CAR-T cell therapy in melanoma: A future success story?

abstract：:Patients sensitized to para-phenylenediamine (PPD) by semi-permanent tattoos increasingly develop threatening allergic reactions in response to black hair dye. The gold standard to diagnose allergic contact dermatitis is to perform epicutaneous patch tests, however, iatrogenic sensitizations and severe patch test reac...

journal_title：Experimental dermatology

authors： Kneilling M,Caroli U,Grimmel C,Fischer J,Eichner M,Wieder T,Maier FC,Röcken M,Biedermann T

更新日期：2010-05-01 00:00:00

abstract：:Previous reports have demonstrated that cell-derived nanoparticles (CDNPs) composed of bovine or porcine protein complexes exerted therapeutic effects against viral infections and cancer in mice and humans. Based on these observations, we asked whether CDNPs would improve inflammatory skin disorders. To address this, ...

journal_title：Experimental dermatology

authors： Kunz N,Hauenschild E,Maass S,Kalies KU,Klinger M,Barra M,Hecht L,Helbig F,Soellner S,Caldwell CC,Ludwig RJ,Westermann J,Kalies K

更新日期：2017-12-01 00:00:00

abstract：:Human follicle dermal papilla cells (FDPC) are a specialized population of mesenchymal cells located in the skin. They regulate hair follicle (HF) development and growth, and represent a reservoir of multipotent stem cells. Growing evidence supports the hypothesis that HF cycling is associated with vascular remodeling...

journal_title：Experimental dermatology

authors： Bassino E,Gasparri F,Giannini V,Munaron L

更新日期：2015-05-01 00:00:00

abstract：:Primary cutaneous large B-cell lymphomas, leg type (PCLBCL/LT) are primary cutaneous B-cell lymphoma (PCBCL) with an intermediate prognosis. Therefore, antracycline-based polychemotherapy combined with rituximab has been recommended as first-line treatment. Yet, despite this regimen, the 5-year survival rate remains 5...

journal_title：Experimental dermatology

authors： Teichert M,Stumpf C,Booken N,Wobser M,Nashan D,Hallermann C,Mogler C,Müller CS,Becker JC,Moritz RK,Andrulis M,Nicolay JP,Goerdt S,Thomas M,Klemke CD,Augustin HG,Felcht M

更新日期：2015-06-01 00:00:00

abstract：:Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well-known corticosteroid treatments, H1 receptor (H1R) antagonists also have been used. This study observed effects of histamine H4 receptor (H4R) antagonist usage with H1R antagonist in a murine chronic...

journal_title：Experimental dermatology

authors： Matsushita A,Seike M,Okawa H,Kadawaki Y,Ohtsu H

更新日期：2012-09-01 00:00:00

abstract：:Cowden syndrome (CS) is an autosomal dominant inherited disorder characterized by hamartomas in a variety of tissues including the skin, thyroid, breast, endometrium, and the brain. Individuals with CS are predisposed to development of malignancy in these organs, especially the breast and the thyroid. We describe 3 un...

journal_title：Experimental dermatology

authors： Celebi JT,Ping XL,Zhang H,Remington T,Sulica VI,Tsou HC,Peacocke M

更新日期：2000-04-01 00:00:00

abstract：:Collagens are the most abundant proteins in the extracellular matrix. They provide a framework to build organs and tissues and give structural support to make them resistant to mechanical load and forces. Several intra- and extracellular modifications are needed to make functional collagen molecules, intracellular pos...

journal_title：Experimental dermatology

authors： Salo AM,Myllyharju J

更新日期：2021-01-01 00:00:00

abstract：:Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering skin disease and is characterized by the presence of autoantibodies directed against the hemidesmosomal proteins BP180 and BP230 that can be detected in the skin and serum of BP patients. Histologically, the dermal infiltration of eosinophil...

journal_title：Experimental dermatology

authors： Simon D,Borradori L,Simon HU

更新日期：2017-12-01 00:00:00

abstract：:Chemical haptens induce a variety of allergic immune reactions by induction of hapten-specific T cells. Contact sensitizers such as the hapten trinitrochlorobenzene (TNCB) elicit an allergic response, which is confined to the area of antigen exposure. Despite this localized allergic response, we show here that the tri...

journal_title：Experimental dermatology

authors： Martin S,Delattre V,Leicht C,Weltzien HU,Simon JC

更新日期：2003-02-01 00:00:00

abstract：:UVA(Ultraviolet A)-induced gene expression is supposed to be a hallmark for inflammation, for immunosuppression and in long-term cancer formation. In previous studies, we have shown for keratinocytes that physiological doses of UVA radiation result in the upregulation of gene expression mediated by ceramide formation ...

journal_title：Experimental dermatology

authors： Bayer M,Proksch P,Felsner I,Brenden H,Kohne Z,Walli R,Duong TN,Götz C,Krutmann J,Grether-Beck S

更新日期：2011-11-01 00:00:00

abstract：:For almost a quarter of a century, ex vivo studies of human scalp hair follicles (HFs) have permitted major advances in hair research, spanning diverse fields such as chronobiology, endocrinology, immunology, metabolism, mitochondrial biology, neurobiology, pharmacology, pigmentation and stem cell biology. Despite thi...

journal_title：Experimental dermatology

authors： Langan EA,Philpott MP,Kloepper JE,Paus R

更新日期：2015-12-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) induces naïve CD4+ T cells to produce Th2 cytokines. In addition, to low production of Th2 cytokines, strong Th1 response, which plays an important role in vitiligo development, has been induced by blockade of TSLP or TSLP receptor. This study examined whether a functional TSLP poly...

journal_title：Experimental dermatology

authors： Cheong KA,Chae SC,Kim YS,Kwon HB,Chung HT,Lee AY

更新日期：2009-12-01 00:00:00

abstract：:The bioactive lysophospholipid sphingosine-1-phosphate (S1P) is best known for its activity as T-cell-active chemoattractant regulating the egress of T cells from the lymph node and, consequently, the availability of T cells for migration into peripheral tissues. This physiological role of S1P is exploited by the drug...

journal_title：Experimental dermatology

authors： Thieme M,Zillikens D,Sadik CD

更新日期：2017-03-01 00:00:00

abstract：:Despite recent success in melanoma therapy, most patients with metastatic disease still undergo deadly progression. We have identified a novel mechanism of multidrug resistance allowing a small subpopulation of slow-cycling melanoma cells to survive based on elevated oxidative bioenergy metabolism. In this study, we a...

journal_title：Experimental dermatology

authors： Cierlitza M,Chauvistré H,Bogeski I,Zhang X,Hauschild A,Herlyn M,Schadendorf D,Vogt T,Roesch A

更新日期：2015-02-01 00:00:00

abstract：:We characterized the melanogenic apparatus in a family of transplantable gerbil melanomas (melanotic and amelanotic) using a combination of biophysical, ultrastructural and biochemical methods. Melanotic melanomas produced pure eumelanin but in vesiculo-globular melanosomes ('pheomelanosomes'); the eumelanosomes, char...

journal_title：Experimental dermatology

authors： Plonka PM,Slominski AT,Pajak S,Urbanska K

更新日期：2003-08-01 00:00:00

abstract：:Immune escape mechanisms of cancers include some of the mechanisms normally used for immune homeostasis, particular those preventing autoimmunity; one of these is the polarisation of myeloid cells. Thereby, tumors, i.e. the cancerous and stromal cells, also condition distant sites like spleen and bone marrow via solub...

journal_title：Experimental dermatology

authors： Becker JC

更新日期：2014-03-01 00:00:00

abstract：:Detergents irritate skin and affect skin barrier homeostasis. In this study, healthy skin was exposed to 1% sodium lauryl sulphate (SLS) in water for 24 h. Biopsies were taken 6 h to 8 days post exposure. Lipid patterns were stained in situ and real-time polymerase chain reaction (PCR) was used to examine mRNA express...

journal_title：Experimental dermatology

authors： Törmä H,Berne B

更新日期：2009-12-01 00:00:00

abstract：:TNF is critically involved in the pathogenesis of psoriasis. TL1A is a TNF-like cytokine, which, after binding to death domain receptor DR3, provides costimulatory signals to lymphocytes, amplifies Th1- and Th17-mediated immune responses and induces apoptotic cell death. These functions are inhibited when TL1A associa...

journal_title：Experimental dermatology

authors： Bamias G,Evangelou K,Vergou T,Tsimaratou K,Kaltsa G,Antoniou C,Kotsinas A,Kim S,Gorgoulis V,Stratigos AJ,Sfikakis PP

更新日期：2011-09-01 00:00:00

abstract：:Human dermal fibroblasts (HDFs) regulate wound-healing processes in human skin, including the regeneration of skin sensory fibres, in response to various mechanical stimuli. Because nerve growth factor (NGF) has an essential role in sensory regeneration, we evaluated the possible association of NGF with mechanical sti...

journal_title：Experimental dermatology

authors： Kim M,Shin DW,Shin H,Noh M,Shin JH

更新日期：2013-01-01 00:00:00

abstract：:Calcium-mediated signals play important roles in epidermal barrier formation, skin homoeostasis and wound repair. Calmodulin 4 (Calm4) is a small, Ca2+ -binding protein with strong expression in suprabasal keratinocytes. In mice, Calm4 first appears in the skin at the time of barrier formation, and its expression incr...

journal_title：Experimental dermatology

authors： Lessard JC,Kalinin A,Bible PW,Morasso MI

更新日期：2015-01-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are major environmental pollutants, and their effects on the human body critically depend on the aryl hydrocarbon receptor (AhR). The aim of this study was to evaluate the significance of the AhR and its ligands in chronic inflammatory ski...

journal_title：Experimental dermatology

authors： Kim HO,Kim JH,Chung BY,Choi MG,Park CW

更新日期：2014-04-01 00:00:00

abstract：:We have developed a new technique that rapidly and reproducibly allows direct visualization of molecular interactions, including receptor-ligand binding. The technique can be easily applied to examine binding between proteins and glycoproteins, or proteins and glycolipids, including gangliosides. In this novel bead-bi...

journal_title：Experimental dermatology

authors： Irvine AD,Sun P,Kos L,Wang XQ,Paller AS

更新日期：2002-10-01 00:00:00

abstract：:Optical coherence tomography (OCT) is a novel non-invasive imaging technique for in vivo histologic characterization of tissues. Besides pure morphology, additional functional parameters of the tissue investigated can be evaluated at the same time, such as the refractive index and the scattering coefficient. The purpo...

journal_title：Experimental dermatology

authors： de Giorgi V,Stante M,Massi D,Mavilia L,Cappugi P,Carli P

更新日期：2005-01-01 00:00:00

abstract：:A number of single gene mutations in laboratory mice produce hair follicle defects resulting in deformed hair shafts. The radiation-induced (SB/LeJ-Foxq1(sa)) satin mutant mice have a satin-like sheen to their hair and dilute colouration. This sheen is due to failure of the hair shafts to develop normal medullas, whil...

journal_title：Experimental dermatology

authors： Wu B,Herbert Pratt C,Potter CS,Silva KA,Kennedy V,Sundberg JP

更新日期：2013-03-01 00:00:00

abstract：:In mammals, the skin can form complex global and local patterns to meet diverse functional requirements in different parts of the body. To date, the fundamental principles that underlie skin patterning remain poorly understood because of the involvement of multiple interacting processes. Genes involved in the planar c...

journal_title：Experimental dermatology

authors： Chen J,Chuong CM

更新日期：2012-02-01 00:00:00

abstract：:Infiltration of eosinophils in atopic dermatitis (AD), which contains inflammatory molecules and cytokines, recruits more inflammatory cells and causes further skin damage. Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine that induces the proinflammatory Th2 immune response and plays an important role in ...

journal_title：Experimental dermatology

authors： Noh JY,Shin JU,Park CO,Lee N,Jin S,Kim SH,Kim JH,Min A,Shin MH,Lee KH

更新日期：2016-11-01 00:00:00

abstract：:Canine atopic dermatitis (AD), a chronic inflammatory skin disease, shares characteristics with its human counterpart. To get insight into the role of enzymes involved in production of prostaglandin E(2) (PGE2) and leukotriene B(4) (LTB(4)), potent inflammatory mediators originating from membrane-derived arachidonic a...

journal_title：Experimental dermatology

authors： Schlotter YM,Riemers FM,Rutten VP,Knol EF,Willemse T

更新日期：2010-08-01 00:00:00

abstract：:Recent advances in the molecular biology of the dermo-epidermal basement membrane zone have contributed greatly to our understanding of the etiopathogenetic pathways underlying mechanobullous disorders. Genetic linkage was established between the keratin gene clusters and epidermolysis bullosa simplex, and keratin mut...

journal_title：Experimental dermatology

authors： Bruckner-Tuderman L

更新日期：1992-10-01 00:00:00

abstract：:We have characterized a stereospecific transport mechanism for L-dopa into human epidermal Langerhans cells (LCs). It is different from any other amino acid transport system. It is highly concentrative, largely pH-independent, and independent of exogenous Na+, glucose and oxygen, and fuelled by a renewable intracellul...

journal_title：Experimental dermatology

authors： Falck B,Bendsoe N,Ronquist G

更新日期：2003-10-01 00:00:00

abstract：:Diminished suppressive capacity of regulatory T cells (Treg) has been demonstrated in blood and in lesional skin of psoriatic patients. Treatment with anti-TNFα restored the number and function of circulating Treg in psoriasis. We aimed to study Treg in the skin of psoriatic patients undergoing topical treatment with ...

journal_title：Experimental dermatology

authors： Keijsers RR,Joosten I,Hendriks AG,Koenen HJ,van Erp PE,van de Kerkhof PC

更新日期：2015-01-01 00:00:00