当前位置： SCI文献检索 > EXPERIMENTAL DERMATOLOGY期刊下所有文献 > A reappraisal of the use of 5-methoxypsoralen in the therapy of psoriasis.

A reappraisal of the use of 5-methoxypsoralen in the therapy of psoriasis.

Abstract：

:5-methoxypsoralen (5-MOP) is considered an alternative to 8-methoxypsoralen (8-MOP) for photochemotherapy of psoriasis. We have compared the clinical efficacy and tolerability of 5-MOP (1.2 mg/kg)-UVA versus 8-MOP (0.6 mg/kg)-UVA therapy in 25 patients of skin type III and IV, affected by relapsing plaque-type psoriasis of similar body involvement; indeed, the same patients were given 8-MOP during 1 year and 5-MOP during the subsequent year after relapsing. Both treatments cleared psoriatic lesions with a comparable number of exposures, but 5-MOP required significantly higher cumulative UVA doses. The difference was due to the lower phototoxicity of 5-MOP, as assessed by the determination of the minimal phototoxic dose, and to its higher tanning activity, as assessed by the weekly grading of pigmentation. Nevertheless, therapy by 5-MOP-UVA seemed particularly interesting in that it showed a higher tolerability since only 1 patient experienced nausea, whereas during therapy with 8-MOP-UVA nausea and/or vomiting occurred in 7 patients, sunburn in 6 and itching in 3. Since we have treated the same patients with the two drugs, our results were not influenced by interindividual variations of phototoxic responses, tanning ability and susceptibility to develop psoralen-induced short-term side-effects. It was concluded that, although long-term side-effects of the 5-MOP-UVA treatment have still to be determined, such treatment of psoriasis should be reappraised due to its higher tolerability in comparison to 8-MOP-UVA treatment.

journal_name

Exp Dermatol

journal_title

Experimental dermatology

authors

Calzavara-Pinton P,Ortel B,Carlino A,Honigsmann H,De Panfilis G

doi

10.1111/j.1600-0625.1992.tb00071.x

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

46-51

issue

1

eissn

0906-6705

issn

1600-0625

journal_volume

1

pub_type

临床试验,杂志文章

相关文献

EXPERIMENTAL DERMATOLOGY文献大全
  • R-Ras regulates vascular permeability, but not overall healing in skin wounds.

    abstract：:Wounds close by keratinocytes migrating from the edge of the wound and re-epithelializing the epidermis. It has been proposed that the major stimuli for wound closure are blood-derived growth factors, chemokines and cytokines. The small GTPase R-Ras, a known integrin activator, also regulates vascular permeability dur...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/exd.13851

    authors： Ketomäki T,Vähätupa M,May U,Pemmari T,Ruikka E,Hietamo J,Kaipiainen P,Barker H,Parkkila S,Uusitalo-Järvinen H,Järvinen TAH

    更新日期：2019-02-01 00:00:00

  • Epidermal growth factor (EGF)-mediated DNA-binding activity of AP-1 is attenuated in senescent human epidermal keratinocytes.

    abstract：:The proliferative responses of cells to mitogens decrease during aging, and this may result from age-related defects in signal transduction in response to mitogens. In this study, we have investigated the age-related alteration of responses to epidermal growth factor (EGF) in cultured human keratinocytes that were sen...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.0906-6705.2005.00317.x

    authors： Shi B,Isseroff RR

    更新日期：2005-07-01 00:00:00

  • Deposition of chromatin-IgG complexes in skin of nephritic MRL-lpr/lpr mice is associated with increased local matrix metalloprotease activities.

    abstract：:Chromatin-IgG complexes appear as electron dense structures (EDS) in glomerular basement membranes in lupus nephritis. Here, we present results of comparative analyses of the composition of EDS in murine lupus dermatitis and nephritis. One focus was to perform an analytical approach to understand why such complex stru...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.2010.01064.x

    authors： Hedberg A,Fismen S,Fenton KA,Mortensen ES,Rekvig OP

    更新日期：2010-08-01 00:00:00

  • P2Y13 and P2X7 receptors modulate mechanically induced adenosine triphosphate release from mast cells.

    abstract：:Subcutaneous mast cells (MCs) are vulnerable to mechanical stimulation from external environment. Thus, MCs immune function could be modulated by their mechanosensitivity. This property has been identified as the trigger mechanism of needling acupuncture, a traditional oriental therapy. Previously we have demonstrated...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/exd.14093

    authors： Shen D,Shen X,Schwarz W,Grygorczyk R,Wang L

    更新日期：2020-05-01 00:00:00

  • Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency.

    abstract：:Hair loss (alopecia) can result from a variety of metabolic, endocrine, immunologic, and environmental causes. This investigation was undertaken to determine the mechanisms underlying the sporadic development of alopecia in litters from C57BL/6 interleukin-10-deficient (Il10(-/-)) mice. All pups in affected litters de...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.2009.01032.x

    authors： Vanderford DA,Greer PK,Sharp JM,Chichlowski M,Rouse DC,Selim MA,Hale LP

    更新日期：2010-06-01 00:00:00

  • Tropisetron via α7 nicotinic acetylcholine receptor suppresses tumor necrosis factor-α-mediated cell responses of human keratinocytes.

    abstract：:Tropisetron is a serotonin receptor (5-HT-R)-modulating agent and approved as an antiemetic for patients undergoing chemotherapy. In the gut, it acts via specific serotonin receptors, 5-HT3 -R, to elicit its beneficial effects against nausea. We investigated whether tropisetron can affect inflammatory cell responses o...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/exd.13883

    authors： Stegemann A,Böhm M

    更新日期：2019-03-01 00:00:00

  • PUVA suppresses the expression of cell adhesion molecules of lymphocytes.

    abstract：:To determine the therapeutic mechanism of PUVA in psoriasis vulgaris, the effects of PUVA on activated T lymphocytes were investigated in vitro. Peripheral blood mononuclear cells (PBMC) obtained from healthy volunteers were activated with Con A stimulation (Con A blasts). Both untreated PBMC and Con A blasts were irr...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.1995.tb00219.x

    authors： Urano K,Matsuyama T,Urano R,Matsuo I,Habu S

    更新日期：1995-02-01 00:00:00

  • CCL7 contributes to the TNF-alpha-dependent inflammation of lesional psoriatic skin.

    abstract：:Chemokines are small chemotactic proteins that have a crucial role in leukocyte recruitment into tissue. Targeting these mediators has been suggested as a potential therapeutic option in inflammatory skin diseases such as psoriasis. Using quantitative RT-PCR, we found CCL7, a chemokine ligand known to interact with mu...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/exd.12709

    authors： Brunner PM,Glitzner E,Reininger B,Klein I,Stary G,Mildner M,Uhrin P,Sibilia M,Stingl G

    更新日期：2015-07-01 00:00:00

  • Modulation of keratinocyte growth factor (KGF) mRNA expression in human dermal fibroblasts grown in monolayer or within a collagen matrix.

    abstract：:In this study, we analysed the modulation of keratinocyte growth factor (KGF) mRNA expression in human dermal fibroblasts cultured either in monolayer or within a collagen matrix (dermal equivalent). In monolayer cultures, KGF expression by quiescent fibroblasts was stimulated by different growth substances such as se...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.1996.tb00103.x

    authors： Le Panse R,Bouchard B,Lebreton C,Coulomb B

    更新日期：1996-04-01 00:00:00

  • Optimization of reference gene panels for gene expression analysis in preclinical models of inflammatory skin diseases.

    abstract：:Reverse transcriptase qPCR is the most common method to determine and compare mRNA expression levels and relies on normalization using reference genes. The expression levels of the latter, however, are themselves often variable between experimental conditions, thus compromising the results. Using the geNorm algorithm,...

    journal_title：Experimental dermatology

    pub_type： 信件

    doi：10.1111/exd.13989

    authors： Braun A,Sezin T,Bezdek S,Doxastaki I,Zillikens D,Busch HS,Sadik CD

    更新日期：2019-08-01 00:00:00

  • Rapid, high-quality and epidermal-specific isolation of RNA from human skin.

    abstract：:As global transcriptome analyses with a growing demand on layer-specific applications are widely used in cutaneous biology, we investigated the effect of established and optimized dermo-epidermal separation methods on the quality of RNA. We compared enzymatic separation with dispase, chemical separation with 1 M sodiu...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.2006.00534.x

    authors： Trost A,Bauer JW,Lanschützer C,Laimer M,Emberger M,Hintner H,Onder K

    更新日期：2007-03-01 00:00:00

  • Inhibiting scar formation in vitro and in vivo by adenovirus-mediated mutant Smad4: a preliminary report.

    abstract：:The best characterized signalling pathway employed by transforming growth factor-beta (TGF-β) is the Smad pathway. We focused on Smad4, because it is essential for the activation of Smad-dependent target genes. We aimed to explore the possibility of inhibiting scar formation after wounding by blocking TGF-β signalling...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.2010.01186.x

    authors： Tan WQ,Gao ZJ,Xu JH,Yao HP

    更新日期：2011-02-01 00:00:00

  • Systemic therapy for metastatic malignant melanoma--from deeply disappointing to bright future?

    abstract：:The last decade has seen a considerable improvement in the understanding of the biology of melanoma. Advances have come in the understanding of the importance of critical oncogenes and tumour suppressor genes, epigenetic phenomena, signalling pathways, drug resistance mechanisms, the pivotal role of the local immune s...

    journal_title：Experimental dermatology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1600-0625.2007.00673.x

    authors： Lorigan P,Eisen T,Hauschild A

    更新日期：2008-05-01 00:00:00

  • Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation.

    abstract：:The bioactive lysophospholipid sphingosine-1-phosphate (S1P) is best known for its activity as T-cell-active chemoattractant regulating the egress of T cells from the lymph node and, consequently, the availability of T cells for migration into peripheral tissues. This physiological role of S1P is exploited by the drug...

    journal_title：Experimental dermatology

    pub_type： 杂志文章,评审

    doi：10.1111/exd.13174

    authors： Thieme M,Zillikens D,Sadik CD

    更新日期：2017-03-01 00:00:00

  • Texture analysis of second-harmonic-generation images for quantitative analysis of reticular dermal collagen fibre in vivo in human facial cheek skin.

    abstract：:Second-harmonic-generation (SHG) microscopy is a powerful tool for in vivo visualisation of collagen fibres in human skin because of its specific collagen selectivity without the need for staining, non-invasiveness and high-resolution three-dimensional imaging. Although texture analysis of SHG images is a promising me...

    journal_title：Experimental dermatology

    pub_type： 临床试验,杂志文章

    doi：10.1111/exd.13560

    authors： Ogura Y,Tanaka Y,Hase E,Yamashita T,Yasui T

    更新日期：2019-08-01 00:00:00

  • Bacterial soft tissue infection in psoriasis despite induction of epidermal antimicrobial peptides.

    abstract：:Antimicrobial peptides and proteins (AMP) are highly active molecules with a broad-spectrum of microbicidal activity. Human beta-defensins (hBD)-2 and hBD-3 were initially isolated from psoriatic-scale extracts, and other AMP have been identified in high concentrations in psoriatic skin explaining the uncommonness of ...

    journal_title：Experimental dermatology

    pub_type： 信件

    doi：10.1111/exd.12538

    authors： Steinz K,Schubert S,Harder J,Gerdes S,Mrowietz U,Gläser R

    更新日期：2014-11-01 00:00:00

  • Detection of alpha- and beta-human papillomavirus (HPV) in cutaneous melanoma: a matched and controlled study using specific multiplex PCR combined with DNA microarray primer extension.

    abstract：:There are few contradictory studies investigating the involvement of HPV in melanoma. We designed a controlled study to evaluate the HPV DNA prevalence in melanoma. One hundred patients with cutaneous malignant melanoma diagnosed between 2002 and 2006 were included. Complementary wide excision (healthy skin) was perfo...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.2009.00866.x

    authors： Ruer JB,Pépin L,Gheit T,Vidal C,Kantelip B,Tommasino M,Prétet JL,Mougin C,Aubin F

    更新日期：2009-10-01 00:00:00

  • Possible histopathologic correlates of dermoscopic features in pigmented melanocytic lesions identified by means of optical coherence tomography.

    abstract：:Optical coherence tomography (OCT) is a novel non-invasive imaging technique for in vivo histologic characterization of tissues. Besides pure morphology, additional functional parameters of the tissue investigated can be evaluated at the same time, such as the refractive index and the scattering coefficient. The purpo...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.0906-6705.2005.00229.x

    authors： de Giorgi V,Stante M,Massi D,Mavilia L,Cappugi P,Carli P

    更新日期：2005-01-01 00:00:00

  • Role of protein kinase C delta in X-ray-induced apoptosis of keratinocyte.

    abstract：:In this study, we investigated the process of X-ray-induced apoptosis of skin keratinocyte, and the functional role of protein kinase C delta (PKCdelta) and downstream signalling cascade. High-dose X-ray irradiation (10 Gy) led to the apoptosis of HaCaT keratinocyte, accompanied by PKCdelta cleavage. Treatment with PK...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.2008.00761.x

    authors： Lee YS,Sohn KC,Kim KH,Cho MJ,Hur GM,Yoon TJ,Kim SK,Lee K,Lee JH,Kim CD

    更新日期：2009-01-01 00:00:00

  • TCR Vbeta expression in the small bowel of patients with dermatitis herpetiformis and gluten sensitive enteropathy. Limited expression in dermatitis herpetiformis and treated asymptomatic gluten sensitive enteropathy.

    abstract：:Dermatitis herpetiformis (DH) is a blistering skin disease characterized by cutaneous deposits of IgA and an associated, most often asymptomatic, gluten sensitive enteropathy (GSE). Gluten sensitive enteropathy is also seen in patients that do not have skin disease or cutaneous IgA deposits, but do have significant ga...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1034/j.1600-0625.2000.009004275.x

    authors： Hall RP 3rd,Owen S,Smith A,Keough M,Bagheri B,Church P,Streilein R

    更新日期：2000-08-01 00:00:00

  • Comparison of two in vitro dendritic cell maturation models for screening contact sensitizers using a panel of methacrylates.

    abstract：:Allergen-induced emigration and maturation of dendritic cells (DC) are pivotal steps in sparking off allergic contact dermatitis. In vitro models, reflecting these steps, may provide tools for assessment of sensitizing capacities of putative contact allergens. Here, we evaluated the applicability of such models for a ...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1034/j.1600-0625.2003.00077.x

    authors： Rustemeyer T,Preuss M,von Blomberg BM,Das PK,Scheper RJ

    更新日期：2003-10-01 00:00:00

  • Expression of dipeptidyl-peptidase IV (CD26) on CD8+ T cells is significantly decreased in patients with psoriasis vulgaris and atopic dermatitis.

    abstract：:T cells play a major role in inflammatory skin disorders such as psoriasis vulgaris and atopic dermatitis. They are both active on the level of cell-to-cell interaction and by the secretion of pro-inflammatory mediators. CD26 is a lymphocyte membrane-associated dipeptidyl peptidase IV (DPP IV), which is able to inacti...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1034/j.1600-0625.2001.100604.x

    authors： Bock O,Kreiselmeyer I,Mrowietz U

    更新日期：2001-12-01 00:00:00

  • The nitroxide Tempol affords protection against ultraviolet radiation in a transgenic murine fibroblast culture model of cutaneous photoaging.

    abstract：:The generation of reactive oxygen species is among the various mechanisms by which ultraviolet radiation damages skin. Tempol, a superoxide dismutase analogue which readily penetrates cell membranes when administered exogenously, has been shown to provide protection against some forms of oxygen-dependent damage. In th...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1034/j.1600-0625.2001.100107.x

    authors： Bernstein EF,Kong SK,Brown DB,Kwak BC,Takeuchi T,Gasparro FP,Uitto J

    更新日期：2001-02-01 00:00:00

  • Pigmented skin lesions displaying regression features: Dermoscopy and reflectance confocal microscopy criteria for diagnosis.

    abstract：:Melanomas and nevi displaying regression features can be difficult to differentiate. To describe reflectance confocal microscopy features in benign and malignant pigmented skin lesions characterized by regression features in dermoscopy. Observational retrospective study. Inclusion criteria were presence of dermoscopic...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/exd.13853

    authors： Moscarella E,Bombonato C,Pampena R,Kyrgidis A,Benati E,Piana S,Borsari S,Lallas A,Pellacani G,Argenziano G,Longo C

    更新日期：2019-02-01 00:00:00

  • Restoration of hair growth in mice with an alopecia areata-like disease using topical anthralin.

    abstract：:Anthralin is a widely used topical anti-psoriatic drug that may have an immunomodulating effect on alopecia areata (AA) as it does in psoriasis. The aims of the present study were to investigate the effects of anthralin on hair growth in balding C3H/HeJ mice affected by an AA-like disease and to study the underlying m...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.0906-6705.2004.00098.x

    authors： Tang L,Cao L,Sundberg JP,Lui H,Shapiro J

    更新日期：2004-01-01 00:00:00

  • Specific binding of Clostridium perfringens enterotoxin fragment to Claudin-b and modulation of zebrafish epidermal barrier.

    abstract：:Claudins (Cldn) are the major components of tight junctions (TJs) sealing the paracellular cleft in tissue barriers of various organs. Zebrafish Cldnb, the homolog of mammalian Cldn4, is expressed at epithelial cell-cell contacts and is important for regulating epidermal permeability. The bacterial toxin Clostridium p...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/exd.12728

    authors： Zhang J,Ni C,Yang Z,Piontek A,Chen H,Wang S,Fan Y,Qin Z,Piontek J

    更新日期：2015-08-01 00:00:00

  • Leptin of dermal adipose tissue is differentially expressed during the hair cycle and contributes to adipocyte-mediated growth inhibition of anagen-phase vibrissa hair.

    abstract：:Adipose tissue encircles the lower portion of anagen hair follicles and may regulate hair cycle progression. As leptin is a major adipokine, its level of expression from the dermal white adipose tissue during hair cycle progression was studied. The result shows that leptin level is differentially expressed during hair...

    journal_title：Experimental dermatology

    pub_type： 信件

    doi：10.1111/exd.12566

    authors： Yang CC,Sheu HM,Chung PL,Chang CH,Tsai YS,Hughes MW,Tuan TL,Huang LL

    更新日期：2015-01-01 00:00:00

  • Antiflammin 1 peptide delivered non-invasively by iontophoresis reduces irritant-induced inflammation in vivo.

    abstract：:The potential of an anti-inflammatory peptide (antiflammin 1) to reduce irritation when delivered transdermally by iontophoresis was examined. A model drug irritant, chlorpromazine, was co-delivered with and without antiflammin 1 by iontophoresis to hairless guinea pigs transdermally. Quantitative skin irritation meas...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/j.1600-0625.1997.tb00203.x

    authors： Mize NK,Buttery M,Ruis N,Leung I,Cormier M,Daddona P

    更新日期：1997-08-01 00:00:00

  • Nilotinib induction of melanogenesis via reactive oxygen species-dependent JNK activation in B16F0 mouse melanoma cells.

    abstract：:Nilotinib (AMN), a second-generation tyrosine kinase inhibitor, induces apoptosis in various cancer cells, and our recent study showed that AMN effectively reduced the viability of human ovarian cancer cells via mitochondrion-dependent apoptosis. The effect of AMN in the melanogenesis of melanoma cells is still unclea...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/exd.13797

    authors： Chang SP,Huang HM,Shen SC,Lee WR,Chen YC

    更新日期：2018-12-01 00:00:00

  • CCL3, IL-7, IL-13 and IFNγ transcripts are increased in skin's biopsy of systemic sclerosis.

    abstract：:Although several cytokines and chemokines have been investigated as possible mediators of fibrosis in systemic sclerosis (SSc), specific correlation between cytokines and organ involvement have not been found yet, and a cytokine profile characteristic of SSc is far to be identified. We studied the profile of antifibro...

    journal_title：Experimental dermatology

    pub_type： 杂志文章

    doi：10.1111/exd.13982

    authors： Gonçalves RSG,Pereira MC,Dantas AT,Almeida AR,Rego MJBM,Lima EA,Pitta IDR,Duarte ALBP,Pitta MGDR

    更新日期：2019-10-01 00:00:00