Abstract:
:During aging, increases in the number of senescent cells are seen in various tissues. On the other hand, stem cells play crucial roles in tissue repair and homeostasis. Therefore, it is likely that stem cells give rise to new cells that replace senescent cells. However, how stem cells contribute to homeostasis in the dermis has not been elucidated. Here, we investigated the effects of factors secreted from senescent fibroblasts on stem cells. We found that senescent human dermal fibroblast (HDF) conditioned medium (CM) significantly enhanced stem cell migration compared with young HDF CM. The senescent HDF CM strongly secreted chemokine ligand 2 (CCL2). Furthermore, CCL2 was found to enhance stem cell migration, and the inhibition of CCR2, a receptor for CCL2, reduced stem cell migration. These results suggest that senescent fibroblasts recruit stem cells by secreting various factors and that the CCL2/CCR2 axis is one of the mechanisms underlying this phenomenon.
journal_name
Exp Dermatoljournal_title
Experimental dermatologyauthors
Ohgo S,Hasegawa S,Hasebe Y,Mizutani H,Nakata S,Akamatsu Hdoi
10.1111/exd.12701subject
Has Abstractpub_date
2015-07-01 00:00:00pages
552-4issue
7eissn
0906-6705issn
1600-0625journal_volume
24pub_type
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