Increased expression of the aryl hydrocarbon receptor in patients with chronic inflammatory skin diseases.

abstract：:Congenital melanocytic nevi (CMN) are benign proliferations that may be associated with various consequences depending on their size. They are characterized by a specific molecular signature, namely a postzygotic somatic NRAS or BRAF mutation. We have recently reported that large CMN (lCMN), which are classically asso...

journal_title：Experimental dermatology

authors： Guégan S,Kadlub N,Picard A,Rouillé T,Charbel C,Coulomb-L'Hermine A,How-Kit A,Fraitag S,Aractingi S,Fontaine RH

更新日期：2016-10-01 00:00:00

abstract：:Psoriasis is a chronic inflammatory disease, and microRNAs have been reported to regulate the pathogenesis of psoriasis. Up-regulated miR-744-3p level was identified to associate with psoriasis while the precise functions of miR-744-3p in psoriasis were not well-elucidated. We first confirmed the up-regulation of miR-...

journal_title：Experimental dermatology

authors： Wang C,Zong J,Li Y,Wang X,Du W,Li L

更新日期：2019-03-01 00:00:00

abstract：:Antibodies, specific to murine DEC205, can be used to target antigens to dendritic cells. The immunodominant domain of human type XVII collagen, hNC16A, was fused to this antibody (DEC-hNC16A) and was administered as expression plasmid by gene gun transfection with the aim of inducing tolerance to human type XVII coll...

journal_title：Experimental dermatology

authors： Ettinger M,Gratz IK,Gruber C,Hauser-Kronberger C,Johnson TS,Mahnke K,Thalhamer J,Hintner H,Peckl-Schmid D,Bauer JW

更新日期：2012-05-01 00:00:00

abstract：:Psoriasis is a chronic skin disease that results in red and scaly lesions. Several psoriasis susceptibility loci have been identified across the genome, of which PSORS1 on 6p21.3 is predominant. There is an ongoing debate regarding whether the HLA-C allele, Cw*0602, can be considered the major predisposing factor in t...

journal_title：Experimental dermatology

authors： Holm SJ,Carlén LM,Mallbris L,Ståhle-Bäckdahl M,O'Brien KP

更新日期：2003-08-01 00:00:00

abstract：:Bullous pemphigoid (BP) and pemphigoid gestationis (PG) are acquired autoimmune subepidermal blistering diseases characterized by autoantibodies against the hemidesmosomal proteins BP180/type XVII collagen and BP230. In the vast majority of BP and PG patients, these autoantibodies bind to epitopes clustered within the...

journal_title：Experimental dermatology

authors： Sitaru C,Dähnrich C,Probst C,Komorowski L,Blöcker I,Schmidt E,Schlumberger W,Rose C,Stöcker W,Zillikens D

更新日期：2007-09-01 00:00:00

abstract：:We have yet to create a human scar model that demonstrates the complex nature of hypertrophic scar and keloid formation as well as ways to prevent them despite emerging advances in our understanding of the immune system, the inflammatory response, and proteomic and genomic changes after injury. Despite more complex in...

journal_title：Experimental dermatology

authors： Williams FN,Herndon DN,Branski LK

更新日期：2014-11-01 00:00:00

abstract：:The present study was designed to examine the expression of proopiomelanocortin (POMC) and its related derivative peptide adrenocorticotropic hormone (ACTH) in murine derived Thy-1+ dendritic cells. Immunostaining using a polyclonal antibody specific to ACTH and parent POMC molecule indicated the presence of POMC and ...

journal_title：Experimental dermatology

authors： Farooqui JZ,Medrano EE,Boissy RE,Tigelaar RE,Nordlund JJ

更新日期：1995-10-01 00:00:00

abstract：:The aim of the present study was to evaluate experimentally whether administration of recombinant (rh) vascular endothelial growth factor (VEGF) can protect skin flaps from necrosis and to study the optimum mode of rh-VEGF administration. We used rats to study the effects of local or systemic administration of rh-VEGF...

journal_title：Experimental dermatology

authors： Scalise A,Tucci MG,Lucarini G,Giantomassi F,Orlando F,Pierangeli M,Pugnaloni A,Bertani A,Ricotti G,Biagini G

更新日期：2004-11-01 00:00:00

abstract：:Nitric oxide (NO) is a reactive endogenous molecule with multiple functions including inflammation and immunity. NO stimulates melanogenesis by activating soluble guanylyl cyclase (sGC) resulting in increases in intracellular guanosine 3',5'-cyclic monophosphate (cGMP). In vitro experiments showed that NO could inhibi...

journal_title：Experimental dermatology

authors： Ivanova K,van den Wijngaard R,Gerzer R,Lamers WH,Das PK

更新日期：2005-06-01 00:00:00

abstract：:Despite the lack of protective melanin and increased oxidative stress due to mM concentrations of epidermal H2O2 in vitiligo, there is no significantly increased risk for chronic actinic damage and non-melanoma skin cancer. Therefore the question arises, which protective mechanisms could be involved in the skin of the...

journal_title：Experimental dermatology

authors： Schallreuter KU,Behrens-Williams S,Khaliq TP,Picksley SM,Peters EM,Marles LK,Westerhof W,Miehe B,Fanghänel J

更新日期：2003-06-01 00:00:00

abstract：:T cells play a major role in inflammatory skin disorders such as psoriasis vulgaris and atopic dermatitis. They are both active on the level of cell-to-cell interaction and by the secretion of pro-inflammatory mediators. CD26 is a lymphocyte membrane-associated dipeptidyl peptidase IV (DPP IV), which is able to inacti...

journal_title：Experimental dermatology

authors： Bock O,Kreiselmeyer I,Mrowietz U

更新日期：2001-12-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer which is twice as lethal as melanoma as more than one-third of MCC patients will die from this cancer. Although MCC, which primarily affects elderly and immune suppressed individuals, is very rare to date, its incidence is rapidly increasing...

journal_title：Experimental dermatology

authors： Houben R,Schrama D,Becker JC

更新日期：2009-03-01 00:00:00

abstract：:Epidermolytic hyperkeratosis (EHK) is a genodermatosis caused by mutations in either the keratin 1 (K1) or keratin 10 (K10) genes, and characterized by erythroderma and blistering at birth, with development of a ribbed, ichthyotic hyperkeratosis and palmoplantar keratoderma. A wide variety of mutations within the high...

journal_title：Experimental dermatology

authors： Michael EJ,Schneiderman P,Grossman ME,Christiano AM

更新日期：1999-12-01 00:00:00

abstract：:Responses to acetylcholine (ACh) and vasoactive intestinal polypeptide (VIP) were investigated in atopic eczema (AE) patients. To elucidate the involvement of histamine to ACh-provoked vasoreactions and sensations, we applied a selective H1-antagonist (cetirizine) 3 h prior to the ACh-administration. Solutions of acet...

journal_title：Experimental dermatology

authors： Rukwied R,Heyer G

更新日期：1999-02-01 00:00:00

abstract：:Patients with the blistering disease, epidermolysis bullosa (EB), frequently suffer from chronic wounds that become colonized by pathogenic bacteria, such as Staphylococcus aureus. To determine S. aureus colonization rates in patients with EB, swabs were collected from the anterior nares, throats and wounds of 52 Dutc...

journal_title：Experimental dermatology

authors： van der Kooi-Pol MM,Veenstra-Kyuchukova YK,Duipmans JC,Pluister GN,Schouls LM,de Neeling AJ,Grundmann H,Jonkman MF,van Dijl JM

更新日期：2012-06-01 00:00:00

abstract：:Chromatin-IgG complexes appear as electron dense structures (EDS) in glomerular basement membranes in lupus nephritis. Here, we present results of comparative analyses of the composition of EDS in murine lupus dermatitis and nephritis. One focus was to perform an analytical approach to understand why such complex stru...

journal_title：Experimental dermatology

authors： Hedberg A,Fismen S,Fenton KA,Mortensen ES,Rekvig OP

更新日期：2010-08-01 00:00:00

abstract：:Chemical haptens induce a variety of allergic immune reactions by induction of hapten-specific T cells. Contact sensitizers such as the hapten trinitrochlorobenzene (TNCB) elicit an allergic response, which is confined to the area of antigen exposure. Despite this localized allergic response, we show here that the tri...

journal_title：Experimental dermatology

authors： Martin S,Delattre V,Leicht C,Weltzien HU,Simon JC

更新日期：2003-02-01 00:00:00

abstract：:Contact allergens induce several accessory signals which promote the activation of antigen-specific T cells. One of these signals is the increased expression of adhesion molecules on antigen-presenting cells and endothelial cells. Epicutaneous application of non-toxic doses of 2,4-dinitrofluorobenzene (DNFB) onto the ...

journal_title：Experimental dermatology

authors： Wildner O,Lipkow T,Knop J

更新日期：1992-11-01 00:00:00

abstract：:Proteoglycans have been suggested to play pivotal roles in hair biology. Decorin is a prototypical member of the small leucine-rich proteoglycan family, which is involved in numerous biological processes. However, the role of decorin in the hair cycle has not been elucidated. Moreover, the effects of decorin on the ac...

journal_title：Experimental dermatology

authors： Inui S,Itami S

更新日期：2014-08-01 00:00:00

abstract：:Neutrophil extravasation is central to inflammatory skin diseases like psoriasis and atopic dermatitis. In vivo, neutrophils have been shown to migrate through cell-to-cell junctions (paracellular pathway) or directly through the body of the endothelial cell (transcellular pathway). In vitro, however, neutrophil migra...

journal_title：Experimental dermatology

authors： Marmon S,Cammer M,Raine CS,Lisanti MP

更新日期：2009-01-01 00:00:00

abstract：:Dendritic cells (DC) are key elements of the immune system. In peripheral tissues, they function as sentinels taking up and processing antigens. After migration to the draining lymph nodes, the DC either present antigenic peptides by themselves or transfer them to lymph node-resident DC. The skin is the primary interf...

journal_title：Experimental dermatology

authors： Kautz-Neu K,Meyer RG,Clausen BE,von Stebut E

更新日期：2010-08-01 00:00:00

abstract：:Alopecia areata (AA) is an autoimmune disease that results in spot baldness in humans. Adequate animal models for AA are currently lacking. The objective of this study was to elucidate the mechanism of autoimmune-like alopecia (ALA) in C57BL/6.CD80CD86-deficient (B6.CD80CD86-/- ) mice. Incidence and severity of alopec...

journal_title：Experimental dermatology

authors： Bae JH,Hwang WS,Jang YJ,Lee YH,Jang DE,Kim JS,Yeom SC

更新日期：2017-11-01 00:00:00

abstract：:Vitamin D3 analogues are widely used topical and oral remedies for various ailments such as psoriasis, osteoporosis and secondary hyperparathyroidism. In topical treatment, high skin permeability and cellular uptake are key criteria for beneficial effects due to the natural barrier properties of skin. In this study, w...

journal_title：Experimental dermatology

authors： Staunstrup NH,Bak RO,Cai Y,Svensson L,Petersen TK,Rosada C,Stenderup K,Bolund L,Mikkelsen JG

更新日期：2013-03-01 00:00:00

abstract：:The proportion of acral melanoma (AM) is much higher in Asian populations than in Caucasian populations. Although mutational profiles associated with AM have been discovered in Caucasian populations, knowledge of its genetic alterations in Asian populations is limited. To describe the molecular nature of AM in Korean ...

journal_title：Experimental dermatology

authors： Shim JH,Shin HT,Park J,Park JH,Lee JH,Yang JM,Kim DH,Jang KT,Lee DY

更新日期：2017-10-01 00:00:00

abstract：:Recognition that cellular retinoic acid binding protein (CRABP)-I and CRABP-II are found in different cell types has provided additional support for the presumably divergent roles of these two proteins in mediating retinoic acid (RA) effects in human skin. CRABP-II is expressed in fibroblasts and keratinocytes, and CR...

journal_title：Experimental dermatology

authors： Sanquer S,Reenstra WR,Eller MS,Gilchrest BA

更新日期：1998-12-01 00:00:00

abstract：:Pemphigus vulgaris (PV) is an autoimmune bullous disease caused by immunoglobulin G (IgG) autoantibodies against desmoglein 3 (Dsg3). We have generated an active disease mouse model for PV by adoptive transfer of Dsg3(-/-) lymphocytes. In this study, we investigated the benefits and limitations of this model as a tool...

journal_title：Experimental dermatology

authors： Takae Y,Nishikawa T,Amagai M

更新日期：2009-03-01 00:00:00

abstract：:Psoriasis is a chronic skin disease caused by immune disorder. The chronic skin inflammation involves inflammatory molecules that are released from T lymphocytes and keratinocytes. Therefore, developing an anti-inflammatory therapy that is suitable for long-term treatment is needed. Electrical stimulation induces biol...

journal_title：Experimental dermatology

authors： Tsurekawa Y,Morita M,Suico MA,Moriuchi M,Nakano Y,Piruzyan M,Takada M,Fukami S,Shuto T,Kai H

更新日期：2018-10-01 00:00:00

abstract：:It is not clear whether TNF-α antagonists used in the treatment of psoriasis need to act systemically, or whether local inhibition of skin-produced TNF-α would be sufficient to silence skin inflammation. To answer this question, we conducted two multicentre, double-blinded, randomized, placebo-controlled clinical tria...

journal_title：Experimental dermatology

authors： Tsianakas A,Brunner PM,Ghoreschi K,Berger C,Loser K,Röcken M,Stingl G,Luger T,Jung T

更新日期：2016-06-01 00:00:00

abstract：:Antimicrobial peptides and proteins (AMP) are highly active molecules with a broad-spectrum of microbicidal activity. Human beta-defensins (hBD)-2 and hBD-3 were initially isolated from psoriatic-scale extracts, and other AMP have been identified in high concentrations in psoriatic skin explaining the uncommonness of ...

journal_title：Experimental dermatology

authors： Steinz K,Schubert S,Harder J,Gerdes S,Mrowietz U,Gläser R

更新日期：2014-11-01 00:00:00

abstract：:Studies have shown that wound pH is a potentially influential factor in the healing process. Due to the flaws of traditional pH measurement approaches, wound pH measurement has not become part of current standard of care. A near-infrared pH-sensitive ratiometric film was created and characterized for measuring wound p...

journal_title：Experimental dermatology

authors： Li S,Vu H,Senkowsky J,Hu W,Tang L

更新日期：2020-01-01 00:00:00