A lentiviral vector-based genetic sensor system for comparative analysis of permeability and activity of vitamin D3 analogues in xenotransplanted human skin.

abstract：:Pemphigus vulgaris (PV) is an autoimmune bullous disease caused by immunoglobulin G (IgG) autoantibodies against desmoglein 3 (Dsg3). We have generated an active disease mouse model for PV by adoptive transfer of Dsg3(-/-) lymphocytes. In this study, we investigated the benefits and limitations of this model as a tool...

journal_title：Experimental dermatology

authors： Takae Y,Nishikawa T,Amagai M

更新日期：2009-03-01 00:00:00

abstract：:Recently, decreased interferon-gamma (IFN-gamma) and increased interleukin (IL)-4 production have been reported in measurements of the content of the cytokines in culture supernatants of peripheral blood mononuclear cells (PBMC) obtained from patients with atopic dermatitis (AD). These data suggest deviation of PBMC i...

journal_title：Experimental dermatology

authors： Nakagawa S,Aiba S,Tagami H

更新日期：1998-04-01 00:00:00

abstract：:Collagens are the most abundant proteins in the extracellular matrix. They provide a framework to build organs and tissues and give structural support to make them resistant to mechanical load and forces. Several intra- and extracellular modifications are needed to make functional collagen molecules, intracellular pos...

journal_title：Experimental dermatology

authors： Salo AM,Myllyharju J

更新日期：2021-01-01 00:00:00

abstract：:C1 inhibitor (C1INH) plays an important role in the classical pathway of the complement system. Mutations in C1INH gene cause quantitative or qualitative deficiencies in C1INH, which can lead to hereditary angioedema (HAE) type I or II. Here, we identified a novel frame-shift mutation c.1391-1445del55 (p.v464fsx556) i...

journal_title：Experimental dermatology

authors： Qu L,Wei B,Liu M,Zhang L,Xiao T,Chen HD,Zhou L,Mi QS,He C

更新日期：2012-10-01 00:00:00

abstract：:The aim of the present study was to evaluate experimentally whether administration of recombinant (rh) vascular endothelial growth factor (VEGF) can protect skin flaps from necrosis and to study the optimum mode of rh-VEGF administration. We used rats to study the effects of local or systemic administration of rh-VEGF...

journal_title：Experimental dermatology

authors： Scalise A,Tucci MG,Lucarini G,Giantomassi F,Orlando F,Pierangeli M,Pugnaloni A,Bertani A,Ricotti G,Biagini G

更新日期：2004-11-01 00:00:00

abstract：:Lipoxygenases (LOX) and cyclooxygenase (COX) are the main enzymes for PUFA metabolism to highly bio-active prostaglandins, leukotrienes, thromboxanes, lipoxins, resolvins and protectins. LOX and COX pathways are important for the regulation of pro-inflammatory or pro-resolving metabolite synthesis and metabolism for v...

journal_title：Experimental dermatology

authors： Töröcsik D,Weise C,Gericke J,Szegedi A,Lucas R,Mihaly J,Worm M,Rühl R

更新日期：2019-02-01 00:00:00

abstract：:Hair follicle central isthmus is surrounded by dense nerve endings and terminal Schwann cells (TSCs), forming a specialized sensory structure called lanceolate complexes. Extracellular matrix protein EGFL6 expressed from epidermis has been found closely associated with lanceolate complexes and important for proper ali...

journal_title：Experimental dermatology

authors： Wei JP,Gong Y,Zhong HB,Hua Wang T,Liao XH

更新日期：2020-04-01 00:00:00

abstract：:Mastocytosis represents a group of disorders characterized by the proliferation and accumulation of mast cells in tissue. The aim of the present study was to examine whether the interstitial histamine concentration in the skin is increased in mastocytosis patients and whether it correlates with the number of mast cell...

journal_title：Experimental dermatology

authors： Krogstad AL,Roupe G

更新日期：2001-04-01 00:00:00

abstract：:Recent studies have demonstrated that keratinocytes closely participate in sensory transduction, and therefore, intra-epidermal free nerve endings are not exclusive transducers of pain. This discovery implies the existence of close afferent communication from keratinocytes to sensory neurons. Although reciprocal inter...

journal_title：Experimental dermatology

authors： Talagas M,Lebonvallet N,Leschiera R,Marcorelles P,Misery L

更新日期：2018-01-01 00:00:00

abstract：:Earlier studies showed that dermal cells lose trichogenic capacity with passage, but studies on the effect of keratinocyte passage on human hair follicle neogenesis and graft quality have been hampered by the lack of a suitable model system. We recently documented human hair follicle neogenesis in grafted dermal-epide...

journal_title：Experimental dermatology

authors： Thangapazham RL,Klover P,Li S,Wang JA,Sperling L,Darling TN

更新日期：2014-06-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are non-haematopoietic cells that reside in most tissues including adult bone marrow. MSCs have recently been extensively studied and used for clinical therapies, including skin wound healing. However, there are still many questions to be answered. In the viewpoint entitled 'Mesenchymal s...

journal_title：Experimental dermatology

authors： Li X,Hamada T,Ohata C,Furumura M,Hashimoto T

更新日期：2013-08-01 00:00:00

abstract：:Pseudoxanthoma elasticum (PXE), a heritable multi-system disorder, is caused by mutations in the ABCC6 gene primarily expressed in the liver. Recent analysis of cultured fibroblasts from patients with PXE has suggested compensatory alterations in the expression of the ABCA-subfamily of genes. We have now determined by...

journal_title：Experimental dermatology

authors： Li Q,Uitto J

更新日期：2011-05-01 00:00:00

abstract：:The presence of albumin in the human epidermis has been reported more than a decade ago, but until now, it was assumed that this protein is synthesized in the liver and transported to the avascular skin. To our knowledge, transcription of albumin in the human epidermis was never considered. In this report, we present ...

journal_title：Experimental dermatology

authors： Hasse S,Kothari S,Rokos H,Kauser S,Schürer NY,Schallreuter KU

更新日期：2005-03-01 00:00:00

abstract：:This study shows that prostaglandins in human FM55 melanoma cells and epidermal melanocytes are produced by COX-1. Prostaglandin production in FM55 melanoma cells was unrelated to that of melanin suggesting that the two processes can occur independently. Alpha-melanocyte-stimulating hormone, which had no effect on mel...

journal_title：Experimental dermatology

authors： Masoodi M,Nicolaou A,Gledhill K,Rhodes LE,Tobin DJ,Thody AJ

更新日期：2010-08-01 00:00:00

abstract：:A two-stage genomewide association (GWA) analysis was conducted to investigate the genetic factors influencing ultraviolet (UV)-induced skin pigmentation in Korean females after UV exposure. Previously, a GWA study evaluating ~500 000 single nucleotide polymorphisms (SNPs) in 99 Korean females identified eight SNPs th...

journal_title：Experimental dermatology

authors： Kwak TJ,Chang YH,Shin YA,Shin JM,Kim JH,Lim SK,Lee SH,Lee MG,Yoon TJ,Kim CD,Lee JH,Koh JS,Seo YK,Chang MY,Lee Y

更新日期：2015-12-01 00:00:00

abstract：:Unpredictable hypertrophic scarring (HS) occurs after approximately 35% of all surgical procedures and causes significant physical and psychological complaints. Parallel to the need to understanding the mechanisms underlying HS formation, a prognostic tool is needed. The objective was to determine whether (systemic) i...

journal_title：Experimental dermatology

authors： de Bakker E,van der Putten MAM,Heymans MW,Spiekstra SW,Waaijman T,Butzelaar L,Negenborn VL,Beekman VK,Akpinar EO,Rustemeyer T,Niessen FB,Gibbs S

更新日期：2021-01-01 00:00:00

abstract：:Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat gl...

journal_title：Experimental dermatology

authors： Bovell DL,MacDonald A,Meyer BA,Corbett AD,MacLaren WM,Holmes SL,Harker M

更新日期：2011-12-01 00:00:00

abstract：:We have previously reported that lymph node cells generated chemotactic factors for Langerhans cells (LCs) in the induction phase of contact dermatitis. In order to clarify the chemotactic factors involved in migration to the regional lymph nodes, we investigated the migratory activity of murine LCs toward several cyt...

journal_title：Experimental dermatology

authors： Yamazaki S,Yokozeki H,Satoh T,Katayama I,Nishioka K

更新日期：1998-02-01 00:00:00

abstract：:Mast cells, eosinophils and basophils are central effector immune cells in allergic skin inflammation including atopic dermatitis (AD). Recent studies revealed that the bidirectional interaction between these three immune cell types (mast cells, eosinophils and basophils) and the nervous system is involved in the path...

journal_title：Experimental dermatology

authors： Nakashima C,Ishida Y,Kitoh A,Otsuka A,Kabashima K

更新日期：2019-12-01 00:00:00

abstract：:Psychological factors are believed to play a role in the pathogenesis of alopecia areata (AA), a frequently encountered hair disorder. In our study, statistically significant elevation of psychological stress was felt by AA patients prior hair loss compared with control, which was strongly believed contributory to hai...

journal_title：Experimental dermatology

authors： Kim HS,Cho DH,Kim HJ,Lee JY,Cho BK,Park HJ

更新日期：2006-07-01 00:00:00

abstract：:In a large-scale ageing study, 30 inbred mouse strains were systematically screened for histologic evidence of lesions in all organ systems. Ten strains were diagnosed with similar nail abnormalities. The highest frequency was noted in NON/ShiLtJ mice. Lesions identified fell into two main categories: acute to chronic...

journal_title：Experimental dermatology

authors： Linn SC,Mustonen AM,Silva KA,Kennedy VE,Sundberg BA,Bechtold LS,Alghamdi S,Hoehndorf R,Schofield PN,Sundberg JP

更新日期：2019-04-01 00:00:00

abstract：:Pemphigus vulgaris (PV) is a regulatory T cell (Treg)-associated autoimmune disease. Treg cells maintain immunosuppression by expressing the signature transcription factor FOXP3. MicroRNAs (miRNAs) have frequently emerged as regulators in Treg-mediated immunosuppression. We previously found that miR-338-3p was overexp...

journal_title：Experimental dermatology

authors： Xu M,Liu Q,Li S,Zhang W,Huang X,Han K,Li C,Zeng K

更新日期：2020-05-09 00:00:00

abstract：:Hypertrophic scarring is a skin disorder characterized by persistent inflammation and fibrosis that may occur after wounding or thermal injury. Altered production of cytokines and growth factors, such as TGF-beta, play an important role in this process. Activin A, a member of the TGF-beta family, shares the same intra...

journal_title：Experimental dermatology

authors： Fumagalli M,Musso T,Vermi W,Scutera S,Daniele R,Alotto D,Cambieri I,Ostorero A,Gentili F,Caposio P,Zucca M,Sozzani S,Stella M,Castagnoli C

更新日期：2007-07-01 00:00:00

abstract：:Quercetin, glycosylated form of flavonoid compound, has potent antioxidant and anti-inflammatory properties. In this study, we have investigated the effects of quercetin on skin lesion, high-mobility group box (HMGB)1 cascade signalling and inflammation in atopic dermatitis (AD) mouse model. AD-like lesion was induced...

journal_title：Experimental dermatology

authors： Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Nomoto M,Miyashita S,Suzuki K,Nakamura M,Watanabe K

更新日期：2015-06-01 00:00:00

abstract：:The effects of prostaglandin (PG) I1 analog, SM-10906 (SM-6) and PGE1 on extracellular matrix formation and the release of cytokines by cultured normal human dermal fibroblasts (NDF) and hypertrophic scar fibroblasts (HSF) were compared in order to evaluate the clinical efficacy of PGs in preventing scar formation. In...

journal_title：Experimental dermatology

authors： Zhou LJ,Inoue M,Ono I,Kaneko F

更新日期：1997-12-01 00:00:00

abstract：:Ultraviolet (UV) radiation contained in sunlight is considered a major risk in the induction of skin cancer. While mast cells are best known for their role in allergic responses, they have also been shown to play a crucial role in suppressing the anti-tumour immune response following UV exposure. Evidence is now emerg...

journal_title：Experimental dermatology

authors： Sarchio SN,Kok LF,O'Sullivan C,Halliday GM,Byrne SN

更新日期：2012-04-01 00:00:00

abstract：:Epidermal gene therapy may benefit a variety of inherited skin disorders and certain systemic diseases. Both in vivo and ex vivo approaches of gene transfer have been used to target human epidermal stem cells and achieve long-term transgene expression in immunodeficient mouse/human chimera models. Immunological respon...

journal_title：Experimental dermatology

authors： Lu Z,Ghazizadeh S

更新日期：2005-10-01 00:00:00

abstract：:Epidermal keratinocytes undergo a continuous process of terminal differentiation, which is accompanied by a dramatic change in the expression and composition of keratins. This complex and carefully orchestrated process is regulated by a large number of signal transduction events and transcriptional factors as well as ...

journal_title：Experimental dermatology

authors： Wang M,Yue Z,Paus R,Ramot Y

更新日期：2014-09-01 00:00:00

abstract：:The role of dendritic cells (DCs) in allergic contact dermatitis has been clearly demonstrated for the induction phase. However, the situation during the elicitation phase is very complex within a distinct inflammatory response. This study was performed to exploit DC migration in the elicitation phase in a mouse model...

journal_title：Experimental dermatology

authors： Bäumer W,Krekeler S,DeVries VC,Niedorf F,Tschernig T,Kietzmann M

更新日期：2006-04-01 00:00:00

abstract：:Given that metastasized melanoma is a fatal disease in most cases, it is tempting to develop strategies to a priori prevent metastasis. We have stimulated the pulmonary innate immune system by macrophage-activating lipopeptide-2 (MALP-2), a specific agonist at Toll-like receptor (TLR) 2/6, and investigated its impact ...

journal_title：Experimental dermatology

authors： Schill T,Schön MP,Pletz N,Emmert S,Schön M

更新日期：2012-02-01 00:00:00