Immune cell regulation of the hair cycle.

abstract：:In a large-scale ageing study, 30 inbred mouse strains were systematically screened for histologic evidence of lesions in all organ systems. Ten strains were diagnosed with similar nail abnormalities. The highest frequency was noted in NON/ShiLtJ mice. Lesions identified fell into two main categories: acute to chronic...

journal_title：Experimental dermatology

authors： Linn SC,Mustonen AM,Silva KA,Kennedy VE,Sundberg BA,Bechtold LS,Alghamdi S,Hoehndorf R,Schofield PN,Sundberg JP

更新日期：2019-04-01 00:00:00

abstract：:Proteases and their receptors have poorly understood roles in skin fibrosis and systemic scleroderma (SSc). We examined the role of protease-activated receptors (PAR(1) and PAR(2) ) in the pathophysiology of human SSc and skin fibrosis. Immunohistochemistry showed that PAR(1) immunoreactivity was positive in fibroblas...

journal_title：Experimental dermatology

authors： Cevikbas F,Seeliger S,Fastrich M,Hinte H,Metze D,Kempkes C,Homey B,Steinhoff M

更新日期：2011-01-01 00:00:00

abstract：:Angiotensin II (Ang II) stimulation has been shown to regulate proliferation of skin fibroblasts and the production of extracellular matrix, which are very important processes in skin wound healing and fibrosis; however, there is little knowledge about the mechanisms involved in this process. We investigated the molec...

journal_title：Experimental dermatology

authors： Zhang GY,Li X,Yi CG,Pan H,He GD,Yu Q,Jiang LF,Xu WH,Li ZJ,Ding J,Lin DS,Gao WY

更新日期：2009-11-01 00:00:00

abstract：:Card9 is a signalling adaptor protein in the downstream of many innate pattern recognition receptors (PRRs) and exerts a significant role in antifungal immunity. To date, Card9 deficiency has been reported to be related to increased susceptibility to many fungal infections. In this study, we established mucormycosis m...

journal_title：Experimental dermatology

authors： Sun L,Wan Z,Li R,Yu J

更新日期：2019-11-01 00:00:00

abstract：:Type XVII collagen (COL17) is a transmembrane protein expressed in the basal epidermis. COL17 serves as a niche for epidermal stem cells, and although its reduction has been implicated in altering cell polarity and ageing of the epidermis, it is unknown how COL17 affects epidermal cell polarity. Here, we uncovered COL...

journal_title：Experimental dermatology

authors： Watanabe M,Kosumi H,Osada SI,Takashima S,Wang Y,Nishie W,Oikawa T,Hirose T,Shimizu H,Natsuga K

更新日期：2021-01-01 00:00:00

abstract：:Unpredictable hypertrophic scarring (HS) occurs after approximately 35% of all surgical procedures and causes significant physical and psychological complaints. Parallel to the need to understanding the mechanisms underlying HS formation, a prognostic tool is needed. The objective was to determine whether (systemic) i...

journal_title：Experimental dermatology

authors： de Bakker E,van der Putten MAM,Heymans MW,Spiekstra SW,Waaijman T,Butzelaar L,Negenborn VL,Beekman VK,Akpinar EO,Rustemeyer T,Niessen FB,Gibbs S

更新日期：2021-01-01 00:00:00

abstract：:Itch is often regarded as unpleasant or bothersome and is accompanied by symptoms of distress and impairments in daily life. The biopsychosocial model of chronic itch describes how psychological factors can contribute to the improvement or exacerbation of chronic itch and related scratching behaviour. Recent research ...

journal_title：Experimental dermatology

authors： Evers AWM,Peerdeman KJ,van Laarhoven AIM

更新日期：2019-12-01 00:00:00

abstract：:Keloids are fibrous overgrowth induced by cutaneous injury. The pathogenesis of keloids is poorly understood, and no convincing animal model exists. Current hypotheses of the pathogenesis classify keloids as an entity of aberrant fibrosis. Hyperactivation of the MCP-1/CCR2 axis reportedly causes fibrosis in liver cirr...

journal_title：Experimental dermatology

authors： Liao WT,Yu HS,Arbiser JL,Hong CH,Govindarajan B,Chai CY,Shan WJ,Lin YF,Chen GS,Lee CH

更新日期：2010-08-01 00:00:00

abstract：:NC/Nga mice are known to develop scratching dermatitis akin to atopic dermatitis, under conventional (Conv), but not under the specific-pathogen-free (SPF) condition. In this study, we examined the effects of mechanical-scratching on the spontaneous scratching counts (sign of itching), in relation to the cutaneous pro...

journal_title：Experimental dermatology

authors： Takaoka A,Arai I,Sugimoto M,Futaki N,Sakurai T,Honma Y,Nakaike S

更新日期：2007-04-01 00:00:00

abstract：:The potential of an anti-inflammatory peptide (antiflammin 1) to reduce irritation when delivered transdermally by iontophoresis was examined. A model drug irritant, chlorpromazine, was co-delivered with and without antiflammin 1 by iontophoresis to hairless guinea pigs transdermally. Quantitative skin irritation meas...

journal_title：Experimental dermatology

authors： Mize NK,Buttery M,Ruis N,Leung I,Cormier M,Daddona P

更新日期：1997-08-01 00:00:00

abstract：:Nilotinib (AMN), a second-generation tyrosine kinase inhibitor, induces apoptosis in various cancer cells, and our recent study showed that AMN effectively reduced the viability of human ovarian cancer cells via mitochondrion-dependent apoptosis. The effect of AMN in the melanogenesis of melanoma cells is still unclea...

journal_title：Experimental dermatology

authors： Chang SP,Huang HM,Shen SC,Lee WR,Chen YC

更新日期：2018-12-01 00:00:00

abstract：:We characterized the melanogenic apparatus in a family of transplantable gerbil melanomas (melanotic and amelanotic) using a combination of biophysical, ultrastructural and biochemical methods. Melanotic melanomas produced pure eumelanin but in vesiculo-globular melanosomes ('pheomelanosomes'); the eumelanosomes, char...

journal_title：Experimental dermatology

authors： Plonka PM,Slominski AT,Pajak S,Urbanska K

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:This study investigated predictors of response to topical diphenylyclopropenone (DPCP) immunotherapy in patients with alopecia areata (AA). OBJECTIVE:To identify predictors of response, or resistance, to treatment for AA through clinical observations and serum tests. METHODS:Eighty four AA patients were tr...

journal_title：Experimental dermatology

authors： Gong Y,Zhao Y,Zhang X,Qi S,Li S,Ye Y,Yang J,Caulloo S,McElwee KJ,Zhang X

更新日期：2020-03-01 00:00:00

abstract：:Quercetin, glycosylated form of flavonoid compound, has potent antioxidant and anti-inflammatory properties. In this study, we have investigated the effects of quercetin on skin lesion, high-mobility group box (HMGB)1 cascade signalling and inflammation in atopic dermatitis (AD) mouse model. AD-like lesion was induced...

journal_title：Experimental dermatology

authors： Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Nomoto M,Miyashita S,Suzuki K,Nakamura M,Watanabe K

更新日期：2015-06-01 00:00:00

abstract：:The role of adhesion molecules in the control of hair follicle (HF) morphogenesis, regression and cycling is still rather enigmatic. Since the adhesion molecules E- and P-cadherin (Ecad and Pcad) are functionally important, e.g. during embryonic pattern formation, we have studied their expression patterns during neona...

journal_title：Experimental dermatology

authors： Müller-Röver S,Tokura Y,Welker P,Furukawa F,Wakita H,Takigawa M,Paus R

更新日期：1999-08-01 00:00:00

abstract：:Tyrosine kinase inhibitors of the tyrphostin family which block EGF receptor kinase are reported to arrest the growth of psoriatic keratinocytes in vitro. Three tyrphostins with the potency ratio AG555 > AG18 > AG814 were found to arrest growth with no adverse cytotoxic effects. The potency ratio to inhibit keratinocy...

journal_title：Experimental dermatology

authors： Ben-Bassat H,Vardi DV,Gazit A,Klaus SN,Chaouat M,Hartzstark Z,Levitzki A

更新日期：1995-04-01 00:00:00

abstract：:Interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) are 3 cytokines that play a key rôle in cutaneous homeostasis and in the immunopathogenesis of a number of dermatologic diseases. Most studies have focused on their production by keratinocytes and Langerhans ce...

journal_title：Experimental dermatology

authors： Boehm KD,Yun JK,Strohl KP,Elmets CA

更新日期：1995-12-01 00:00:00

abstract：:Tissue-invasive T cells are observed in many inflammatory dermatological diseases, but in most cases, it is not known how they were attracted, what they might recognize, and to which extent they are activated. Answering these questions is surely essential for understanding pathogeneses of the diseases. In a recent iss...

journal_title：Experimental dermatology

authors： Dornmair K

更新日期：2014-06-01 00:00:00

abstract：:Pimecrolimus (SDZ ASM981) is a non-steroid member of calcineurin inhibitors recently developed for the treatment of inflammatory skin diseases. In this study, we compared the effect of pimecrolimus and corticosteroids on the differentiation, maturation and function of murine bone marrow-derived dendritic cells (BM-DC)...

journal_title：Experimental dermatology

authors： Krummen MB,Varga G,Steinert M,Stuetz A,Luger TA,Grabbe S

更新日期：2006-01-01 00:00:00

abstract：:This study demonstrates an innovative application of atomic force microscopy (AFM). The combination of high-resolution AFM technology and tape stripping is presented as a tool for the structure analysis of human stratum corneum (SC) at a nanometer scale. Topographic images with a vertical resolution of about 10 nm of ...

journal_title：Experimental dermatology

authors： Gorzelanny C,Goerge T,Schnaeker EM,Thomas K,Luger TA,Schneider SW

更新日期：2006-05-01 00:00:00

abstract：:Type-1 cytokine-producing T cells are important in the pathogenesis of psoriasis vulgaris, for which efficient therapy is provided by means of narrow-band ultraviolet-B (NB-UVB). The expression of the type-1 cytokine interferon-gamma (IFN-gamma) is regulated by interleukin-12 (IL-12), IL-15, IL-18 and IL-23; however, ...

journal_title：Experimental dermatology

authors： Piskin G,Tursen U,Sylva-Steenland RM,Bos JD,Teunissen MB

更新日期：2004-12-01 00:00:00

abstract：:Mast cells, eosinophils and basophils are central effector immune cells in allergic skin inflammation including atopic dermatitis (AD). Recent studies revealed that the bidirectional interaction between these three immune cell types (mast cells, eosinophils and basophils) and the nervous system is involved in the path...

journal_title：Experimental dermatology

authors： Nakashima C,Ishida Y,Kitoh A,Otsuka A,Kabashima K

更新日期：2019-12-01 00:00:00

abstract：:Ultraviolet B (UVB) radiation induces inflammation in the skin specifically at the site of exposure. We unexpectedly found that UVB-induced inflammation was not induced in gp91phox-depleted mice. To test whether gp91phox is directly involved in UVB-induced inflammation, neutrophil- and hyaluronic acid-depleted mice we...

journal_title：Experimental dermatology

authors： Hiramoto K,Kobayashi H,Yamate Y,Ishii M,Sato EF

更新日期：2012-12-01 00:00:00

abstract：:Intraepithelial gammadelta T cells are increased in the inflamed small bowel and are also found in increased numbers in cutaneous lesions from patients with dermatitis herpetiformis (DH). Thus, these cells might play an important role in the pathogenesis of the disease. We investigated the T-cell receptor (TCR) delta ...

journal_title：Experimental dermatology

authors： Holtmeier W,Pfänder M,Zollner TM,Kaufmann R,Caspary WF

更新日期：2002-12-01 00:00:00

abstract：:The miRNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C-ALCL) patients were analysed with miRNA microarrays using the same control group of 12 benign inflammatory dermatoses (BID) as previously used to study the miRNA expression profile of tumor-stage mycosis fungoide...

journal_title：Experimental dermatology

authors： Benner MF,Ballabio E,van Kester MS,Saunders NJ,Vermeer MH,Willemze R,Lawrie CH,Tensen CP

更新日期：2012-08-01 00:00:00

abstract：:Congenital melanocytic nevi (CMN) are benign proliferations that may be associated with various consequences depending on their size. They are characterized by a specific molecular signature, namely a postzygotic somatic NRAS or BRAF mutation. We have recently reported that large CMN (lCMN), which are classically asso...

journal_title：Experimental dermatology

authors： Guégan S,Kadlub N,Picard A,Rouillé T,Charbel C,Coulomb-L'Hermine A,How-Kit A,Fraitag S,Aractingi S,Fontaine RH

更新日期：2016-10-01 00:00:00

abstract：:External assault to the skin is followed by an epidermal response including synthesis of DNA, lipids, cytokines and migration of antigen presenting cells. MIP-3 alpha (CCL20, LARC, Exodus-1, Scya20) is a recently described C-C chemokine, predominantly expressed in extralymphoid tissue, which is known to direct migrati...

journal_title：Experimental dermatology

authors： Schmuth M,Neyer S,Rainer C,Grassegger A,Fritsch P,Romani N,Heufler C

更新日期：2002-04-01 00:00:00

abstract：:Human follicle dermal papilla cells (FDPC) are a specialized population of mesenchymal cells located in the skin. They regulate hair follicle (HF) development and growth, and represent a reservoir of multipotent stem cells. Growing evidence supports the hypothesis that HF cycling is associated with vascular remodeling...

journal_title：Experimental dermatology

authors： Bassino E,Gasparri F,Giannini V,Munaron L

更新日期：2015-05-01 00:00:00

abstract：:Using in situ hybridization, human hair keratin basic 1 (hHb1) gene expression was investigated in human normal scalp. hHb1 transcripts were specifically detected in the cortical cells of hair shaft but neither in the outer and inner root sheaths, nor in the hair cuticle or the medulla. hHb1 expression was detected st...

journal_title：Experimental dermatology

authors： Régnier CH,Asch PH,Grosshans E,Rio MC

更新日期：1997-04-01 00:00:00

abstract：:Nitric oxide (NO) is a reactive endogenous molecule with multiple functions including inflammation and immunity. NO stimulates melanogenesis by activating soluble guanylyl cyclase (sGC) resulting in increases in intracellular guanosine 3',5'-cyclic monophosphate (cGMP). In vitro experiments showed that NO could inhibi...

journal_title：Experimental dermatology

authors： Ivanova K,van den Wijngaard R,Gerzer R,Lamers WH,Das PK

更新日期：2005-06-01 00:00:00