Calmodulin 4 is dispensable for epidermal barrier formation and wound healing in mice.

Abstract:

:Calcium-mediated signals play important roles in epidermal barrier formation, skin homoeostasis and wound repair. Calmodulin 4 (Calm4) is a small, Ca2+ -binding protein with strong expression in suprabasal keratinocytes. In mice, Calm4 first appears in the skin at the time of barrier formation, and its expression increases in response to epidermal barrier challenges. In this study, we report the generation of Calm4 knockout mice and provide evidence that Calm4 is dispensable for epidermal barrier formation, maintenance and repair.

journal_name

Exp Dermatol

journal_title

Experimental dermatology

authors

Lessard JC,Kalinin A,Bible PW,Morasso MI

doi

10.1111/exd.12568

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

55-7

issue

1

eissn

0906-6705

issn

1600-0625

journal_volume

24

pub_type

信件
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