PUVA suppresses the expression of cell adhesion molecules of lymphocytes.

abstract：:Human dermal fibroblasts (HDFs) regulate wound-healing processes in human skin, including the regeneration of skin sensory fibres, in response to various mechanical stimuli. Because nerve growth factor (NGF) has an essential role in sensory regeneration, we evaluated the possible association of NGF with mechanical sti...

journal_title：Experimental dermatology

authors： Kim M,Shin DW,Shin H,Noh M,Shin JH

更新日期：2013-01-01 00:00:00

abstract：:The generation of reactive oxygen species is among the various mechanisms by which ultraviolet radiation damages skin. Tempol, a superoxide dismutase analogue which readily penetrates cell membranes when administered exogenously, has been shown to provide protection against some forms of oxygen-dependent damage. In th...

journal_title：Experimental dermatology

authors： Bernstein EF,Kong SK,Brown DB,Kwak BC,Takeuchi T,Gasparro FP,Uitto J

更新日期：2001-02-01 00:00:00

abstract：:UVA(Ultraviolet A)-induced gene expression is supposed to be a hallmark for inflammation, for immunosuppression and in long-term cancer formation. In previous studies, we have shown for keratinocytes that physiological doses of UVA radiation result in the upregulation of gene expression mediated by ceramide formation ...

journal_title：Experimental dermatology

authors： Bayer M,Proksch P,Felsner I,Brenden H,Kohne Z,Walli R,Duong TN,Götz C,Krutmann J,Grether-Beck S

更新日期：2011-11-01 00:00:00

abstract：:Ultraviolet (UV) triggers induction of matrix metalloproteinase-1 (MMP-1) and also induces the rapid appearance of p53 protein in the epidermis and dermal fibroblasts. However, little is known about the role of p53 on MMP-1 expression in human skin. Here, we investigated the effects of p53 on basal and UV-induced MMP-...

journal_title：Experimental dermatology

authors： Kim S,Lee Y,Lee DH,Kim Y,Cho KH,Chung JH

更新日期：2008-11-01 00:00:00

abstract：:Curcumin (diferuloylmethane) is a polyphenol derived from turmeric (Curcuma longa), which is commonly used as a spice. Recent studies have shown that curcumin has a wide range of pharmacological activities, including anticarcinogenic, antioxidant, anti-inflammatory and antiangiogenic activities. However, the antiphoto...

journal_title：Experimental dermatology

authors： Hwang BM,Noh EM,Kim JS,Kim JM,You YO,Hwang JK,Kwon KB,Lee YR

更新日期：2013-05-01 00:00:00

abstract：:Pseudoxanthoma elasticum (PXE), a systemic heritable connective tissue disorder, is characterized by progressive calcification of elastic structures in the skin, the eyes and the cardiovascular system, with considerable intra- and interfamilial phenotypic variability. Recently, underlying genetic defects have been ide...

journal_title：Experimental dermatology

authors： Ringpfeil F,Pulkkinen L,Uitto J

更新日期：2001-08-01 00:00:00

abstract：:Pheomelanin is supposed to be the first type of melanin found in vertebrates, in contrast to the main type - eumelanin. Our study aimed at detecting pheomelanin in the skin of Hymenochirus boettgerii. We employed electron paramagnetic resonance (EPR) spectroscopy, and transmission electron microscopy (TEM), supplement...

journal_title：Experimental dermatology

authors： Wolnicka-Glubisz A,Pecio A,Podkowa D,Kolodziejczyk LM,Plonka PM

更新日期：2012-07-01 00:00:00

abstract：:Sangre de drago (SD) is a viscous bright red resin collected from Croton lechleri trees that grow in the South American jungle. This sap is used extensively in the native pharmacopoeia to treat skin disorders. Its effectiveness as an inhibitor of neurogenic inflammation has been recently demonstrated. To understand th...

journal_title：Experimental dermatology

authors： Pereira U,Garcia-Le Gal C,Le Gal G,Boulais N,Lebonvallet N,Dorange G,Lefeuvre L,Gougerot A,Misery L

更新日期：2010-09-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are non-haematopoietic cells that reside in most tissues including adult bone marrow. MSCs have recently been extensively studied and used for clinical therapies, including skin wound healing. However, there are still many questions to be answered. In the viewpoint entitled 'Mesenchymal s...

journal_title：Experimental dermatology

authors： Li X,Hamada T,Ohata C,Furumura M,Hashimoto T

更新日期：2013-08-01 00:00:00

abstract：:Ultraviolet (UV) light is an effective treatment for skin disorders like psoriasis in which the cutaneous neurosensory system may have a pathogenic role. In this study, we examined the possibility that UV modulation of the cutaneous neurosensory system and calcitonin gene-related peptide (CGRP) may contribute to local...

journal_title：Experimental dermatology

authors： Legat FJ,Jaiani LT,Wolf P,Wang M,Lang R,Abraham T,Solomon AR,Armstrong CA,Glass JD,Ansel JC

更新日期：2004-04-01 00:00:00

abstract：:Vitamin D-binding protein (VDBP) single nucleotide polymorphisms (SNP) may affect skin carcinogenesis. The objective was to test the association between two functional VDBP SNPs and the susceptibility to (multiple) basal cell carcinomas (BCCs). Of the 7983 participants, 5790 (72.5%) and 5823 (72.9%) participants were ...

journal_title：Experimental dermatology

authors： Flohil SC,de Vries E,van Meurs JB,Fang Y,Stricker BH,Uitterlinden AG,Nijsten T

更新日期：2010-12-01 00:00:00

abstract：:Hair follicle heterogeneity may be regulated by distinct dermal papillae (DP) that represent mesenchymal lineages, which can be defined by Sox2 expression. However, it was recently shown that GFP expression in the Sox2: GFP+/- mouse model occurs in the DPs of all hair follicle types, challenging the idea that hair fol...

journal_title：Experimental dermatology

authors： Salz L,Driskell RR

更新日期：2017-11-01 00:00:00

abstract：:Reactive skin is characterized by marked sensitivity to physical (heat, cold, wind) or chemical (topically applied products) stimuli and by the impairment of the skin barrier's ability to repair itself. Several lines of evidence suggest that beyond their capacity to positively influence the composition of intestinal m...

journal_title：Experimental dermatology

authors： Guéniche A,Bastien P,Ovigne JM,Kermici M,Courchay G,Chevalier V,Breton L,Castiel-Higounenc I

更新日期：2010-08-01 00:00:00

abstract：:In the inherited blistering skin disease, recessive dystrophic epidermolysis bullosa (RDEB), there is clinical heterogeneity with variable scarring and susceptibility to malignancy. Currently, however, there are few biochemical markers of tissue inflammation or disease progression. We assessed whether the non-histone ...

journal_title：Experimental dermatology

authors： Petrof G,Abdul-Wahab A,Proudfoot L,Pramanik R,Mellerio JE,McGrath JA

更新日期：2013-06-01 00:00:00

abstract：:Keloid is a dermal proliferative disorder characterized by the excessive proliferation and migration of keratinocytes and fibroblasts. Over-activation of the serine/threonine protein kinase, mammalian target of rapamycin (mTOR), plays a pivotal role in the process. Here, we show that both mTOR complex 1 (mTORC1) and m...

journal_title：Experimental dermatology

authors： Chen J,Liu K,Liu Y,Wang X,Zhang Z

更新日期：2019-03-01 00:00:00

abstract：:Mycosis fungoides (MF) is the most frequent variant of cutaneous T-cell lymphomas (CTCLs). MF primarily involves the skin initially with patches and plaques. In later stages, cutaneous tumors develop and tumor cells may spread to lymph nodes and finally to visceral sites. Here, we describe an animal model for MF in im...

journal_title：Experimental dermatology

authors： Thaler S,Burger AM,Schulz T,Brill B,Bittner A,Oberholzer PA,Dummer R,Schnierle BS

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:In vivo reflectance confocal microscopy (RCM) represents a promising imaging tool that allows a non-invasive examination of skin morphology in real time at nearly histological resolution, showing microanatomical structures and individual cells. OBJECTIVES:The aim of our study was to evaluate the diagnostic ...

journal_title：Experimental dermatology

authors： Koller S,Gerger A,Ahlgrimm-Siess V,Weger W,Smolle J,Hofmann-Wellenhof R

更新日期：2009-06-01 00:00:00

abstract：:Dermal papilla cells (DPC) control the growth character of the hair follicle through their elaboration of mitogenic factors and extracellular matrix components. Further, the dermal papilla is a primary site of androgen action in the hair follicle. Interleukin-1alpha (IL-1alpha) is prominent in skin wounding and inflam...

journal_title：Experimental dermatology

authors： Boivin WA,Jiang H,Utting OB,Hunt DW

更新日期：2006-10-01 00:00:00

abstract：:Reverse transcription polymerase chain reaction (qRT-PCR) has become a mainstay in many areas of skin research. To enable quantitative analysis, it is necessary to analyse expression of reference genes (RGs) for normalization of target gene expression. The selection of reliable RGs therefore has an important impact on...

journal_title：Experimental dermatology

authors： Beer L,Mlitz V,Gschwandtner M,Berger T,Narzt MS,Gruber F,Brunner PM,Tschachler E,Mildner M

更新日期：2015-10-01 00:00:00

abstract：:Corticotropin releasing factor, adrenocorticotropic hormone (ACTH) and alpha-melanocyte stimulating hormone either inhibit or enhance in a dose-dependent fashion an interleukin-4 (IL-4) driven human IgE synthesis in vitro. Here, we show that culture conditions strongly influence the earlier observed dose- and donor-de...

journal_title：Experimental dermatology

authors： Aebischer I,Stämpfli MR,Miescher S,Horn M,Zürcher AW,Stadler BM

更新日期：1996-02-01 00:00:00

abstract：:CD44 and l-selectin (CD62L) are major adhesion receptors that mediate leucocyte recruitment at inflammatory sites and lymph nodes, by supporting cell rolling under blood flow. Both CD44 and CD62L have been implicated in inflammatory skin disorders, but their specific involvement in an immediate-type allergic reaction ...

journal_title：Experimental dermatology

authors： Gonda A,Gál I,Szántó S,Sarraj B,Glant TT,Hunyadi J,Mikecz K

更新日期：2005-09-01 00:00:00

abstract：:Formation of a stratified epidermis is required for the performance of the essential functions of the skin; to act as an outside-in barrier against the access of microorganisms and other external factors, to prevent loss of water and solutes via inside-out barrier functions and to withstand mechanical stresses. Epider...

journal_title：Experimental dermatology

authors： Rogerson C,O'Shaughnessy RFL

更新日期：2018-08-01 00:00:00

abstract：:Acquisition of potent human dermal papilla (DP) cells that can induce hair follicle neogenesis is an overarching concern, and various approaches have been tried. In an attempt to solve the problem, we previously introduced the three-dimensional (3D) culture of human DP cells and observed de novo formation of hair foll...

journal_title：Experimental dermatology

authors： Seo CH,Kwack MH,Kim MK,Kim JC,Sung YK

更新日期：2017-02-01 00:00:00

abstract：:Glycyrrhizic acid (GA), a natural triterpene, has received attention as an agent that has protective effects against chronic diseases including ultraviolet UV-B-induced skin photodamage. However, the mechanism of its protective effect remains elusive. Here, we used an immortalized human keratinocyte cell line (HaCaT) ...

journal_title：Experimental dermatology

authors： Afnan Q,Kaiser PJ,Rafiq RA,Nazir LA,Bhushan S,Bhardwaj SC,Sandhir R,Tasduq SA

更新日期：2016-06-01 00:00:00

abstract：:Earlier studies showed that dermal cells lose trichogenic capacity with passage, but studies on the effect of keratinocyte passage on human hair follicle neogenesis and graft quality have been hampered by the lack of a suitable model system. We recently documented human hair follicle neogenesis in grafted dermal-epide...

journal_title：Experimental dermatology

authors： Thangapazham RL,Klover P,Li S,Wang JA,Sperling L,Darling TN

更新日期：2014-06-01 00:00:00

abstract：:Melasma is a frequent pigmentary disorder caused by abnormal melanin deposits in the skin. In vivo reflectance confocal microscopy (RCM) is a repetitive imaging tool that provides real-time images of the skin at nearly histological resolution. As melanin is the strongest endogenous contrast in human skin, pigmentary d...

journal_title：Experimental dermatology

authors： Kang HY,Bahadoran P,Suzuki I,Zugaj D,Khemis A,Passeron T,Andres P,Ortonne JP

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Recently, germline variants of the melanocortin-1 receptor (MC1R) have been shown to be associated with an increased risk for BRAF mutant but not BRAF wild-type cutaneous melanoma. Similar to melanoma, BRAF mutations are also commonly found in papillary thyroid carcinomas. Furthermore, patients with melanoma...

journal_title：Experimental dermatology

authors： Bauer J,Weng J,Kebebew E,Soares P,Trovisco V,Bastian BC

更新日期：2009-06-01 00:00:00

abstract：:Type VII collagen is the major component of anchoring fibrils in the epidermal basement membrane. Its expression has been analyzed by immunostaining or Northern blotting, but rarely at the protein level. In this study, we have quantitatively examined the effects of ascorbic acid and various cytokines/growth factors on...

journal_title：Experimental dermatology

authors： Amano S,Ogura Y,Akutsu N,Nishiyama T

更新日期：2007-02-01 00:00:00

abstract：:The present study was designed to examine the expression of proopiomelanocortin (POMC) and its related derivative peptide adrenocorticotropic hormone (ACTH) in murine derived Thy-1+ dendritic cells. Immunostaining using a polyclonal antibody specific to ACTH and parent POMC molecule indicated the presence of POMC and ...

journal_title：Experimental dermatology

authors： Farooqui JZ,Medrano EE,Boissy RE,Tigelaar RE,Nordlund JJ

更新日期：1995-10-01 00:00:00

abstract：:The p53 gene is mutated in numerous human cancers. We used it as a molecular target to characterize and try to understand the induction of mutations in human skin cancers. About 40-50% of all skin cancers in normal individuals and 60-80% of the DNA-repair-deficient xeroderma pigmentosum patients exhibit p53 mutations....

journal_title：Experimental dermatology

authors： Sarasin A,Giglia-Mari G

更新日期：2002-01-01 00:00:00