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Epidemiologic risk factors of basal cell carcinoma development and age at onset in a Southern European population from Greece.

Abstract：

BACKGROUND:Basal cell carcinoma (BCC) is the most common form of skin cancer with increasing incidence rates worldwide. METHODS:To assess the association of BCC with epidemiologic risk factors in a Southern European population from Greece, we conducted a hospital-based case-control study of 199 patients with BCC and 200 controls. RESULTS:In the multivariate analysis, fair skin colour was associated with increased risk of BCC (OR: 4.9, 95% CI: 2.4-10.0). However, darker skin phototypes III/IV (patient's reported sun sensitivity/tanning ability) showed a higher BCC risk (OR: 3.9, 95% CI: 1.8-8.5). Persons with occupational UV exposure of 5 years or more had a 2.7-fold increased risk (95% CI:1.4-5.3). There was an increased risk of BCC related to the number of sunburns after the age of 20 years (OR: 3.2, 95% CI: 1.4-7.3) and solar lentigines (OR: 6.8, 95% CI: 3.6-12.8). Subgroup analysis showed that different risk factors are associated with early onset BCC including the presence of dysplastic nevi (OR: 6.4, 95% CI: 1.5-27.2), the number of weeks per year spent at the beach during childhood (OR: 8.9, 95% CI: 3.3-24.1) and the history of sunburns during childhood (OR:5.0, 95% CI: 1.3-19.1). CONCLUSIONS:Fair skin colour was significantly associated with BCC risk. The relation of sunburns during adulthood with BCC underlies the importance of sunburn prevention throughout life time. Early onset BCCs seem to have a different pathogenetic background and were associated with dysplastic nevi as well as intermittent sun exposure and sunburns during the early years of life.

journal_name

Exp Dermatol

journal_title

Experimental dermatology

authors

Dessinioti C,Tzannis K,Sypsa V,Nikolaou V,Kypreou K,Antoniou C,Katsambas A,Stratigos AJ

doi

10.1111/j.1600-0625.2011.01275.x

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

622-6

issue

8

eissn

0906-6705

issn

1600-0625

journal_volume

20

pub_type

杂志文章

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