Nilotinib induction of melanogenesis via reactive oxygen species-dependent JNK activation in B16F0 mouse melanoma cells.

abstract：:The reliability of the methods currently used for diagnosing hair loss is ill defined. We studied 41 subjects complaining of hair loss, including androgenetic alopecia and telogen effluvium, and compared the results obtained with the modified wash test (MWT) and TrichoScan(®) . Data were analysed statistically with th...

journal_title：Experimental dermatology

authors： Guarrera M,Fiorucci MC,Rebora A

更新日期：2013-07-01 00:00:00

abstract：:Mast cells (MCs) have been intensely investigated over the past two decades, e.g. the numbers of PubMed-listed reports on MCs have steadily increased and doubled over the past twenty years. Surprisingly, many recent findings that have fundamentally changed our understanding of MC biology and functions have yet to be s...

journal_title：Experimental dermatology

authors： Maurer M,Metz M

更新日期：2005-12-01 00:00:00

abstract：INTRODUCTION:The aetiology of mycosis fungoides and parapsoriasis (which may be considered as an early stage of mycosis fungoides) remains debated. Previous recent studies have suspected the involvement of viral agents and particularly human herpes viruses (HHV).The aim of the present study was to screen for the presen...

journal_title：Experimental dermatology

authors： Quéreux G,André-Garnier E,Knol AC,Imbert-Marcille BM,Dréno B

更新日期：2009-04-01 00:00:00

abstract：:Lipoid proteinosis (OMIM 247100), also known as Urbach-Wiethe disease or hyalinosis cutis et mucosae, is a rare autosomal recessive disorder characterized by generalized thickening and scarring of the skin and mucosae. In 2002, the disorder was mapped to a locus on chromosome 1q21 and pathogenic mutations were identif...

journal_title：Experimental dermatology

authors： Chan I,Liu L,Hamada T,Sethuraman G,McGrath JA

更新日期：2007-11-01 00:00:00

abstract：:Skin barrier damage induces various harmful or even protective reactions in the skin, as represented by enhancement of keratinocyte cytokine production. To investigate whether acute removal of stratum corneum modulates the production of chemokines by epidermal cells, we treated ears of BALB/c and C57BL/6 mice by tape-...

journal_title：Experimental dermatology

authors： Onoue A,Kabashima K,Kobayashi M,Mori T,Tokura Y

更新日期：2009-12-01 00:00:00

abstract：:Canine atopic dermatitis (AD), a chronic inflammatory skin disease, shares characteristics with its human counterpart. To get insight into the role of enzymes involved in production of prostaglandin E(2) (PGE2) and leukotriene B(4) (LTB(4)), potent inflammatory mediators originating from membrane-derived arachidonic a...

journal_title：Experimental dermatology

authors： Schlotter YM,Riemers FM,Rutten VP,Knol EF,Willemse T

更新日期：2010-08-01 00:00:00

abstract：:The molecular nature of the hair cycle clock (HCC), the intrinsic oscillator system that drives hair follicle (HF) cycling, remains incompletely understood; therefore, all relevant key players need to be identified. Here, we present evidence that implicates myelin protein zero-like 3 (MPZL3), a multifunctional nuclear...

journal_title：Experimental dermatology

authors： Nicu C,Wikramanayake TC,Paus R

更新日期：2020-12-01 00:00:00

abstract：:In the last decades melanoma incidence has been increasing worldwide, while mortality remained on a high level. Until now, there is no suitable therapy for metastasized melanoma, which could lead to a significant increase in overall survival. Apoptosis deficiency is supposed to be a critical factor for therapy resista...

journal_title：Experimental dermatology

authors： Eberle J,Fecker LF,Hossini AM,Kurbanov BM,Fechner H

更新日期：2008-01-01 00:00:00

abstract：:Optimized delivery of antigens combined with sustainable maturation of dendritic cells (DCs) is crucial for generation of effective antitumoral immune responses. Multiple approaches for ex vivo antigen loading and improvement in immunogenicity have been described. We have recently established a single-step protocol co...

journal_title：Experimental dermatology

authors： Buhl T,Braun A,Forkel S,Möbius W,van Werven L,Jahn O,Rezaei-Ghaleh N,Zweckstetter M,Mempel M,Schön MP,Haenssle HA

更新日期：2014-01-01 00:00:00

abstract：:Somatostatin (SST) is a regulatory peptide hormone that acts through five different G protein-coupled receptors (SSTR1-5). Whereas expression of all five SSTR subtypes in epidermis has been shown, the biological relevance of the SST/SSTR system in the skin is completely unknown. We show here that SST is expressed in h...

journal_title：Experimental dermatology

authors： Vockel M,Breitenbach U,Kreienkamp HJ,Brandner JM

更新日期：2010-10-01 00:00:00

abstract：:Both CCL27 and CCL28 are ligands for CCR10 and attract CCR10(+) lymphocytes. We previously demonstrated that CCL27 and CCL28 were strongly expressed in sera and lesional keratinocytes of patients with atopic dermatitis and psoriasis vulgaris. However, the regulation of CCL27 and CCL28 production in keratinocytes has n...

journal_title：Experimental dermatology

authors： Kagami S,Saeki H,Komine M,Kakinuma T,Nakamura K,Tsunemi Y,Sasaki K,Asahina A,Tamaki K

更新日期：2006-02-01 00:00:00

abstract：:Ultraviolet (UV) light is an effective treatment for skin disorders like psoriasis in which the cutaneous neurosensory system may have a pathogenic role. In this study, we examined the possibility that UV modulation of the cutaneous neurosensory system and calcitonin gene-related peptide (CGRP) may contribute to local...

journal_title：Experimental dermatology

authors： Legat FJ,Jaiani LT,Wolf P,Wang M,Lang R,Abraham T,Solomon AR,Armstrong CA,Glass JD,Ansel JC

更新日期：2004-04-01 00:00:00

abstract：:Despite as yet limited clinical effectiveness, dendritic cell (DC)-based immunotherapy remains a promising approach for the treatment of cancer, but requires further improvement in its immunostimulatory effectiveness. Potent anti-tumor immunity often depends on the induction of type 1 (T(H)1) immune responses. Therefo...

journal_title：Experimental dermatology

authors： Balkow S,Loser K,Krummen M,Higuchi T,Rothoeft T,Apelt J,Tuettenberg A,Weishaupt C,Beissert S,Grabbe S

更新日期：2009-01-01 00:00:00

abstract：:The expression of amphiregulin (AR) in the basal epidermis of transgenic mice [keratin 14 promoter AR gene (K14-ARGE)] has been previously shown to induce an early-onset and severe skin pathology, with many similarities to psoriasis. In this study, it is demonstrated that involucrin enhancer/promoter-dependent express...

journal_title：Experimental dermatology

authors： Cook PW,Brown JR,Cornell KA,Pittelkow MR

更新日期：2004-06-01 00:00:00

abstract：:We previously reported that sphingosine-1-phosphate (S1P) decreases melanin synthesis via extracellular signal-regulated protein kinase (ERK) activation and microphthalmia-associated transcription factor (MITF) degradation. Although FTY720 is an S1P structural analogue, the effects of FTY720 on melanogenesis are not c...

journal_title：Experimental dermatology

authors： Lee JE,Kim SY,Jeong YM,Yun HY,Baek KJ,Kwon NS,Park KC,Kim DS

更新日期：2011-03-01 00:00:00

abstract：:Patients belonging to xeroderma pigmentosum (XP) complementation group C comprise one-third of all XP patients. Only four major reports compiled larger groups of XP-C patients from southern Europe (12 pts), North America (16 pts) and Africa (14 and 56 pts) as well as their genetic background (46 XPC mutations). We ide...

journal_title：Experimental dermatology

authors： Schäfer A,Hofmann L,Gratchev A,Laspe P,Schubert S,Schürer A,Ohlenbusch A,Tzvetkov M,Hallermann C,Reichrath J,Schön MP,Emmert S

更新日期：2013-01-01 00:00:00

abstract：:Pemphigus foliaceus (PF) is a severe autoimmune bullous disorder, characterized by autoantibodies (autoAb) against desmoglein 1 (Dsg1). As T cells may be critical in the pathology of PF, the aim of the present study was to identify and characterize autoaggressive T-helper cells reactive to Dsg1 in PF patients and heal...

journal_title：Experimental dermatology

authors： Gebhard KL,Veldman CM,Wassmuth R,Schultz E,Schuler G,Hertl M

更新日期：2005-08-01 00:00:00

abstract：:Flavonoids belong to a large group of polyphenolic compounds that are widely present in plants. Certain flavonoids, including naringenin, have cytoprotective properties. Although the antioxidant effect has long been thought to be a crucial factor accounting for the cellular effects of flavonoids, mitochondrial channel...

journal_title：Experimental dermatology

authors： Kampa RP,Kicinska A,Jarmuszkiewicz W,Pasikowska-Piwko M,Dolegowska B,Debowska R,Szewczyk A,Bednarczyk P

更新日期：2019-05-01 00:00:00

abstract：:Filaggrin (FLG) loss-of-function (LOF) variants are a major risk factor for the common inflammatory skin disease, atopic dermatitis (AD) and are often population-specific. African-American (AA) children are disproportionately affected with AD, often later developing asthma and/or allergic rhinitis and comprise an atop...

journal_title：Experimental dermatology

authors： Mathyer ME,Quiggle AM,Wong XFCC,Denil SLIJ,Kumar MG,Ciliberto HM,Bayliss SJ,Common JE,de Guzman Strong C

更新日期：2018-09-01 00:00:00

abstract：:Vitamin D3 analogues are widely used topical and oral remedies for various ailments such as psoriasis, osteoporosis and secondary hyperparathyroidism. In topical treatment, high skin permeability and cellular uptake are key criteria for beneficial effects due to the natural barrier properties of skin. In this study, w...

journal_title：Experimental dermatology

authors： Staunstrup NH,Bak RO,Cai Y,Svensson L,Petersen TK,Rosada C,Stenderup K,Bolund L,Mikkelsen JG

更新日期：2013-03-01 00:00:00

abstract：:Patch-clamp recordings were carried out in the inside-out configuration in human keratinocytes of the cell line HaCaT. Patch pipettes were filled with 150 mM KCl, 1 mM CaCl(2) and 10 mM HEPES. In symmetrical KCl solutions, single channel currents from a large conductance channel (about 170 pS) were measured. Replaceme...

journal_title：Experimental dermatology

authors： Nguyen VH,Markwardt F

更新日期：2002-08-01 00:00:00

abstract：:Although several cytokines and chemokines have been investigated as possible mediators of fibrosis in systemic sclerosis (SSc), specific correlation between cytokines and organ involvement have not been found yet, and a cytokine profile characteristic of SSc is far to be identified. We studied the profile of antifibro...

journal_title：Experimental dermatology

authors： Gonçalves RSG,Pereira MC,Dantas AT,Almeida AR,Rego MJBM,Lima EA,Pitta IDR,Duarte ALBP,Pitta MGDR

更新日期：2019-10-01 00:00:00

abstract：:Psoriasis is a chronic skin disease caused by immune disorder. The chronic skin inflammation involves inflammatory molecules that are released from T lymphocytes and keratinocytes. Therefore, developing an anti-inflammatory therapy that is suitable for long-term treatment is needed. Electrical stimulation induces biol...

journal_title：Experimental dermatology

authors： Tsurekawa Y,Morita M,Suico MA,Moriuchi M,Nakano Y,Piruzyan M,Takada M,Fukami S,Shuto T,Kai H

更新日期：2018-10-01 00:00:00

abstract：:In recent years, hyaluronan (HA) has become an increasingly attractive substance as a non-immunogenic filler and scaffolding material in cosmetic dermatology. Despite its wide use for skin augmentation and rejuvenation, relatively little is known about the molecular structures and interacting proteins of HA in normal ...

journal_title：Experimental dermatology

authors： Anderegg U,Simon JC,Averbeck M

更新日期：2014-05-01 00:00:00

abstract：:We have identified a spliced mRNA transcript of CD20 (named D393-CD20) which was associated with resistance to RTX in primary B cell from patients with lymphoma and leukaemia. In the present work, we wished to investigate whether D393-CD20 variant was expressed by B cells from patients with pemphigus. Ten patients wit...

journal_title：Experimental dermatology

authors： Gamonet C,Ferrand C,Colliou N,Musette P,Joly P,Girardin M,Humbert P,Aubin F

更新日期：2014-01-01 00:00:00

abstract：:Dendritic cells (DCs) can be differentiated from CD14+ monocytes in the presence of interferon-α (IFNα) and granulocyte/macrophage-colony stimulating factor (GM-CSF) in vitro and are known as IFN-DCs. Circulating blood CD56+ cells expressing high levels of CD14, HLA-DR and CD86 have been shown to spontaneously differe...

journal_title：Experimental dermatology

authors： Nieda M,Terunuma H,Eiraku Y,Deng X,Nicol AJ

更新日期：2015-01-01 00:00:00

abstract：:The effects of prostaglandin (PG) I1 analog, SM-10906 (SM-6) and PGE1 on extracellular matrix formation and the release of cytokines by cultured normal human dermal fibroblasts (NDF) and hypertrophic scar fibroblasts (HSF) were compared in order to evaluate the clinical efficacy of PGs in preventing scar formation. In...

journal_title：Experimental dermatology

authors： Zhou LJ,Inoue M,Ono I,Kaneko F

更新日期：1997-12-01 00:00:00

abstract：:Lipoxygenases (LOX) and cyclooxygenase (COX) are the main enzymes for PUFA metabolism to highly bio-active prostaglandins, leukotrienes, thromboxanes, lipoxins, resolvins and protectins. LOX and COX pathways are important for the regulation of pro-inflammatory or pro-resolving metabolite synthesis and metabolism for v...

journal_title：Experimental dermatology

authors： Töröcsik D,Weise C,Gericke J,Szegedi A,Lucas R,Mihaly J,Worm M,Rühl R

更新日期：2019-02-01 00:00:00

abstract：:Recent advances in the molecular biology of the dermo-epidermal basement membrane zone have contributed greatly to our understanding of the etiopathogenetic pathways underlying mechanobullous disorders. Genetic linkage was established between the keratin gene clusters and epidermolysis bullosa simplex, and keratin mut...

journal_title：Experimental dermatology

authors： Bruckner-Tuderman L

更新日期：1992-10-01 00:00:00

abstract：:The growth of our knowledge in T-cell biology, in particular the molecular biology of the T-cell receptor (TCR), has provided a means to molecularly characterize lymphoproliferative diseases of the skin based on the presence or absence of a clonal population of T lymphocytes. TCR gene rearrangement studies, by Souther...

journal_title：Experimental dermatology

authors： Lessin SR,Rook AH

更新日期：1993-03-01 00:00:00