当前位置： SCI文献检索 > EXPERIMENTAL DERMATOLOGY期刊下所有文献 > Influence of interleukin-1alpha on androgen receptor expression and cytokine secretion by cultured human dermal papilla cells.

Influence of interleukin-1alpha on androgen receptor expression and cytokine secretion by cultured human dermal papilla cells.

Abstract：

:Dermal papilla cells (DPC) control the growth character of the hair follicle through their elaboration of mitogenic factors and extracellular matrix components. Further, the dermal papilla is a primary site of androgen action in the hair follicle. Interleukin-1alpha (IL-1alpha) is prominent in skin wounding and inflammatory responses although regarded as a negative hair growth regulator. We studied the effect of IL-1alpha and the potent androgen 5alpha-dihydrotestosterone (DHT) on the expression of the androgen receptor (AR) and various factors secreted by cultured human temporal scalp DPC. IL-1alpha triggered cellular changes consistent with nuclear factor-kappaB pathway activation as well as reduced AR mRNA and protein expression levels for DHT-stimulated DPC. This cytokine also increased DPC supernatant keratinocyte growth factor (KGF), vascular endothelial growth factor (VEGF), IL-8 and granulocyte-macrophage colony-stimulating factor (GM-CSF) concentrations. IL-1alpha did not influence DPC supernatant levels of transforming growth factor-beta1, a negative hair growth regulator. The stimulatory effect of IL-1alpha on DPC VEGF, GM-CSF, KGF, and IL-8 expression was also evident at the mRNA level for these cytokines. IL-1alpha also increased mRNA transcript levels of protease-nexin-1, a secreted serine protease inhibitor expressed in the dermal papilla of anagen-stage hair follicles. Although DHT did not affect supernatant cytokine concentrations, the androgen altered mRNA transcript levels of several factors for DPC co-stimulated with IL-1alpha. In consideration of its in vitro activity profile, IL-1alpha may be an important modifier of dermal papilla activity as well as potentially influence androgen-regulated gene expression in DPC.

journal_name

Exp Dermatol

journal_title

Experimental dermatology

authors

Boivin WA,Jiang H,Utting OB,Hunt DW

doi

10.1111/j.1600-0625.2006.00462.x

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

784-93

issue

10

eissn

0906-6705

issn

1600-0625

pii

EXD462

journal_volume

15

pub_type

杂志文章

相关文献

EXPERIMENTAL DERMATOLOGY文献大全
  • Rapid, high-quality and epidermal-specific isolation of RNA from human skin.

    abstract：:As global transcriptome analyses with a growing demand on layer-specific applications are widely used in cutaneous biology, we investigated the effect of established and optimized dermo-epidermal separation methods on the quality of RNA. We compared enzymatic separation with dispase, chemical separation with 1 M sodiu...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.2006.00534.x

    authors： Trost A,Bauer JW,Lanschützer C,Laimer M,Emberger M,Hintner H,Onder K

    更新日期：2007-03-01 00:00:00

  • Cystatin M/E knockdown by lentiviral delivery of shRNA impairs epidermal morphogenesis of human skin equivalents.

    abstract：:The protease inhibitor cystatin M/E (CST6) regulates a biochemical pathway involved in stratum corneum homeostasis, and its deficiency in mice causes ichthyosis and neonatal lethality. Cystatin M/E deficiency has not been described in humans so far, and we did not detect disease-causing mutations in the CST6 gene in a...

    journal_title：Experimental dermatology

    pub_type： 信件

    doi：10.1111/exd.12022

    authors： Jansen PA,van den Bogaard EH,Kersten FF,Oostendorp C,van Vlijmen-Willems IM,Oji V,Traupe H,Hennies HC,Schalkwijk J,Zeeuwen PL

    更新日期：2012-11-01 00:00:00

  • Hair growth-promotion effects of different alternating current parameter settings are mediated by the activation of Wnt/β-catenin and MAPK pathway.

    abstract：:Electrical stimulation is being used in variable skin therapeutic conditions. There have been clinical studies demonstrating the positive effect of electrical stimuli on hair regrowth. However, the underlying exact mechanism and optimal parameter settings are not clarified yet. To investigate the effects of different ...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/exd.12827

    authors： Sohn KM,Jeong KH,Kim JE,Park YM,Kang H

    更新日期：2015-12-01 00:00:00

  • Long-term efficacy of etanercept in hidradenitis suppurativa: results from an open-label phase II prospective trial.

    abstract：OBJECTIVE:To evaluate the long-term efficacy of etanercept for the management of hidradenitis suppurativa. METHODS:Analysis was based on the long-term follow-up (weeks 24-144) of 10 patients enrolled in a prospective open-label phase II study; etanercept was initially administered subcutaneously 50 mg once weekly for ...

    journal_title：Experimental dermatology

    pub_type： 信件

    doi：10.1111/j.1600-0625.2009.00967.x

    authors： Pelekanou A,Kanni T,Savva A,Mouktaroudi M,Raftogiannis M,Kotsaki A,Giamarellos-Bourboulis EJ

    更新日期：2010-06-01 00:00:00

  • Therapies for inherited skin fragility disorders.

    abstract：:Inherited skin fragility comprises disorders characterized by mechanical induced blistering and erosions within the skin and mucosal membranes as a consequence of mutations in genes encoding proteins involved in intra-epidermal or dermal-epidermal adhesion. As the molecular pathology is largely known, it is a prototyp...

    journal_title：Experimental dermatology

    pub_type： 杂志文章,评审

    doi：10.1111/exd.12666

    authors： Has C,Kiritsi D

    更新日期：2015-05-01 00:00:00

  • Correlation between the properties of the lipid matrix and the degrees of integrity and cohesion in healthy human Stratum corneum.

    abstract：:The correlation between the degrees of integrity and cohesion in healthy human Stratum corneum (SC) and the properties of the SC lipid matrix could be examined non-invasively in vivo using ATR-FTIR spectroscopy and measurements of pH, conductance, and transepidermal water loss (TEWL) taken in the course of tape-stripp...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.2010.01164.x

    authors： Berthaud F,Boncheva M

    更新日期：2011-03-01 00:00:00

  • Involvement of changes in stratum corneum keratin in wrinkle formation by chronic ultraviolet irradiation in hairless mice.

    abstract：:Chronic exposure to ultraviolet (UV) radiation alters components of the skin. We previously reported that chronic low-dose UV irradiation induced wrinkle formation but did not significantly alter dermal components of hairless mice. In the present study, we examined whether the epidermal changes by UV irradiation could...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1034/j.1600-0625.12.s2.4.x

    authors： Kambayashi H,Odake Y,Takada K,Funasaka Y,Ichihashi M

    更新日期：2003-01-01 00:00:00

  • Neuroendocrine regulation of sebocytes -- a pathogenetic link between stress and acne.

    abstract：:A causative link between emotional stress and acne has long been postulated. There is mounting evidence that the molecular mechanism underlying this observation is related to the expression of receptors for several neuroendocrine mediators by the sebaceous gland. Recent and ongoing studies have indicated that human se...

    journal_title：Experimental dermatology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1600-0625.2004.00254.x

    authors： Zouboulis CC,Böhm M

    更新日期：2004-01-01 00:00:00

  • Dopa oxidase activity in the hair, skin and ocular melanocytes is increased in the presence of stressed fibroblasts.

    abstract：:We previously reported that mesenchymal cells (dermal fibroblasts and dermal papilla cells) can stimulate dopa oxidase activity in the skin melanocytes. This study extends the investigation of the influence of the fibroblast in a comparative study of melanogenesis in melanocytes from the hair, the skin and the eye. Cu...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.0906-6705.2005.00287.x

    authors： Balafa C,Smith-Thomas L,Phillips J,Moustafa M,George E,Blount M,Nicol S,Westgate G,MacNeil S

    更新日期：2005-05-01 00:00:00

  • Mitochondrial oxidative stress as a novel therapeutic target to overcome intrinsic drug resistance in melanoma cell subpopulations.

    abstract：:Despite recent success in melanoma therapy, most patients with metastatic disease still undergo deadly progression. We have identified a novel mechanism of multidrug resistance allowing a small subpopulation of slow-cycling melanoma cells to survive based on elevated oxidative bioenergy metabolism. In this study, we a...

    journal_title：Experimental dermatology

    pub_type： 信件

    doi：10.1111/exd.12613

    authors： Cierlitza M,Chauvistré H,Bogeski I,Zhang X,Hauschild A,Herlyn M,Schadendorf D,Vogt T,Roesch A

    更新日期：2015-02-01 00:00:00

  • Decreased incidence of papillomas in mice with impaired EGFR function during multi-stage skin carcinogenesis.

    abstract：:Genetically modified mouse lines revealed that the epidermal growth factor receptor (EGFR) is essential for the development and homoeostasis of the epidermis and hair follicles. However, more detailed studies have been precluded by the shortened lifespan of Egfr knockout mice. We employed the mouse line Wa5 (carrying ...

    journal_title：Experimental dermatology

    pub_type： 信件

    doi：10.1111/j.1600-0625.2010.01192.x

    authors： Dahlhoff M,Rose C,Wolf E,Schneider MR

    更新日期：2011-03-01 00:00:00

  • Curcumin nanoparticles as a photoprotective adjuvant.

    abstract：:With rising skin cancer rates and interest in preventing photoaging, adjuvants for sunscreens are in high demand. The potential of curcumin has been posited due to its anti-inflammatory, antioxidant and wound healing properties. In prior studies, curcumin decreased UV-induced inflammation, apoptotic changes in human k...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/exd.14282

    authors： Adusumilli NC,Mordorski B,Nosanchuk J,Friedman JM,Friedman AJ

    更新日期：2021-01-15 00:00:00

  • Nail abnormalities identified in an ageing study of 30 inbred mouse strains.

    abstract：:In a large-scale ageing study, 30 inbred mouse strains were systematically screened for histologic evidence of lesions in all organ systems. Ten strains were diagnosed with similar nail abnormalities. The highest frequency was noted in NON/ShiLtJ mice. Lesions identified fell into two main categories: acute to chronic...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/exd.13759

    authors： Linn SC,Mustonen AM,Silva KA,Kennedy VE,Sundberg BA,Bechtold LS,Alghamdi S,Hoehndorf R,Schofield PN,Sundberg JP

    更新日期：2019-04-01 00:00:00

  • Eosinophils as putative therapeutic targets in bullous pemphigoid.

    abstract：:Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering skin disease and is characterized by the presence of autoantibodies directed against the hemidesmosomal proteins BP180 and BP230 that can be detected in the skin and serum of BP patients. Histologically, the dermal infiltration of eosinophil...

    journal_title：Experimental dermatology

    pub_type： 杂志文章,评审

    doi：10.1111/exd.13416

    authors： Simon D,Borradori L,Simon HU

    更新日期：2017-12-01 00:00:00

  • Modulation of HMGB1 translocation and RAGE/NFκB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice.

    abstract：:Quercetin, glycosylated form of flavonoid compound, has potent antioxidant and anti-inflammatory properties. In this study, we have investigated the effects of quercetin on skin lesion, high-mobility group box (HMGB)1 cascade signalling and inflammation in atopic dermatitis (AD) mouse model. AD-like lesion was induced...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/exd.12685

    authors： Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Nomoto M,Miyashita S,Suzuki K,Nakamura M,Watanabe K

    更新日期：2015-06-01 00:00:00

  • Tetracycline suppresses ATP gamma S-induced CXCL8 and CXCL1 production by the human dermal microvascular endothelial cell-1 (HMEC-1) cell line and primary human dermal microvascular endothelial cells.

    abstract：:Tetracyclines (TCN) have powerful anti-inflammatory properties in addition to their anti-microbial effects. These anti-inflammatory effects are thought to play a role in inhibiting cutaneous inflammation in patients with rosacea and acne; however, the mechanism(s) of this action remains poorly understood. We have prev...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.2008.00716.x

    authors： Bender A,Zapolanski T,Watkins S,Khosraviani A,Seiffert K,Ding W,Wagner JA,Granstein RD

    更新日期：2008-09-01 00:00:00

  • Itch-associated scratching contributes to the development of dermatitis and hyperimmunoglobulinaemia E in NC/Nga mice.

    abstract：:Atopic dermatitis (AD) is related to immunoglobulin E (IgE) production, and a type-1 and type-2 helper T cell (Th1/Th2) imbalance has been hypothesized as the aetiology. While itching and scratching are important factors in the development of dermatitis, the mechanisms underlying these phenomena are poorly understood....

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.2011.01337.x

    authors： Hashimoto Y,Takaoka A,Sugimoto M,Honma Y,Sakurai T,Futaki N,Arai I

    更新日期：2011-10-01 00:00:00

  • Chemiluminescent restriction fragment length polymorphism analysis (DNA fingerprinting) to identify keratinocytes from two donors in co-culture.

    abstract：:The transplantation of allogeneic cells such as pancreatic islet cells, bone marrow, and keratinocytes for skin replacement is in growing use clinically. Present techniques which are used to distinguish transplanted allogeneic cells from phenotypically identical host cells in chimeric tissue have serious limitations. ...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.1993.tb00195.x

    authors： Young DM,Summers WC,Cuono CB

    更新日期：1993-02-01 00:00:00

  • A HCl/alcohol formulation increased 5-aminolevulinic acid skin distribution using an ex vivo full thickness porcine skin model.

    abstract：:Topical photodynamic therapy with 5-aminolevulinic acid (5-ALA) is a newly established treatment modality for epithelial skin cancer. Skin distribution of different 20% 5-ALA formulations was investigated by detection of protoporphyrin IX (PpIX) using an ex vivo porcine skin model. Fluorescence of PpIX was first detec...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.2008.00705.x

    authors： Maisch T,Worlicek C,Babilas P,Landthaler M,Szeimies RM

    更新日期：2008-10-01 00:00:00

  • Molecular genetic analysis of 16 XP-C patients from Germany: environmental factors predominately contribute to phenotype variations.

    abstract：:Patients belonging to xeroderma pigmentosum (XP) complementation group C comprise one-third of all XP patients. Only four major reports compiled larger groups of XP-C patients from southern Europe (12 pts), North America (16 pts) and Africa (14 and 56 pts) as well as their genetic background (46 XPC mutations). We ide...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/exd.12052

    authors： Schäfer A,Hofmann L,Gratchev A,Laspe P,Schubert S,Schürer A,Ohlenbusch A,Tzvetkov M,Hallermann C,Reichrath J,Schön MP,Emmert S

    更新日期：2013-01-01 00:00:00

  • Internalization routes of cell-penetrating melanoma antigen peptides into human dendritic cells.

    abstract：:Optimized delivery of antigens combined with sustainable maturation of dendritic cells (DCs) is crucial for generation of effective antitumoral immune responses. Multiple approaches for ex vivo antigen loading and improvement in immunogenicity have been described. We have recently established a single-step protocol co...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/exd.12285

    authors： Buhl T,Braun A,Forkel S,Möbius W,van Werven L,Jahn O,Rezaei-Ghaleh N,Zweckstetter M,Mempel M,Schön MP,Haenssle HA

    更新日期：2014-01-01 00:00:00

  • Igf1r signalling acts on the anagen-to-catagen transition in the hair cycle.

    abstract：:Insulin-like growth factor 1 (Igf1) is important for skin development and homoeostasis. However, overexpression and inactivation studies have produced variable findings regarding its role in hair follicle (HF) biology. Here, we studied a conditional and inducible knockout of the Igf1 receptor (Igf1r) in keratin 15-exp...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/exd.13287

    authors： Castela M,Linay F,Roy E,Moguelet P,Xu J,Holzenberger M,Khosrotehrani K,Aractingi S

    更新日期：2017-09-01 00:00:00

  • The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis.

    abstract：:Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat gl...

    journal_title：Experimental dermatology

    pub_type： 信件

    doi：10.1111/j.1600-0625.2011.01361.x

    authors： Bovell DL,MacDonald A,Meyer BA,Corbett AD,MacLaren WM,Holmes SL,Harker M

    更新日期：2011-12-01 00:00:00

  • Fluorescence induction of protoporphyrin IX by a new 5-aminolevulinic acid nanoemulsion used for photodynamic therapy in a full-thickness ex vivo skin model.

    abstract：:An ex vivo porcine skin model was utilized to analyse the penetration of 5-aminolevulinic acid (5-ALA) contained in a nanoemulsion-based formulation BF-200 ALA (10% 5-ALA-hydrochloride) versus 16% aminolevulinate methyl ester-hydrochloride in a commercially cream (MAL cream) by fluorescence microscopy of their common ...

    journal_title：Experimental dermatology

    pub_type： 信件

    doi：10.1111/j.1600-0625.2009.01001.x

    authors： Maisch T,Santarelli F,Schreml S,Babilas P,Szeimies RM

    更新日期：2010-08-01 00:00:00

  • Shortened telomere length is demonstrated in T-cell subsets together with a pronounced increased telomerase activity in CD4 positive T cells from blood of patients with mycosis fungoides and parapsoriasis.

    abstract：:We have recently demonstrated that telomerase activity is increased and telomere length shortened in lymphocytes from peripheral blood of patients with cutaneous T-cell lymphoma. In order to determine which cell type has increased telomerase activity and shortened telomere length, CD4+, CD8+, CLA+ CD3+ and CLA- CD3+ T...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1034/j.1600-0625.2001.100505.x

    authors： Wu KD,Hansen ER

    更新日期：2001-10-01 00:00:00

  • Divalent cations (Mg2+, Ca2+) differentially influence the beta 1 integrin-mediated migration of human fibroblasts and keratinocytes to different extracellular matrix proteins.

    abstract：:Directed migration of keratinocytes and fibroblasts is a fundamental prerequisite in wound healing. Cation-dependent affinity changes of integrins are responsible for cell adhesion to and deadhesion from extracellular matrix proteins and have been implicated in driving cell migration. The specific requirements for div...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.1995.tb00236.x

    authors： Lange TS,Kirchberg J,Bielinsky AK,Leuker A,Bank I,Ruzicka T,Scharffetter-Kochanek K

    更新日期：1995-06-01 00:00:00

  • Carnosic acid, a phenolic diterpene from rosemary, prevents UV-induced expression of matrix metalloproteinases in human skin fibroblasts and keratinocytes.

    abstract：:Exposure of the skin to ultraviolet (UV) irradiation induces photoageing through the up-regulation of matrix metalloproteinases (MMPs) and subsequent breakdown of extracellular matrices. Reactive oxygen species (ROS) and epidermal growth factor receptor (EGFR) activation play central roles in UV-induced MMP expression...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/exd.12138

    authors： Park M,Han J,Lee CS,Soo BH,Lim KM,Ha H

    更新日期：2013-05-01 00:00:00

  • Protein kinases involved in epidermal barrier formation: The AKT family and other animals.

    abstract：:Formation of a stratified epidermis is required for the performance of the essential functions of the skin; to act as an outside-in barrier against the access of microorganisms and other external factors, to prevent loss of water and solutes via inside-out barrier functions and to withstand mechanical stresses. Epider...

    journal_title：Experimental dermatology

    pub_type： 杂志文章,评审

    doi：10.1111/exd.13696

    authors： Rogerson C,O'Shaughnessy RFL

    更新日期：2018-08-01 00:00:00

  • The role of skin barrier in occupational contact dermatitis.

    abstract：:Skin diseases represent one of the most common work-related diseases and may have a detrimental effect on social, personal and occupational aspects of life. Contact dermatitis (CD), which comprises predominately irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), accounts for vast majority of occu...

    journal_title：Experimental dermatology

    pub_type： 杂志文章,评审

    doi：10.1111/exd.13704

    authors： Jakasa I,Thyssen JP,Kezic S

    更新日期：2018-08-01 00:00:00

  • Optimization of electron paramagnetic resonance imaging for visualization of human skin melanoma in various stages of invasion.

    abstract：:Malignant melanoma is a tumor characterized by the uncontrolled proliferation of melanocytes, mainly in skin, but also in eyes. Its incidence is rising each year. To improve the diagnosis and treatment of the tumor, it is essential to develop new effective methods to early detect and characterize melanoma. Previously,...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.2012.01461.x

    authors： Godechal Q,Leveque P,Marot L,Baurain JF,Gallez B

    更新日期：2012-05-01 00:00:00