Leptin of dermal adipose tissue is differentially expressed during the hair cycle and contributes to adipocyte-mediated growth inhibition of anagen-phase vibrissa hair.

Abstract:

:Adipose tissue encircles the lower portion of anagen hair follicles and may regulate hair cycle progression. As leptin is a major adipokine, its level of expression from the dermal white adipose tissue during hair cycle progression was studied. The result shows that leptin level is differentially expressed during hair cycle, the lowest in early anagen phase, upregulated in late anagen phase and the highest in the telogen phase. On the other hand, leptin receptor is detected in keratin 15-positive hair bulge epithelium of both anagen- and telogen-phase hair follicles of mice pelage and vibrissa hair, and hair from human scalp. Leptin contributes to adipocyte-mediated growth inhibition of anagen-phase vibrissa hair as demonstrated in organ culture and coculture system. Our data suggest that leptin of dermal white adipose tissue might regulate hair growth and, therefore, hair cycle progression via leptin receptor on the hair follicle epithelium.

journal_name

Exp Dermatol

journal_title

Experimental dermatology

authors

Yang CC,Sheu HM,Chung PL,Chang CH,Tsai YS,Hughes MW,Tuan TL,Huang LL

doi

10.1111/exd.12566

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

57-60

issue

1

eissn

0906-6705

issn

1600-0625

journal_volume

24

pub_type

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