Abstract:
:Chronic pruritus (CP) is defined by itching lasting 6 weeks or more and is known to be both a highly prevalent and burdensome symptom of many pruritogenic diseases. Its status as a symptom has many implications mainly that the symptom should evolve and subside with the disease. However, according to the clinical experience, CP often does not parallel the disease course and requires an own management. It is speculated that neuronal sensitization processes take place, which lead to disconnection of the symptom from the underlying disease and establishment of an own course of pruritus. It is thus discussed that pruritus can be both a symptom of diseases and an entity by itself. Further studies are needed to learn more and improve our understanding of this condition. This article compares its role in pruritogenic diseases, encourages discussion on the topic and provides an overview of the proper questions to ask.
journal_name
Exp Dermatoljournal_title
Experimental dermatologyauthors
Ständer Sdoi
10.1111/exd.13953subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1461-1465issue
12eissn
0906-6705issn
1600-0625journal_volume
28pub_type
杂志文章abstract::Leukotrienes constitute a group of lipid mediators, which may be subdivided into two groups, with leukotriene B4 on the one hand and cysteinyl leukotrienes on the other. Although leukotrienes are abundantly expressed in skin affected by diverse chronic inflammatory diseases, including atopic dermatitis, psoriasis, pem...
journal_title:Experimental dermatology
pub_type: 杂志文章
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/exd.12688
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journal_title:Experimental dermatology
pub_type: 信件
doi:10.1111/j.1600-0625.2012.01559.x
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journal_title:Experimental dermatology
pub_type: 信件
doi:10.1111/j.1600-0625.2011.01310.x
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/exd.13797
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.2005.00390.x
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.2006.00514.x
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journal_title:Experimental dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0625.2008.00823.x
更新日期:2009-03-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
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journal_title:Experimental dermatology
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.2010.01164.x
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/exd.12900
更新日期:2016-02-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章,评审
doi:10.1111/exd.13179
更新日期:2017-02-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
abstract::The early growth response (Egr)-1 is a transcriptional factor which plays an important role in the regulation of cell growth, differentiation, cell survival and immune responses. Emerging evidences including our data demonstrate that the Egr-1 expression is up-regulated in the psoriatic skin lesions. The purpose of th...
journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/exd.12554
更新日期:2014-12-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1034/j.1600-0625.2003.00077.x
更新日期:2003-10-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.1998.tb00337.x
更新日期:1998-12-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 信件
doi:10.1111/exd.13458
更新日期:2017-12-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.2008.00800.x
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pub_type: 杂志文章,评审
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journal_title:Experimental dermatology
pub_type: 信件
doi:10.1111/j.1600-0625.2010.01184.x
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pub_type: 杂志文章
doi:10.1111/exd.12253
更新日期:2013-11-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1034/j.1600-0625.2000.009001016.x
更新日期:2000-02-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1034/j.1600-0625.2000.009002152.x
更新日期:2000-04-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.2008.00705.x
更新日期:2008-10-01 00:00:00
abstract::Atopic dermatitis (AD) is related to immunoglobulin E (IgE) production, and a type-1 and type-2 helper T cell (Th1/Th2) imbalance has been hypothesized as the aetiology. While itching and scratching are important factors in the development of dermatitis, the mechanisms underlying these phenomena are poorly understood....
journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.2011.01337.x
更新日期:2011-10-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/exd.12285
更新日期:2014-01-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 信件
doi:10.1111/exd.12152
更新日期:2013-06-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 信件
doi:10.1111/j.1600-0625.2009.01008.x
更新日期:2010-08-01 00:00:00
abstract::Pemphigus vulgaris (PV) is a severe autoimmune blistering disease of the skin and mucous membranes. As autoantibodies play an essential role in the disease pathogenesis, the serological detection of anti-desmoglein 3 IgG represents a central tool in the diagnosis of the disease. In this study, we show the validation o...
journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/exd.13488
更新日期:2018-03-01 00:00:00