The molecular basis of lipoid proteinosis: mutations in extracellular matrix protein 1.

abstract：:Pimecrolimus (SDZ ASM981) is a non-steroid member of calcineurin inhibitors recently developed for the treatment of inflammatory skin diseases. In this study, we compared the effect of pimecrolimus and corticosteroids on the differentiation, maturation and function of murine bone marrow-derived dendritic cells (BM-DC)...

journal_title：Experimental dermatology

authors： Krummen MB,Varga G,Steinert M,Stuetz A,Luger TA,Grabbe S

更新日期：2006-01-01 00:00:00

abstract：:Pemphigus vulgaris (PV) is a severe autoimmune blistering disease of the skin and mucous membranes. As autoantibodies play an essential role in the disease pathogenesis, the serological detection of anti-desmoglein 3 IgG represents a central tool in the diagnosis of the disease. In this study, we show the validation o...

journal_title：Experimental dermatology

authors： Schmidt T,Mauracher S,Bender L,Greene B,Kurzhals J,Eming R,Dostatni R,Hertl M

更新日期：2018-03-01 00:00:00

abstract：:Antibodies, specific to murine DEC205, can be used to target antigens to dendritic cells. The immunodominant domain of human type XVII collagen, hNC16A, was fused to this antibody (DEC-hNC16A) and was administered as expression plasmid by gene gun transfection with the aim of inducing tolerance to human type XVII coll...

journal_title：Experimental dermatology

authors： Ettinger M,Gratz IK,Gruber C,Hauser-Kronberger C,Johnson TS,Mahnke K,Thalhamer J,Hintner H,Peckl-Schmid D,Bauer JW

更新日期：2012-05-01 00:00:00

abstract：:We have previously demonstrated that serum of patients with pemphigus vulgaris induces reduction of desmoglein 3 (Dsg3) half-life in keratinocytes (FEBS Lett 2006: 580: 3276). This phenomenon seems to occur as a consequence of the progressive depletion of Dsg3 from desmosomes. Here we reported that reduction of full-l...

journal_title：Experimental dermatology

authors： Cirillo N,Campisi G,Gombos F,Perillo L,Femiano F,Lanza A

更新日期：2008-10-01 00:00:00

abstract：:Human dermal fibroblasts (HDFs) regulate wound-healing processes in human skin, including the regeneration of skin sensory fibres, in response to various mechanical stimuli. Because nerve growth factor (NGF) has an essential role in sensory regeneration, we evaluated the possible association of NGF with mechanical sti...

journal_title：Experimental dermatology

authors： Kim M,Shin DW,Shin H,Noh M,Shin JH

更新日期：2013-01-01 00:00:00

abstract：:For decades, an extensive debate is continued on the pathophysiology of vitiligo. Numerous hypotheses have been put forward, and many supported by well-documented arguments. Regardless of the initiating steps, most experts agree that an immune-based melanocyte destruction is responsible for the final steps leading to ...

journal_title：Experimental dermatology

authors： Speeckaert R,van Geel N

更新日期：2017-07-01 00:00:00

abstract：:It is well known that the trigger for actinic keratosis (AK) mainly depends on UV exposure. We evaluated the effects of long-term use of sunscreen on the histopathological and dermoscopic changes of AK in aged patients. Eighteen months use of sunscreen produced no change in the number of actinic keratoses or the advan...

journal_title：Experimental dermatology

authors： Kunimoto K,Furukawa F,Uede M,Mizuno M,Yamamoto Y

更新日期：2016-08-01 00:00:00

abstract：:Pseudoxanthoma elasticum (PXE), a heritable multi-system disorder, is caused by mutations in the ABCC6 gene primarily expressed in the liver. Recent analysis of cultured fibroblasts from patients with PXE has suggested compensatory alterations in the expression of the ABCA-subfamily of genes. We have now determined by...

journal_title：Experimental dermatology

authors： Li Q,Uitto J

更新日期：2011-05-01 00:00:00

abstract：:Ultra-violet B (UVB)-induced oxidative stress crucially perturbs the epidermal homeostasis, and the skin is endowed with protective mechanisms to take action against such damage. Here, we show the possible involvement of t-SNARE protein syntaxin3, a membrane fusion mediator of cytoplasmic vesicles, and which is releas...

journal_title：Experimental dermatology

authors： Miyazaki T,Kadono N,Konishi Y,Hagiwara N,Maekubo K,Hirai Y

更新日期：2013-12-01 00:00:00

abstract：:The early growth response (Egr)-1 is a transcriptional factor which plays an important role in the regulation of cell growth, differentiation, cell survival and immune responses. Emerging evidences including our data demonstrate that the Egr-1 expression is up-regulated in the psoriatic skin lesions. The purpose of th...

journal_title：Experimental dermatology

authors： Jeong SH,Kim HJ,Jang Y,Ryu WI,Lee H,Kim JH,Bae HC,Choi JE,Kye YC,Son SW

更新日期：2014-12-01 00:00:00

abstract：:Keloids are fibrous overgrowth induced by cutaneous injury. The pathogenesis of keloids is poorly understood, and no convincing animal model exists. Current hypotheses of the pathogenesis classify keloids as an entity of aberrant fibrosis. Hyperactivation of the MCP-1/CCR2 axis reportedly causes fibrosis in liver cirr...

journal_title：Experimental dermatology

authors： Liao WT,Yu HS,Arbiser JL,Hong CH,Govindarajan B,Chai CY,Shan WJ,Lin YF,Chen GS,Lee CH

更新日期：2010-08-01 00:00:00

abstract：:Delayed wound healing is one of the major complications in diabetes and is characterized by chronic proinflammatory response, and abnormalities in angiogenesis and collagen deposition. Sirtuin family proteins regulate numerous pathophysiological processes, including those involved in promotion of longevity, DNA repair...

journal_title：Experimental dermatology

authors： Thandavarayan RA,Garikipati VN,Joladarashi D,Suresh Babu S,Jeyabal P,Verma SK,Mackie AR,Khan M,Arumugam S,Watanabe K,Kishore R,Krishnamurthy P

更新日期：2015-10-01 00:00:00

abstract：:The capacity of adult hair follicle dermal cells to participate in new follicle induction and regeneration, and to elicit responses from diverse epithelial partners, demonstrates a level of developmental promiscuity and influence far exceeding that of interfollicular fibroblasts. We have recently suggested that adult ...

journal_title：Experimental dermatology

authors： Gharzi A,Reynolds AJ,Jahoda CA

更新日期：2003-04-01 00:00:00

abstract：:Tissue-invasive T cells are observed in many inflammatory dermatological diseases, but in most cases, it is not known how they were attracted, what they might recognize, and to which extent they are activated. Answering these questions is surely essential for understanding pathogeneses of the diseases. In a recent iss...

journal_title：Experimental dermatology

authors： Dornmair K

更新日期：2014-06-01 00:00:00

abstract：:Epidermal keratinocytes undergo a continuous process of terminal differentiation, which is accompanied by a dramatic change in the expression and composition of keratins. This complex and carefully orchestrated process is regulated by a large number of signal transduction events and transcriptional factors as well as ...

journal_title：Experimental dermatology

authors： Wang M,Yue Z,Paus R,Ramot Y

更新日期：2014-09-01 00:00:00

abstract：:Psoriasis is a chronic skin disease that affects about 1.5% of the Caucasian population and is characterized by typical macroscopic and microscopic skin alterations. Psoriatic lesions are sharply demarcated, red and slightly raised lesions with silver-whitish scales. The microscopic alterations of psoriatic plaques in...

journal_title：Experimental dermatology

authors： Sabat R,Philipp S,Höflich C,Kreutzer S,Wallace E,Asadullah K,Volk HD,Sterry W,Wolk K

更新日期：2007-10-01 00:00:00

abstract：:The transplantation of allogeneic cells such as pancreatic islet cells, bone marrow, and keratinocytes for skin replacement is in growing use clinically. Present techniques which are used to distinguish transplanted allogeneic cells from phenotypically identical host cells in chimeric tissue have serious limitations. ...

journal_title：Experimental dermatology

authors： Young DM,Summers WC,Cuono CB

更新日期：1993-02-01 00:00:00

abstract：:For screening of a potential irritant it is essential that an early marker for irritation should be chosen which could be detected before the physiological signs of irritation occur. Interleukin 1 alpha (IL-1alpha) is widely accepted as such a marker in both in vivo and in vitro test systems. In this study, we have de...

journal_title：Experimental dermatology

authors： Gibbs S,Vietsch H,Meier U,Ponec M

更新日期：2002-06-01 00:00:00

abstract：:An ex vivo porcine skin model was utilized to analyse the penetration of 5-aminolevulinic acid (5-ALA) contained in a nanoemulsion-based formulation BF-200 ALA (10% 5-ALA-hydrochloride) versus 16% aminolevulinate methyl ester-hydrochloride in a commercially cream (MAL cream) by fluorescence microscopy of their common ...

journal_title：Experimental dermatology

authors： Maisch T,Santarelli F,Schreml S,Babilas P,Szeimies RM

更新日期：2010-08-01 00:00:00

abstract：:The potential of an anti-inflammatory peptide (antiflammin 1) to reduce irritation when delivered transdermally by iontophoresis was examined. A model drug irritant, chlorpromazine, was co-delivered with and without antiflammin 1 by iontophoresis to hairless guinea pigs transdermally. Quantitative skin irritation meas...

journal_title：Experimental dermatology

authors： Mize NK,Buttery M,Ruis N,Leung I,Cormier M,Daddona P

更新日期：1997-08-01 00:00:00

abstract：:We have shown previously in psoriasis a very high prevalence of epidermodysplasia verruciforms-associated human papillomavirus 5 (EVHPV5) DNA and antibodies to human papillomavirus 5 (HPV5) virus-like particle (VLP) L1, and we suggested that this benign hyperproliferative disorder could be a reservoir for EVHPVs. Here...

journal_title：Experimental dermatology

authors： Majewski S,Jablonska S

更新日期：2003-12-01 00:00:00

abstract：:Acne is the most common inflammatory skin disease, affecting up to 85% of the 11-30 years old world population. Skin microbiota appears as a key player involved in several skin dermatoses physiopathology. Here, we show that inflammatory skin is associated with changes in the skin microbiota composition on the back of ...

journal_title：Experimental dermatology

authors： Dagnelie MA,Montassier E,Khammari A,Mounier C,Corvec S,Dréno B

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:This study investigated predictors of response to topical diphenylyclopropenone (DPCP) immunotherapy in patients with alopecia areata (AA). OBJECTIVE:To identify predictors of response, or resistance, to treatment for AA through clinical observations and serum tests. METHODS:Eighty four AA patients were tr...

journal_title：Experimental dermatology

authors： Gong Y,Zhao Y,Zhang X,Qi S,Li S,Ye Y,Yang J,Caulloo S,McElwee KJ,Zhang X

更新日期：2020-03-01 00:00:00

abstract：:Hair follicles cyclically regenerate throughout adult mammalian life, owing to a resident population of epithelial hair follicle stem cells. Stem cell (SC) activity drives bouts of follicle growth, which are periodically interrupted by follicle regression and rest. These phases and the transitions between them are tig...

journal_title：Experimental dermatology

authors： Martino PA,Heitman N,Rendl M

更新日期：2020-10-02 00:00:00

abstract：:The generation of reactive oxygen species is among the various mechanisms by which ultraviolet radiation damages skin. Tempol, a superoxide dismutase analogue which readily penetrates cell membranes when administered exogenously, has been shown to provide protection against some forms of oxygen-dependent damage. In th...

journal_title：Experimental dermatology

authors： Bernstein EF,Kong SK,Brown DB,Kwak BC,Takeuchi T,Gasparro FP,Uitto J

更新日期：2001-02-01 00:00:00

abstract：:Drug resistance in melanoma is commonly attributed to ineffective apoptotic pathways. Targeting apoptosis regulators is thus considered a promising approach to sensitizing melanoma to therapy. In the previous issue of Experimental Dermatology, Plötz and Eberle discuss the role that apoptosis plays in melanoma progress...

journal_title：Experimental dermatology

authors： Haass NK,Schumacher U

更新日期：2014-07-01 00:00:00

abstract：:Quercetin, glycosylated form of flavonoid compound, has potent antioxidant and anti-inflammatory properties. In this study, we have investigated the effects of quercetin on skin lesion, high-mobility group box (HMGB)1 cascade signalling and inflammation in atopic dermatitis (AD) mouse model. AD-like lesion was induced...

journal_title：Experimental dermatology

authors： Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Nomoto M,Miyashita S,Suzuki K,Nakamura M,Watanabe K

更新日期：2015-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules, which function in RNA silencing and post-transcriptional regulation of gene expression. Psoriasis is an inflammatory skin disease characterized by the dysfunction of keratinocytes, with the immune dysregulation. We reviewed the recent studies on the roles of miRNA...

journal_title：Experimental dermatology

authors： Liu Q,Wu DH,Han L,Deng JW,Zhou L,He R,Lu CJ,Mi QS

更新日期：2017-04-01 00:00:00

abstract：:Sunburn cell (SBC) formation in the epidermis is a characteristic consequence of ultraviolet radiation (UVR) exposure at doses around or above the minimum erythema dose. SBC have been identified morphologically and biologically as keratinocytes undergoing apoptosis. There is evidence that SBC formation is a protective...

journal_title：Experimental dermatology

authors： Murphy G,Young AR,Wulf HC,Kulms D,Schwarz T

更新日期：2001-06-01 00:00:00

abstract：:Opioids exert major effects not only in the central nervous system but also in immune responses. We investigated the effects of μ-opioid peptides, secreted by tumor cells, on anti-tumor immune responses. For this purpose, tumor growth was studied in wild-type and μ-opioid receptor-deficient (MOR-/-) mice injected with...

journal_title：Experimental dermatology

authors： Boehncke S,Hardt K,Schadendorf D,Henschler R,Boehncke WH,Duthey B

更新日期：2011-01-01 00:00:00