Decreased incidence of papillomas in mice with impaired EGFR function during multi-stage skin carcinogenesis.


:Genetically modified mouse lines revealed that the epidermal growth factor receptor (EGFR) is essential for the development and homoeostasis of the epidermis and hair follicles. However, more detailed studies have been precluded by the shortened lifespan of Egfr knockout mice. We employed the mouse line Wa5 (carrying a point mutation resulting in the expression of a dominant negative receptor) to analyse the impact of significantly reduced EGFR signalling during multi-stage chemical skin carcinogenesis. Seven-week-old Wa5 females and control littermates received a single application of 7,12-dimethylbenz(a)anthracene followed by multiple applications of 12-O-tetradecanoylphorbol-13-acetate for 26 weeks. Wa5 mice remained free of papillomas for a longer time and developed significantly fewer tumors than control littermates. In contrast, the mean tumor size was not different between groups. The present data indicate that EGFR signalling contributes to tumor growth during multi-stage chemical carcinogenesis of the skin in mice possibly by acting as a survival factor for skin tumor cells.


Exp Dermatol


Experimental dermatology


Dahlhoff M,Rose C,Wolf E,Schneider MR




Has Abstract


2011-03-01 00:00:00












  • Immunopathogenesis of psoriasis.

    abstract::Psoriasis is a chronic skin disease that affects about 1.5% of the Caucasian population and is characterized by typical macroscopic and microscopic skin alterations. Psoriatic lesions are sharply demarcated, red and slightly raised lesions with silver-whitish scales. The microscopic alterations of psoriatic plaques in...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Sabat R,Philipp S,Höflich C,Kreutzer S,Wallace E,Asadullah K,Volk HD,Sterry W,Wolk K

    更新日期:2007-10-01 00:00:00

  • Influence of interleukin-1alpha on androgen receptor expression and cytokine secretion by cultured human dermal papilla cells.

    abstract::Dermal papilla cells (DPC) control the growth character of the hair follicle through their elaboration of mitogenic factors and extracellular matrix components. Further, the dermal papilla is a primary site of androgen action in the hair follicle. Interleukin-1alpha (IL-1alpha) is prominent in skin wounding and inflam...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Boivin WA,Jiang H,Utting OB,Hunt DW

    更新日期:2006-10-01 00:00:00

  • Vaspin--a link of obesity and psoriasis?

    abstract::Psoriasis is an inflammatory skin disease often associated with obesity. The anti-inflammatory adipokine vaspin, a suggested serine proteinase inhibitor of the serpin family, is discussed as a new link between inflammation and obesity. Here, we demonstrate that - different from healthy controls - vaspin serum levels i...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Saalbach A,Vester K,Rall K,Tremel J,Anderegg U,Beck-Sickinger AG,Blüher M,Simon JC

    更新日期:2012-04-01 00:00:00

  • In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions.

    abstract::The anti-inflammatory mechanisms of adapalene, a synthetic retinoid used for the treatment of acne patients, are partially understood. They seem particularly related to the modulation of the non-specific immunity. Recent studies have shown that Toll-like receptor (TLR)-2 expression, a receptor of the innate immune sys...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Tenaud I,Khammari A,Dreno B

    更新日期:2007-06-01 00:00:00

  • Bioactive tetrapeptide GEKG boosts extracellular matrix formation: in vitro and in vivo molecular and clinical proof.

    abstract::The 'matrikine' concept claims that processing of the precursors for collagen results in the formation of peptides such as KTTKS which in turn augments extracellular matrix (ECM) production. In the present study, we show the development of an anti-ageing active from an in silico approach by molecular design resulting ...

    journal_title:Experimental dermatology

    pub_type: 信件,随机对照试验


    authors: Farwick M,Grether-Beck S,Marini A,Maczkiewitz U,Lange J,Köhler T,Lersch P,Falla T,Felsner I,Brenden H,Jaenicke T,Franke S,Krutmann J

    更新日期:2011-07-01 00:00:00

  • Dermal mast cells affect the development of sunlight-induced skin tumours.

    abstract::Ultraviolet (UV) radiation contained in sunlight is considered a major risk in the induction of skin cancer. While mast cells are best known for their role in allergic responses, they have also been shown to play a crucial role in suppressing the anti-tumour immune response following UV exposure. Evidence is now emerg...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Sarchio SN,Kok LF,O'Sullivan C,Halliday GM,Byrne SN

    更新日期:2012-04-01 00:00:00

  • Mutational profiling of acral melanomas in Korean populations.

    abstract::The proportion of acral melanoma (AM) is much higher in Asian populations than in Caucasian populations. Although mutational profiles associated with AM have been discovered in Caucasian populations, knowledge of its genetic alterations in Asian populations is limited. To describe the molecular nature of AM in Korean ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Shim JH,Shin HT,Park J,Park JH,Lee JH,Yang JM,Kim DH,Jang KT,Lee DY

    更新日期:2017-10-01 00:00:00

  • Melanoma risk alleles are associated with downregulation of the MTAP gene and hypermethylation of a CpG island upstream of the gene in dermal fibroblasts.

    abstract::Several association studies and GWAS on melanoma skin cancer risk have reported statistically significant signals on 9p21.3 region, where MTAP gene maps. None of the associated SNPs identified in these studies lie in the coding region of the gene and the causative relation of risk alleles with melanoma predisposition ...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Sangalli A,Malerba G,Tessari G,Rodolfo M,Gomez-Lira M

    更新日期:2017-08-01 00:00:00

  • Prognostic tools for hypertrophic scar formation based on fundamental differences in systemic immunity.

    abstract::Unpredictable hypertrophic scarring (HS) occurs after approximately 35% of all surgical procedures and causes significant physical and psychological complaints. Parallel to the need to understanding the mechanisms underlying HS formation, a prognostic tool is needed. The objective was to determine whether (systemic) i...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: de Bakker E,van der Putten MAM,Heymans MW,Spiekstra SW,Waaijman T,Butzelaar L,Negenborn VL,Beekman VK,Akpinar EO,Rustemeyer T,Niessen FB,Gibbs S

    更新日期:2021-01-01 00:00:00

  • Electrophysiological characterization of human keratinocytes using the patch-clamp technique.

    abstract::The living, not-cornified part of the epidermis consists mainly of keratinocytes. The control mechanisms of proliferation and differentiation are only partly understood. Similarly, the influence of ionic channels of the cell membrane on the proliferation of keratinocytes remains unclear. Preliminary investigations poi...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Wohlrab D,Wohlrab J,Markwardt F

    更新日期:2000-06-01 00:00:00

  • Dendritic cells--why can they help and hurt us.

    abstract::Dendritic cells (DCs) show a Janus-like functional behavior. They help us by their orchestration of numerous immune responses to defend our body against invading pathogenic micro-organisms and also induce regulatory T cells to inhibit immune reactions against autoantigens as well as diverse harmless environmental anti...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Schäkel K

    更新日期:2009-03-01 00:00:00

  • High death rate in mice treated topically with diclofenac.

    abstract::Recently, 3% diclofenacnatrium gel (diclofenac) was introduced for the treatment of actinic keratoses. Data on photocarcinogenesis of topical diclofenac are limited, and we wished to investigate whether topical diclofenac can accelerate photocarcinogenesis using simulated solar radiation (SSR). Diclofenac was applied ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Lerche CM,Philipsen PA,Poulsen T,Wulf HC

    更新日期:2011-04-01 00:00:00

  • Neuroendocrine regulation of sebocytes -- a pathogenetic link between stress and acne.

    abstract::A causative link between emotional stress and acne has long been postulated. There is mounting evidence that the molecular mechanism underlying this observation is related to the expression of receptors for several neuroendocrine mediators by the sebaceous gland. Recent and ongoing studies have indicated that human se...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Zouboulis CC,Böhm M

    更新日期:2004-01-01 00:00:00

  • Dissection of macrophage differentiation pathways in cutaneous macrophage disorders and in vitro.

    abstract::Macrophages play important roles in immunity and inflammation, and in allergic, granulomatous and neoplastic diseases. Here, we present the indepth results of an ongoing study of macrophage differentiation pathways in cutaneous macrophage disorders and in vitro. Up to now, a total of 40 cases of cutaneous macrophage d...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Kodelja V,Goerdt S

    更新日期:1994-12-01 00:00:00

  • Modulation of keratinocyte growth factor (KGF) mRNA expression in human dermal fibroblasts grown in monolayer or within a collagen matrix.

    abstract::In this study, we analysed the modulation of keratinocyte growth factor (KGF) mRNA expression in human dermal fibroblasts cultured either in monolayer or within a collagen matrix (dermal equivalent). In monolayer cultures, KGF expression by quiescent fibroblasts was stimulated by different growth substances such as se...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Le Panse R,Bouchard B,Lebreton C,Coulomb B

    更新日期:1996-04-01 00:00:00

  • Para-phenylenediamine-specific lymphocyte activation test: a sensitive in vitro assay to detect para-phenylenediamine sensitization in patients with severe allergic reactions.

    abstract::Patients sensitized to para-phenylenediamine (PPD) by semi-permanent tattoos increasingly develop threatening allergic reactions in response to black hair dye. The gold standard to diagnose allergic contact dermatitis is to perform epicutaneous patch tests, however, iatrogenic sensitizations and severe patch test reac...

    journal_title:Experimental dermatology

    pub_type: 临床试验,杂志文章


    authors: Kneilling M,Caroli U,Grimmel C,Fischer J,Eichner M,Wieder T,Maier FC,Röcken M,Biedermann T

    更新日期:2010-05-01 00:00:00

  • Tropisetron via α7 nicotinic acetylcholine receptor suppresses tumor necrosis factor-α-mediated cell responses of human keratinocytes.

    abstract::Tropisetron is a serotonin receptor (5-HT-R)-modulating agent and approved as an antiemetic for patients undergoing chemotherapy. In the gut, it acts via specific serotonin receptors, 5-HT3 -R, to elicit its beneficial effects against nausea. We investigated whether tropisetron can affect inflammatory cell responses o...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Stegemann A,Böhm M

    更新日期:2019-03-01 00:00:00

  • CD44, but not l-selectin, is critically involved in leucocyte migration into the skin in a murine model of allergic dermatitis.

    abstract::CD44 and l-selectin (CD62L) are major adhesion receptors that mediate leucocyte recruitment at inflammatory sites and lymph nodes, by supporting cell rolling under blood flow. Both CD44 and CD62L have been implicated in inflammatory skin disorders, but their specific involvement in an immediate-type allergic reaction ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Gonda A,Gál I,Szántó S,Sarraj B,Glant TT,Hunyadi J,Mikecz K

    更新日期:2005-09-01 00:00:00

  • Down-regulated SHARPIN may accelerate the development of atopic dermatitis through activating interleukin-33/ST2 signalling.

    abstract::SHARPIN is an important component of the linear ubiquitin chain assembly complex (LUBAC). Loss of function of SHARPIN results in eosinophilic inflammation in multiple organs including skin with Th2 -dominant cytokines and dysregulated development of lymphoid tissues in mice. The clinicopathological features are simila...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Tang L,Wang J,Zhu J,Liang Y

    更新日期:2018-12-01 00:00:00

  • The status quo and quo vadis of mast cells.

    abstract::Mast cells (MCs) have been intensely investigated over the past two decades, e.g. the numbers of PubMed-listed reports on MCs have steadily increased and doubled over the past twenty years. Surprisingly, many recent findings that have fundamentally changed our understanding of MC biology and functions have yet to be s...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Maurer M,Metz M

    更新日期:2005-12-01 00:00:00

  • The dermal sheath: An emerging component of the hair follicle stem cell niche.

    abstract::Hair follicles cyclically regenerate throughout adult mammalian life, owing to a resident population of epithelial hair follicle stem cells. Stem cell (SC) activity drives bouts of follicle growth, which are periodically interrupted by follicle regression and rest. These phases and the transitions between them are tig...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Martino PA,Heitman N,Rendl M

    更新日期:2020-10-02 00:00:00

  • Promoter region polymorphism in the human TNF-alpha gene is not associated with lichen sclerosus.

    abstract::The pathogenesis of lichen sclerosus remains unknown. However, it has been frequently associated clinically with autoimmunity. The MHC haplotype A1, B8, DR3 is associated with many autoimmune conditions and has also been associated with the uncommon allele of the tumour necrosis factor (TNF-alpha) promoter polymorphis...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Clay FE,Cork MJ,Wilson AG,Crane AM,Lewis F,Harrington CI,Duff GW

    更新日期:1996-08-01 00:00:00

  • Inflammatory skin is associated with changes in the skin microbiota composition on the back of severe acne patients.

    abstract::Acne is the most common inflammatory skin disease, affecting up to 85% of the 11-30 years old world population. Skin microbiota appears as a key player involved in several skin dermatoses physiopathology. Here, we show that inflammatory skin is associated with changes in the skin microbiota composition on the back of ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Dagnelie MA,Montassier E,Khammari A,Mounier C,Corvec S,Dréno B

    更新日期:2019-08-01 00:00:00

  • Divalent cations (Mg2+, Ca2+) differentially influence the beta 1 integrin-mediated migration of human fibroblasts and keratinocytes to different extracellular matrix proteins.

    abstract::Directed migration of keratinocytes and fibroblasts is a fundamental prerequisite in wound healing. Cation-dependent affinity changes of integrins are responsible for cell adhesion to and deadhesion from extracellular matrix proteins and have been implicated in driving cell migration. The specific requirements for div...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Lange TS,Kirchberg J,Bielinsky AK,Leuker A,Bank I,Ruzicka T,Scharffetter-Kochanek K

    更新日期:1995-06-01 00:00:00

  • Glycyrrhizic acid prevents ultraviolet-B-induced photodamage: a role for mitogen-activated protein kinases, nuclear factor kappa B and mitochondrial apoptotic pathway.

    abstract::Glycyrrhizic acid (GA), a natural triterpene, has received attention as an agent that has protective effects against chronic diseases including ultraviolet UV-B-induced skin photodamage. However, the mechanism of its protective effect remains elusive. Here, we used an immortalized human keratinocyte cell line (HaCaT) ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Afnan Q,Kaiser PJ,Rafiq RA,Nazir LA,Bhushan S,Bhardwaj SC,Sandhir R,Tasduq SA

    更新日期:2016-06-01 00:00:00

  • Melanoma never says die.

    abstract::Drug resistance in melanoma is commonly attributed to ineffective apoptotic pathways. Targeting apoptosis regulators is thus considered a promising approach to sensitizing melanoma to therapy. In the previous issue of Experimental Dermatology, Plötz and Eberle discuss the role that apoptosis plays in melanoma progress...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Haass NK,Schumacher U

    更新日期:2014-07-01 00:00:00

  • Involvement of changes in stratum corneum keratin in wrinkle formation by chronic ultraviolet irradiation in hairless mice.

    abstract::Chronic exposure to ultraviolet (UV) radiation alters components of the skin. We previously reported that chronic low-dose UV irradiation induced wrinkle formation but did not significantly alter dermal components of hairless mice. In the present study, we examined whether the epidermal changes by UV irradiation could...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Kambayashi H,Odake Y,Takada K,Funasaka Y,Ichihashi M

    更新日期:2003-01-01 00:00:00

  • Interaction of peripheral nerves and mast cells, eosinophils, and basophils in the development of pruritus.

    abstract::Mast cells, eosinophils and basophils are central effector immune cells in allergic skin inflammation including atopic dermatitis (AD). Recent studies revealed that the bidirectional interaction between these three immune cell types (mast cells, eosinophils and basophils) and the nervous system is involved in the path...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Nakashima C,Ishida Y,Kitoh A,Otsuka A,Kabashima K

    更新日期:2019-12-01 00:00:00

  • Epidermal caspase-3 cleavage associated with interferon-gamma-expressing lymphocytes in acute atopic dermatitis lesions.

    abstract::Keratinocyte apoptosis mediated by Fas/Fas ligand molecular interactions and subsequent caspase activation is believed to play an important role in the pathogenesis of atopic dermatitis (AD), in particular for the formation of spongiosis. To estimate epidermal caspase activation in normal and AD skin under in vivo con...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Simon D,Lindberg RL,Kozlowski E,Braathen LR,Simon HU

    更新日期:2006-06-01 00:00:00

  • A mutation detection strategy for the human keratin 6A gene and novel missense mutations in two cases of pachyonychia congenita type 1.

    abstract::Pachyonychia congenita type 1 (PC-1) is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy, focal non-epidermolytic palmoplantar keratoderma and variable features of oral leukokeratosis and follicular keratosis. Previously, we have shown that this disease can be caused by mutations...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Smith FJ,McKenna KE,Irvine AD,Bingham EA,Coleman CM,Uitto J,McLean WH

    更新日期:1999-04-01 00:00:00