Prostaglandin D production in FM55 melanoma cells is regulated by alpha-melanocyte-stimulating hormone and is not related to melanin production.

abstract：:It has been suggested that the increased rate of bacterial infection in atopic dermatitis (AD) may be caused by reduced antimicrobial protein (AMP) expression. We were interested whether common treatments in AD affect antimicrobial defense. We investigated the effects of topically applied corticosteroids betamethasone...

journal_title：Experimental dermatology

authors： Jensen JM,Ahrens K,Meingassner J,Scherer A,Bräutigam M,Stütz A,Schwarz T,Fölster-Holst R,Harder J,Gläser R,Proksch E

更新日期：2011-10-01 00:00:00

abstract：:Tyrosine kinase inhibitors of the tyrphostin family which block EGF receptor kinase are reported to arrest the growth of psoriatic keratinocytes in vitro. Three tyrphostins with the potency ratio AG555 > AG18 > AG814 were found to arrest growth with no adverse cytotoxic effects. The potency ratio to inhibit keratinocy...

journal_title：Experimental dermatology

authors： Ben-Bassat H,Vardi DV,Gazit A,Klaus SN,Chaouat M,Hartzstark Z,Levitzki A

更新日期：1995-04-01 00:00:00

abstract：:The proliferative responses of cells to mitogens decrease during aging, and this may result from age-related defects in signal transduction in response to mitogens. In this study, we have investigated the age-related alteration of responses to epidermal growth factor (EGF) in cultured human keratinocytes that were sen...

journal_title：Experimental dermatology

authors： Shi B,Isseroff RR

更新日期：2005-07-01 00:00:00

abstract：:The ethanolic extract of Resina Draconis (RDEE) has been reported beneficial to normal wound healing yielding more regularly arranged collagen fibres. Loureirin B, a major component in RDEE, has been supposed to be effective on the prevention and treatment of pathological scars. To investigate the therapeutic effects ...

journal_title：Experimental dermatology

authors： Bai X,He T,Liu J,Wang Y,Fan L,Tao K,Shi J,Tang C,Su L,Hu D

更新日期：2015-05-01 00:00:00

abstract：:5-methoxypsoralen (5-MOP) is considered an alternative to 8-methoxypsoralen (8-MOP) for photochemotherapy of psoriasis. We have compared the clinical efficacy and tolerability of 5-MOP (1.2 mg/kg)-UVA versus 8-MOP (0.6 mg/kg)-UVA therapy in 25 patients of skin type III and IV, affected by relapsing plaque-type psorias...

journal_title：Experimental dermatology

authors： Calzavara-Pinton P,Ortel B,Carlino A,Honigsmann H,De Panfilis G

更新日期：1992-07-01 00:00:00

abstract：:The molecular nature of the hair cycle clock (HCC), the intrinsic oscillator system that drives hair follicle (HF) cycling, remains incompletely understood; therefore, all relevant key players need to be identified. Here, we present evidence that implicates myelin protein zero-like 3 (MPZL3), a multifunctional nuclear...

journal_title：Experimental dermatology

authors： Nicu C,Wikramanayake TC,Paus R

更新日期：2020-12-01 00:00:00

abstract：:Pheomelanin is supposed to be the first type of melanin found in vertebrates, in contrast to the main type - eumelanin. Our study aimed at detecting pheomelanin in the skin of Hymenochirus boettgerii. We employed electron paramagnetic resonance (EPR) spectroscopy, and transmission electron microscopy (TEM), supplement...

journal_title：Experimental dermatology

authors： Wolnicka-Glubisz A,Pecio A,Podkowa D,Kolodziejczyk LM,Plonka PM

更新日期：2012-07-01 00:00:00

abstract：:Ultraviolet (UV) triggers induction of matrix metalloproteinase-1 (MMP-1) and also induces the rapid appearance of p53 protein in the epidermis and dermal fibroblasts. However, little is known about the role of p53 on MMP-1 expression in human skin. Here, we investigated the effects of p53 on basal and UV-induced MMP-...

journal_title：Experimental dermatology

authors： Kim S,Lee Y,Lee DH,Kim Y,Cho KH,Chung JH

更新日期：2008-11-01 00:00:00

abstract：:Pro- and anti-apoptotic members of the Bcl-2 family are fundamental in the control of apoptosis. Among them, Bax plays a key role in apoptosis induction by mediating the release of apoptogenic factors from mitochondria to the cytosol. In this report, we investigated, by immunohistofluorescence, the in vivo distributio...

journal_title：Experimental dermatology

authors： Zuliani T,Obriot H,Tual M,Lachman-Weber N,Dumas M,Formstecher P,Polakowska R,Ratinaud MH

更新日期：2008-02-01 00:00:00

abstract：:Human follicle dermal papilla cells (FDPC) are a specialized population of mesenchymal cells located in the skin. They regulate hair follicle (HF) development and growth, and represent a reservoir of multipotent stem cells. Growing evidence supports the hypothesis that HF cycling is associated with vascular remodeling...

journal_title：Experimental dermatology

authors： Bassino E,Gasparri F,Giannini V,Munaron L

更新日期：2015-05-01 00:00:00

abstract：:Mast cells, eosinophils and basophils are central effector immune cells in allergic skin inflammation including atopic dermatitis (AD). Recent studies revealed that the bidirectional interaction between these three immune cell types (mast cells, eosinophils and basophils) and the nervous system is involved in the path...

journal_title：Experimental dermatology

authors： Nakashima C,Ishida Y,Kitoh A,Otsuka A,Kabashima K

更新日期：2019-12-01 00:00:00

abstract：:Despite the increasing use of gene transfer strategies in the study of cellular and molecular biology, melanoma cells have remained difficult to transfect in a safe, efficient, and reproducible manner. In the present study, we report the successful use of nucleofector technology to transfect human melanoma cell lines....

journal_title：Experimental dermatology

authors： Han SY,Gai W,Yancovitz M,Osman I,Di Como CJ,Polsky D

更新日期：2008-05-01 00:00:00

abstract：:Solar ultraviolet (UV) radiation has hazardous effects on human health that are, in part, associated with its immunosuppressive effects via the induction of interleukin (IL)-10 production. Although IL-10 is produced by both T helper type 2 (Th2) cells and T-regulatory type 1 (Tr1) cells, the relative contribution of e...

journal_title：Experimental dermatology

authors： Stoebner PE,Rahmoun M,Ferrand C,Meunier L,Yssel H,Pène J

更新日期：2006-08-01 00:00:00

abstract：:Interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) are 3 cytokines that play a key rôle in cutaneous homeostasis and in the immunopathogenesis of a number of dermatologic diseases. Most studies have focused on their production by keratinocytes and Langerhans ce...

journal_title：Experimental dermatology

authors： Boehm KD,Yun JK,Strohl KP,Elmets CA

更新日期：1995-12-01 00:00:00

abstract：:The ability to manipulate the mammalian hair cycle will lead to novel therapies and strategies to combat all forms of alopecia. Thus, in addition to the epithelial-mesenchymal interactions in the hair follicle, niche and microenvironmental signals that accompany the phases of growth, regression and rest need to be scr...

journal_title：Experimental dermatology

authors： Wang ECE,Higgins CA

更新日期：2020-03-01 00:00:00

abstract：:Skin irritation is one of the most common adverse reactions in hydroquinone (HQ) and retinoic acid (RA). Although melanocytes have rarely been considered to be involved in skin irritation, RA and particularly HQ could induce melanocyte toxicity, resulting in depigmentation. We chose S100B as a candidate gene for melan...

journal_title：Experimental dermatology

authors： Cheong KA,Noh M,Kim CH,Lee AY

更新日期：2014-03-01 00:00:00

abstract：:In this study, we analysed the modulation of keratinocyte growth factor (KGF) mRNA expression in human dermal fibroblasts cultured either in monolayer or within a collagen matrix (dermal equivalent). In monolayer cultures, KGF expression by quiescent fibroblasts was stimulated by different growth substances such as se...

journal_title：Experimental dermatology

authors： Le Panse R,Bouchard B,Lebreton C,Coulomb B

更新日期：1996-04-01 00:00:00

abstract：:Hair follicle central isthmus is surrounded by dense nerve endings and terminal Schwann cells (TSCs), forming a specialized sensory structure called lanceolate complexes. Extracellular matrix protein EGFL6 expressed from epidermis has been found closely associated with lanceolate complexes and important for proper ali...

journal_title：Experimental dermatology

authors： Wei JP,Gong Y,Zhong HB,Hua Wang T,Liao XH

更新日期：2020-04-01 00:00:00

abstract：:A two-stage genomewide association (GWA) analysis was conducted to investigate the genetic factors influencing ultraviolet (UV)-induced skin pigmentation in Korean females after UV exposure. Previously, a GWA study evaluating ~500 000 single nucleotide polymorphisms (SNPs) in 99 Korean females identified eight SNPs th...

journal_title：Experimental dermatology

authors： Kwak TJ,Chang YH,Shin YA,Shin JM,Kim JH,Lim SK,Lee SH,Lee MG,Yoon TJ,Kim CD,Lee JH,Koh JS,Seo YK,Chang MY,Lee Y

更新日期：2015-12-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are non-haematopoietic cells that reside in most tissues including adult bone marrow. MSCs have recently been extensively studied and used for clinical therapies, including skin wound healing. However, there are still many questions to be answered. In the viewpoint entitled 'Mesenchymal s...

journal_title：Experimental dermatology

authors： Li X,Hamada T,Ohata C,Furumura M,Hashimoto T

更新日期：2013-08-01 00:00:00

abstract：:NC/Nga mice are known to develop scratching dermatitis akin to atopic dermatitis, under conventional (Conv), but not under the specific-pathogen-free (SPF) condition. In this study, we examined the effects of mechanical-scratching on the spontaneous scratching counts (sign of itching), in relation to the cutaneous pro...

journal_title：Experimental dermatology

authors： Takaoka A,Arai I,Sugimoto M,Futaki N,Sakurai T,Honma Y,Nakaike S

更新日期：2007-04-01 00:00:00

abstract：:Earlier studies showed that dermal cells lose trichogenic capacity with passage, but studies on the effect of keratinocyte passage on human hair follicle neogenesis and graft quality have been hampered by the lack of a suitable model system. We recently documented human hair follicle neogenesis in grafted dermal-epide...

journal_title：Experimental dermatology

authors： Thangapazham RL,Klover P,Li S,Wang JA,Sperling L,Darling TN

更新日期：2014-06-01 00:00:00

abstract：:Despite the lack of protective melanin and increased oxidative stress due to mM concentrations of epidermal H2O2 in vitiligo, there is no significantly increased risk for chronic actinic damage and non-melanoma skin cancer. Therefore the question arises, which protective mechanisms could be involved in the skin of the...

journal_title：Experimental dermatology

authors： Schallreuter KU,Behrens-Williams S,Khaliq TP,Picksley SM,Peters EM,Marles LK,Westerhof W,Miehe B,Fanghänel J

更新日期：2003-06-01 00:00:00

abstract：:Despite as yet limited clinical effectiveness, dendritic cell (DC)-based immunotherapy remains a promising approach for the treatment of cancer, but requires further improvement in its immunostimulatory effectiveness. Potent anti-tumor immunity often depends on the induction of type 1 (T(H)1) immune responses. Therefo...

journal_title：Experimental dermatology

authors： Balkow S,Loser K,Krummen M,Higuchi T,Rothoeft T,Apelt J,Tuettenberg A,Weishaupt C,Beissert S,Grabbe S

更新日期：2009-01-01 00:00:00

abstract：:Hypertrophic scarring is a skin disorder characterized by persistent inflammation and fibrosis that may occur after wounding or thermal injury. Altered production of cytokines and growth factors, such as TGF-beta, play an important role in this process. Activin A, a member of the TGF-beta family, shares the same intra...

journal_title：Experimental dermatology

authors： Fumagalli M,Musso T,Vermi W,Scutera S,Daniele R,Alotto D,Cambieri I,Ostorero A,Gentili F,Caposio P,Zucca M,Sozzani S,Stella M,Castagnoli C

更新日期：2007-07-01 00:00:00

abstract：:The therapeutic hypothesis proposed by Speeckaert and van Geel in this issue (1) is based on the dramatic effects of the new drugs targeting immune privilege checkpoints (PD1/PDL, CTLA4) in current advanced melanoma therapy as major inductors of vitiligo changes in the skin. Such striking clinical manifestations canno...

journal_title：Experimental dermatology

authors： Boniface K,Seneschal J,Taïeb A,Merched A

更新日期：2017-07-01 00:00:00

abstract：:In a large-scale ageing study, 30 inbred mouse strains were systematically screened for histologic evidence of lesions in all organ systems. Ten strains were diagnosed with similar nail abnormalities. The highest frequency was noted in NON/ShiLtJ mice. Lesions identified fell into two main categories: acute to chronic...

journal_title：Experimental dermatology

authors： Linn SC,Mustonen AM,Silva KA,Kennedy VE,Sundberg BA,Bechtold LS,Alghamdi S,Hoehndorf R,Schofield PN,Sundberg JP

更新日期：2019-04-01 00:00:00

abstract：:The last decade has seen a considerable improvement in the understanding of the biology of melanoma. Advances have come in the understanding of the importance of critical oncogenes and tumour suppressor genes, epigenetic phenomena, signalling pathways, drug resistance mechanisms, the pivotal role of the local immune s...

journal_title：Experimental dermatology

authors： Lorigan P,Eisen T,Hauschild A

更新日期：2008-05-01 00:00:00

abstract：:Quercetin, glycosylated form of flavonoid compound, has potent antioxidant and anti-inflammatory properties. In this study, we have investigated the effects of quercetin on skin lesion, high-mobility group box (HMGB)1 cascade signalling and inflammation in atopic dermatitis (AD) mouse model. AD-like lesion was induced...

journal_title：Experimental dermatology

authors： Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Nomoto M,Miyashita S,Suzuki K,Nakamura M,Watanabe K

更新日期：2015-06-01 00:00:00

abstract：:The transplantation of allogeneic cells such as pancreatic islet cells, bone marrow, and keratinocytes for skin replacement is in growing use clinically. Present techniques which are used to distinguish transplanted allogeneic cells from phenotypically identical host cells in chimeric tissue have serious limitations. ...

journal_title：Experimental dermatology

authors： Young DM,Summers WC,Cuono CB

更新日期：1993-02-01 00:00:00