane) is a polyphenol derived from turmeric (Curcuma longa), which is commonly used as a spice. Recent studies have shown that curcumin has a wide range of pharmacological activities, including anticarcinogenic, antioxidant, anti-inflammatory and antiangiogenic activities. However, the antiphoto...

journal_title：Experimental dermatology

authors： Hwang BM,Noh EM,Kim JS,Kim JM,You YO,Hwang JK,Kwon KB,Lee YR

更新日期：2013-05-01 00:00:00

abstract：:Rosacea is one of the most common dermatoses of adults. Although the detailed pathophysiology remains unknown, it is thought that rosacea is caused by a consistently aberrant, innate immune response, and that LL-37 plays an important role. However, involvement of the inflammatory cytokine IL-33 has not yet been studie...

journal_title：Experimental dermatology

authors： Suhng E,Kim BH,Choi YW,Choi HY,Cho H,Byun JY

更新日期：2018-09-01 00:00:00

abstract：:Th17 cells play crucial roles in the pathogenesis of autoimmune diseases. We previously reported that Th17 cells are recruited to the lesional skin in pemphigus vulgaris (PV) and pemphigus foliaceus (PF). The aim of this study was to evaluate lesional Th17 cells and Treg cells in bullous pemphigoid (BP). Correlations ...

journal_title：Experimental dermatology

authors： Arakawa M,Dainichi T,Ishii N,Hamada T,Karashima T,Nakama T,Yasumoto S,Tsuruta D,Hashimoto T

更新日期：2011-12-01 00:00:00

abstract：:There have been few reports of successful long-term culture of cells established from cutaneous basal cell carcinoma (BCC) tumors. Here, we describe techniques that have enabled us to establish three long-term cultures of BCC cells isolated from BCC tumors that arose in irradiated Patched 1 (Ptch1)(+/-) mice. All thre...

journal_title：Experimental dermatology

authors： So PL,Langston AW,Daniallinia N,Hebert JL,Fujimoto MA,Khaimskiy Y,Aszterbaum M,Epstein EH Jr

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:The accuracy of diagnosis of skin cancer and especially of early malignant melanoma is most important to reduce its morbidity and mortality. Previous pilot studies using electrical impedance measurements indicate statistically significant accuracies for the detection of skin cancer. OBJECTIVES:The aim of th...

journal_title：Experimental dermatology

authors： Aberg P,Birgersson U,Elsner P,Mohr P,Ollmar S

更新日期：2011-08-01 00:00:00

abstract：:Mycosis fungoides (MF) is the most frequent variant of cutaneous T-cell lymphomas (CTCLs). MF primarily involves the skin initially with patches and plaques. In later stages, cutaneous tumors develop and tumor cells may spread to lymph nodes and finally to visceral sites. Here, we describe an animal model for MF in im...

journal_title：Experimental dermatology

authors： Thaler S,Burger AM,Schulz T,Brill B,Bittner A,Oberholzer PA,Dummer R,Schnierle BS

更新日期：2004-07-01 00:00:00

abstract：:Optical coherence tomography (OCT) is a novel non-invasive imaging technique for in vivo histologic characterization of tissues. Besides pure morphology, additional functional parameters of the tissue investigated can be evaluated at the same time, such as the refractive index and the scattering coefficient. The purpo...

journal_title：Experimental dermatology

authors： de Giorgi V,Stante M,Massi D,Mavilia L,Cappugi P,Carli P

更新日期：2005-01-01 00:00:00

abstract：:Itch is often regarded as unpleasant or bothersome and is accompanied by symptoms of distress and impairments in daily life. The biopsychosocial model of chronic itch describes how psychological factors can contribute to the improvement or exacerbation of chronic itch and related scratching behaviour. Recent research ...

journal_title：Experimental dermatology

authors： Evers AWM,Peerdeman KJ,van Laarhoven AIM

更新日期：2019-12-01 00:00:00

abstract：:We characterized the melanogenic apparatus in a family of transplantable gerbil melanomas (melanotic and amelanotic) using a combination of biophysical, ultrastructural and biochemical methods. Melanotic melanomas produced pure eumelanin but in vesiculo-globular melanosomes ('pheomelanosomes'); the eumelanosomes, char...

journal_title：Experimental dermatology

authors： Plonka PM,Slominski AT,Pajak S,Urbanska K

更新日期：2003-08-01 00:00:00

abstract：:Wounds close by keratinocytes migrating from the edge of the wound and re-epithelializing the epidermis. It has been proposed that the major stimuli for wound closure are blood-derived growth factors, chemokines and cytokines. The small GTPase R-Ras, a known integrin activator, also regulates vascular permeability dur...

journal_title：Experimental dermatology

authors： Ketomäki T,Vähätupa M,May U,Pemmari T,Ruikka E,Hietamo J,Kaipiainen P,Barker H,Parkkila S,Uusitalo-Järvinen H,Järvinen TAH

更新日期：2019-02-01 00:00:00

abstract：:Epidermal keratinocytes undergo a continuous process of terminal differentiation, which is accompanied by a dramatic change in the expression and composition of keratins. This complex and carefully orchestrated process is regulated by a large number of signal transduction events and transcriptional factors as well as ...

journal_title：Experimental dermatology

authors： Wang M,Yue Z,Paus R,Ramot Y

更新日期：2014-09-01 00:00:00

abstract：:Claudins (Cldn) are the major components of tight junctions (TJs) sealing the paracellular cleft in tissue barriers of various organs. Zebrafish Cldnb, the homolog of mammalian Cldn4, is expressed at epithelial cell-cell contacts and is important for regulating epidermal permeability. The bacterial toxin Clostridium p...

journal_title：Experimental dermatology

authors： Zhang J,Ni C,Yang Z,Piontek A,Chen H,Wang S,Fan Y,Qin Z,Piontek J

更新日期：2015-08-01 00:00:00

abstract：:The anti-inflammatory mechanisms of adapalene, a synthetic retinoid used for the treatment of acne patients, are partially understood. They seem particularly related to the modulation of the non-specific immunity. Recent studies have shown that Toll-like receptor (TLR)-2 expression, a receptor of the innate immune sys...

journal_title：Experimental dermatology

authors： Tenaud I,Khammari A,Dreno B

更新日期：2007-06-01 00:00:00

abstract：:The living, not-cornified part of the epidermis consists mainly of keratinocytes. The control mechanisms of proliferation and differentiation are only partly understood. Similarly, the influence of ionic channels of the cell membrane on the proliferation of keratinocytes remains unclear. Preliminary investigations poi...

journal_title：Experimental dermatology

authors： Wohlrab D,Wohlrab J,Markwardt F

更新日期：2000-06-01 00:00:00

abstract：:This study shows that prostaglandins in human FM55 melanoma cells and epidermal melanocytes are produced by COX-1. Prostaglandin production in FM55 melanoma cells was unrelated to that of melanin suggesting that the two processes can occur independently. Alpha-melanocyte-stimulating hormone, which had no effect on mel...

journal_title：Experimental dermatology

authors： Masoodi M,Nicolaou A,Gledhill K,Rhodes LE,Tobin DJ,Thody AJ

更新日期：2010-08-01 00:00:00

abstract：:Shprintzen-Goldberg syndrome (SGS) is a rare disorder characterized by a Marfan-like habitus, mental retardation and craniosynostosis. Cardiac abnormalities, such as aortic root dilation have also been noted as well as several skeletal abnormalities. Its nosological status is unclear as it is hard to delineate SGS fro...

journal_title：Experimental dermatology

authors： van Steensel MA,van Geel M,Parren LJ,Schrander-Stumpel CT,Marcus-Soekarman D

更新日期：2008-04-01 00:00:00

abstract：:UVA(Ultraviolet A)-induced gene expression is supposed to be a hallmark for inflammation, for immunosuppression and in long-term cancer formation. In previous studies, we have shown for keratinocytes that physiological doses of UVA radiation result in the upregulation of gene expression mediated by ceramide formation ...

journal_title：Experimental dermatology

authors： Bayer M,Proksch P,Felsner I,Brenden H,Kohne Z,Walli R,Duong TN,Götz C,Krutmann J,Grether-Beck S

更新日期：2011-11-01 00:00:00

abstract：:Dendritic cells (DCs) can be differentiated from CD14+ monocytes in the presence of interferon-α (IFNα) and granulocyte/macrophage-colony stimulating factor (GM-CSF) in vitro and are known as IFN-DCs. Circulating blood CD56+ cells expressing high levels of CD14, HLA-DR and CD86 have been shown to spontaneously differe...

journal_title：Experimental dermatology

authors： Nieda M,Terunuma H,Eiraku Y,Deng X,Nicol AJ

更新日期：2015-01-01 00:00:00

abstract：:We investigated the effects of a single dose of mouse interleukin-31 (IL-31) on scratching behaviour in comparison with spontaneous skin-lesion- or serotonin (5-HT)- induced scratching behaviour in NC/Nga and BALB/c mice. Intradermal (i.d.) injection of IL-31 caused a gradual increase in long-lasting scratching (LLS, ...

journal_title：Experimental dermatology

authors： Arai I,Tsuji M,Takeda H,Akiyama N,Saito S

更新日期：2013-10-01 00:00:00

abstract：:Melasma is a frequent pigmentary disorder caused by abnormal melanin deposits in the skin. In vivo reflectance confocal microscopy (RCM) is a repetitive imaging tool that provides real-time images of the skin at nearly histological resolution. As melanin is the strongest endogenous contrast in human skin, pigmentary d...

journal_title：Experimental dermatology

authors： Kang HY,Bahadoran P,Suzuki I,Zugaj D,Khemis A,Passeron T,Andres P,Ortonne JP

更新日期：2010-08-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are thought to have various functions other than RNA silencing. We tried to evaluate the expression of lncRNAs in patients with systemic sclerosis (SSc) and determined whether lncRNAs controls collagen expression in dermal fibroblasts. lncRNA expression was determined by real-time PCR an...

journal_title：Experimental dermatology

authors： Wang Z,Jinnin M,Nakamura K,Harada M,Kudo H,Nakayama W,Inoue K,Nakashima T,Honda N,Fukushima S,Ihn H

更新日期：2016-02-01 00:00:00

abstract：:C1 inhibitor (C1INH) plays an important role in the classical pathway of the complement system. Mutations in C1INH gene cause quantitative or qualitative deficiencies in C1INH, which can lead to hereditary angioedema (HAE) type I or II. Here, we identified a novel frame-shift mutation c.1391-1445del55 (p.v464fsx556) i...

journal_title：Experimental dermatology

authors： Qu L,Wei B,Liu M,Zhang L,Xiao T,Chen HD,Zhou L,Mi QS,He C

更新日期：2012-10-01 00:00:00

abstract：:Exposure of the skin to ultraviolet (UV) irradiation induces photoageing through the up-regulation of matrix metalloproteinases (MMPs) and subsequent breakdown of extracellular matrices. Reactive oxygen species (ROS) and epidermal growth factor receptor (EGFR) activation play central roles in UV-induced MMP expression...

journal_title：Experimental dermatology

authors： Park M,Han J,Lee CS,Soo BH,Lim KM,Ha H

更新日期：2013-05-01 00:00:00

abstract：:Hair loss (alopecia) can result from a variety of metabolic, endocrine, immunologic, and environmental causes. This investigation was undertaken to determine the mechanisms underlying the sporadic development of alopecia in litters from C57BL/6 interleukin-10-deficient (Il10(-/-)) mice. All pups in affected litters de...

journal_title：Experimental dermatology

authors： Vanderford DA,Greer PK,Sharp JM,Chichlowski M,Rouse DC,Selim MA,Hale LP

更新日期：2010-06-01 00:00:00

abstract：:Hair follicles cyclically regenerate throughout adult mammalian life, owing to a resident population of epithelial hair follicle stem cells. Stem cell (SC) activity drives bouts of follicle growth, which are periodically interrupted by follicle regression and rest. These phases and the transitions between them are tig...

journal_title：Experimental dermatology

authors： Martino PA,Heitman N,Rendl M

更新日期：2020-10-02 00:00:00

abstract：:Cutaneous wound pain causes physical and psychological stress for patients with wounds. Previous studies reported that stress induces hyperalgesia and deteriorates wound healing. However, the effect of the stress response such as in hypothalamic-pituitary-adrenal (HPA) axis on local wound area is unclear. We aimed to ...

journal_title：Experimental dermatology

authors： Goto T,Nakagami G,Minematsu T,Tomida S,Shinoda M,Iwata K,Sanada H

更新日期：2019-09-01 00:00:00

abstract：:The reliability of the methods currently used for diagnosing hair loss is ill defined. We studied 41 subjects complaining of hair loss, including androgenetic alopecia and telogen effluvium, and compared the results obtained with the modified wash test (MWT) and TrichoScan(®) . Data were analysed statistically with th...

journal_title：Experimental dermatology

authors： Guarrera M,Fiorucci MC,Rebora A

更新日期：2013-07-01 00:00:00