Abstract：
:Chronic pruritus of any origin is a frequent discomfort in daily medical practice, and its therapy is challenging. Frequently, the underlying origin may not be identified and symptomatic therapy is necessary. Conventional treatment modalities such as antihistamines often lack efficacy, and hence new therapeutic strategies are necessary. The neuronal mechanisms underlying chronic pruritus have been partly identified during the past years and offer new therapeutic strategies. For example, mast cell degranulation, activation of neuroreceptors on sensory nerve fibres and neurogenic inflammation have been identified to be involved in induction and chronification of the symptom. Accordingly, controlling neuroreceptors such as cannabinoid receptors by agonists or antagonists showed high antipruritic efficacy. Pruritus is transmitted to the central nervous system by specialized nerve fibres and sensory receptors. It has been demonstrated that pruritus and pain have their own neuronal pathways with broad interactions. Accordingly, classical analgesics for neuropathic pain (gabapentin, antidepressants) also exhibit antipruritic efficacy upon clinical use. In summary, these recent developments show that highlighting the basis of pruritus offers modern neurophysiological and neurochemical therapeutic models and the possibility to treat patients with refractory itching of different origin.
journal_name
Exp Dermatoljournal_title
Experimental dermatologyauthors
Ständer S,Weisshaar E,Luger TAdoi
10.1111/j.1600-0625.2007.00664.xsubject
Has Abstractpub_date
2008-03-01 00:00:00pages
161-9issue
3eissn
0906-6705issn
1600-0625pii
EXD664journal_volume
17pub_type
杂志文章,评审abstract：:Ultraviolet (UV) triggers induction of matrix metalloproteinase-1 (MMP-1) and also induces the rapid appearance of p53 protein in the epidermis and dermal fibroblasts. However, little is known about the role of p53 on MMP-1 expression in human skin. Here, we investigated the effects of p53 on basal and UV-induced MMP-...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1600-0625.2008.00729.x
更新日期：2008-11-01 00:00:00
abstract：:Portulaca oleracea extracts, known as Ma Chi Hyun in the traditional Korean medicine, show a variety of biomedical efficacies including those in anti-inflammation and anti-allergy. In this study, we investigate the protective activity of the P. oleracea extracts against UVB-induced damage in human epithelial keratinoc...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/exd.12396
更新日期：2014-10-01 00:00:00
abstract：:CD44 and l-selectin (CD62L) are major adhesion receptors that mediate leucocyte recruitment at inflammatory sites and lymph nodes, by supporting cell rolling under blood flow. Both CD44 and CD62L have been implicated in inflammatory skin disorders, but their specific involvement in an immediate-type allergic reaction ...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.0906-6705.2005.00348.x
更新日期：2005-09-01 00:00:00
abstract：:Ichthyosis follicularis, alopecia and photophobia (IFAP) syndrome is an X-linked genodermatosis with congenital atrichia being the most prominent feature. Recently, we have shown that functional deficiency of MBTPS2 (membrane-bound transcription factor protease site 2) - a zinc metalloprotease essential for cholestero...
journal_title：Experimental dermatology
pub_type： 信件
doi：10.1111/j.1600-0625.2010.01238.x
更新日期：2011-05-01 00:00:00
abstract：:Pseudoxanthoma elasticum (PXE), a systemic heritable connective tissue disorder, is characterized by progressive calcification of elastic structures in the skin, the eyes and the cardiovascular system, with considerable intra- and interfamilial phenotypic variability. Recently, underlying genetic defects have been ide...
journal_title：Experimental dermatology
pub_type： 杂志文章,评审
doi：10.1034/j.1600-0625.2001.100401.x
更新日期：2001-08-01 00:00:00
abstract：:Patients sensitized to para-phenylenediamine (PPD) by semi-permanent tattoos increasingly develop threatening allergic reactions in response to black hair dye. The gold standard to diagnose allergic contact dermatitis is to perform epicutaneous patch tests, however, iatrogenic sensitizations and severe patch test reac...
journal_title：Experimental dermatology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1600-0625.2009.01043.x
更新日期：2010-05-01 00:00:00
abstract：:Chimeric antigen receptor (CAR)-T cells are one of the impressive recent success stories of anti-cancer immunotherapy. Especially in haematological malignancies, this treatment strategy has shown promising results leading to the recent approval of two CAR-T cell constructs targeting CD19 in the United States and the E...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/exd.13792
更新日期：2018-12-01 00:00:00
abstract：:Flavonoids belong to a large group of polyphenolic compounds that are widely present in plants. Certain flavonoids, including naringenin, have cytoprotective properties. Although the antioxidant effect has long been thought to be a crucial factor accounting for the cellular effects of flavonoids, mitochondrial channel...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/exd.13903
更新日期：2019-05-01 00:00:00
abstract：:Curcumin (diferuloylmethane) is a polyphenol derived from turmeric (Curcuma longa), which is commonly used as a spice. Recent studies have shown that curcumin has a wide range of pharmacological activities, including anticarcinogenic, antioxidant, anti-inflammatory and antiangiogenic activities. However, the antiphoto...
journal_title：Experimental dermatology
pub_type： 信件
doi：10.1111/exd.12137
更新日期：2013-05-01 00:00:00
abstract：:Type VII collagen is the major component of anchoring fibrils in the epidermal basement membrane. Its expression has been analyzed by immunostaining or Northern blotting, but rarely at the protein level. In this study, we have quantitatively examined the effects of ascorbic acid and various cytokines/growth factors on...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1600-0625.2006.00514.x
更新日期：2007-02-01 00:00:00
abstract：:The high-frequency electrical conductance of tape-stripped human skin in vivo can be used to evaluate the hydration profile of Stratum corneum (SC). Tape-stripping provides access to the underlying SC layers, and the conductance of these layers (as measured by the Skicon instrument) correlates well with their water co...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1600-0625.2009.00868.x
更新日期：2009-10-01 00:00:00
abstract：:Second-harmonic-generation (SHG) microscopy is a powerful tool for in vivo visualisation of collagen fibres in human skin because of its specific collagen selectivity without the need for staining, non-invasiveness and high-resolution three-dimensional imaging. Although texture analysis of SHG images is a promising me...
journal_title：Experimental dermatology
pub_type： 临床试验,杂志文章
doi：10.1111/exd.13560
更新日期：2019-08-01 00:00:00
abstract：:Ultraviolet (UV) radiation contained in sunlight is considered a major risk in the induction of skin cancer. While mast cells are best known for their role in allergic responses, they have also been shown to play a crucial role in suppressing the anti-tumour immune response following UV exposure. Evidence is now emerg...
journal_title：Experimental dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0625.2012.01438.x
更新日期：2012-04-01 00:00:00
abstract：:Studies have shown that wound pH is a potentially influential factor in the healing process. Due to the flaws of traditional pH measurement approaches, wound pH measurement has not become part of current standard of care. A near-infrared pH-sensitive ratiometric film was created and characterized for measuring wound p...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/exd.14046
更新日期：2020-01-01 00:00:00
abstract：:Basal cell carcinoma of the skin (BCC) is caused by constitutive activation of the Sonic hedgehog (Shh) pathway, mainly through mutations either in the Shh receptor Patched (PTCH) or in its co-receptor Smoothened (Smo). Inhibitors of this pathway that are currently in clinical trials inhibit Smo. However, mutations in...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/exd.12016
更新日期：2012-11-01 00:00:00
abstract：:The outcome of a cutaneous immune response is critically dependent upon the ability of dendritic cells (DC) to migrate from skin to the draining lymph nodes - a process that is influenced by the cutaneous tissue microenvironment. Here, the role of fibroblasts - a major component of the dermal microenvironment - on the...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/exd.12722
更新日期：2015-08-01 00:00:00
abstract：:We have recently demonstrated that telomerase activity is increased and telomere length shortened in lymphocytes from peripheral blood of patients with cutaneous T-cell lymphoma. In order to determine which cell type has increased telomerase activity and shortened telomere length, CD4+, CD8+, CLA+ CD3+ and CLA- CD3+ T...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1034/j.1600-0625.2001.100505.x
更新日期：2001-10-01 00:00:00
abstract：:Systemic sclerosis (SSc) is a complex autoimmune connective tissue disease combining inflammatory, vasculopathic and fibrotic manifestations. Skin features, which give their name to the disease and are considered as diagnostic as well as prognostic markers, have not been thoroughly investigated in terms of therapeutic...
journal_title：Experimental dermatology
pub_type： 杂志文章,评审
doi：10.1111/exd.13806
更新日期：2019-01-01 00:00:00
abstract：:Lipoxygenases (LOX) and cyclooxygenase (COX) are the main enzymes for PUFA metabolism to highly bio-active prostaglandins, leukotrienes, thromboxanes, lipoxins, resolvins and protectins. LOX and COX pathways are important for the regulation of pro-inflammatory or pro-resolving metabolite synthesis and metabolism for v...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/exd.13867
更新日期：2019-02-01 00:00:00
abstract：:Chemokines are small chemotactic proteins that have a crucial role in leukocyte recruitment into tissue. Targeting these mediators has been suggested as a potential therapeutic option in inflammatory skin diseases such as psoriasis. Using quantitative RT-PCR, we found CCL7, a chemokine ligand known to interact with mu...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/exd.12709
更新日期：2015-07-01 00:00:00
abstract：:Keloids are fibrous overgrowth induced by cutaneous injury. The pathogenesis of keloids is poorly understood, and no convincing animal model exists. Current hypotheses of the pathogenesis classify keloids as an entity of aberrant fibrosis. Hyperactivation of the MCP-1/CCR2 axis reportedly causes fibrosis in liver cirr...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1600-0625.2009.01021.x
更新日期：2010-08-01 00:00:00
abstract：:There have been few reports of successful long-term culture of cells established from cutaneous basal cell carcinoma (BCC) tumors. Here, we describe techniques that have enabled us to establish three long-term cultures of BCC cells isolated from BCC tumors that arose in irradiated Patched 1 (Ptch1)(+/-) mice. All thre...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1600-0625.2006.00465.x
更新日期：2006-09-01 00:00:00
abstract：:Calcium-mediated signals play important roles in epidermal barrier formation, skin homoeostasis and wound repair. Calmodulin 4 (Calm4) is a small, Ca2+ -binding protein with strong expression in suprabasal keratinocytes. In mice, Calm4 first appears in the skin at the time of barrier formation, and its expression incr...
journal_title：Experimental dermatology
pub_type： 信件
doi：10.1111/exd.12568
更新日期：2015-01-01 00:00:00
abstract：:While the central role of mast cells (MC) in allergy and inflammation is well-appreciated, much less is known about their physiological functions. The impressive battery of potent growth modulatory MC products, and increasing evidence of MC involvement in hyperproliferative and fibrotic disorders suggest that tissue r...
journal_title：Experimental dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0625.1995.tb00256.x
更新日期：1995-08-01 00:00:00
abstract：:Keratinocytes (KCs) play a critical role in maintaining the cutaneous structure and are involved in various physiological and pathologic processes of the skin. Many inflammatory skin diseases and skin cancers result from excessive proliferation and insufficient apoptosis of KCs. Recent data suggested that the sonic he...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/exd.12556
更新日期：2014-12-01 00:00:00
abstract：:Glomuvenous malformations (GVM) are hamartomas characterized histologically by glomus cells, which should be distinguished from glomus tumors. Familial GVM are rare, often present as multiple lesions, and exhibit familial aggregation, with autosomal dominant transmission. GVM are caused by mutations of the glomulin (G...
journal_title：Experimental dermatology
pub_type： 信件
doi：10.1111/j.1600-0625.2011.01387.x
更新日期：2011-12-01 00:00:00
abstract：:Vitamin D-binding protein (VDBP) single nucleotide polymorphisms (SNP) may affect skin carcinogenesis. The objective was to test the association between two functional VDBP SNPs and the susceptibility to (multiple) basal cell carcinomas (BCCs). Of the 7983 participants, 5790 (72.5%) and 5823 (72.9%) participants were ...
journal_title：Experimental dermatology
pub_type： 信件
doi：10.1111/j.1600-0625.2010.01139.x
更新日期：2010-12-01 00:00:00
abstract：:Psoriasis is a chronic skin disease caused by immune disorder. The chronic skin inflammation involves inflammatory molecules that are released from T lymphocytes and keratinocytes. Therefore, developing an anti-inflammatory therapy that is suitable for long-term treatment is needed. Electrical stimulation induces biol...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/exd.13720
更新日期：2018-10-01 00:00:00
abstract：:In this study, we analysed the modulation of keratinocyte growth factor (KGF) mRNA expression in human dermal fibroblasts cultured either in monolayer or within a collagen matrix (dermal equivalent). In monolayer cultures, KGF expression by quiescent fibroblasts was stimulated by different growth substances such as se...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1600-0625.1996.tb00103.x
更新日期：1996-04-01 00:00:00
abstract：:Card9 is a signalling adaptor protein in the downstream of many innate pattern recognition receptors (PRRs) and exerts a significant role in antifungal immunity. To date, Card9 deficiency has been reported to be related to increased susceptibility to many fungal infections. In this study, we established mucormycosis m...
journal_title：Experimental dermatology
pub_type： 杂志文章
doi：10.1111/exd.14020
更新日期：2019-11-01 00:00:00
