Systemic therapy for metastatic malignant melanoma--from deeply disappointing to bright future?

abstract：:Pheomelanin is supposed to be the first type of melanin found in vertebrates, in contrast to the main type - eumelanin. Our study aimed at detecting pheomelanin in the skin of Hymenochirus boettgerii. We employed electron paramagnetic resonance (EPR) spectroscopy, and transmission electron microscopy (TEM), supplement...

journal_title：Experimental dermatology

authors： Wolnicka-Glubisz A,Pecio A,Podkowa D,Kolodziejczyk LM,Plonka PM

更新日期：2012-07-01 00:00:00

abstract：:Proteases and their receptors have poorly understood roles in skin fibrosis and systemic scleroderma (SSc). We examined the role of protease-activated receptors (PAR(1) and PAR(2) ) in the pathophysiology of human SSc and skin fibrosis. Immunohistochemistry showed that PAR(1) immunoreactivity was positive in fibroblas...

journal_title：Experimental dermatology

authors： Cevikbas F,Seeliger S,Fastrich M,Hinte H,Metze D,Kempkes C,Homey B,Steinhoff M

更新日期：2011-01-01 00:00:00

abstract：:Inter-α-trypsin inhibitors are protease inhibitors that are thought to be important regulators in various acute-phase processes. They are composed of one light chain (bikunin) and different heavy chains (ITIHs). The only function known so far of ITIHs is the covalent linkage to hyaluronan (HA). As there is virtually n...

journal_title：Experimental dermatology

authors： Huth S,Heise R,Vetter-Kauczok CS,Skazik C,Marquardt Y,Czaja K,Knüchel R,Merk HF,Dahl E,Baron JM

更新日期：2015-09-01 00:00:00

abstract：:Quercetin, glycosylated form of flavonoid compound, has potent antioxidant and anti-inflammatory properties. In this study, we have investigated the effects of quercetin on skin lesion, high-mobility group box (HMGB)1 cascade signalling and inflammation in atopic dermatitis (AD) mouse model. AD-like lesion was induced...

journal_title：Experimental dermatology

authors： Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Nomoto M,Miyashita S,Suzuki K,Nakamura M,Watanabe K

更新日期：2015-06-01 00:00:00

abstract：:Keloids are fibrous overgrowth induced by cutaneous injury. The pathogenesis of keloids is poorly understood, and no convincing animal model exists. Current hypotheses of the pathogenesis classify keloids as an entity of aberrant fibrosis. Hyperactivation of the MCP-1/CCR2 axis reportedly causes fibrosis in liver cirr...

journal_title：Experimental dermatology

authors： Liao WT,Yu HS,Arbiser JL,Hong CH,Govindarajan B,Chai CY,Shan WJ,Lin YF,Chen GS,Lee CH

更新日期：2010-08-01 00:00:00

abstract：:We analysed the correlation between the expression of HIF-1α (hypoxia-inducible factor 1 alpha), the nuclear receptors: VDR (vitamin D receptor), RORα (retinoic acid receptor-related orphan receptor alpha), and RORγ and CYP24A1 (cytochrome P450 family 24 subfamily A member 1) and CYP27B1 (cytochrome P450 family 27 sub...

journal_title：Experimental dermatology

authors： Brożyna AA,Jóźwicki W,Jetten AM,Slominski AT

更新日期：2019-09-01 00:00:00

abstract：:Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have i...

journal_title：Experimental dermatology

authors： Niyonsaba F,Kiatsurayanon C,Chieosilapatham P,Ogawa H

更新日期：2017-11-01 00:00:00

abstract：:Mast cells (MCs) have been intensely investigated over the past two decades, e.g. the numbers of PubMed-listed reports on MCs have steadily increased and doubled over the past twenty years. Surprisingly, many recent findings that have fundamentally changed our understanding of MC biology and functions have yet to be s...

journal_title：Experimental dermatology

authors： Maurer M,Metz M

更新日期：2005-12-01 00:00:00

abstract：:Optimized delivery of antigens combined with sustainable maturation of dendritic cells (DCs) is crucial for generation of effective antitumoral immune responses. Multiple approaches for ex vivo antigen loading and improvement in immunogenicity have been described. We have recently established a single-step protocol co...

journal_title：Experimental dermatology

authors： Buhl T,Braun A,Forkel S,Möbius W,van Werven L,Jahn O,Rezaei-Ghaleh N,Zweckstetter M,Mempel M,Schön MP,Haenssle HA

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Previously, we have reported a frequent association of active plaque psoriasis with inflammation-mediated cytomegalovirus (CMV) reactivation. OBJECTIVES:This study aimed at characterizing the impact of CMV infection on psoriasis disease activity and peripheral cellular adaptive immune response. PATIENTS/ME...

journal_title：Experimental dermatology

authors： Weitz M,Kiessling C,Friedrich M,Prösch S,Höflich C,Kern F,Volk HD,Sterry W,Asadullah K,Döcke WD

更新日期：2011-07-01 00:00:00

abstract：:Cowden syndrome (CS) is an autosomal dominant inherited disorder characterized by hamartomas in a variety of tissues including the skin, thyroid, breast, endometrium, and the brain. Individuals with CS are predisposed to development of malignancy in these organs, especially the breast and the thyroid. We describe 3 un...

journal_title：Experimental dermatology

authors： Celebi JT,Ping XL,Zhang H,Remington T,Sulica VI,Tsou HC,Peacocke M

更新日期：2000-04-01 00:00:00

abstract：:Keratinocytes (KCs) play a critical role in maintaining the cutaneous structure and are involved in various physiological and pathologic processes of the skin. Many inflammatory skin diseases and skin cancers result from excessive proliferation and insufficient apoptosis of KCs. Recent data suggested that the sonic he...

journal_title：Experimental dermatology

authors： Liu H,Jian Q,Xue K,Ma C,Xie F,Wang R,Liao W,Liu Y,Chi S,Li C

更新日期：2014-12-01 00:00:00

abstract：:Dendritic cells (DCs) show a Janus-like functional behavior. They help us by their orchestration of numerous immune responses to defend our body against invading pathogenic micro-organisms and also induce regulatory T cells to inhibit immune reactions against autoantigens as well as diverse harmless environmental anti...

journal_title：Experimental dermatology

authors： Schäkel K

更新日期：2009-03-01 00:00:00

abstract：:The bioactive lysophospholipid sphingosine-1-phosphate (S1P) is best known for its activity as T-cell-active chemoattractant regulating the egress of T cells from the lymph node and, consequently, the availability of T cells for migration into peripheral tissues. This physiological role of S1P is exploited by the drug...

journal_title：Experimental dermatology

authors： Thieme M,Zillikens D,Sadik CD

更新日期：2017-03-01 00:00:00

abstract：:Nitric oxide (NO) is a reactive endogenous molecule with multiple functions including inflammation and immunity. NO stimulates melanogenesis by activating soluble guanylyl cyclase (sGC) resulting in increases in intracellular guanosine 3',5'-cyclic monophosphate (cGMP). In vitro experiments showed that NO could inhibi...

journal_title：Experimental dermatology

authors： Ivanova K,van den Wijngaard R,Gerzer R,Lamers WH,Das PK

更新日期：2005-06-01 00:00:00

abstract：:The role of angiogenesis in tumour growth and metastasis is well established. However, investigations of tumour microcirculation to date have used either biopsy material from human tumours, or animal models in vivo. We have studied the tumour microcirculation in vivo in human skin cancers using video-microscopy to exa...

journal_title：Experimental dermatology

authors： Bedlow AJ,Stanton AW,Cliff S,Mortimer PS

更新日期：1999-06-01 00:00:00

abstract：:The molecular nature of the hair cycle clock (HCC), the intrinsic oscillator system that drives hair follicle (HF) cycling, remains incompletely understood; therefore, all relevant key players need to be identified. Here, we present evidence that implicates myelin protein zero-like 3 (MPZL3), a multifunctional nuclear...

journal_title：Experimental dermatology

authors： Nicu C,Wikramanayake TC,Paus R

更新日期：2020-12-01 00:00:00

abstract：:Solar ultraviolet (UV) radiation has hazardous effects on human health that are, in part, associated with its immunosuppressive effects via the induction of interleukin (IL)-10 production. Although IL-10 is produced by both T helper type 2 (Th2) cells and T-regulatory type 1 (Tr1) cells, the relative contribution of e...

journal_title：Experimental dermatology

authors： Stoebner PE,Rahmoun M,Ferrand C,Meunier L,Yssel H,Pène J

更新日期：2006-08-01 00:00:00

abstract：:The potentially severe side effects of systemic corticosteroids and immunosuppressants used in Pemphigus vulgaris (PV) call for novel therapeutic approaches. In this context, pharmacological inhibition of major pathogenic signalling effectors represents a promising alternative. However, we have also shown that overinh...

journal_title：Experimental dermatology

authors： Hariton WVJ,Galichet A,Vanden Berghe T,Overmiller AM,Mahoney MG,Declercq W,Müller EJ

更新日期：2017-12-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are thought to have various functions other than RNA silencing. We tried to evaluate the expression of lncRNAs in patients with systemic sclerosis (SSc) and determined whether lncRNAs controls collagen expression in dermal fibroblasts. lncRNA expression was determined by real-time PCR an...

journal_title：Experimental dermatology

authors： Wang Z,Jinnin M,Nakamura K,Harada M,Kudo H,Nakayama W,Inoue K,Nakashima T,Honda N,Fukushima S,Ihn H

更新日期：2016-02-01 00:00:00

abstract：:Chemical haptens induce a variety of allergic immune reactions by induction of hapten-specific T cells. Contact sensitizers such as the hapten trinitrochlorobenzene (TNCB) elicit an allergic response, which is confined to the area of antigen exposure. Despite this localized allergic response, we show here that the tri...

journal_title：Experimental dermatology

authors： Martin S,Delattre V,Leicht C,Weltzien HU,Simon JC

更新日期：2003-02-01 00:00:00

abstract：:Reverse transcription polymerase chain reaction (qRT-PCR) has become a mainstay in many areas of skin research. To enable quantitative analysis, it is necessary to analyse expression of reference genes (RGs) for normalization of target gene expression. The selection of reliable RGs therefore has an important impact on...

journal_title：Experimental dermatology

authors： Beer L,Mlitz V,Gschwandtner M,Berger T,Narzt MS,Gruber F,Brunner PM,Tschachler E,Mildner M

更新日期：2015-10-01 00:00:00

abstract：:Topical photodynamic therapy with 5-aminolevulinic acid (5-ALA) is a newly established treatment modality for epithelial skin cancer. Skin distribution of different 20% 5-ALA formulations was investigated by detection of protoporphyrin IX (PpIX) using an ex vivo porcine skin model. Fluorescence of PpIX was first detec...

journal_title：Experimental dermatology

authors： Maisch T,Worlicek C,Babilas P,Landthaler M,Szeimies RM

更新日期：2008-10-01 00:00:00

abstract：:Activating transcription factor 3 (ATF3) expression is increased in erythema multiforme and is regulated by IFN-gamma in human keratinocytes. Experimental Dermatology 2010; 19: e310-e313. Abstract: Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP responsive element-binding protein (CREB) fami...

journal_title：Experimental dermatology

authors： Pollack BP,Sapkota B,Haun PL

更新日期：2010-08-01 00:00:00

abstract：:Skin irritation is one of the most common adverse reactions in hydroquinone (HQ) and retinoic acid (RA). Although melanocytes have rarely been considered to be involved in skin irritation, RA and particularly HQ could induce melanocyte toxicity, resulting in depigmentation. We chose S100B as a candidate gene for melan...

journal_title：Experimental dermatology

authors： Cheong KA,Noh M,Kim CH,Lee AY

更新日期：2014-03-01 00:00:00

abstract：:Stratum corneum (SC) exposed to living tissues, induces inflammation characterized by the formation of mixed cell granulomas consisting of infiltrative polymorphonuclear leukocytes (PMNs) and monocytes/macrophages. In this study, to clarify the mechanism for the later monocyte accumulation in SC-induced granulomas, we...

journal_title：Experimental dermatology

authors： Ozawa M,Terui T,Tanita M,Kato T,Tagami H

更新日期：1998-08-01 00:00:00

abstract：:Congenital melanocytic nevi (CMN) are benign proliferations that may be associated with various consequences depending on their size. They are characterized by a specific molecular signature, namely a postzygotic somatic NRAS or BRAF mutation. We have recently reported that large CMN (lCMN), which are classically asso...

journal_title：Experimental dermatology

authors： Guégan S,Kadlub N,Picard A,Rouillé T,Charbel C,Coulomb-L'Hermine A,How-Kit A,Fraitag S,Aractingi S,Fontaine RH

更新日期：2016-10-01 00:00:00

abstract：:Chronic spontaneous urticaria (CSU) is a frequent disorder with recurrent itchy wheals and/or angioedema, and nearly 35% patients respond poorly to non-sedating H1 antihistamine treatment. CRP gene encodes the C-reactive protein, which is involved in the pathogenesis of CSU. To investigate the impacts of CRP polymorph...

journal_title：Experimental dermatology

authors： Yan S,Chen W,Peng C,Zhu W,Chen M,Zhang J,Su J,Li F,Liu Z,Zhang W,Li Q,Li J,Chen X

更新日期：2019-03-01 00:00:00

abstract：:We have employed a panel of antibodies directed against several newly-defined and well-characterized components of the epidermal basement membrane (BM) to investigate the biology of basal cell carcinoma (BCC) by indirect immunofluorescence and to determine whether alterations in BM components may play a significant ro...

journal_title：Experimental dermatology

authors： Korman NJ,Hrabovsky SL

更新日期：1993-06-01 00:00:00

abstract：:Patients belonging to xeroderma pigmentosum (XP) complementation group C comprise one-third of all XP patients. Only four major reports compiled larger groups of XP-C patients from southern Europe (12 pts), North America (16 pts) and Africa (14 and 56 pts) as well as their genetic background (46 XPC mutations). We ide...

journal_title：Experimental dermatology

authors： Schäfer A,Hofmann L,Gratchev A,Laspe P,Schubert S,Schürer A,Ohlenbusch A,Tzvetkov M,Hallermann C,Reichrath J,Schön MP,Emmert S

更新日期：2013-01-01 00:00:00