Role of protein kinase C delta in X-ray-induced apoptosis of keratinocyte.

abstract：:The skin forms an effective barrier between the organism and the environment preventing invasion of pathogens and fending off chemical and physical assaults, as well as the unregulated loss of water and solutes. In this review we provide an overview of several components of the physical barrier, explaining how barrier...

journal_title：Experimental dermatology

authors： Proksch E,Brandner JM,Jensen JM

更新日期：2008-12-01 00:00:00

abstract：:Recent studies have demonstrated that keratinocytes closely participate in sensory transduction, and therefore, intra-epidermal free nerve endings are not exclusive transducers of pain. This discovery implies the existence of close afferent communication from keratinocytes to sensory neurons. Although reciprocal inter...

journal_title：Experimental dermatology

authors： Talagas M,Lebonvallet N,Leschiera R,Marcorelles P,Misery L

更新日期：2018-01-01 00:00:00

abstract：:Hair follicles cyclically regenerate throughout adult mammalian life, owing to a resident population of epithelial hair follicle stem cells. Stem cell (SC) activity drives bouts of follicle growth, which are periodically interrupted by follicle regression and rest. These phases and the transitions between them are tig...

journal_title：Experimental dermatology

authors： Martino PA,Heitman N,Rendl M

更新日期：2020-10-02 00:00:00

abstract：:Patients belonging to xeroderma pigmentosum (XP) complementation group C comprise one-third of all XP patients. Only four major reports compiled larger groups of XP-C patients from southern Europe (12 pts), North America (16 pts) and Africa (14 and 56 pts) as well as their genetic background (46 XPC mutations). We ide...

journal_title：Experimental dermatology

authors： Schäfer A,Hofmann L,Gratchev A,Laspe P,Schubert S,Schürer A,Ohlenbusch A,Tzvetkov M,Hallermann C,Reichrath J,Schön MP,Emmert S

更新日期：2013-01-01 00:00:00

abstract：:Sangre de drago (SD) is a viscous bright red resin collected from Croton lechleri trees that grow in the South American jungle. This sap is used extensively in the native pharmacopoeia to treat skin disorders. Its effectiveness as an inhibitor of neurogenic inflammation has been recently demonstrated. To understand th...

journal_title：Experimental dermatology

authors： Pereira U,Garcia-Le Gal C,Le Gal G,Boulais N,Lebonvallet N,Dorange G,Lefeuvre L,Gougerot A,Misery L

更新日期：2010-09-01 00:00:00

abstract：:A causative link between emotional stress and acne has long been postulated. There is mounting evidence that the molecular mechanism underlying this observation is related to the expression of receptors for several neuroendocrine mediators by the sebaceous gland. Recent and ongoing studies have indicated that human se...

journal_title：Experimental dermatology

authors： Zouboulis CC,Böhm M

更新日期：2004-01-01 00:00:00

abstract：:We applied atomic force microscopy (AFM) to visualize ultrastructural changes of the keratinocyte morphology after narrow-band ultraviolet B (NB-UVB) irradiation. Immortalized human keratinocytes were cultured under standard conditions, irradiated with NB-UVB light at doses ranging from 50 to 800 mJ/cm2 and imaged by ...

journal_title：Experimental dermatology

authors： Reich A,Lehmann B,Meurer M,Muller DJ

更新日期：2007-12-01 00:00:00

abstract：:Patch-clamp recordings were carried out in the inside-out configuration in human keratinocytes of the cell line HaCaT. Patch pipettes were filled with 150 mM KCl, 1 mM CaCl(2) and 10 mM HEPES. In symmetrical KCl solutions, single channel currents from a large conductance channel (about 170 pS) were measured. Replaceme...

journal_title：Experimental dermatology

authors： Nguyen VH,Markwardt F

更新日期：2002-08-01 00:00:00

abstract：:This study was stimulated by the clinical observation of a rapid response of a chilblain lupus patient to treatment with JAK1/2-kinase inhibitor ruxolitinib. We investigated the in vivo expression of phospho-JAK2 in CLE skin samples as well as the immunomodulatory in vitro effect of ruxolitinib in cultured immortalize...

journal_title：Experimental dermatology

authors： Klaeschen AS,Wolf D,Brossart P,Bieber T,Wenzel J

更新日期：2017-08-01 00:00:00

abstract：:Stratum corneum (SC) exposed to living tissues, induces inflammation characterized by the formation of mixed cell granulomas consisting of infiltrative polymorphonuclear leukocytes (PMNs) and monocytes/macrophages. In this study, to clarify the mechanism for the later monocyte accumulation in SC-induced granulomas, we...

journal_title：Experimental dermatology

authors： Ozawa M,Terui T,Tanita M,Kato T,Tagami H

更新日期：1998-08-01 00:00:00

abstract：:The pathogenesis of lichen sclerosus remains unknown. However, it has been frequently associated clinically with autoimmunity. The MHC haplotype A1, B8, DR3 is associated with many autoimmune conditions and has also been associated with the uncommon allele of the tumour necrosis factor (TNF-alpha) promoter polymorphis...

journal_title：Experimental dermatology

authors： Clay FE,Cork MJ,Wilson AG,Crane AM,Lewis F,Harrington CI,Duff GW

更新日期：1996-08-01 00:00:00

abstract：:Melasma is a frequent pigmentary disorder caused by abnormal melanin deposits in the skin. In vivo reflectance confocal microscopy (RCM) is a repetitive imaging tool that provides real-time images of the skin at nearly histological resolution. As melanin is the strongest endogenous contrast in human skin, pigmentary d...

journal_title：Experimental dermatology

authors： Kang HY,Bahadoran P,Suzuki I,Zugaj D,Khemis A,Passeron T,Andres P,Ortonne JP

更新日期：2010-08-01 00:00:00

abstract：:Psoriasis is a chronic immune-mediated skin disease in which the balance in the interplay of immune cells and keratinocytes is disturbed. MicroRNAs (miRNAs) are endogenous small regulatory RNAs that stabilize cellular phenotypes and fine-tune signal transduction feedback loops through the regulation of gene networks. ...

journal_title：Experimental dermatology

authors： Pivarcsi A,Ståhle M,Sonkoly E

更新日期：2014-09-01 00:00:00

abstract：:Ultraviolet (UV) irradiation on skin triggers photoageing-related phenotypes such as formation of wrinkles. UV ray upregulates matrix metalloproteinase-1 (MMP-1), which in turn degrades extracellular matrix proteins, mostly collagens. Serum amyloid A1 (SAA1) is an acute-phase protein of which plasma concentration incr...

journal_title：Experimental dermatology

authors： Han S,Jin SP,Oh JH,Seo EY,Park CH,Yoon HS,Lee DH,Chung JH

更新日期：2016-07-01 00:00:00

abstract：:Despite the lack of protective melanin and increased oxidative stress due to mM concentrations of epidermal H2O2 in vitiligo, there is no significantly increased risk for chronic actinic damage and non-melanoma skin cancer. Therefore the question arises, which protective mechanisms could be involved in the skin of the...

journal_title：Experimental dermatology

authors： Schallreuter KU,Behrens-Williams S,Khaliq TP,Picksley SM,Peters EM,Marles LK,Westerhof W,Miehe B,Fanghänel J

更新日期：2003-06-01 00:00:00

abstract：:Somatostatin (SST) is a regulatory peptide hormone that acts through five different G protein-coupled receptors (SSTR1-5). Whereas expression of all five SSTR subtypes in epidermis has been shown, the biological relevance of the SST/SSTR system in the skin is completely unknown. We show here that SST is expressed in h...

journal_title：Experimental dermatology

authors： Vockel M,Breitenbach U,Kreienkamp HJ,Brandner JM

更新日期：2010-10-01 00:00:00

abstract：:Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering skin disease and is characterized by the presence of autoantibodies directed against the hemidesmosomal proteins BP180 and BP230 that can be detected in the skin and serum of BP patients. Histologically, the dermal infiltration of eosinophil...

journal_title：Experimental dermatology

authors： Simon D,Borradori L,Simon HU

更新日期：2017-12-01 00:00:00

abstract：:We have identified a spliced mRNA transcript of CD20 (named D393-CD20) which was associated with resistance to RTX in primary B cell from patients with lymphoma and leukaemia. In the present work, we wished to investigate whether D393-CD20 variant was expressed by B cells from patients with pemphigus. Ten patients wit...

journal_title：Experimental dermatology

authors： Gamonet C,Ferrand C,Colliou N,Musette P,Joly P,Girardin M,Humbert P,Aubin F

更新日期：2014-01-01 00:00:00

abstract：:We characterized the melanogenic apparatus in a family of transplantable gerbil melanomas (melanotic and amelanotic) using a combination of biophysical, ultrastructural and biochemical methods. Melanotic melanomas produced pure eumelanin but in vesiculo-globular melanosomes ('pheomelanosomes'); the eumelanosomes, char...

journal_title：Experimental dermatology

authors： Plonka PM,Slominski AT,Pajak S,Urbanska K

更新日期：2003-08-01 00:00:00

abstract：:Intraepithelial gammadelta T cells are increased in the inflamed small bowel and are also found in increased numbers in cutaneous lesions from patients with dermatitis herpetiformis (DH). Thus, these cells might play an important role in the pathogenesis of the disease. We investigated the T-cell receptor (TCR) delta ...

journal_title：Experimental dermatology

authors： Holtmeier W,Pfänder M,Zollner TM,Kaufmann R,Caspary WF

更新日期：2002-12-01 00:00:00

abstract：:In mammals, the skin can form complex global and local patterns to meet diverse functional requirements in different parts of the body. To date, the fundamental principles that underlie skin patterning remain poorly understood because of the involvement of multiple interacting processes. Genes involved in the planar c...

journal_title：Experimental dermatology

authors： Chen J,Chuong CM

更新日期：2012-02-01 00:00:00

abstract：:During aging, increases in the number of senescent cells are seen in various tissues. On the other hand, stem cells play crucial roles in tissue repair and homeostasis. Therefore, it is likely that stem cells give rise to new cells that replace senescent cells. However, how stem cells contribute to homeostasis in the ...

journal_title：Experimental dermatology

authors： Ohgo S,Hasegawa S,Hasebe Y,Mizutani H,Nakata S,Akamatsu H

更新日期：2015-07-01 00:00:00

abstract：:Exposure of the skin to ultraviolet (UV) irradiation induces photoageing through the up-regulation of matrix metalloproteinases (MMPs) and subsequent breakdown of extracellular matrices. Reactive oxygen species (ROS) and epidermal growth factor receptor (EGFR) activation play central roles in UV-induced MMP expression...

journal_title：Experimental dermatology

authors： Park M,Han J,Lee CS,Soo BH,Lim KM,Ha H

更新日期：2013-05-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play a critical role in various pathological conditions including cutaneous inflammation. Thus far, serial assessment of MMP activity in ongoing inflammation is hampered due to technical limitations. Here, we present an innovative method for longitudinal detection of MMP activity by in...

journal_title：Experimental dermatology

authors： Steingräber AK,Schelhaas S,Faust A,Jacobs AH,Schäfers M,Goerge T

更新日期：2013-11-01 00:00:00

abstract：:The primary trigger of polymorphic light eruption (PLE) remains to be uncovered. We hypothesize that PLE may be initiated by elements resulting from UV-induced damage to microbial communities of the skin, leading to a cascade of events eventually resulting in the skin rash of the disease. One mechanism by which epider...

journal_title：Experimental dermatology

authors： Patra V,Wolf P

更新日期：2016-12-01 00:00:00

abstract：:Psoriasis is a chronic skin disease caused by immune disorder. The chronic skin inflammation involves inflammatory molecules that are released from T lymphocytes and keratinocytes. Therefore, developing an anti-inflammatory therapy that is suitable for long-term treatment is needed. Electrical stimulation induces biol...

journal_title：Experimental dermatology

authors： Tsurekawa Y,Morita M,Suico MA,Moriuchi M,Nakano Y,Piruzyan M,Takada M,Fukami S,Shuto T,Kai H

更新日期：2018-10-01 00:00:00

abstract：:Terence Kealey first pioneered the isolation and organ maintenance of human eccrine and sebaceous glands in the early to mid-1980. This led to subsequent methods describing the isolation and culture of human hair follicles, the human pilosebaceous unit as well as the sebaceous duct. The importance of these models in t...

journal_title：Experimental dermatology

authors： Philpott MP

更新日期：2018-05-01 00:00:00

abstract：:Recent advances in the molecular biology of the dermo-epidermal basement membrane zone have contributed greatly to our understanding of the etiopathogenetic pathways underlying mechanobullous disorders. Genetic linkage was established between the keratin gene clusters and epidermolysis bullosa simplex, and keratin mut...

journal_title：Experimental dermatology

authors： Bruckner-Tuderman L

更新日期：1992-10-01 00:00:00

abstract：:We have yet to create a human scar model that demonstrates the complex nature of hypertrophic scar and keloid formation as well as ways to prevent them despite emerging advances in our understanding of the immune system, the inflammatory response, and proteomic and genomic changes after injury. Despite more complex in...

journal_title：Experimental dermatology

authors： Williams FN,Herndon DN,Branski LK

更新日期：2014-11-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer which is twice as lethal as melanoma as more than one-third of MCC patients will die from this cancer. Although MCC, which primarily affects elderly and immune suppressed individuals, is very rare to date, its incidence is rapidly increasing...

journal_title：Experimental dermatology

authors： Houben R,Schrama D,Becker JC

更新日期：2009-03-01 00:00:00