Abstract:
:Interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) are 3 cytokines that play a key rôle in cutaneous homeostasis and in the immunopathogenesis of a number of dermatologic diseases. Most studies have focused on their production by keratinocytes and Langerhans cells. To determine whether there are non-epidermal sites of cytokine transcription, biopsy specimens of normal human skin were probed for IL-1 alpha, IL-1 beta and TNF-alpha messenger RNAs using the method of in situ hybridization. The results demonstrate that each cytokine mRNA is present at multiple sites within the skin, including epidermal appendages and adnexal structures (hair follicles, sebaceous glands), the dermal microvasculature, arrectores pilorum smooth muscle, and the dermal connective tissue. These data provide evidence that in vivo there are multiple sites other than the epidermis of constitutive IL-1 alpha, IL-1 beta, and TNF-alpha gene transcription in normal human skin.
journal_name
Exp Dermatoljournal_title
Experimental dermatologyauthors
Boehm KD,Yun JK,Strohl KP,Elmets CAdoi
10.1111/j.1600-0625.1995.tb00057.xsubject
Has Abstractpub_date
1995-12-01 00:00:00pages
335-41issue
6eissn
0906-6705issn
1600-0625journal_volume
4pub_type
杂志文章abstract::Earlier studies showed that dermal cells lose trichogenic capacity with passage, but studies on the effect of keratinocyte passage on human hair follicle neogenesis and graft quality have been hampered by the lack of a suitable model system. We recently documented human hair follicle neogenesis in grafted dermal-epide...
journal_title:Experimental dermatology
pub_type: 信件
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Experimental dermatology
pub_type: 信件
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2005-12-01 00:00:00
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pub_type: 信件
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更新日期:2013-01-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/exd.13371
更新日期:2017-11-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
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pub_type: 评论,杂志文章
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journal_title:Experimental dermatology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Experimental dermatology
pub_type: 杂志文章,评审
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journal_title:Experimental dermatology
pub_type: 杂志文章
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pub_type: 信件
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更新日期:2010-08-01 00:00:00
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pub_type: 信件
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Experimental dermatology
pub_type: 杂志文章,评审
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更新日期:1992-10-01 00:00:00