Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases.

abstract：:In the 1970s, studies of tissue architecture and cell proliferation were used to formulate a new model of epidermal homeostasis. This asserted that the tissue was maintained by long-lived, slow-cycling, self-renewing stem cells that generate a short-lived population of transit amplifying (TA) cells, which undergo term...

journal_title：Experimental dermatology

authors： Doupé DP,Jones PH

更新日期：2012-04-01 00:00:00

abstract：:Serum levels of B-cell activating factor belonging to the tumor necrosis factor family (BAFF), a potent B-cell survival factor, are elevated in patients with systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis and systemic sclerosis (SSc). The objective of this study was to d...

journal_title：Experimental dermatology

authors： Matsushita T,Hasegawa M,Matsushita Y,Echigo T,Wayaku T,Horikawa M,Ogawa F,Takehara K,Sato S

更新日期：2007-02-01 00:00:00

abstract：:Chemical haptens induce a variety of allergic immune reactions by induction of hapten-specific T cells. Contact sensitizers such as the hapten trinitrochlorobenzene (TNCB) elicit an allergic response, which is confined to the area of antigen exposure. Despite this localized allergic response, we show here that the tri...

journal_title：Experimental dermatology

authors： Martin S,Delattre V,Leicht C,Weltzien HU,Simon JC

更新日期：2003-02-01 00:00:00

abstract：:Terence Kealey first pioneered the isolation and organ maintenance of human eccrine and sebaceous glands in the early to mid-1980. This led to subsequent methods describing the isolation and culture of human hair follicles, the human pilosebaceous unit as well as the sebaceous duct. The importance of these models in t...

journal_title：Experimental dermatology

authors： Philpott MP

更新日期：2018-05-01 00:00:00

abstract：:We aimed to evaluate the effect of small interfering RNA (siRNA) targeting CTGF on extracellular matrices (ECMs) metabolism in normal and SSc fibroblasts. Normal and SSc fibroblasts were transfected with CTGF-specific siRNAs to silence CTGF synthesis. After silencing CTGF, production of type I collagen and matrix meta...

journal_title：Experimental dermatology

authors： Ishibuchi H,Abe M,Yokoyama Y,Ishikawa O

更新日期：2010-08-01 00:00:00

abstract：:Despite groundbreaking new treatments such as checkpoint inhibition and targeted therapy, the overall response and survival rates are limited in patients with metastatic melanoma. Here, we hypothesize that melatonin and its metabolites could be promising boosters of the efficacy of BRAF/MEK inhibitors in patients with...

journal_title：Experimental dermatology

authors： Kleszczyński K,Böhm M

更新日期：2020-09-01 00:00:00

abstract：:Several association studies and GWAS on melanoma skin cancer risk have reported statistically significant signals on 9p21.3 region, where MTAP gene maps. None of the associated SNPs identified in these studies lie in the coding region of the gene and the causative relation of risk alleles with melanoma predisposition ...

journal_title：Experimental dermatology

authors： Sangalli A,Malerba G,Tessari G,Rodolfo M,Gomez-Lira M

更新日期：2017-08-01 00:00:00

abstract：:Ultraviolet B (UVB) radiation induces inflammation in the skin specifically at the site of exposure. We unexpectedly found that UVB-induced inflammation was not induced in gp91phox-depleted mice. To test whether gp91phox is directly involved in UVB-induced inflammation, neutrophil- and hyaluronic acid-depleted mice we...

journal_title：Experimental dermatology

authors： Hiramoto K,Kobayashi H,Yamate Y,Ishii M,Sato EF

更新日期：2012-12-01 00:00:00

abstract：:Infiltration of eosinophils in atopic dermatitis (AD), which contains inflammatory molecules and cytokines, recruits more inflammatory cells and causes further skin damage. Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine that induces the proinflammatory Th2 immune response and plays an important role in ...

journal_title：Experimental dermatology

authors： Noh JY,Shin JU,Park CO,Lee N,Jin S,Kim SH,Kim JH,Min A,Shin MH,Lee KH

更新日期：2016-11-01 00:00:00

abstract：:UVA(Ultraviolet A)-induced gene expression is supposed to be a hallmark for inflammation, for immunosuppression and in long-term cancer formation. In previous studies, we have shown for keratinocytes that physiological doses of UVA radiation result in the upregulation of gene expression mediated by ceramide formation ...

journal_title：Experimental dermatology

authors： Bayer M,Proksch P,Felsner I,Brenden H,Kohne Z,Walli R,Duong TN,Götz C,Krutmann J,Grether-Beck S

更新日期：2011-11-01 00:00:00

abstract：:Recently, 3% diclofenacnatrium gel (diclofenac) was introduced for the treatment of actinic keratoses. Data on photocarcinogenesis of topical diclofenac are limited, and we wished to investigate whether topical diclofenac can accelerate photocarcinogenesis using simulated solar radiation (SSR). Diclofenac was applied ...

journal_title：Experimental dermatology

authors： Lerche CM,Philipsen PA,Poulsen T,Wulf HC

更新日期：2011-04-01 00:00:00

abstract：:We applied atomic force microscopy (AFM) to visualize ultrastructural changes of the keratinocyte morphology after narrow-band ultraviolet B (NB-UVB) irradiation. Immortalized human keratinocytes were cultured under standard conditions, irradiated with NB-UVB light at doses ranging from 50 to 800 mJ/cm2 and imaged by ...

journal_title：Experimental dermatology

authors： Reich A,Lehmann B,Meurer M,Muller DJ

更新日期：2007-12-01 00:00:00

abstract：:For screening of a potential irritant it is essential that an early marker for irritation should be chosen which could be detected before the physiological signs of irritation occur. Interleukin 1 alpha (IL-1alpha) is widely accepted as such a marker in both in vivo and in vitro test systems. In this study, we have de...

journal_title：Experimental dermatology

authors： Gibbs S,Vietsch H,Meier U,Ponec M

更新日期：2002-06-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are major environmental pollutants, and their effects on the human body critically depend on the aryl hydrocarbon receptor (AhR). The aim of this study was to evaluate the significance of the AhR and its ligands in chronic inflammatory ski...

journal_title：Experimental dermatology

authors： Kim HO,Kim JH,Chung BY,Choi MG,Park CW

更新日期：2014-04-01 00:00:00

abstract：:Somatostatin (SST) is a regulatory peptide hormone that acts through five different G protein-coupled receptors (SSTR1-5). Whereas expression of all five SSTR subtypes in epidermis has been shown, the biological relevance of the SST/SSTR system in the skin is completely unknown. We show here that SST is expressed in h...

journal_title：Experimental dermatology

authors： Vockel M,Breitenbach U,Kreienkamp HJ,Brandner JM

更新日期：2010-10-01 00:00:00

abstract：:Immunohistochemical study of tissues from purulent wounds in rats after treatment with the collagenase isolated from the King crab Paralithodes camtschatica was undertaken. The enzymotherapy resulted in a rapid and efficient removal of necrotic debris. It was accompanied by fibrin elimination from the wound bed and su...

journal_title：Experimental dermatology

authors： Sakharov IYu,Shekhonin BV,Glyanzev SP,Litvin FE

更新日期：1994-04-01 00:00:00

abstract：:Inherited skin fragility comprises disorders characterized by mechanical induced blistering and erosions within the skin and mucosal membranes as a consequence of mutations in genes encoding proteins involved in intra-epidermal or dermal-epidermal adhesion. As the molecular pathology is largely known, it is a prototyp...

journal_title：Experimental dermatology

authors： Has C,Kiritsi D

更新日期：2015-05-01 00:00:00

abstract：:Antibodies, specific to murine DEC205, can be used to target antigens to dendritic cells. The immunodominant domain of human type XVII collagen, hNC16A, was fused to this antibody (DEC-hNC16A) and was administered as expression plasmid by gene gun transfection with the aim of inducing tolerance to human type XVII coll...

journal_title：Experimental dermatology

authors： Ettinger M,Gratz IK,Gruber C,Hauser-Kronberger C,Johnson TS,Mahnke K,Thalhamer J,Hintner H,Peckl-Schmid D,Bauer JW

更新日期：2012-05-01 00:00:00

abstract：:The protease inhibitor cystatin M/E (CST6) regulates a biochemical pathway involved in stratum corneum homeostasis, and its deficiency in mice causes ichthyosis and neonatal lethality. Cystatin M/E deficiency has not been described in humans so far, and we did not detect disease-causing mutations in the CST6 gene in a...

journal_title：Experimental dermatology

authors： Jansen PA,van den Bogaard EH,Kersten FF,Oostendorp C,van Vlijmen-Willems IM,Oji V,Traupe H,Hennies HC,Schalkwijk J,Zeeuwen PL

更新日期：2012-11-01 00:00:00

abstract：:Newborn foreskin and adult skin keratinocytes (KTs) were cultured in 24-well plates using keratinocyte basal medium (KBM) either alone or supplemented with epidermal growth factor (EGF) or nerve growth factor (NGF), plus one of the following: insulin (INS), insulin-like growth factors (IGF)-1 or -2, transforming growt...

journal_title：Experimental dermatology

authors： Wilkinson DI,Theeuwes MJ,Farber EM

更新日期：1994-10-01 00:00:00

abstract：:In the area of dermatological research, the knowledge of rate and extent of substance penetration into the human skin is essential not only for evaluation of therapeutics, but also for risk assessment of chemicals and cosmetic ingredients. Recently, confocal Raman microscopy emerged as a novel analytical technique for...

journal_title：Experimental dermatology

authors： Franzen L,Anderski J,Planz V,Kostka KH,Windbergs M

更新日期：2014-12-01 00:00:00

abstract：:Despite as yet limited clinical effectiveness, dendritic cell (DC)-based immunotherapy remains a promising approach for the treatment of cancer, but requires further improvement in its immunostimulatory effectiveness. Potent anti-tumor immunity often depends on the induction of type 1 (T(H)1) immune responses. Therefo...

journal_title：Experimental dermatology

authors： Balkow S,Loser K,Krummen M,Higuchi T,Rothoeft T,Apelt J,Tuettenberg A,Weishaupt C,Beissert S,Grabbe S

更新日期：2009-01-01 00:00:00

abstract：:Drug resistance in melanoma is commonly attributed to ineffective apoptotic pathways. Targeting apoptosis regulators is thus considered a promising approach to sensitizing melanoma to therapy. In the previous issue of Experimental Dermatology, Plötz and Eberle discuss the role that apoptosis plays in melanoma progress...

journal_title：Experimental dermatology

authors： Haass NK,Schumacher U

更新日期：2014-07-01 00:00:00

abstract：:Dendritic cells (DCs) can be differentiated from CD14+ monocytes in the presence of interferon-α (IFNα) and granulocyte/macrophage-colony stimulating factor (GM-CSF) in vitro and are known as IFN-DCs. Circulating blood CD56+ cells expressing high levels of CD14, HLA-DR and CD86 have been shown to spontaneously differe...

journal_title：Experimental dermatology

authors： Nieda M,Terunuma H,Eiraku Y,Deng X,Nicol AJ

更新日期：2015-01-01 00:00:00

abstract：:Ultraviolet (UV) triggers induction of matrix metalloproteinase-1 (MMP-1) and also induces the rapid appearance of p53 protein in the epidermis and dermal fibroblasts. However, little is known about the role of p53 on MMP-1 expression in human skin. Here, we investigated the effects of p53 on basal and UV-induced MMP-...

journal_title：Experimental dermatology

authors： Kim S,Lee Y,Lee DH,Kim Y,Cho KH,Chung JH

更新日期：2008-11-01 00:00:00

abstract：:Atopic dermatitis (AD) is related to immunoglobulin E (IgE) production, and a type-1 and type-2 helper T cell (Th1/Th2) imbalance has been hypothesized as the aetiology. While itching and scratching are important factors in the development of dermatitis, the mechanisms underlying these phenomena are poorly understood....

journal_title：Experimental dermatology

authors： Hashimoto Y,Takaoka A,Sugimoto M,Honma Y,Sakurai T,Futaki N,Arai I

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Recently, germline variants of the melanocortin-1 receptor (MC1R) have been shown to be associated with an increased risk for BRAF mutant but not BRAF wild-type cutaneous melanoma. Similar to melanoma, BRAF mutations are also commonly found in papillary thyroid carcinomas. Furthermore, patients with melanoma...

journal_title：Experimental dermatology

authors： Bauer J,Weng J,Kebebew E,Soares P,Trovisco V,Bastian BC

更新日期：2009-06-01 00:00:00

abstract：:Basal cell carcinoma of the skin (BCC) is caused by constitutive activation of the Sonic hedgehog (Shh) pathway, mainly through mutations either in the Shh receptor Patched (PTCH) or in its co-receptor Smoothened (Smo). Inhibitors of this pathway that are currently in clinical trials inhibit Smo. However, mutations in...

journal_title：Experimental dermatology

authors： Makinodan E,Marneros AG

更新日期：2012-11-01 00:00:00

abstract：:Chimeric antigen receptor (CAR)-T cells are one of the impressive recent success stories of anti-cancer immunotherapy. Especially in haematological malignancies, this treatment strategy has shown promising results leading to the recent approval of two CAR-T cell constructs targeting CD19 in the United States and the E...

journal_title：Experimental dermatology

authors： Simon B,Uslu U

更新日期：2018-12-01 00:00:00

abstract：:The p53 gene is mutated in numerous human cancers. We used it as a molecular target to characterize and try to understand the induction of mutations in human skin cancers. About 40-50% of all skin cancers in normal individuals and 60-80% of the DNA-repair-deficient xeroderma pigmentosum patients exhibit p53 mutations....

journal_title：Experimental dermatology

authors： Sarasin A,Giglia-Mari G

更新日期：2002-01-01 00:00:00