Aggressive primary cutaneous B-cell lymphomas show increased Angiopoietin-2-induced angiogenesis.


:Primary cutaneous large B-cell lymphomas, leg type (PCLBCL/LT) are primary cutaneous B-cell lymphoma (PCBCL) with an intermediate prognosis. Therefore, antracycline-based polychemotherapy combined with rituximab has been recommended as first-line treatment. Yet, despite this regimen, the 5-year survival rate remains 50-66% only. Angiogenesis, the formation of a vascular network, is essential for the pathogenesis of nodal lymphomas. So far, no study has analysed angiogenesis and its key factors in PCLBCL/LT. The present study was aimed at characterizing angiogenesis in PCLBCL/LT to identify the angiogenic molecules as potential therapeutic targets. The intra-tumoral microvessel density (MVD) was assessed by immunohistochemical studies of CD20 and CD31. The MVD was higher in PCLBCL/LT compared with indolent PCBCL. Analyses of open-source microarray data showed correlation between the angiogenic molecule angiopoietin-2 (Ang-2) and pan-endothelial cell markers. ELISA studies determined a shift between Ang-2 and Ang-1 towards Ang-2 in the peripheral blood of PCLBCL/LT patients. Immunofluorescence costainings against the Ang receptor Tie2/angiogenic integrins/CD34 revealed that the vasculature in both aggressive and indolent PCBCL tumors harbours an endothelial cell subpopulation with reduced expression of Tie2. In contrast, the alternative Ang-2 binding partners, angiogenic integrins, are strongly expressed in PCBCL. In line with these findings, downstream targets of Ang-2-integrin signalling, that is phosphorylation of focal adhesion kinase at Tyr397, and sprouting angiogenesis are enhanced in PCLBCL/LT. Our data present Ang-2 as a promising therapeutic target and anti-angiogenic therapy as a new line in treatment of PCLBCL/LT as a hitherto intractable disease.


Exp Dermatol


Experimental dermatology


Teichert M,Stumpf C,Booken N,Wobser M,Nashan D,Hallermann C,Mogler C,Müller CS,Becker JC,Moritz RK,Andrulis M,Nicolay JP,Goerdt S,Thomas M,Klemke CD,Augustin HG,Felcht M




Has Abstract


2015-06-01 00:00:00












  • Shprintzen-Goldberg syndrome associated with a novel missense mutation in TGFBR2.

    abstract::Shprintzen-Goldberg syndrome (SGS) is a rare disorder characterized by a Marfan-like habitus, mental retardation and craniosynostosis. Cardiac abnormalities, such as aortic root dilation have also been noted as well as several skeletal abnormalities. Its nosological status is unclear as it is hard to delineate SGS fro...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: van Steensel MA,van Geel M,Parren LJ,Schrander-Stumpel CT,Marcus-Soekarman D

    更新日期:2008-04-01 00:00:00

  • Deposition of chromatin-IgG complexes in skin of nephritic MRL-lpr/lpr mice is associated with increased local matrix metalloprotease activities.

    abstract::Chromatin-IgG complexes appear as electron dense structures (EDS) in glomerular basement membranes in lupus nephritis. Here, we present results of comparative analyses of the composition of EDS in murine lupus dermatitis and nephritis. One focus was to perform an analytical approach to understand why such complex stru...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Hedberg A,Fismen S,Fenton KA,Mortensen ES,Rekvig OP

    更新日期:2010-08-01 00:00:00

  • IL-15 and IL-23 synergize to trigger Th17 response by CLA+ T cells in psoriasis.

    abstract::IL-15 has emerged as a potentially relevant target in the IL-17 response in psoriasis. However, its mechanism is poorly characterized in humans. IL-15 and IL-23 are constitutively expressed in the psoriatic lesion. Also, IL-15 is considered a susceptibility-associated gene in psoriasis, as are IL-23R, and HLACW6. Here...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: de Jesús-Gil C,Ruiz-Romeu E,Ferran M,Sagristà M,Chiriac A,García P,Celada A,Pujol RM,Santamaria-Babí LF

    更新日期:2020-05-31 00:00:00

  • p53 gene mutations in human skin cancers.

    abstract::The p53 gene is mutated in numerous human cancers. We used it as a molecular target to characterize and try to understand the induction of mutations in human skin cancers. About 40-50% of all skin cancers in normal individuals and 60-80% of the DNA-repair-deficient xeroderma pigmentosum patients exhibit p53 mutations....

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Sarasin A,Giglia-Mari G

    更新日期:2002-01-01 00:00:00

  • Nail abnormalities identified in an ageing study of 30 inbred mouse strains.

    abstract::In a large-scale ageing study, 30 inbred mouse strains were systematically screened for histologic evidence of lesions in all organ systems. Ten strains were diagnosed with similar nail abnormalities. The highest frequency was noted in NON/ShiLtJ mice. Lesions identified fell into two main categories: acute to chronic...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Linn SC,Mustonen AM,Silva KA,Kennedy VE,Sundberg BA,Bechtold LS,Alghamdi S,Hoehndorf R,Schofield PN,Sundberg JP

    更新日期:2019-04-01 00:00:00

  • Structural alterations provoked by narrow-band ultraviolet B in immortalized keratinocytes: assessment by atomic force microscopy.

    abstract::We applied atomic force microscopy (AFM) to visualize ultrastructural changes of the keratinocyte morphology after narrow-band ultraviolet B (NB-UVB) irradiation. Immortalized human keratinocytes were cultured under standard conditions, irradiated with NB-UVB light at doses ranging from 50 to 800 mJ/cm2 and imaged by ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Reich A,Lehmann B,Meurer M,Muller DJ

    更新日期:2007-12-01 00:00:00

  • In vivo reflectance confocal microscopy of erythematosquamous skin diseases.

    abstract:BACKGROUND:In vivo reflectance confocal microscopy (RCM) represents a promising imaging tool that allows a non-invasive examination of skin morphology in real time at nearly histological resolution, showing microanatomical structures and individual cells. OBJECTIVES:The aim of our study was to evaluate the diagnostic ...

    journal_title:Experimental dermatology

    pub_type: 临床试验,杂志文章


    authors: Koller S,Gerger A,Ahlgrimm-Siess V,Weger W,Smolle J,Hofmann-Wellenhof R

    更新日期:2009-06-01 00:00:00

  • Enhanced MCP-1 release by keloid CD14+ cells augments fibroblast proliferation: role of MCP-1 and Akt pathway in keloids.

    abstract::Keloids are fibrous overgrowth induced by cutaneous injury. The pathogenesis of keloids is poorly understood, and no convincing animal model exists. Current hypotheses of the pathogenesis classify keloids as an entity of aberrant fibrosis. Hyperactivation of the MCP-1/CCR2 axis reportedly causes fibrosis in liver cirr...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Liao WT,Yu HS,Arbiser JL,Hong CH,Govindarajan B,Chai CY,Shan WJ,Lin YF,Chen GS,Lee CH

    更新日期:2010-08-01 00:00:00

  • Activin A-induced signalling controls hair follicle neogenesis.

    abstract::Acquisition of potent human dermal papilla (DP) cells that can induce hair follicle neogenesis is an overarching concern, and various approaches have been tried. In an attempt to solve the problem, we previously introduced the three-dimensional (3D) culture of human DP cells and observed de novo formation of hair foll...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Seo CH,Kwack MH,Kim MK,Kim JC,Sung YK

    更新日期:2017-02-01 00:00:00

  • Decreased incidence of papillomas in mice with impaired EGFR function during multi-stage skin carcinogenesis.

    abstract::Genetically modified mouse lines revealed that the epidermal growth factor receptor (EGFR) is essential for the development and homoeostasis of the epidermis and hair follicles. However, more detailed studies have been precluded by the shortened lifespan of Egfr knockout mice. We employed the mouse line Wa5 (carrying ...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Dahlhoff M,Rose C,Wolf E,Schneider MR

    更新日期:2011-03-01 00:00:00

  • Mitochondrial oxidative stress as a novel therapeutic target to overcome intrinsic drug resistance in melanoma cell subpopulations.

    abstract::Despite recent success in melanoma therapy, most patients with metastatic disease still undergo deadly progression. We have identified a novel mechanism of multidrug resistance allowing a small subpopulation of slow-cycling melanoma cells to survive based on elevated oxidative bioenergy metabolism. In this study, we a...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Cierlitza M,Chauvistré H,Bogeski I,Zhang X,Hauschild A,Herlyn M,Schadendorf D,Vogt T,Roesch A

    更新日期:2015-02-01 00:00:00

  • Messenger RNAs for the multifunctional cytokines interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor-alpha are present in adnexal tissues and in dermis of normal human skin.

    abstract::Interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) are 3 cytokines that play a key rôle in cutaneous homeostasis and in the immunopathogenesis of a number of dermatologic diseases. Most studies have focused on their production by keratinocytes and Langerhans ce...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Boehm KD,Yun JK,Strohl KP,Elmets CA

    更新日期:1995-12-01 00:00:00

  • Topically injected adrenocorticotropic hormone induces mechanical hypersensitivity on a full-thickness cutaneous wound model in rats.

    abstract::Cutaneous wound pain causes physical and psychological stress for patients with wounds. Previous studies reported that stress induces hyperalgesia and deteriorates wound healing. However, the effect of the stress response such as in hypothalamic-pituitary-adrenal (HPA) axis on local wound area is unclear. We aimed to ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Goto T,Nakagami G,Minematsu T,Tomida S,Shinoda M,Iwata K,Sanada H

    更新日期:2019-09-01 00:00:00

  • Immune cell regulation of the hair cycle.

    abstract::The ability to manipulate the mammalian hair cycle will lead to novel therapies and strategies to combat all forms of alopecia. Thus, in addition to the epithelial-mesenchymal interactions in the hair follicle, niche and microenvironmental signals that accompany the phases of growth, regression and rest need to be scr...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Wang ECE,Higgins CA

    更新日期:2020-03-01 00:00:00

  • Tiled array-based sequencing identifies enrichment of loss-of-function variants in the highly homologous filaggrin gene in African-American children with severe atopic dermatitis.

    abstract::Filaggrin (FLG) loss-of-function (LOF) variants are a major risk factor for the common inflammatory skin disease, atopic dermatitis (AD) and are often population-specific. African-American (AA) children are disproportionately affected with AD, often later developing asthma and/or allergic rhinitis and comprise an atop...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Mathyer ME,Quiggle AM,Wong XFCC,Denil SLIJ,Kumar MG,Ciliberto HM,Bayliss SJ,Common JE,de Guzman Strong C

    更新日期:2018-09-01 00:00:00

  • Persistent CMV infection correlates with disease activity and dominates the phenotype of peripheral CD8+ T cells in psoriasis.

    abstract:BACKGROUND:Previously, we have reported a frequent association of active plaque psoriasis with inflammation-mediated cytomegalovirus (CMV) reactivation. OBJECTIVES:This study aimed at characterizing the impact of CMV infection on psoriasis disease activity and peripheral cellular adaptive immune response. PATIENTS/ME...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Weitz M,Kiessling C,Friedrich M,Prösch S,Höflich C,Kern F,Volk HD,Sterry W,Asadullah K,Döcke WD

    更新日期:2011-07-01 00:00:00

  • TNF-alpha, RANTES, and MCP-1 are major chemoattractants of murine Langerhans cells to the regional lymph nodes.

    abstract::We have previously reported that lymph node cells generated chemotactic factors for Langerhans cells (LCs) in the induction phase of contact dermatitis. In order to clarify the chemotactic factors involved in migration to the regional lymph nodes, we investigated the migratory activity of murine LCs toward several cyt...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Yamazaki S,Yokozeki H,Satoh T,Katayama I,Nishioka K

    更新日期:1998-02-01 00:00:00

  • R164C mutation in FOXQ1 H3 domain affects formation of the hair medulla.

    abstract::A number of single gene mutations in laboratory mice produce hair follicle defects resulting in deformed hair shafts. The radiation-induced (SB/LeJ-Foxq1(sa)) satin mutant mice have a satin-like sheen to their hair and dilute colouration. This sheen is due to failure of the hair shafts to develop normal medullas, whil...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Wu B,Herbert Pratt C,Potter CS,Silva KA,Kennedy V,Sundberg JP

    更新日期:2013-03-01 00:00:00

  • Pemphigus mouse model as a tool to evaluate various immunosuppressive therapies.

    abstract::Pemphigus vulgaris (PV) is an autoimmune bullous disease caused by immunoglobulin G (IgG) autoantibodies against desmoglein 3 (Dsg3). We have generated an active disease mouse model for PV by adoptive transfer of Dsg3(-/-) lymphocytes. In this study, we investigated the benefits and limitations of this model as a tool...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Takae Y,Nishikawa T,Amagai M

    更新日期:2009-03-01 00:00:00

  • The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis.

    abstract::Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat gl...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Bovell DL,MacDonald A,Meyer BA,Corbett AD,MacLaren WM,Holmes SL,Harker M

    更新日期:2011-12-01 00:00:00

  • Altered regulation of collagen metabolism in scleroderma fibroblasts grown within three-dimensional collagen gels.

    abstract::In systemic scleroderma (SSc) excessive deposition of collagen leads to fibrosis of various tissues including the skin. Previous studies have demonstrated that scleroderma fibroblasts in explant monolayer cultures are heterogeneous with respect to their levels of collagen synthesis. The critical role played by the ext...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Mauch C,Kozlowska E,Eckes B,Krieg T

    更新日期:1992-11-01 00:00:00

  • Regulatory T cells in autoimmune skin diseases.

    abstract::CD4+ Foxp3+ regulatory T cells (Tregs) are suppressors of immune activation and play a crucial role in the maintenance of peripheral tolerance. Mutations of Foxp3 result in fatal autoimmunity in multiple organs, including the skin, in both humans and mice. Many studies have demonstrated the altered frequency and funct...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Ujiie H

    更新日期:2019-06-01 00:00:00

  • Activating transcription factor 3 (ATF3) expression is increased in erythema multiforme and is regulated by IFN-gamma in human keratinocytes.

    abstract::Activating transcription factor 3 (ATF3) expression is increased in erythema multiforme and is regulated by IFN-gamma in human keratinocytes. Experimental Dermatology 2010; 19: e310-e313. Abstract: Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP responsive element-binding protein (CREB) fami...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Pollack BP,Sapkota B,Haun PL

    更新日期:2010-08-01 00:00:00

  • Expression analysis of PD-1 and Tim-3 immune checkpoint receptors in patients with vitiligo; positive association with disease activity.

    abstract::The contribution of immune checkpoint receptors in the immunopathogenesis of various autoimmune diseases has been addressed in previous reports. In this study,  the expression profile of T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) and programmed cell death-1 (PD-1) checkpoint molecules was investigated...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Rahimi A,Hossein-Nataj H,Hajheydari Z,Aryanian Z,Shayannia A,Ajami A,Asgarian-Omran H

    更新日期:2019-06-01 00:00:00

  • Therapies for inherited skin fragility disorders.

    abstract::Inherited skin fragility comprises disorders characterized by mechanical induced blistering and erosions within the skin and mucosal membranes as a consequence of mutations in genes encoding proteins involved in intra-epidermal or dermal-epidermal adhesion. As the molecular pathology is largely known, it is a prototyp...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Has C,Kiritsi D

    更新日期:2015-05-01 00:00:00

  • Activation of NLRP3 signalling accelerates skin wound healing.

    abstract::The process of skin wound healing involves the following three steps: inflammation, tissue formation and tissue remodelling. These optimal steps are required for the development of normal wound healing. Recent reports demonstrated that inflammasomes are involved in the innate immune response. In the present study, we ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Ito H,Kanbe A,Sakai H,Seishima M

    更新日期:2018-01-01 00:00:00

  • Role of scratch-induced cutaneous prostaglandin D production on atopic-like scratching behaviour in mice.

    abstract::NC/Nga mice are known to develop scratching dermatitis akin to atopic dermatitis, under conventional (Conv), but not under the specific-pathogen-free (SPF) condition. In this study, we examined the effects of mechanical-scratching on the spontaneous scratching counts (sign of itching), in relation to the cutaneous pro...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Takaoka A,Arai I,Sugimoto M,Futaki N,Sakurai T,Honma Y,Nakaike S

    更新日期:2007-04-01 00:00:00

  • A novel mutation of the glomulin gene in an Italian family with autosomal dominant cutaneous glomuvenous malformations.

    abstract::Glomuvenous malformations (GVM) are hamartomas characterized histologically by glomus cells, which should be distinguished from glomus tumors. Familial GVM are rare, often present as multiple lesions, and exhibit familial aggregation, with autosomal dominant transmission. GVM are caused by mutations of the glomulin (G...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Borroni RG,Narula N,Diegoli M,Grasso M,Concardi M,Rosso R,Cerica A,Brazzelli V,Arbustini E

    更新日期:2011-12-01 00:00:00

  • Egr-1 is a key regulator of IL-17A-induced psoriasin upregulation in psoriasis.

    abstract::The early growth response (Egr)-1 is a transcriptional factor which plays an important role in the regulation of cell growth, differentiation, cell survival and immune responses. Emerging evidences including our data demonstrate that the Egr-1 expression is up-regulated in the psoriatic skin lesions. The purpose of th...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Jeong SH,Kim HJ,Jang Y,Ryu WI,Lee H,Kim JH,Bae HC,Choi JE,Kye YC,Son SW

    更新日期:2014-12-01 00:00:00

  • Mitochondrial dysfunction: a neglected component of skin diseases.

    abstract::Aberrant mitochondrial structure and function influence tissue homeostasis and thereby contribute to multiple human disorders and ageing. Ten per cent of patients with primary mitochondrial disorders present skin manifestations that can be categorized into hair abnormalities, rashes, pigmentation abnormalities and acr...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Feichtinger RG,Sperl W,Bauer JW,Kofler B

    更新日期:2014-09-01 00:00:00