Role of the vitamin D3 pathway in healthy and diseased skin--facts, contradictions and hypotheses.


:Irradiation of human keratinocytes with UVB (280-320 nm) in vitro and in vivo activates the metabolism of 7-dehydrocholesterol to hormonally active calcitriol. The production of calcitriol in the skin strongly depends on the photosynthesis of vitamin D(3) which is biologically inactive in the first instance. Vitamin D(3) serves as the starting substrate for two subsequent enzymatic hydroxylation steps in epidermal keratinocytes. Both the amount of vitamin D(3) and the activity of anabolic and catabolic vitamin D hydroxylases determine the cutaneous level of calcitriol. The hormonally active metabolite of vitamin D(3) regulates a huge number of genes in keratinocytes, and thus acts in an autocrine and/or paracrine manner. This local pathway of vitamin D(3) is unique, but its relevance for healthy and diseased skin is widely unknown, yet. Experimental findings implicate several questions: (1) Is UVB-induced formation of calcitriol involved in regulation of growth and differentaition of epidermal cells as well as immunological and skin protective processes? (2) What endogenous and exogenous factors including drugs affect the cutaneous vitamin D(3) pathway? From a therapeutical point of view, it has been known for a long time that topical application of calcitriol and its analogs can improve hyperproliferative skin diseases like psoriasis. In spite of many encouraging studies in recent years, the fields of the routinely therapeutical application of calcitriol or vitamin D analogs in dermatology (e.g. treatment of immunological, inflammatory, malignancies and infectious skin diseases) have not been intensified. Why is that?


Exp Dermatol


Experimental dermatology


Lehmann B




Has Abstract


2009-02-01 00:00:00














  • Persistent CMV infection correlates with disease activity and dominates the phenotype of peripheral CD8+ T cells in psoriasis.

    abstract:BACKGROUND:Previously, we have reported a frequent association of active plaque psoriasis with inflammation-mediated cytomegalovirus (CMV) reactivation. OBJECTIVES:This study aimed at characterizing the impact of CMV infection on psoriasis disease activity and peripheral cellular adaptive immune response. PATIENTS/ME...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Weitz M,Kiessling C,Friedrich M,Prösch S,Höflich C,Kern F,Volk HD,Sterry W,Asadullah K,Döcke WD

    更新日期:2011-07-01 00:00:00

  • Probing skin physiology through the volatile footprint: Discriminating volatile emissions before and after acute barrier disruption.

    abstract::Volatile organic compounds emitted by human skin were sampled before and after acute barrier disruption of the volar forearm to investigate the significance of this approach to skin physiology research. A small wearable housing integrating a solid-phase micro-extraction fibre permitting rapid enclosed headspace sampli...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Duffy E,Jacobs MR,Kirby B,Morrin A

    更新日期:2017-10-01 00:00:00

  • A high frequency of allergen-specific CD8+ Tc1 cells is associated with the murine immune response to the contact sensitizer trinitrophenyl.

    abstract::Chemical haptens induce a variety of allergic immune reactions by induction of hapten-specific T cells. Contact sensitizers such as the hapten trinitrochlorobenzene (TNCB) elicit an allergic response, which is confined to the area of antigen exposure. Despite this localized allergic response, we show here that the tri...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Martin S,Delattre V,Leicht C,Weltzien HU,Simon JC

    更新日期:2003-02-01 00:00:00

  • The role of skin barrier in occupational contact dermatitis.

    abstract::Skin diseases represent one of the most common work-related diseases and may have a detrimental effect on social, personal and occupational aspects of life. Contact dermatitis (CD), which comprises predominately irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), accounts for vast majority of occu...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Jakasa I,Thyssen JP,Kezic S

    更新日期:2018-08-01 00:00:00

  • Prostaglandin D production in FM55 melanoma cells is regulated by alpha-melanocyte-stimulating hormone and is not related to melanin production.

    abstract::This study shows that prostaglandins in human FM55 melanoma cells and epidermal melanocytes are produced by COX-1. Prostaglandin production in FM55 melanoma cells was unrelated to that of melanin suggesting that the two processes can occur independently. Alpha-melanocyte-stimulating hormone, which had no effect on mel...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Masoodi M,Nicolaou A,Gledhill K,Rhodes LE,Tobin DJ,Thody AJ

    更新日期:2010-08-01 00:00:00

  • Messenger RNAs for the multifunctional cytokines interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor-alpha are present in adnexal tissues and in dermis of normal human skin.

    abstract::Interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) are 3 cytokines that play a key rôle in cutaneous homeostasis and in the immunopathogenesis of a number of dermatologic diseases. Most studies have focused on their production by keratinocytes and Langerhans ce...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Boehm KD,Yun JK,Strohl KP,Elmets CA

    更新日期:1995-12-01 00:00:00

  • Potential mesenchymal stem cell therapy for skin diseases.

    abstract::Mesenchymal stem cells (MSCs) are non-haematopoietic cells that reside in most tissues including adult bone marrow. MSCs have recently been extensively studied and used for clinical therapies, including skin wound healing. However, there are still many questions to be answered. In the viewpoint entitled 'Mesenchymal s...

    journal_title:Experimental dermatology

    pub_type: 评论,杂志文章


    authors: Li X,Hamada T,Ohata C,Furumura M,Hashimoto T

    更新日期:2013-08-01 00:00:00

  • IL-24 is expressed during wound repair and inhibits TGFalpha-induced migration and proliferation of keratinocytes.

    abstract::Interleukin (IL)-24 is the protein product of melanoma differentiation-associated gene 7 (MDA-7). Originally identified as a tumor suppressor molecule, MDA-7 was renamed IL-24 and classified as a cytokine because of its chromosomal location in the IL-10 locus, its mRNA expression in leukocytes, and its secretory seque...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Poindexter NJ,Williams RR,Powis G,Jen E,Caudle AS,Chada S,Grimm EA

    更新日期:2010-08-01 00:00:00

  • Activin A-induced signalling controls hair follicle neogenesis.

    abstract::Acquisition of potent human dermal papilla (DP) cells that can induce hair follicle neogenesis is an overarching concern, and various approaches have been tried. In an attempt to solve the problem, we previously introduced the three-dimensional (3D) culture of human DP cells and observed de novo formation of hair foll...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Seo CH,Kwack MH,Kim MK,Kim JC,Sung YK

    更新日期:2017-02-01 00:00:00

  • CCN proteins as potential actionable targets in scleroderma.

    abstract::Systemic sclerosis (SSc) is a complex autoimmune connective tissue disease combining inflammatory, vasculopathic and fibrotic manifestations. Skin features, which give their name to the disease and are considered as diagnostic as well as prognostic markers, have not been thoroughly investigated in terms of therapeutic...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Henrot P,Truchetet ME,Fisher G,Taïeb A,Cario M

    更新日期:2019-01-01 00:00:00

  • Expression of the Abca-subfamily of genes in Abcc6-/- mice--upregulation of Abca4.

    abstract::Pseudoxanthoma elasticum (PXE), a heritable multi-system disorder, is caused by mutations in the ABCC6 gene primarily expressed in the liver. Recent analysis of cultured fibroblasts from patients with PXE has suggested compensatory alterations in the expression of the ABCA-subfamily of genes. We have now determined by...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Li Q,Uitto J

    更新日期:2011-05-01 00:00:00

  • In vivo and in vitro evidence for autocrine DCoH/HNF-1alpha transcription of albumin in the human epidermis.

    abstract::The presence of albumin in the human epidermis has been reported more than a decade ago, but until now, it was assumed that this protein is synthesized in the liver and transported to the avascular skin. To our knowledge, transcription of albumin in the human epidermis was never considered. In this report, we present ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Hasse S,Kothari S,Rokos H,Kauser S,Schürer NY,Schallreuter KU

    更新日期:2005-03-01 00:00:00

  • Elevated serum BAFF levels in patients with localized scleroderma in contrast to other organ-specific autoimmune diseases.

    abstract::Serum levels of B-cell activating factor belonging to the tumor necrosis factor family (BAFF), a potent B-cell survival factor, are elevated in patients with systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis and systemic sclerosis (SSc). The objective of this study was to d...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Matsushita T,Hasegawa M,Matsushita Y,Echigo T,Wayaku T,Horikawa M,Ogawa F,Takehara K,Sato S

    更新日期:2007-02-01 00:00:00

  • Mitochondrial oxidative stress as a novel therapeutic target to overcome intrinsic drug resistance in melanoma cell subpopulations.

    abstract::Despite recent success in melanoma therapy, most patients with metastatic disease still undergo deadly progression. We have identified a novel mechanism of multidrug resistance allowing a small subpopulation of slow-cycling melanoma cells to survive based on elevated oxidative bioenergy metabolism. In this study, we a...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Cierlitza M,Chauvistré H,Bogeski I,Zhang X,Hauschild A,Herlyn M,Schadendorf D,Vogt T,Roesch A

    更新日期:2015-02-01 00:00:00

  • Quantitative analysis of the synthesis and secretion of type VII collagen in cultured human dermal fibroblasts with a sensitive sandwich enzyme-linked immunoassay.

    abstract::Type VII collagen is the major component of anchoring fibrils in the epidermal basement membrane. Its expression has been analyzed by immunostaining or Northern blotting, but rarely at the protein level. In this study, we have quantitatively examined the effects of ascorbic acid and various cytokines/growth factors on...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Amano S,Ogura Y,Akutsu N,Nishiyama T

    更新日期:2007-02-01 00:00:00

  • JAK inhibitor ruxolitinib inhibits the expression of cytokines characteristic of cutaneous lupus erythematosus.

    abstract::This study was stimulated by the clinical observation of a rapid response of a chilblain lupus patient to treatment with JAK1/2-kinase inhibitor ruxolitinib. We investigated the in vivo expression of phospho-JAK2 in CLE skin samples as well as the immunomodulatory in vitro effect of ruxolitinib in cultured immortalize...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Klaeschen AS,Wolf D,Brossart P,Bieber T,Wenzel J

    更新日期:2017-08-01 00:00:00

  • Glycyrrhizic acid prevents ultraviolet-B-induced photodamage: a role for mitogen-activated protein kinases, nuclear factor kappa B and mitochondrial apoptotic pathway.

    abstract::Glycyrrhizic acid (GA), a natural triterpene, has received attention as an agent that has protective effects against chronic diseases including ultraviolet UV-B-induced skin photodamage. However, the mechanism of its protective effect remains elusive. Here, we used an immortalized human keratinocyte cell line (HaCaT) ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Afnan Q,Kaiser PJ,Rafiq RA,Nazir LA,Bhushan S,Bhardwaj SC,Sandhir R,Tasduq SA

    更新日期:2016-06-01 00:00:00

  • Association of thymic stromal lymphopoietin gene -847C>T polymorphism in generalized vitiligo.

    abstract::Thymic stromal lymphopoietin (TSLP) induces naïve CD4+ T cells to produce Th2 cytokines. In addition, to low production of Th2 cytokines, strong Th1 response, which plays an important role in vitiligo development, has been induced by blockade of TSLP or TSLP receptor. This study examined whether a functional TSLP poly...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Cheong KA,Chae SC,Kim YS,Kwon HB,Chung HT,Lee AY

    更新日期:2009-12-01 00:00:00

  • Biology of the wool follicle: an excursion into a unique tissue interaction system waiting to be re-discovered.

    abstract::Wool fibres are hairs and the term 'wool' is usually restricted to describe the fine curly hairs that constitute the fleece produced by sheep. In a broader sense, it can be used to describe the fleeces produced by related species such as goat or yak. Research into the biology of wool growth and the structure of the wo...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Rogers GE

    更新日期:2006-12-01 00:00:00

  • Fluorescence induction of protoporphyrin IX by a new 5-aminolevulinic acid nanoemulsion used for photodynamic therapy in a full-thickness ex vivo skin model.

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    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Maisch T,Santarelli F,Schreml S,Babilas P,Szeimies RM

    更新日期:2010-08-01 00:00:00

  • Basal cell carcinomas display extensive abnormalities in the hemidesmosome anchoring fibril complex.

    abstract::We have employed a panel of antibodies directed against several newly-defined and well-characterized components of the epidermal basement membrane (BM) to investigate the biology of basal cell carcinoma (BCC) by indirect immunofluorescence and to determine whether alterations in BM components may play a significant ro...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


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  • Tumor-educated myeloid cells: impact the micro- and macroenvironment.

    abstract::Immune escape mechanisms of cancers include some of the mechanisms normally used for immune homeostasis, particular those preventing autoimmunity; one of these is the polarisation of myeloid cells. Thereby, tumors, i.e. the cancerous and stromal cells, also condition distant sites like spleen and bone marrow via solub...

    journal_title:Experimental dermatology

    pub_type: 评论,杂志文章


    authors: Becker JC

    更新日期:2014-03-01 00:00:00

  • Vitamin D-binding protein polymorphisms are not associated with development of (multiple) basal cell carcinomas.

    abstract::Vitamin D-binding protein (VDBP) single nucleotide polymorphisms (SNP) may affect skin carcinogenesis. The objective was to test the association between two functional VDBP SNPs and the susceptibility to (multiple) basal cell carcinomas (BCCs). Of the 7983 participants, 5790 (72.5%) and 5823 (72.9%) participants were ...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Flohil SC,de Vries E,van Meurs JB,Fang Y,Stricker BH,Uitterlinden AG,Nijsten T

    更新日期:2010-12-01 00:00:00

  • Placental extracts regulate melanin synthesis in normal human melanocytes with alterations of mitochondrial respiration.

    abstract::Placental extracts have been widely used as skin lightening agents in the Japanese cosmetic market. Here, we show that placental extracts contain factors that can decrease or increase melanin synthesis by normal human melanocytes in vitro in possible association with mitochondrial respiration. When normal human melano...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Yoshimoto S,Ohagi Y,Yoshida M,Yanagi H,Hibino S,Ichihashi M,Ando H

    更新日期:2019-02-01 00:00:00

  • Immune cell regulation of the hair cycle.

    abstract::The ability to manipulate the mammalian hair cycle will lead to novel therapies and strategies to combat all forms of alopecia. Thus, in addition to the epithelial-mesenchymal interactions in the hair follicle, niche and microenvironmental signals that accompany the phases of growth, regression and rest need to be scr...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Wang ECE,Higgins CA

    更新日期:2020-03-01 00:00:00

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    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Gong Y,Zhao Y,Zhang X,Qi S,Li S,Ye Y,Yang J,Caulloo S,McElwee KJ,Zhang X

    更新日期:2020-03-01 00:00:00

  • The Sox2: GFP+/- knock-in mouse model does not faithfully recapitulate Sox2 expression in skin.

    abstract::Hair follicle heterogeneity may be regulated by distinct dermal papillae (DP) that represent mesenchymal lineages, which can be defined by Sox2 expression. However, it was recently shown that GFP expression in the Sox2: GFP+/- mouse model occurs in the DPs of all hair follicle types, challenging the idea that hair fol...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Salz L,Driskell RR

    更新日期:2017-11-01 00:00:00

  • Fibroblasts support migration of monocyte-derived dendritic cells by secretion of PGE2 and MMP-1.

    abstract::The outcome of a cutaneous immune response is critically dependent upon the ability of dendritic cells (DC) to migrate from skin to the draining lymph nodes - a process that is influenced by the cutaneous tissue microenvironment. Here, the role of fibroblasts - a major component of the dermal microenvironment - on the...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Saalbach A,Janik T,Busch M,Herbert D,Anderegg U,Simon JC

    更新日期:2015-08-01 00:00:00

  • Influence of interleukin-1alpha on androgen receptor expression and cytokine secretion by cultured human dermal papilla cells.

    abstract::Dermal papilla cells (DPC) control the growth character of the hair follicle through their elaboration of mitogenic factors and extracellular matrix components. Further, the dermal papilla is a primary site of androgen action in the hair follicle. Interleukin-1alpha (IL-1alpha) is prominent in skin wounding and inflam...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Boivin WA,Jiang H,Utting OB,Hunt DW

    更新日期:2006-10-01 00:00:00

  • The regulatory mechanism of melanogenesis by FTY720, a sphingolipid analogue.

    abstract::We previously reported that sphingosine-1-phosphate (S1P) decreases melanin synthesis via extracellular signal-regulated protein kinase (ERK) activation and microphthalmia-associated transcription factor (MITF) degradation. Although FTY720 is an S1P structural analogue, the effects of FTY720 on melanogenesis are not c...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Lee JE,Kim SY,Jeong YM,Yun HY,Baek KJ,Kwon NS,Park KC,Kim DS

    更新日期:2011-03-01 00:00:00