In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions.

abstract：:T cells play a major role in inflammatory skin disorders such as psoriasis vulgaris and atopic dermatitis. They are both active on the level of cell-to-cell interaction and by the secretion of pro-inflammatory mediators. CD26 is a lymphocyte membrane-associated dipeptidyl peptidase IV (DPP IV), which is able to inacti...

journal_title：Experimental dermatology

authors： Bock O,Kreiselmeyer I,Mrowietz U

更新日期：2001-12-01 00:00:00

abstract：:With rising skin cancer rates and interest in preventing photoaging, adjuvants for sunscreens are in high demand. The potential of curcumin has been posited due to its anti-inflammatory, antioxidant and wound healing properties. In prior studies, curcumin decreased UV-induced inflammation, apoptotic changes in human k...

journal_title：Experimental dermatology

authors： Adusumilli NC,Mordorski B,Nosanchuk J,Friedman JM,Friedman AJ

更新日期：2021-01-15 00:00:00

abstract：:Psychological factors are believed to play a role in the pathogenesis of alopecia areata (AA), a frequently encountered hair disorder. In our study, statistically significant elevation of psychological stress was felt by AA patients prior hair loss compared with control, which was strongly believed contributory to hai...

journal_title：Experimental dermatology

authors： Kim HS,Cho DH,Kim HJ,Lee JY,Cho BK,Park HJ

更新日期：2006-07-01 00:00:00

abstract：:Immune escape mechanisms of cancers include some of the mechanisms normally used for immune homeostasis, particular those preventing autoimmunity; one of these is the polarisation of myeloid cells. Thereby, tumors, i.e. the cancerous and stromal cells, also condition distant sites like spleen and bone marrow via solub...

journal_title：Experimental dermatology

authors： Becker JC

更新日期：2014-03-01 00:00:00

abstract：:A feature of black African hair is an apparent increased fragility of the hair shaft compared to other ethnic groups (as measured by the tensile force needed to break the hair fibre). This has certain similarities to that reported for trichorrhexis nodosa (weathering secondary to physical damage) and trichothiodystrop...

journal_title：Experimental dermatology

authors： Khumalo NP,Dawber RP,Ferguson DJ

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Methylenetetrahydrofolate reductase (MTHFR) is involved in the formation of methyl donors, which contribute to DNA methylation. DNA methylation is an essential epigenetic feature playing a critical role in gene regulation and cellular differentiation. In addition, MTHFR activity affects plasma homocysteine l...

journal_title：Experimental dermatology

authors： Weger W,Hofer A,Stanger O,Wolf P,El-Shabrawi Y,Renner W,Kerl H,Salmhofer W

更新日期：2008-09-01 00:00:00

abstract：:This study shows that prostaglandins in human FM55 melanoma cells and epidermal melanocytes are produced by COX-1. Prostaglandin production in FM55 melanoma cells was unrelated to that of melanin suggesting that the two processes can occur independently. Alpha-melanocyte-stimulating hormone, which had no effect on mel...

journal_title：Experimental dermatology

authors： Masoodi M,Nicolaou A,Gledhill K,Rhodes LE,Tobin DJ,Thody AJ

更新日期：2010-08-01 00:00:00

abstract：:Drug resistance in melanoma is commonly attributed to ineffective apoptotic pathways. Targeting apoptosis regulators is thus considered a promising approach to sensitizing melanoma to therapy. In the previous issue of Experimental Dermatology, Plötz and Eberle discuss the role that apoptosis plays in melanoma progress...

journal_title：Experimental dermatology

authors： Haass NK,Schumacher U

更新日期：2014-07-01 00:00:00

abstract：:Patients belonging to xeroderma pigmentosum (XP) complementation group C comprise one-third of all XP patients. Only four major reports compiled larger groups of XP-C patients from southern Europe (12 pts), North America (16 pts) and Africa (14 and 56 pts) as well as their genetic background (46 XPC mutations). We ide...

journal_title：Experimental dermatology

authors： Schäfer A,Hofmann L,Gratchev A,Laspe P,Schubert S,Schürer A,Ohlenbusch A,Tzvetkov M,Hallermann C,Reichrath J,Schön MP,Emmert S

更新日期：2013-01-01 00:00:00

abstract：:We have characterized a stereospecific transport mechanism for L-dopa into human epidermal Langerhans cells (LCs). It is different from any other amino acid transport system. It is highly concentrative, largely pH-independent, and independent of exogenous Na+, glucose and oxygen, and fuelled by a renewable intracellul...

journal_title：Experimental dermatology

authors： Falck B,Bendsoe N,Ronquist G

更新日期：2003-10-01 00:00:00

abstract：:To determine the therapeutic mechanism of PUVA in psoriasis vulgaris, the effects of PUVA on activated T lymphocytes were investigated in vitro. Peripheral blood mononuclear cells (PBMC) obtained from healthy volunteers were activated with Con A stimulation (Con A blasts). Both untreated PBMC and Con A blasts were irr...

journal_title：Experimental dermatology

authors： Urano K,Matsuyama T,Urano R,Matsuo I,Habu S

更新日期：1995-02-01 00:00:00

abstract：:Mastocytosis represents a group of disorders characterized by the proliferation and accumulation of mast cells in tissue. The aim of the present study was to examine whether the interstitial histamine concentration in the skin is increased in mastocytosis patients and whether it correlates with the number of mast cell...

journal_title：Experimental dermatology

authors： Krogstad AL,Roupe G

更新日期：2001-04-01 00:00:00

abstract：:It is well known that the trigger for actinic keratosis (AK) mainly depends on UV exposure. We evaluated the effects of long-term use of sunscreen on the histopathological and dermoscopic changes of AK in aged patients. Eighteen months use of sunscreen produced no change in the number of actinic keratoses or the advan...

journal_title：Experimental dermatology

authors： Kunimoto K,Furukawa F,Uede M,Mizuno M,Yamamoto Y

更新日期：2016-08-01 00:00:00

abstract：:Mast cells (MCs) have been intensely investigated over the past two decades, e.g. the numbers of PubMed-listed reports on MCs have steadily increased and doubled over the past twenty years. Surprisingly, many recent findings that have fundamentally changed our understanding of MC biology and functions have yet to be s...

journal_title：Experimental dermatology

authors： Maurer M,Metz M

更新日期：2005-12-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer which is twice as lethal as melanoma as more than one-third of MCC patients will die from this cancer. Although MCC, which primarily affects elderly and immune suppressed individuals, is very rare to date, its incidence is rapidly increasing...

journal_title：Experimental dermatology

authors： Houben R,Schrama D,Becker JC

更新日期：2009-03-01 00:00:00

abstract：:Nitric oxide (NO) is a reactive endogenous molecule with multiple functions including inflammation and immunity. NO stimulates melanogenesis by activating soluble guanylyl cyclase (sGC) resulting in increases in intracellular guanosine 3',5'-cyclic monophosphate (cGMP). In vitro experiments showed that NO could inhibi...

journal_title：Experimental dermatology

authors： Ivanova K,van den Wijngaard R,Gerzer R,Lamers WH,Das PK

更新日期：2005-06-01 00:00:00

abstract：:It is widely recognized that tobacco smoke causes skin pigmentation. No studies, however, have directly evaluated the mechanisms of the changes in smoker's skin pigmentation. In this study, when cultured with water-soluble tobacco smoke extract, the human epidermal melanocytes grew to a large size and produced more me...

journal_title：Experimental dermatology

authors： Nakamura M,Ueda Y,Hayashi M,Kato H,Furuhashi T,Morita A

更新日期：2013-08-01 00:00:00

abstract：:We analysed the correlation between the expression of HIF-1α (hypoxia-inducible factor 1 alpha), the nuclear receptors: VDR (vitamin D receptor), RORα (retinoic acid receptor-related orphan receptor alpha), and RORγ and CYP24A1 (cytochrome P450 family 24 subfamily A member 1) and CYP27B1 (cytochrome P450 family 27 sub...

journal_title：Experimental dermatology

authors： Brożyna AA,Jóźwicki W,Jetten AM,Slominski AT

更新日期：2019-09-01 00:00:00

abstract：:In the inherited blistering skin disease, recessive dystrophic epidermolysis bullosa (RDEB), there is clinical heterogeneity with variable scarring and susceptibility to malignancy. Currently, however, there are few biochemical markers of tissue inflammation or disease progression. We assessed whether the non-histone ...

journal_title：Experimental dermatology

authors： Petrof G,Abdul-Wahab A,Proudfoot L,Pramanik R,Mellerio JE,McGrath JA

更新日期：2013-06-01 00:00:00

abstract：:The transplantation of allogeneic cells such as pancreatic islet cells, bone marrow, and keratinocytes for skin replacement is in growing use clinically. Present techniques which are used to distinguish transplanted allogeneic cells from phenotypically identical host cells in chimeric tissue have serious limitations. ...

journal_title：Experimental dermatology

authors： Young DM,Summers WC,Cuono CB

更新日期：1993-02-01 00:00:00

abstract：:Aberrant mitochondrial structure and function influence tissue homeostasis and thereby contribute to multiple human disorders and ageing. Ten per cent of patients with primary mitochondrial disorders present skin manifestations that can be categorized into hair abnormalities, rashes, pigmentation abnormalities and acr...

journal_title：Experimental dermatology

authors： Feichtinger RG,Sperl W,Bauer JW,Kofler B

更新日期：2014-09-01 00:00:00

abstract：:Card9 is a signalling adaptor protein in the downstream of many innate pattern recognition receptors (PRRs) and exerts a significant role in antifungal immunity. To date, Card9 deficiency has been reported to be related to increased susceptibility to many fungal infections. In this study, we established mucormycosis m...

journal_title：Experimental dermatology

authors： Sun L,Wan Z,Li R,Yu J

更新日期：2019-11-01 00:00:00

abstract：:Activating transcription factor 3 (ATF3) expression is increased in erythema multiforme and is regulated by IFN-gamma in human keratinocytes. Experimental Dermatology 2010; 19: e310-e313. Abstract: Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP responsive element-binding protein (CREB) fami...

journal_title：Experimental dermatology

authors： Pollack BP,Sapkota B,Haun PL

更新日期：2010-08-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) induces naïve CD4+ T cells to produce Th2 cytokines. In addition, to low production of Th2 cytokines, strong Th1 response, which plays an important role in vitiligo development, has been induced by blockade of TSLP or TSLP receptor. This study examined whether a functional TSLP poly...

journal_title：Experimental dermatology

authors： Cheong KA,Chae SC,Kim YS,Kwon HB,Chung HT,Lee AY

更新日期：2009-12-01 00:00:00

abstract：:The high-frequency electrical conductance of tape-stripped human skin in vivo can be used to evaluate the hydration profile of Stratum corneum (SC). Tape-stripping provides access to the underlying SC layers, and the conductance of these layers (as measured by the Skicon instrument) correlates well with their water co...

journal_title：Experimental dermatology

authors： Boncheva M,de Sterke J,Caspers PJ,Puppels GJ

更新日期：2009-10-01 00:00:00

abstract：:Despite the lack of protective melanin and increased oxidative stress due to mM concentrations of epidermal H2O2 in vitiligo, there is no significantly increased risk for chronic actinic damage and non-melanoma skin cancer. Therefore the question arises, which protective mechanisms could be involved in the skin of the...

journal_title：Experimental dermatology

authors： Schallreuter KU,Behrens-Williams S,Khaliq TP,Picksley SM,Peters EM,Marles LK,Westerhof W,Miehe B,Fanghänel J

更新日期：2003-06-01 00:00:00

abstract：:The best characterized signalling pathway employed by transforming growth factor-beta (TGF-β) is the Smad pathway. We focused on Smad4, because it is essential for the activation of Smad-dependent target genes. We aimed to explore the possibility of inhibiting scar formation after wounding by blocking TGF-β signalling...

journal_title：Experimental dermatology

authors： Tan WQ,Gao ZJ,Xu JH,Yao HP

更新日期：2011-02-01 00:00:00

abstract：:CD4+ Foxp3+ regulatory T cells (Tregs) are suppressors of immune activation and play a crucial role in the maintenance of peripheral tolerance. Mutations of Foxp3 result in fatal autoimmunity in multiple organs, including the skin, in both humans and mice. Many studies have demonstrated the altered frequency and funct...

journal_title：Experimental dermatology

authors： Ujiie H

更新日期：2019-06-01 00:00:00

abstract：:Topical photodynamic therapy with 5-aminolevulinic acid (5-ALA) is a newly established treatment modality for epithelial skin cancer. Skin distribution of different 20% 5-ALA formulations was investigated by detection of protoporphyrin IX (PpIX) using an ex vivo porcine skin model. Fluorescence of PpIX was first detec...

journal_title：Experimental dermatology

authors： Maisch T,Worlicek C,Babilas P,Landthaler M,Szeimies RM

更新日期：2008-10-01 00:00:00

abstract：:Adipose tissue encircles the lower portion of anagen hair follicles and may regulate hair cycle progression. As leptin is a major adipokine, its level of expression from the dermal white adipose tissue during hair cycle progression was studied. The result shows that leptin level is differentially expressed during hair...

journal_title：Experimental dermatology

authors： Yang CC,Sheu HM,Chung PL,Chang CH,Tsai YS,Hughes MW,Tuan TL,Huang LL

更新日期：2015-01-01 00:00:00