Abstract:
:Ultraviolet (UV) triggers induction of matrix metalloproteinase-1 (MMP-1) and also induces the rapid appearance of p53 protein in the epidermis and dermal fibroblasts. However, little is known about the role of p53 on MMP-1 expression in human skin. Here, we investigated the effects of p53 on basal and UV-induced MMP-1 in human dermal fibroblasts. To verify the role of p53 on MMP-1 expression, adenoviral p53 (Ad-p53) gene was infected to human dermal fibroblasts. Our results showed that basal and UV-induced MMP-1 expression was prevented by Ad-p53. In contrast, p53 inhibitor, pifithrin-alpha augmented the UV-induced MMP-1 expression. On the other hand, p53 activator, etoposide, decreased the MMP-1 expression in both normal and p53-overexpressed cells. In addition, MMP-1 expression was not changed by etoposide and/or pifithrin-alpha in HaCaT cells, which have mutation of p53. Taken together, we suggest that p53 inhibits basal and UV-induced MMP-1 expression in human dermal fibroblasts.
journal_name
Exp Dermatoljournal_title
Experimental dermatologyauthors
Kim S,Lee Y,Lee DH,Kim Y,Cho KH,Chung JHdoi
10.1111/j.1600-0625.2008.00729.xsubject
Has Abstractpub_date
2008-11-01 00:00:00pages
939-45issue
11eissn
0906-6705issn
1600-0625pii
EXD729journal_volume
17pub_type
杂志文章abstract:BACKGROUND:The accuracy of diagnosis of skin cancer and especially of early malignant melanoma is most important to reduce its morbidity and mortality. Previous pilot studies using electrical impedance measurements indicate statistically significant accuracies for the detection of skin cancer. OBJECTIVES:The aim of th...
journal_title:Experimental dermatology
pub_type: 杂志文章,多中心研究
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更新日期:2011-08-01 00:00:00
abstract::There is increasing awareness that psoriasis is more than 'skin deep'. Several recent reviews focussed on biomarkers indicating the systemic dimension of psoriasis and the aspect of comorbidity psoriasis shares with other chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. Of emerging sign...
journal_title:Experimental dermatology
pub_type: 杂志文章
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abstract::Detergents irritate skin and affect skin barrier homeostasis. In this study, healthy skin was exposed to 1% sodium lauryl sulphate (SLS) in water for 24 h. Biopsies were taken 6 h to 8 days post exposure. Lipid patterns were stained in situ and real-time polymerase chain reaction (PCR) was used to examine mRNA express...
journal_title:Experimental dermatology
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journal_title:Experimental dermatology
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.2010.01101.x
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abstract::Dermal papilla cells (DPC) control the growth character of the hair follicle through their elaboration of mitogenic factors and extracellular matrix components. Further, the dermal papilla is a primary site of androgen action in the hair follicle. Interleukin-1alpha (IL-1alpha) is prominent in skin wounding and inflam...
journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.2006.00462.x
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journal_title:Experimental dermatology
pub_type: 杂志文章
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journal_title:Experimental dermatology
pub_type: 杂志文章
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更新日期:1995-02-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
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pub_type: 评论,杂志文章
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abstract::Terence Kealey first pioneered the isolation and organ maintenance of human eccrine and sebaceous glands in the early to mid-1980. This led to subsequent methods describing the isolation and culture of human hair follicles, the human pilosebaceous unit as well as the sebaceous duct. The importance of these models in t...
journal_title:Experimental dermatology
pub_type: 杂志文章,评审
doi:10.1111/exd.13669
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abstract::White adipose tissue is known to be involved in numerous physiological processes such as insulin-mediated functions, lipid and glucose metabolism, vascular changes and coagulation. These processes are mainly mediated by adipokines that are secreted either from adipocytes or cells of the stromal-vascular fraction of ad...
journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.2011.01402.x
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abstract::Keloids are fibrous overgrowth induced by cutaneous injury. The pathogenesis of keloids is poorly understood, and no convincing animal model exists. Current hypotheses of the pathogenesis classify keloids as an entity of aberrant fibrosis. Hyperactivation of the MCP-1/CCR2 axis reportedly causes fibrosis in liver cirr...
journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.2009.01021.x
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abstract::Alopecia areata (AA) is an autoimmune disease that results in spot baldness in humans. Adequate animal models for AA are currently lacking. The objective of this study was to elucidate the mechanism of autoimmune-like alopecia (ALA) in C57BL/6.CD80CD86-deficient (B6.CD80CD86-/- ) mice. Incidence and severity of alopec...
journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/exd.13371
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.2010.01148.x
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abstract::Pruritus is the most distressing symptom in haemodialysis (HD) patients. Its aetiology has not yet been delineated, and thus there are no good therapeutical options. Case reports and series attribute antipruritic potency to the serotonin receptor antagonists of the 5-HT3 type in renal pruritus. It was the aim of this ...
journal_title:Experimental dermatology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-05-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/exd.13111
更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1111/j.1600-0625.2007.00664.x
更新日期:2008-03-01 00:00:00
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pub_type: 评论,杂志文章
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pub_type: 信件
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pub_type: 杂志文章
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journal_title:Experimental dermatology
pub_type: 评论,杂志文章
doi:10.1111/exd.12194
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/exd.13441
更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.2012.01461.x
更新日期:2012-05-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/exd.14085
更新日期:2020-04-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.2008.00787.x
更新日期:2009-04-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
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journal_title:Experimental dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0625.2009.00853.x
更新日期:2009-03-01 00:00:00
abstract::Rosacea is one of the most common dermatoses of adults. Although the detailed pathophysiology remains unknown, it is thought that rosacea is caused by a consistently aberrant, innate immune response, and that LL-37 plays an important role. However, involvement of the inflammatory cytokine IL-33 has not yet been studie...
journal_title:Experimental dermatology
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00