Role of the vitamin D3 pathway in healthy and diseased skin--facts, contradictions and hypotheses.

abstract：:We have characterized a stereospecific transport mechanism for L-dopa into human epidermal Langerhans cells (LCs). It is different from any other amino acid transport system. It is highly concentrative, largely pH-independent, and independent of exogenous Na+, glucose and oxygen, and fuelled by a renewable intracellul...

journal_title：Experimental dermatology

authors： Falck B,Bendsoe N,Ronquist G

更新日期：2003-10-01 00:00:00

abstract：:More than 40 null mutations in the filaggrin (FLG) gene are described. It is therefore possible to find two different null mutations in one individual (compound heterozygosity). It has been generally perceived that homozygous and compound heterozygous individuals were genotypically comparable; however, this has not be...

journal_title：Experimental dermatology

authors： Carlsen BC,Meldgaard M,Johansen JD,Thyssen JP,Menné T,Szecsi PB,Stender S

更新日期：2013-09-01 00:00:00

abstract：:Epidermal keratinocytes undergo a continuous process of terminal differentiation, which is accompanied by a dramatic change in the expression and composition of keratins. This complex and carefully orchestrated process is regulated by a large number of signal transduction events and transcriptional factors as well as ...

journal_title：Experimental dermatology

authors： Wang M,Yue Z,Paus R,Ramot Y

更新日期：2014-09-01 00:00:00

abstract：:The aim of the present study was to evaluate experimentally whether administration of recombinant (rh) vascular endothelial growth factor (VEGF) can protect skin flaps from necrosis and to study the optimum mode of rh-VEGF administration. We used rats to study the effects of local or systemic administration of rh-VEGF...

journal_title：Experimental dermatology

authors： Scalise A,Tucci MG,Lucarini G,Giantomassi F,Orlando F,Pierangeli M,Pugnaloni A,Bertani A,Ricotti G,Biagini G

更新日期：2004-11-01 00:00:00

abstract：:Human follicle dermal papilla cells (FDPC) are a specialized population of mesenchymal cells located in the skin. They regulate hair follicle (HF) development and growth, and represent a reservoir of multipotent stem cells. Growing evidence supports the hypothesis that HF cycling is associated with vascular remodeling...

journal_title：Experimental dermatology

authors： Bassino E,Gasparri F,Giannini V,Munaron L

更新日期：2015-05-01 00:00:00

abstract：:Filaggrin (FLG) loss-of-function (LOF) variants are a major risk factor for the common inflammatory skin disease, atopic dermatitis (AD) and are often population-specific. African-American (AA) children are disproportionately affected with AD, often later developing asthma and/or allergic rhinitis and comprise an atop...

journal_title：Experimental dermatology

authors： Mathyer ME,Quiggle AM,Wong XFCC,Denil SLIJ,Kumar MG,Ciliberto HM,Bayliss SJ,Common JE,de Guzman Strong C

更新日期：2018-09-01 00:00:00

abstract：:This study was stimulated by the clinical observation of a rapid response of a chilblain lupus patient to treatment with JAK1/2-kinase inhibitor ruxolitinib. We investigated the in vivo expression of phospho-JAK2 in CLE skin samples as well as the immunomodulatory in vitro effect of ruxolitinib in cultured immortalize...

journal_title：Experimental dermatology

authors： Klaeschen AS,Wolf D,Brossart P,Bieber T,Wenzel J

更新日期：2017-08-01 00:00:00

abstract：:The miRNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C-ALCL) patients were analysed with miRNA microarrays using the same control group of 12 benign inflammatory dermatoses (BID) as previously used to study the miRNA expression profile of tumor-stage mycosis fungoide...

journal_title：Experimental dermatology

authors： Benner MF,Ballabio E,van Kester MS,Saunders NJ,Vermeer MH,Willemze R,Lawrie CH,Tensen CP

更新日期：2012-08-01 00:00:00

abstract：:Psoriasis is a chronic skin disease that results in red and scaly lesions. Several psoriasis susceptibility loci have been identified across the genome, of which PSORS1 on 6p21.3 is predominant. There is an ongoing debate regarding whether the HLA-C allele, Cw*0602, can be considered the major predisposing factor in t...

journal_title：Experimental dermatology

authors： Holm SJ,Carlén LM,Mallbris L,Ståhle-Bäckdahl M,O'Brien KP

更新日期：2003-08-01 00:00:00

abstract：:Pimecrolimus (SDZ ASM981) is a non-steroid member of calcineurin inhibitors recently developed for the treatment of inflammatory skin diseases. In this study, we compared the effect of pimecrolimus and corticosteroids on the differentiation, maturation and function of murine bone marrow-derived dendritic cells (BM-DC)...

journal_title：Experimental dermatology

authors： Krummen MB,Varga G,Steinert M,Stuetz A,Luger TA,Grabbe S

更新日期：2006-01-01 00:00:00

abstract：:Proteases and their receptors have poorly understood roles in skin fibrosis and systemic scleroderma (SSc). We examined the role of protease-activated receptors (PAR(1) and PAR(2) ) in the pathophysiology of human SSc and skin fibrosis. Immunohistochemistry showed that PAR(1) immunoreactivity was positive in fibroblas...

journal_title：Experimental dermatology

authors： Cevikbas F,Seeliger S,Fastrich M,Hinte H,Metze D,Kempkes C,Homey B,Steinhoff M

更新日期：2011-01-01 00:00:00

abstract：:Patch-clamp recordings were carried out in the inside-out configuration in human keratinocytes of the cell line HaCaT. Patch pipettes were filled with 150 mM KCl, 1 mM CaCl(2) and 10 mM HEPES. In symmetrical KCl solutions, single channel currents from a large conductance channel (about 170 pS) were measured. Replaceme...

journal_title：Experimental dermatology

authors： Nguyen VH,Markwardt F

更新日期：2002-08-01 00:00:00

abstract：:Optimized delivery of antigens combined with sustainable maturation of dendritic cells (DCs) is crucial for generation of effective antitumoral immune responses. Multiple approaches for ex vivo antigen loading and improvement in immunogenicity have been described. We have recently established a single-step protocol co...

journal_title：Experimental dermatology

authors： Buhl T,Braun A,Forkel S,Möbius W,van Werven L,Jahn O,Rezaei-Ghaleh N,Zweckstetter M,Mempel M,Schön MP,Haenssle HA

更新日期：2014-01-01 00:00:00

abstract：:The immune system is called into action by alarm signals generated from injured tissues. We examined the nature of these alarm signals after exposure of skin residential cells to contact allergens (nickel sulfate and potassium dichromate) and a contact irritant [sodium dodecyl sulfate (SDS)]. Nickel sulfate, potassium...

journal_title：Experimental dermatology

authors： Spiekstra SW,Toebak MJ,Sampat-Sardjoepersad S,van Beek PJ,Boorsma DM,Stoof TJ,von Blomberg BM,Scheper RJ,Bruynzeel DP,Rustemeyer T,Gibbs S

更新日期：2005-02-01 00:00:00

abstract：:Tetracyclines (TCN) have powerful anti-inflammatory properties in addition to their anti-microbial effects. These anti-inflammatory effects are thought to play a role in inhibiting cutaneous inflammation in patients with rosacea and acne; however, the mechanism(s) of this action remains poorly understood. We have prev...

journal_title：Experimental dermatology

authors： Bender A,Zapolanski T,Watkins S,Khosraviani A,Seiffert K,Ding W,Wagner JA,Granstein RD

更新日期：2008-09-01 00:00:00

abstract：:Reactive skin is characterized by marked sensitivity to physical (heat, cold, wind) or chemical (topically applied products) stimuli and by the impairment of the skin barrier's ability to repair itself. Several lines of evidence suggest that beyond their capacity to positively influence the composition of intestinal m...

journal_title：Experimental dermatology

authors： Guéniche A,Bastien P,Ovigne JM,Kermici M,Courchay G,Chevalier V,Breton L,Castiel-Higounenc I

更新日期：2010-08-01 00:00:00

abstract：:Recently, 3% diclofenacnatrium gel (diclofenac) was introduced for the treatment of actinic keratoses. Data on photocarcinogenesis of topical diclofenac are limited, and we wished to investigate whether topical diclofenac can accelerate photocarcinogenesis using simulated solar radiation (SSR). Diclofenac was applied ...

journal_title：Experimental dermatology

authors： Lerche CM,Philipsen PA,Poulsen T,Wulf HC

更新日期：2011-04-01 00:00:00

abstract：:Pseudoxanthoma elasticum (PXE), a heritable multi-system disorder, is caused by mutations in the ABCC6 gene primarily expressed in the liver. Recent analysis of cultured fibroblasts from patients with PXE has suggested compensatory alterations in the expression of the ABCA-subfamily of genes. We have now determined by...

journal_title：Experimental dermatology

authors： Li Q,Uitto J

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:The accuracy of diagnosis of skin cancer and especially of early malignant melanoma is most important to reduce its morbidity and mortality. Previous pilot studies using electrical impedance measurements indicate statistically significant accuracies for the detection of skin cancer. OBJECTIVES:The aim of th...

journal_title：Experimental dermatology

authors： Aberg P,Birgersson U,Elsner P,Mohr P,Ollmar S

更新日期：2011-08-01 00:00:00

abstract：:Terence Kealey first pioneered the isolation and organ maintenance of human eccrine and sebaceous glands in the early to mid-1980. This led to subsequent methods describing the isolation and culture of human hair follicles, the human pilosebaceous unit as well as the sebaceous duct. The importance of these models in t...

journal_title：Experimental dermatology

authors： Philpott MP

更新日期：2018-05-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) gene amplification and protein overexpression are common in several cancers. EGFR status has seldom been studied in cutaneous squamous carcinomas (SCCs), or their precursors, actinic keratoses (AKs). We evaluated the presence of EGFR genomic aberrations and EGFR protein overexpr...

journal_title：Experimental dermatology

authors： Toll A,Salgado R,Yébenes M,Martín-Ezquerra G,Gilaberte M,Baró T,Solé F,Alameda F,Espinet B,Pujol RM

更新日期：2010-02-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer which is twice as lethal as melanoma as more than one-third of MCC patients will die from this cancer. Although MCC, which primarily affects elderly and immune suppressed individuals, is very rare to date, its incidence is rapidly increasing...

journal_title：Experimental dermatology

authors： Houben R,Schrama D,Becker JC

更新日期：2009-03-01 00:00:00

abstract：:Seasonal variations can be found in almost any parameter of an organism's biochemistry, physiology, endocrinology, and behaviour. This phenomenon, generally called photoperiodism, results from one of the major functions of the circadian system, i.e. the translation of environmental information into rhythmic intraorgan...

journal_title：Experimental dermatology

authors： Lang R,Hintner H,Hermann A,Brandstaetter R

更新日期：2003-08-01 00:00:00

abstract：:Primary cutaneous large B-cell lymphomas, leg type (PCLBCL/LT) are primary cutaneous B-cell lymphoma (PCBCL) with an intermediate prognosis. Therefore, antracycline-based polychemotherapy combined with rituximab has been recommended as first-line treatment. Yet, despite this regimen, the 5-year survival rate remains 5...

journal_title：Experimental dermatology

authors： Teichert M,Stumpf C,Booken N,Wobser M,Nashan D,Hallermann C,Mogler C,Müller CS,Becker JC,Moritz RK,Andrulis M,Nicolay JP,Goerdt S,Thomas M,Klemke CD,Augustin HG,Felcht M

更新日期：2015-06-01 00:00:00

abstract：:Pemphigus vulgaris (PV) is an autoimmune bullous disease caused by immunoglobulin G (IgG) autoantibodies against desmoglein 3 (Dsg3). We have generated an active disease mouse model for PV by adoptive transfer of Dsg3(-/-) lymphocytes. In this study, we investigated the benefits and limitations of this model as a tool...

journal_title：Experimental dermatology

authors： Takae Y,Nishikawa T,Amagai M

更新日期：2009-03-01 00:00:00

abstract：:DECORIN is a prototypical member of the small leucine-rich proteoglycan (SLRP) family that plays important roles in numerous biological processes and cellular biological pathways. We previously showed that Decorin expression was highly enhanced in mouse dorsal hair follicles (HFs) during the anagen phase and was reduc...

journal_title：Experimental dermatology

authors： Zhou L,Jing J,Wang H,Wu X,Lu Z

更新日期：2018-11-01 00:00:00

abstract：:Genetically modified mouse lines revealed that the epidermal growth factor receptor (EGFR) is essential for the development and homoeostasis of the epidermis and hair follicles. However, more detailed studies have been precluded by the shortened lifespan of Egfr knockout mice. We employed the mouse line Wa5 (carrying ...

journal_title：Experimental dermatology

authors： Dahlhoff M,Rose C,Wolf E,Schneider MR

更新日期：2011-03-01 00:00:00

abstract：:Vitamin D-binding protein (VDBP) single nucleotide polymorphisms (SNP) may affect skin carcinogenesis. The objective was to test the association between two functional VDBP SNPs and the susceptibility to (multiple) basal cell carcinomas (BCCs). Of the 7983 participants, 5790 (72.5%) and 5823 (72.9%) participants were ...

journal_title：Experimental dermatology

authors： Flohil SC,de Vries E,van Meurs JB,Fang Y,Stricker BH,Uitterlinden AG,Nijsten T

更新日期：2010-12-01 00:00:00

abstract：:Studies have shown that wound pH is a potentially influential factor in the healing process. Due to the flaws of traditional pH measurement approaches, wound pH measurement has not become part of current standard of care. A near-infrared pH-sensitive ratiometric film was created and characterized for measuring wound p...

journal_title：Experimental dermatology

authors： Li S,Vu H,Senkowsky J,Hu W,Tang L

更新日期：2020-01-01 00:00:00

abstract：:Current gold standard lower extremity cutaneous wound management is not always effective. Cutaneous wounds generate a "current of injury" which is directly involved in wound healing processes. Application of exogenous electrical stimulation has been hypothesised to imitate the natural electric current that occurs in c...

journal_title：Experimental dermatology

authors： Ashrafi M,Alonso-Rasgado T,Baguneid M,Bayat A

更新日期：2017-02-01 00:00:00