Ex vivo analysis of desmoglein 1-responsive T-helper (Th) 1 and Th2 cells in patients with pemphigus foliaceus and healthy individuals.

abstract：:Earlier studies showed that dermal cells lose trichogenic capacity with passage, but studies on the effect of keratinocyte passage on human hair follicle neogenesis and graft quality have been hampered by the lack of a suitable model system. We recently documented human hair follicle neogenesis in grafted dermal-epide...

journal_title：Experimental dermatology

authors： Thangapazham RL,Klover P,Li S,Wang JA,Sperling L,Darling TN

更新日期：2014-06-01 00:00:00

abstract：:The proportion of acral melanoma (AM) is much higher in Asian populations than in Caucasian populations. Although mutational profiles associated with AM have been discovered in Caucasian populations, knowledge of its genetic alterations in Asian populations is limited. To describe the molecular nature of AM in Korean ...

journal_title：Experimental dermatology

authors： Shim JH,Shin HT,Park J,Park JH,Lee JH,Yang JM,Kim DH,Jang KT,Lee DY

更新日期：2017-10-01 00:00:00

abstract：:The role of angiogenesis in tumour growth and metastasis is well established. However, investigations of tumour microcirculation to date have used either biopsy material from human tumours, or animal models in vivo. We have studied the tumour microcirculation in vivo in human skin cancers using video-microscopy to exa...

journal_title：Experimental dermatology

authors： Bedlow AJ,Stanton AW,Cliff S,Mortimer PS

更新日期：1999-06-01 00:00:00

abstract：:The bioactive lysophospholipid sphingosine-1-phosphate (S1P) is best known for its activity as T-cell-active chemoattractant regulating the egress of T cells from the lymph node and, consequently, the availability of T cells for migration into peripheral tissues. This physiological role of S1P is exploited by the drug...

journal_title：Experimental dermatology

authors： Thieme M,Zillikens D,Sadik CD

更新日期：2017-03-01 00:00:00

abstract：:The contribution of immune checkpoint receptors in the immunopathogenesis of various autoimmune diseases has been addressed in previous reports. In this study,  the expression profile of T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) and programmed cell death-1 (PD-1) checkpoint molecules was investigated...

journal_title：Experimental dermatology

authors： Rahimi A,Hossein-Nataj H,Hajheydari Z,Aryanian Z,Shayannia A,Ajami A,Asgarian-Omran H

更新日期：2019-06-01 00:00:00

abstract：:Stratum corneum (SC) exposed to living tissues, induces inflammation characterized by the formation of mixed cell granulomas consisting of infiltrative polymorphonuclear leukocytes (PMNs) and monocytes/macrophages. In this study, to clarify the mechanism for the later monocyte accumulation in SC-induced granulomas, we...

journal_title：Experimental dermatology

authors： Ozawa M,Terui T,Tanita M,Kato T,Tagami H

更新日期：1998-08-01 00:00:00

abstract：:The correlation between the degrees of integrity and cohesion in healthy human Stratum corneum (SC) and the properties of the SC lipid matrix could be examined non-invasively in vivo using ATR-FTIR spectroscopy and measurements of pH, conductance, and transepidermal water loss (TEWL) taken in the course of tape-stripp...

journal_title：Experimental dermatology

authors： Berthaud F,Boncheva M

更新日期：2011-03-01 00:00:00

abstract：:Human sebaceous gland possesses all the steroidogenic enzymes required for androgen synthesis. It remains unclear whether the testosterone produced in situ mainly derives from circulating dehydroepiandrosterone (DHEA) or from de novo synthesis utilizing serum cholesterol. Using testosterone radioimmunoassay, we found ...

journal_title：Experimental dermatology

authors： Chen W,Tsai SJ,Sheu HM,Tsai JC,Zouboulis CC

更新日期：2010-05-01 00:00:00

abstract：:CD44 and l-selectin (CD62L) are major adhesion receptors that mediate leucocyte recruitment at inflammatory sites and lymph nodes, by supporting cell rolling under blood flow. Both CD44 and CD62L have been implicated in inflammatory skin disorders, but their specific involvement in an immediate-type allergic reaction ...

journal_title：Experimental dermatology

authors： Gonda A,Gál I,Szántó S,Sarraj B,Glant TT,Hunyadi J,Mikecz K

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Basal cell carcinoma (BCC) is the most common form of skin cancer with increasing incidence rates worldwide. METHODS:To assess the association of BCC with epidemiologic risk factors in a Southern European population from Greece, we conducted a hospital-based case-control study of 199 patients with BCC and 2...

journal_title：Experimental dermatology

authors： Dessinioti C,Tzannis K,Sypsa V,Nikolaou V,Kypreou K,Antoniou C,Katsambas A,Stratigos AJ

更新日期：2011-08-01 00:00:00

abstract：:Chronic exposure to ultraviolet (UV) radiation alters components of the skin. We previously reported that chronic low-dose UV irradiation induced wrinkle formation but did not significantly alter dermal components of hairless mice. In the present study, we examined whether the epidermal changes by UV irradiation could...

journal_title：Experimental dermatology

authors： Kambayashi H,Odake Y,Takada K,Funasaka Y,Ichihashi M

更新日期：2003-01-01 00:00:00

abstract：:For many years, the function of the sebaceous gland (SG) was underestimated and suggested by Albert M. Kligman as a remnant of human development, a 'living fossil with a past but no future'. However, the last two decades of studies and the discovery of neuro-endocrine pathways in skin have determined the importance of...

journal_title：Experimental dermatology

authors： Nejati R,Skobowiat C,Slominski AT

更新日期：2013-10-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play a critical role in various pathological conditions including cutaneous inflammation. Thus far, serial assessment of MMP activity in ongoing inflammation is hampered due to technical limitations. Here, we present an innovative method for longitudinal detection of MMP activity by in...

journal_title：Experimental dermatology

authors： Steingräber AK,Schelhaas S,Faust A,Jacobs AH,Schäfers M,Goerge T

更新日期：2013-11-01 00:00:00

abstract：:Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have i...

journal_title：Experimental dermatology

authors： Niyonsaba F,Kiatsurayanon C,Chieosilapatham P,Ogawa H

更新日期：2017-11-01 00:00:00

abstract：:Pheomelanin is supposed to be the first type of melanin found in vertebrates, in contrast to the main type - eumelanin. Our study aimed at detecting pheomelanin in the skin of Hymenochirus boettgerii. We employed electron paramagnetic resonance (EPR) spectroscopy, and transmission electron microscopy (TEM), supplement...

journal_title：Experimental dermatology

authors： Wolnicka-Glubisz A,Pecio A,Podkowa D,Kolodziejczyk LM,Plonka PM

更新日期：2012-07-01 00:00:00

abstract：:The role of dendritic cells (DCs) in allergic contact dermatitis has been clearly demonstrated for the induction phase. However, the situation during the elicitation phase is very complex within a distinct inflammatory response. This study was performed to exploit DC migration in the elicitation phase in a mouse model...

journal_title：Experimental dermatology

authors： Bäumer W,Krekeler S,DeVries VC,Niedorf F,Tschernig T,Kietzmann M

更新日期：2006-04-01 00:00:00

abstract：:4-(4-Hydroxyphenyl)-2-butanol (rhododendrol, RD), a skin-whitening agent, was reported to cause skin depigmentation in some users, which is attributed to its cytotoxicity to melanocyte. It was reported that cytotoxicity to melanocyte is possibly mediated by oxidative stress in a tyrosinase activity-dependent manner. W...

journal_title：Experimental dermatology

authors： Goto N,Tsujimoto M,Nagai H,Masaki T,Ito S,Wakamatsu K,Nishigori C

更新日期：2018-07-01 00:00:00

abstract：:Type-1 cytokine-producing T cells are important in the pathogenesis of psoriasis vulgaris, for which efficient therapy is provided by means of narrow-band ultraviolet-B (NB-UVB). The expression of the type-1 cytokine interferon-gamma (IFN-gamma) is regulated by interleukin-12 (IL-12), IL-15, IL-18 and IL-23; however, ...

journal_title：Experimental dermatology

authors： Piskin G,Tursen U,Sylva-Steenland RM,Bos JD,Teunissen MB

更新日期：2004-12-01 00:00:00

abstract：:Terence Kealey first pioneered the isolation and organ maintenance of human eccrine and sebaceous glands in the early to mid-1980. This led to subsequent methods describing the isolation and culture of human hair follicles, the human pilosebaceous unit as well as the sebaceous duct. The importance of these models in t...

journal_title：Experimental dermatology

authors： Philpott MP

更新日期：2018-05-01 00:00:00

abstract：:The proliferative responses of cells to mitogens decrease during aging, and this may result from age-related defects in signal transduction in response to mitogens. In this study, we have investigated the age-related alteration of responses to epidermal growth factor (EGF) in cultured human keratinocytes that were sen...

journal_title：Experimental dermatology

authors： Shi B,Isseroff RR

更新日期：2005-07-01 00:00:00

abstract：:NC/Nga mice are known to develop scratching dermatitis akin to atopic dermatitis, under conventional (Conv), but not under the specific-pathogen-free (SPF) condition. In this study, we examined the effects of mechanical-scratching on the spontaneous scratching counts (sign of itching), in relation to the cutaneous pro...

journal_title：Experimental dermatology

authors： Takaoka A,Arai I,Sugimoto M,Futaki N,Sakurai T,Honma Y,Nakaike S

更新日期：2007-04-01 00:00:00

abstract：:Glycyrrhizic acid (GA), a natural triterpene, has received attention as an agent that has protective effects against chronic diseases including ultraviolet UV-B-induced skin photodamage. However, the mechanism of its protective effect remains elusive. Here, we used an immortalized human keratinocyte cell line (HaCaT) ...

journal_title：Experimental dermatology

authors： Afnan Q,Kaiser PJ,Rafiq RA,Nazir LA,Bhushan S,Bhardwaj SC,Sandhir R,Tasduq SA

更新日期：2016-06-01 00:00:00

abstract：:IL-15 has emerged as a potentially relevant target in the IL-17 response in psoriasis. However, its mechanism is poorly characterized in humans. IL-15 and IL-23 are constitutively expressed in the psoriatic lesion. Also, IL-15 is considered a susceptibility-associated gene in psoriasis, as are IL-23R, and HLACW6. Here...

journal_title：Experimental dermatology

authors： de Jesús-Gil C,Ruiz-Romeu E,Ferran M,Sagristà M,Chiriac A,García P,Celada A,Pujol RM,Santamaria-Babí LF

更新日期：2020-05-31 00:00:00

abstract：:Dermatitis herpetiformis (DH) is a blistering skin disease characterized by cutaneous deposits of IgA and an associated, most often asymptomatic, gluten sensitive enteropathy (GSE). Gluten sensitive enteropathy is also seen in patients that do not have skin disease or cutaneous IgA deposits, but do have significant ga...

journal_title：Experimental dermatology

authors： Hall RP 3rd,Owen S,Smith A,Keough M,Bagheri B,Church P,Streilein R

更新日期：2000-08-01 00:00:00

abstract：:In the last decade, significant progress has been made in understanding skin cancer cell death resistance mechanisms, and a number of new treatment strategies have been developed. Systematic approach genomic studies of various cancer types have opened new possibilities for the development of anticancer therapies. Howe...

journal_title：Experimental dermatology

authors： Feoktistova M,Panayotova-Dimitrova D

更新日期：2017-10-01 00:00:00

abstract：:Vitamin D3 analogues are widely used topical and oral remedies for various ailments such as psoriasis, osteoporosis and secondary hyperparathyroidism. In topical treatment, high skin permeability and cellular uptake are key criteria for beneficial effects due to the natural barrier properties of skin. In this study, w...

journal_title：Experimental dermatology

authors： Staunstrup NH,Bak RO,Cai Y,Svensson L,Petersen TK,Rosada C,Stenderup K,Bolund L,Mikkelsen JG

更新日期：2013-03-01 00:00:00

abstract：:Collagens are the most abundant proteins in the extracellular matrix. They provide a framework to build organs and tissues and give structural support to make them resistant to mechanical load and forces. Several intra- and extracellular modifications are needed to make functional collagen molecules, intracellular pos...

journal_title：Experimental dermatology

authors： Salo AM,Myllyharju J

更新日期：2021-01-01 00:00:00

abstract：:Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat gl...

journal_title：Experimental dermatology

authors： Bovell DL,MacDonald A,Meyer BA,Corbett AD,MacLaren WM,Holmes SL,Harker M

更新日期：2011-12-01 00:00:00

abstract：:Pseudoxanthoma elasticum (PXE), a heritable multi-system disorder, is caused by mutations in the ABCC6 gene primarily expressed in the liver. Recent analysis of cultured fibroblasts from patients with PXE has suggested compensatory alterations in the expression of the ABCA-subfamily of genes. We have now determined by...

journal_title：Experimental dermatology

authors： Li Q,Uitto J

更新日期：2011-05-01 00:00:00

abstract：:Reactive skin is characterized by marked sensitivity to physical (heat, cold, wind) or chemical (topically applied products) stimuli and by the impairment of the skin barrier's ability to repair itself. Several lines of evidence suggest that beyond their capacity to positively influence the composition of intestinal m...

journal_title：Experimental dermatology

authors： Guéniche A,Bastien P,Ovigne JM,Kermici M,Courchay G,Chevalier V,Breton L,Castiel-Higounenc I

更新日期：2010-08-01 00:00:00