MiR-744-3p regulates keratinocyte proliferation and differentiation via targeting KLLN in psoriasis.

abstract：:4-(4-Hydroxyphenyl)-2-butanol (rhododendrol, RD), a skin-whitening agent, was reported to cause skin depigmentation in some users, which is attributed to its cytotoxicity to melanocyte. It was reported that cytotoxicity to melanocyte is possibly mediated by oxidative stress in a tyrosinase activity-dependent manner. W...

journal_title：Experimental dermatology

authors： Goto N,Tsujimoto M,Nagai H,Masaki T,Ito S,Wakamatsu K,Nishigori C

更新日期：2018-07-01 00:00:00

abstract：:The growth of our knowledge in T-cell biology, in particular the molecular biology of the T-cell receptor (TCR), has provided a means to molecularly characterize lymphoproliferative diseases of the skin based on the presence or absence of a clonal population of T lymphocytes. TCR gene rearrangement studies, by Souther...

journal_title：Experimental dermatology

authors： Lessin SR,Rook AH

更新日期：1993-03-01 00:00:00

abstract：:The expansive use of immunosuppressive medications in fields such as transplantational medicine and oncology, the higher frequency of invasive procedures in an ageing population and the HIV/AIDS pandemic have increased the frequency of systemic fungal infections. At the same time, increased resistance of pathogenic fu...

journal_title：Experimental dermatology

authors： Mehra T,Köberle M,Braunsdorf C,Mailänder-Sanchez D,Borelli C,Schaller M

更新日期：2012-10-01 00:00:00

abstract：:In this study, we investigated the process of X-ray-induced apoptosis of skin keratinocyte, and the functional role of protein kinase C delta (PKCdelta) and downstream signalling cascade. High-dose X-ray irradiation (10 Gy) led to the apoptosis of HaCaT keratinocyte, accompanied by PKCdelta cleavage. Treatment with PK...

journal_title：Experimental dermatology

authors： Lee YS,Sohn KC,Kim KH,Cho MJ,Hur GM,Yoon TJ,Kim SK,Lee K,Lee JH,Kim CD

更新日期：2009-01-01 00:00:00

abstract：:Epidermal keratinocytes undergo a continuous process of terminal differentiation, which is accompanied by a dramatic change in the expression and composition of keratins. This complex and carefully orchestrated process is regulated by a large number of signal transduction events and transcriptional factors as well as ...

journal_title：Experimental dermatology

authors： Wang M,Yue Z,Paus R,Ramot Y

更新日期：2014-09-01 00:00:00

abstract：:Previous reports have demonstrated that cell-derived nanoparticles (CDNPs) composed of bovine or porcine protein complexes exerted therapeutic effects against viral infections and cancer in mice and humans. Based on these observations, we asked whether CDNPs would improve inflammatory skin disorders. To address this, ...

journal_title：Experimental dermatology

authors： Kunz N,Hauenschild E,Maass S,Kalies KU,Klinger M,Barra M,Hecht L,Helbig F,Soellner S,Caldwell CC,Ludwig RJ,Westermann J,Kalies K

更新日期：2017-12-01 00:00:00

abstract：:White adipose tissue is known to be involved in numerous physiological processes such as insulin-mediated functions, lipid and glucose metabolism, vascular changes and coagulation. These processes are mainly mediated by adipokines that are secreted either from adipocytes or cells of the stromal-vascular fraction of ad...

journal_title：Experimental dermatology

authors： Gerdes S,Osadtschy S,Rostami-Yazdi M,Buhles N,Weichenthal M,Mrowietz U

更新日期：2012-01-01 00:00:00

abstract：:Melasma is a frequent pigmentary disorder caused by abnormal melanin deposits in the skin. In vivo reflectance confocal microscopy (RCM) is a repetitive imaging tool that provides real-time images of the skin at nearly histological resolution. As melanin is the strongest endogenous contrast in human skin, pigmentary d...

journal_title：Experimental dermatology

authors： Kang HY,Bahadoran P,Suzuki I,Zugaj D,Khemis A,Passeron T,Andres P,Ortonne JP

更新日期：2010-08-01 00:00:00

abstract：:There are few contradictory studies investigating the involvement of HPV in melanoma. We designed a controlled study to evaluate the HPV DNA prevalence in melanoma. One hundred patients with cutaneous malignant melanoma diagnosed between 2002 and 2006 were included. Complementary wide excision (healthy skin) was perfo...

journal_title：Experimental dermatology

authors： Ruer JB,Pépin L,Gheit T,Vidal C,Kantelip B,Tommasino M,Prétet JL,Mougin C,Aubin F

更新日期：2009-10-01 00:00:00

abstract：:Lipoxygenases (LOX) and cyclooxygenase (COX) are the main enzymes for PUFA metabolism to highly bio-active prostaglandins, leukotrienes, thromboxanes, lipoxins, resolvins and protectins. LOX and COX pathways are important for the regulation of pro-inflammatory or pro-resolving metabolite synthesis and metabolism for v...

journal_title：Experimental dermatology

authors： Töröcsik D,Weise C,Gericke J,Szegedi A,Lucas R,Mihaly J,Worm M,Rühl R

更新日期：2019-02-01 00:00:00

abstract：:Anthralin is a widely used topical anti-psoriatic drug that may have an immunomodulating effect on alopecia areata (AA) as it does in psoriasis. The aims of the present study were to investigate the effects of anthralin on hair growth in balding C3H/HeJ mice affected by an AA-like disease and to study the underlying m...

journal_title：Experimental dermatology

authors： Tang L,Cao L,Sundberg JP,Lui H,Shapiro J

更新日期：2004-01-01 00:00:00

abstract：:Ultraviolet (UV) irradiation on skin triggers photoageing-related phenotypes such as formation of wrinkles. UV ray upregulates matrix metalloproteinase-1 (MMP-1), which in turn degrades extracellular matrix proteins, mostly collagens. Serum amyloid A1 (SAA1) is an acute-phase protein of which plasma concentration incr...

journal_title：Experimental dermatology

authors： Han S,Jin SP,Oh JH,Seo EY,Park CH,Yoon HS,Lee DH,Chung JH

更新日期：2016-07-01 00:00:00

abstract：:The immune system is called into action by alarm signals generated from injured tissues. We examined the nature of these alarm signals after exposure of skin residential cells to contact allergens (nickel sulfate and potassium dichromate) and a contact irritant [sodium dodecyl sulfate (SDS)]. Nickel sulfate, potassium...

journal_title：Experimental dermatology

authors： Spiekstra SW,Toebak MJ,Sampat-Sardjoepersad S,van Beek PJ,Boorsma DM,Stoof TJ,von Blomberg BM,Scheper RJ,Bruynzeel DP,Rustemeyer T,Gibbs S

更新日期：2005-02-01 00:00:00

abstract：:Terence Kealey first pioneered the isolation and organ maintenance of human eccrine and sebaceous glands in the early to mid-1980. This led to subsequent methods describing the isolation and culture of human hair follicles, the human pilosebaceous unit as well as the sebaceous duct. The importance of these models in t...

journal_title：Experimental dermatology

authors： Philpott MP

更新日期：2018-05-01 00:00:00

abstract：:Stratum corneum (SC) exposed to living tissues, induces inflammation characterized by the formation of mixed cell granulomas consisting of infiltrative polymorphonuclear leukocytes (PMNs) and monocytes/macrophages. In this study, to clarify the mechanism for the later monocyte accumulation in SC-induced granulomas, we...

journal_title：Experimental dermatology

authors： Ozawa M,Terui T,Tanita M,Kato T,Tagami H

更新日期：1998-08-01 00:00:00

abstract：:A two-stage genomewide association (GWA) analysis was conducted to investigate the genetic factors influencing ultraviolet (UV)-induced skin pigmentation in Korean females after UV exposure. Previously, a GWA study evaluating ~500 000 single nucleotide polymorphisms (SNPs) in 99 Korean females identified eight SNPs th...

journal_title：Experimental dermatology

authors： Kwak TJ,Chang YH,Shin YA,Shin JM,Kim JH,Lim SK,Lee SH,Lee MG,Yoon TJ,Kim CD,Lee JH,Koh JS,Seo YK,Chang MY,Lee Y

更新日期：2015-12-01 00:00:00

abstract：:Despite recent success in melanoma therapy, most patients with metastatic disease still undergo deadly progression. We have identified a novel mechanism of multidrug resistance allowing a small subpopulation of slow-cycling melanoma cells to survive based on elevated oxidative bioenergy metabolism. In this study, we a...

journal_title：Experimental dermatology

authors： Cierlitza M,Chauvistré H,Bogeski I,Zhang X,Hauschild A,Herlyn M,Schadendorf D,Vogt T,Roesch A

更新日期：2015-02-01 00:00:00

abstract：:Serum levels of B-cell activating factor belonging to the tumor necrosis factor family (BAFF), a potent B-cell survival factor, are elevated in patients with systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis and systemic sclerosis (SSc). The objective of this study was to d...

journal_title：Experimental dermatology

authors： Matsushita T,Hasegawa M,Matsushita Y,Echigo T,Wayaku T,Horikawa M,Ogawa F,Takehara K,Sato S

更新日期：2007-02-01 00:00:00

abstract：:Chimeric antigen receptor (CAR)-T cells are one of the impressive recent success stories of anti-cancer immunotherapy. Especially in haematological malignancies, this treatment strategy has shown promising results leading to the recent approval of two CAR-T cell constructs targeting CD19 in the United States and the E...

journal_title：Experimental dermatology

authors： Simon B,Uslu U

更新日期：2018-12-01 00:00:00

abstract：:Glycyrrhizic acid (GA), a natural triterpene, has received attention as an agent that has protective effects against chronic diseases including ultraviolet UV-B-induced skin photodamage. However, the mechanism of its protective effect remains elusive. Here, we used an immortalized human keratinocyte cell line (HaCaT) ...

journal_title：Experimental dermatology

authors： Afnan Q,Kaiser PJ,Rafiq RA,Nazir LA,Bhushan S,Bhardwaj SC,Sandhir R,Tasduq SA

更新日期：2016-06-01 00:00:00

abstract：:Proteoglycans have been suggested to play pivotal roles in hair biology. Decorin is a prototypical member of the small leucine-rich proteoglycan family, which is involved in numerous biological processes. However, the role of decorin in the hair cycle has not been elucidated. Moreover, the effects of decorin on the ac...

journal_title：Experimental dermatology

authors： Inui S,Itami S

更新日期：2014-08-01 00:00:00

abstract：:Dendritic cells (DC) are key elements of the immune system. In peripheral tissues, they function as sentinels taking up and processing antigens. After migration to the draining lymph nodes, the DC either present antigenic peptides by themselves or transfer them to lymph node-resident DC. The skin is the primary interf...

journal_title：Experimental dermatology

authors： Kautz-Neu K,Meyer RG,Clausen BE,von Stebut E

更新日期：2010-08-01 00:00:00

abstract：:The organ culture of human scalp hair follicles (HFs) is the best currently available assay for hair research in the human system. In order to determine the hair growth-modulatory effects of agents in this assay, one critical read-out parameter is the assessment of whether the test agent has prolonged anagen duration ...

journal_title：Experimental dermatology

authors： Kloepper JE,Sugawara K,Al-Nuaimi Y,Gáspár E,van Beek N,Paus R

更新日期：2010-03-01 00:00:00

abstract：:Cowden syndrome (CS) is an autosomal dominant inherited disorder characterized by hamartomas in a variety of tissues including the skin, thyroid, breast, endometrium, and the brain. Individuals with CS are predisposed to development of malignancy in these organs, especially the breast and the thyroid. We describe 3 un...

journal_title：Experimental dermatology

authors： Celebi JT,Ping XL,Zhang H,Remington T,Sulica VI,Tsou HC,Peacocke M

更新日期：2000-04-01 00:00:00

abstract：:Malignant melanoma is a tumor characterized by the uncontrolled proliferation of melanocytes, mainly in skin, but also in eyes. Its incidence is rising each year. To improve the diagnosis and treatment of the tumor, it is essential to develop new effective methods to early detect and characterize melanoma. Previously,...

journal_title：Experimental dermatology

authors： Godechal Q,Leveque P,Marot L,Baurain JF,Gallez B

更新日期：2012-05-01 00:00:00

abstract：:Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well-known corticosteroid treatments, H1 receptor (H1R) antagonists also have been used. This study observed effects of histamine H4 receptor (H4R) antagonist usage with H1R antagonist in a murine chronic...

journal_title：Experimental dermatology

authors： Matsushita A,Seike M,Okawa H,Kadawaki Y,Ohtsu H

更新日期：2012-09-01 00:00:00

abstract：:The potential of an anti-inflammatory peptide (antiflammin 1) to reduce irritation when delivered transdermally by iontophoresis was examined. A model drug irritant, chlorpromazine, was co-delivered with and without antiflammin 1 by iontophoresis to hairless guinea pigs transdermally. Quantitative skin irritation meas...

journal_title：Experimental dermatology

authors： Mize NK,Buttery M,Ruis N,Leung I,Cormier M,Daddona P

更新日期：1997-08-01 00:00:00

abstract：:The living, not-cornified part of the epidermis consists mainly of keratinocytes. The control mechanisms of proliferation and differentiation are only partly understood. Similarly, the influence of ionic channels of the cell membrane on the proliferation of keratinocytes remains unclear. Preliminary investigations poi...

journal_title：Experimental dermatology

authors： Wohlrab D,Wohlrab J,Markwardt F

更新日期：2000-06-01 00:00:00

abstract：:Nitric oxide (NO) is a potent intercellular mediator of melanogenesis, whereas metallothionein (MT) is an inducible intracellular antioxidant that has been reported to scavenge NO. We investigated the existence and induction of MT in melanocytes, and its inhibitory effect on NO-induced melanogenesis. The expression of...

journal_title：Experimental dermatology

authors： Sasaki M,Kizawa K,Igarashi S,Horikoshi T,Uchiwa H,Miyachi Y

更新日期：2004-08-01 00:00:00

abstract：:It is not clear whether TNF-α antagonists used in the treatment of psoriasis need to act systemically, or whether local inhibition of skin-produced TNF-α would be sufficient to silence skin inflammation. To answer this question, we conducted two multicentre, double-blinded, randomized, placebo-controlled clinical tria...

journal_title：Experimental dermatology

authors： Tsianakas A,Brunner PM,Ghoreschi K,Berger C,Loser K,Röcken M,Stingl G,Luger T,Jung T

更新日期：2016-06-01 00:00:00