Role of scratch-induced cutaneous prostaglandin D production on atopic-like scratching behaviour in mice.

Abstract:

:NC/Nga mice are known to develop scratching dermatitis akin to atopic dermatitis, under conventional (Conv), but not under the specific-pathogen-free (SPF) condition. In this study, we examined the effects of mechanical-scratching on the spontaneous scratching counts (sign of itching), in relation to the cutaneous prostaglandin D2 (PGD2) levels in NC/Nga or BALB/c mice. Mechanical-scratching increased the cutaneous barrier damage and PGD2 levels in both strain mice under the SPF condition. By 4 weeks of cohabitation with the skin-lesioned NC/Nga mice, both the increase in the spontaneous scratching and development of dermatitis score were higher in the Conv-NC/Nga than in the Conv-BALB/c mice. At this time-point, the cutaneous PGD2 level induced by mechanical-scratching was significantly lower in the Conv-NC/Nga when compared with that in the SPF-NC/Nga mice, and that in the Conv-BALB/c was almost equal to that in the SPF-BALB/c mice. With mechanical scratches, the cohabitation-induced scratching was suppressed in the Conv-BALB/c, but not in the Conv-NC/Nga mice. These results suggest that the scratch-induced cutaneous PGD2 inhibits scratching and the subsequent development of dermatitis in BALB/c, while the impaired scratch-induced cutaneous PGD2 production in the NC/Nga mice resulted in no suppression of scratching, and aggravated the dermatitis.

journal_name

Exp Dermatol

journal_title

Experimental dermatology

authors

Takaoka A,Arai I,Sugimoto M,Futaki N,Sakurai T,Honma Y,Nakaike S

doi

10.1111/j.1600-0625.2006.00540.x

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

331-9

issue

4

eissn

0906-6705

issn

1600-0625

pii

EXD540

journal_volume

16

pub_type

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