Role of protease-activated receptors in human skin fibrosis and scleroderma.

abstract：:The miRNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C-ALCL) patients were analysed with miRNA microarrays using the same control group of 12 benign inflammatory dermatoses (BID) as previously used to study the miRNA expression profile of tumor-stage mycosis fungoide...

journal_title：Experimental dermatology

authors： Benner MF,Ballabio E,van Kester MS,Saunders NJ,Vermeer MH,Willemze R,Lawrie CH,Tensen CP

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:The circadian rhythm is an endogenous clock that governs a wide range of physiological functions. In the skin, rhythmic changes in skin barrier function have been investigated at the physiological level; however, few studies at the molecular level have been reported. Additionally, there is no study on lipido...

journal_title：Experimental dermatology

authors： Jia Y,Zhou M,Huang H,Gan Y,Yang M,Ding R

更新日期：2019-07-01 00:00:00

abstract：:Skin diseases represent one of the most common work-related diseases and may have a detrimental effect on social, personal and occupational aspects of life. Contact dermatitis (CD), which comprises predominately irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), accounts for vast majority of occu...

journal_title：Experimental dermatology

authors： Jakasa I,Thyssen JP,Kezic S

更新日期：2018-08-01 00:00:00

abstract：:Card9 is a signalling adaptor protein in the downstream of many innate pattern recognition receptors (PRRs) and exerts a significant role in antifungal immunity. To date, Card9 deficiency has been reported to be related to increased susceptibility to many fungal infections. In this study, we established mucormycosis m...

journal_title：Experimental dermatology

authors： Sun L,Wan Z,Li R,Yu J

更新日期：2019-11-01 00:00:00

abstract：:Reverse transcriptase qPCR is the most common method to determine and compare mRNA expression levels and relies on normalization using reference genes. The expression levels of the latter, however, are themselves often variable between experimental conditions, thus compromising the results. Using the geNorm algorithm,...

journal_title：Experimental dermatology

authors： Braun A,Sezin T,Bezdek S,Doxastaki I,Zillikens D,Busch HS,Sadik CD

更新日期：2019-08-01 00:00:00

abstract：:For screening of a potential irritant it is essential that an early marker for irritation should be chosen which could be detected before the physiological signs of irritation occur. Interleukin 1 alpha (IL-1alpha) is widely accepted as such a marker in both in vivo and in vitro test systems. In this study, we have de...

journal_title：Experimental dermatology

authors： Gibbs S,Vietsch H,Meier U,Ponec M

更新日期：2002-06-01 00:00:00

abstract：:Proteoglycans have been suggested to play pivotal roles in hair biology. Decorin is a prototypical member of the small leucine-rich proteoglycan family, which is involved in numerous biological processes. However, the role of decorin in the hair cycle has not been elucidated. Moreover, the effects of decorin on the ac...

journal_title：Experimental dermatology

authors： Inui S,Itami S

更新日期：2014-08-01 00:00:00

abstract：:Dermal white adipose tissue (DWAT) is a main component of human skin, composed of individual lipid-laden mesenchymal cells known as dermal adipocytes (DAs). Besides their well-known role in lipid storage and release, DAs also promote skin immunity, wound healing and hair follicle cycling and are important players in c...

journal_title：Experimental dermatology

authors： Nicu C,Pople J,Bonsell L,Bhogal R,Ansell DM,Paus R

更新日期：2018-06-01 00:00:00

abstract：:Malignant melanoma is a tumor characterized by the uncontrolled proliferation of melanocytes, mainly in skin, but also in eyes. Its incidence is rising each year. To improve the diagnosis and treatment of the tumor, it is essential to develop new effective methods to early detect and characterize melanoma. Previously,...

journal_title：Experimental dermatology

authors： Godechal Q,Leveque P,Marot L,Baurain JF,Gallez B

更新日期：2012-05-01 00:00:00

abstract：:We applied atomic force microscopy (AFM) to visualize ultrastructural changes of the keratinocyte morphology after narrow-band ultraviolet B (NB-UVB) irradiation. Immortalized human keratinocytes were cultured under standard conditions, irradiated with NB-UVB light at doses ranging from 50 to 800 mJ/cm2 and imaged by ...

journal_title：Experimental dermatology

authors： Reich A,Lehmann B,Meurer M,Muller DJ

更新日期：2007-12-01 00:00:00

abstract：:The role of angiogenesis in tumour growth and metastasis is well established. However, investigations of tumour microcirculation to date have used either biopsy material from human tumours, or animal models in vivo. We have studied the tumour microcirculation in vivo in human skin cancers using video-microscopy to exa...

journal_title：Experimental dermatology

authors： Bedlow AJ,Stanton AW,Cliff S,Mortimer PS

更新日期：1999-06-01 00:00:00

abstract：:Dendritic cells (DCs) show a Janus-like functional behavior. They help us by their orchestration of numerous immune responses to defend our body against invading pathogenic micro-organisms and also induce regulatory T cells to inhibit immune reactions against autoantigens as well as diverse harmless environmental anti...

journal_title：Experimental dermatology

authors： Schäkel K

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:The accuracy of diagnosis of skin cancer and especially of early malignant melanoma is most important to reduce its morbidity and mortality. Previous pilot studies using electrical impedance measurements indicate statistically significant accuracies for the detection of skin cancer. OBJECTIVES:The aim of th...

journal_title：Experimental dermatology

authors： Aberg P,Birgersson U,Elsner P,Mohr P,Ollmar S

更新日期：2011-08-01 00:00:00

abstract：:Despite the increasing use of gene transfer strategies in the study of cellular and molecular biology, melanoma cells have remained difficult to transfect in a safe, efficient, and reproducible manner. In the present study, we report the successful use of nucleofector technology to transfect human melanoma cell lines....

journal_title：Experimental dermatology

authors： Han SY,Gai W,Yancovitz M,Osman I,Di Como CJ,Polsky D

更新日期：2008-05-01 00:00:00

abstract：:Pseudoxanthoma elasticum (PXE), a heritable multi-system disorder, is caused by mutations in the ABCC6 gene primarily expressed in the liver. Recent analysis of cultured fibroblasts from patients with PXE has suggested compensatory alterations in the expression of the ABCA-subfamily of genes. We have now determined by...

journal_title：Experimental dermatology

authors： Li Q,Uitto J

更新日期：2011-05-01 00:00:00

abstract：:We have identified a spliced mRNA transcript of CD20 (named D393-CD20) which was associated with resistance to RTX in primary B cell from patients with lymphoma and leukaemia. In the present work, we wished to investigate whether D393-CD20 variant was expressed by B cells from patients with pemphigus. Ten patients wit...

journal_title：Experimental dermatology

authors： Gamonet C,Ferrand C,Colliou N,Musette P,Joly P,Girardin M,Humbert P,Aubin F

更新日期：2014-01-01 00:00:00

abstract：:Vitamin D3 analogues are widely used topical and oral remedies for various ailments such as psoriasis, osteoporosis and secondary hyperparathyroidism. In topical treatment, high skin permeability and cellular uptake are key criteria for beneficial effects due to the natural barrier properties of skin. In this study, w...

journal_title：Experimental dermatology

authors： Staunstrup NH,Bak RO,Cai Y,Svensson L,Petersen TK,Rosada C,Stenderup K,Bolund L,Mikkelsen JG

更新日期：2013-03-01 00:00:00

abstract：:Epidermal gene therapy may benefit a variety of inherited skin disorders and certain systemic diseases. Both in vivo and ex vivo approaches of gene transfer have been used to target human epidermal stem cells and achieve long-term transgene expression in immunodeficient mouse/human chimera models. Immunological respon...

journal_title：Experimental dermatology

authors： Lu Z,Ghazizadeh S

更新日期：2005-10-01 00:00:00

abstract：:Both CCL27 and CCL28 are ligands for CCR10 and attract CCR10(+) lymphocytes. We previously demonstrated that CCL27 and CCL28 were strongly expressed in sera and lesional keratinocytes of patients with atopic dermatitis and psoriasis vulgaris. However, the regulation of CCL27 and CCL28 production in keratinocytes has n...

journal_title：Experimental dermatology

authors： Kagami S,Saeki H,Komine M,Kakinuma T,Nakamura K,Tsunemi Y,Sasaki K,Asahina A,Tamaki K

更新日期：2006-02-01 00:00:00

abstract：:This review focuses on the photoprotection conferred by lycopene, one of the most potent anti-oxidants. Lycopene has been recently proposed to play a critical role on anticarcinogenic action at different levels. The photoprotective properties of lycopene remain contradictory. Some studies point out a positive and othe...

journal_title：Experimental dermatology

authors： Ascenso A,Ribeiro H,Marques HC,Oliveira H,Santos C,Simões S

更新日期：2014-12-01 00:00:00

abstract：:We have characterized a stereospecific transport mechanism for L-dopa into human epidermal Langerhans cells (LCs). It is different from any other amino acid transport system. It is highly concentrative, largely pH-independent, and independent of exogenous Na+, glucose and oxygen, and fuelled by a renewable intracellul...

journal_title：Experimental dermatology

authors： Falck B,Bendsoe N,Ronquist G

更新日期：2003-10-01 00:00:00

abstract：:Seasonal variations can be found in almost any parameter of an organism's biochemistry, physiology, endocrinology, and behaviour. This phenomenon, generally called photoperiodism, results from one of the major functions of the circadian system, i.e. the translation of environmental information into rhythmic intraorgan...

journal_title：Experimental dermatology

authors： Lang R,Hintner H,Hermann A,Brandstaetter R

更新日期：2003-08-01 00:00:00

abstract：:Psoriasis is a chronic skin disease that results in red and scaly lesions. Several psoriasis susceptibility loci have been identified across the genome, of which PSORS1 on 6p21.3 is predominant. There is an ongoing debate regarding whether the HLA-C allele, Cw*0602, can be considered the major predisposing factor in t...

journal_title：Experimental dermatology

authors： Holm SJ,Carlén LM,Mallbris L,Ståhle-Bäckdahl M,O'Brien KP

更新日期：2003-08-01 00:00:00

abstract：:Dermal mast cells protect the skin from inflammatory effects of ultraviolet (UV) radiation and are required for UV-induced immune suppression. We sought to determine a potential mechanistic role of mast cells in reducing the sensitivity to UV radiation (i.e. phototolerance induction) through photohardening. We adminis...

journal_title：Experimental dermatology

authors： Schweintzger NA,Bambach I,Reginato E,Mayer G,Limón-Flores AY,Ullrich SE,Byrne SN,Wolf P

更新日期：2015-07-01 00:00:00

abstract：:The role of placebo and nocebo effects-that is positive or negative treatment effects that are entirely a consequence of the patient's expectations and beliefs about a treatment outcome in terms of efficacy, safety, usability or side effects-has been shown for almost all types of diseases and physiological response sy...

journal_title：Experimental dermatology

authors： Evers AW

更新日期：2017-01-01 00:00:00

abstract：:Unpredictable hypertrophic scarring (HS) occurs after approximately 35% of all surgical procedures and causes significant physical and psychological complaints. Parallel to the need to understanding the mechanisms underlying HS formation, a prognostic tool is needed. The objective was to determine whether (systemic) i...

journal_title：Experimental dermatology

authors： de Bakker E,van der Putten MAM,Heymans MW,Spiekstra SW,Waaijman T,Butzelaar L,Negenborn VL,Beekman VK,Akpinar EO,Rustemeyer T,Niessen FB,Gibbs S

更新日期：2021-01-01 00:00:00

abstract：:Lipoid proteinosis (OMIM 247100), also known as Urbach-Wiethe disease or hyalinosis cutis et mucosae, is a rare autosomal recessive disorder characterized by generalized thickening and scarring of the skin and mucosae. In 2002, the disorder was mapped to a locus on chromosome 1q21 and pathogenic mutations were identif...

journal_title：Experimental dermatology

authors： Chan I,Liu L,Hamada T,Sethuraman G,McGrath JA

更新日期：2007-11-01 00:00:00

abstract：:The p53 gene is mutated in numerous human cancers. We used it as a molecular target to characterize and try to understand the induction of mutations in human skin cancers. About 40-50% of all skin cancers in normal individuals and 60-80% of the DNA-repair-deficient xeroderma pigmentosum patients exhibit p53 mutations....

journal_title：Experimental dermatology

authors： Sarasin A,Giglia-Mari G

更新日期：2002-01-01 00:00:00

abstract：:Psoriasis is a 'pacemaker' in dermatology. Substantial progress has been made regarding our understanding of its pathophysiology and genetic background, fuelling developments in cutaneous biology in general. Besides, the clinical perspective on psoriasis is currently changing, taking into consideration comorbidity and...

journal_title：Experimental dermatology

authors： Boehncke S,Boehncke WH

更新日期：2014-10-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) gene amplification and protein overexpression are common in several cancers. EGFR status has seldom been studied in cutaneous squamous carcinomas (SCCs), or their precursors, actinic keratoses (AKs). We evaluated the presence of EGFR genomic aberrations and EGFR protein overexpr...

journal_title：Experimental dermatology

authors： Toll A,Salgado R,Yébenes M,Martín-Ezquerra G,Gilaberte M,Baró T,Solé F,Alameda F,Espinet B,Pujol RM

更新日期：2010-02-01 00:00:00