Abstract:
:Formation of a stratified epidermis is required for the performance of the essential functions of the skin; to act as an outside-in barrier against the access of microorganisms and other external factors, to prevent loss of water and solutes via inside-out barrier functions and to withstand mechanical stresses. Epidermal barrier function is initiated during embryonic development and is then maintained throughout life and restored after injury. A variety of interrelated processes are required for the formation of a stratified epidermis, and how these processes are both temporally and spatially regulated has long been an aspect of dermatological research. In this review, we describe the roles of multiple protein kinases in the regulation of processes required for epidermal barrier formation.
journal_name
Exp Dermatoljournal_title
Experimental dermatologyauthors
Rogerson C,O'Shaughnessy RFLdoi
10.1111/exd.13696subject
Has Abstractpub_date
2018-08-01 00:00:00pages
892-900issue
8eissn
0906-6705issn
1600-0625journal_volume
27pub_type
杂志文章,评审abstract::In the last decade, significant progress has been made in understanding skin cancer cell death resistance mechanisms, and a number of new treatment strategies have been developed. Systematic approach genomic studies of various cancer types have opened new possibilities for the development of anticancer therapies. Howe...
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