R-Ras regulates vascular permeability, but not overall healing in skin wounds.


:Wounds close by keratinocytes migrating from the edge of the wound and re-epithelializing the epidermis. It has been proposed that the major stimuli for wound closure are blood-derived growth factors, chemokines and cytokines. The small GTPase R-Ras, a known integrin activator, also regulates vascular permeability during angiogenesis, and blood vessels lacking R-Ras leak plasma proteins constantly. We explored whether the access to blood-derived proteins influences skin wound healing in R-Ras knockout (KO) mice. In skin wounds, R-Ras expression was mostly restricted to the vasculature in the granulation tissue. Angiogenic blood vessels in the R-Ras KO mice were significantly more permeable than in wild-type (WT) controls. Although the distances between epidermal tongues, and the panniculus carnosus muscles, were significantly longer in R-Ras KO than WT controls before the granulation tissue formation took place, there were no differences in the wound closure or re-epithelialization rates or granulation tissue formation. These findings were also corroborated in a special splint excision wound model. Our study shows that although R-Ras does not influence the skin wound healing itself, the blood vessels lacking R-Ras are leaky and thus could facilitate the access of blood-derived proteins to the wound.


Exp Dermatol


Experimental dermatology


Ketomäki T,Vähätupa M,May U,Pemmari T,Ruikka E,Hietamo J,Kaipiainen P,Barker H,Parkkila S,Uusitalo-Järvinen H,Järvinen TAH




Has Abstract


2019-02-01 00:00:00












  • A high frequency of allergen-specific CD8+ Tc1 cells is associated with the murine immune response to the contact sensitizer trinitrophenyl.

    abstract::Chemical haptens induce a variety of allergic immune reactions by induction of hapten-specific T cells. Contact sensitizers such as the hapten trinitrochlorobenzene (TNCB) elicit an allergic response, which is confined to the area of antigen exposure. Despite this localized allergic response, we show here that the tri...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Martin S,Delattre V,Leicht C,Weltzien HU,Simon JC

    更新日期:2003-02-01 00:00:00

  • Molecular genetic analysis of 16 XP-C patients from Germany: environmental factors predominately contribute to phenotype variations.

    abstract::Patients belonging to xeroderma pigmentosum (XP) complementation group C comprise one-third of all XP patients. Only four major reports compiled larger groups of XP-C patients from southern Europe (12 pts), North America (16 pts) and Africa (14 and 56 pts) as well as their genetic background (46 XPC mutations). We ide...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Schäfer A,Hofmann L,Gratchev A,Laspe P,Schubert S,Schürer A,Ohlenbusch A,Tzvetkov M,Hallermann C,Reichrath J,Schön MP,Emmert S

    更新日期:2013-01-01 00:00:00

  • Characterization of circadian human facial surface lipid composition.

    abstract:BACKGROUND:The circadian rhythm is an endogenous clock that governs a wide range of physiological functions. In the skin, rhythmic changes in skin barrier function have been investigated at the physiological level; however, few studies at the molecular level have been reported. Additionally, there is no study on lipido...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Jia Y,Zhou M,Huang H,Gan Y,Yang M,Ding R

    更新日期:2019-07-01 00:00:00

  • Calcitonin gene-related peptide (CGRP) may award relative protection from interferon-γ-induced collapse of human hair follicle immune privilege.

    abstract::Interferon-γ (IFNγ)-induced collapse of hair follicle (HF) immune privilege (IP) is a key element in the pathogenesis of alopecia areata. In this pilot study, we investigated whether the immunosuppressive neuropeptide, calcitonin gene-related peptide (CGRP), can protect from and/or restore IFNγ-induced HF-IP collapse....

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Kinori M,Bertolini M,Funk W,Samuelov L,Meyer KC,Emelianov VU,Hasse S,Paus R

    更新日期:2012-03-01 00:00:00

  • Antipsoriatic drug anthralin induces EGF receptor phosphorylation in keratinocytes: requirement for H(2)O(2) generation.

    abstract::Even though anthralin is a well-established topical therapeutic agent for psoriasis, little is known about its effects and biochemical mechanisms of signal transduction. In contrast to a previous report, we found that anthralin induced time- and concentration-dependent phosphorylation of epidermal growth factor recept...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Peus D,Beyerle A,Vasa M,Pott M,Meves A,Pittelkow MR

    更新日期:2004-02-01 00:00:00

  • Prognostic tools for hypertrophic scar formation based on fundamental differences in systemic immunity.

    abstract::Unpredictable hypertrophic scarring (HS) occurs after approximately 35% of all surgical procedures and causes significant physical and psychological complaints. Parallel to the need to understanding the mechanisms underlying HS formation, a prognostic tool is needed. The objective was to determine whether (systemic) i...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: de Bakker E,van der Putten MAM,Heymans MW,Spiekstra SW,Waaijman T,Butzelaar L,Negenborn VL,Beekman VK,Akpinar EO,Rustemeyer T,Niessen FB,Gibbs S

    更新日期:2021-01-01 00:00:00

  • Highly pigmented Tg(Grm1) mouse melanoma develops non-pigmented melanoma cells in distant metastases.

    abstract::Murine model systems are critically required tools for the investigation of unknown mechanisms of melanoma development and metastasis and for developing more efficient therapies. The Tg(Grm1)EPv melanoma mouse model is characterized by spontaneous development of pigmented cutaneous melanomas at hairless skin regions, ...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Schiffner S,Chen S,Becker JC,Bosserhoff AK

    更新日期:2012-10-01 00:00:00

  • A single sub-erythematous exposure of solar-simulated radiation on the elicitation phase of contact hypersensitivity induces IL-10-producing T-regulatory cells in human skin.

    abstract::Solar ultraviolet (UV) radiation has hazardous effects on human health that are, in part, associated with its immunosuppressive effects via the induction of interleukin (IL)-10 production. Although IL-10 is produced by both T helper type 2 (Th2) cells and T-regulatory type 1 (Tr1) cells, the relative contribution of e...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Stoebner PE,Rahmoun M,Ferrand C,Meunier L,Yssel H,Pène J

    更新日期:2006-08-01 00:00:00

  • Comparison of two in vitro dendritic cell maturation models for screening contact sensitizers using a panel of methacrylates.

    abstract::Allergen-induced emigration and maturation of dendritic cells (DC) are pivotal steps in sparking off allergic contact dermatitis. In vitro models, reflecting these steps, may provide tools for assessment of sensitizing capacities of putative contact allergens. Here, we evaluated the applicability of such models for a ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Rustemeyer T,Preuss M,von Blomberg BM,Das PK,Scheper RJ

    更新日期:2003-10-01 00:00:00

  • Upregulation and nuclear localization of TNF-like cytokine 1A (TL1A) and its receptors DR3 and DcR3 in psoriatic skin lesions.

    abstract::TNF is critically involved in the pathogenesis of psoriasis. TL1A is a TNF-like cytokine, which, after binding to death domain receptor DR3, provides costimulatory signals to lymphocytes, amplifies Th1- and Th17-mediated immune responses and induces apoptotic cell death. These functions are inhibited when TL1A associa...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Bamias G,Evangelou K,Vergou T,Tsimaratou K,Kaltsa G,Antoniou C,Kotsinas A,Kim S,Gorgoulis V,Stratigos AJ,Sfikakis PP

    更新日期:2011-09-01 00:00:00

  • Role of protease-activated receptors in human skin fibrosis and scleroderma.

    abstract::Proteases and their receptors have poorly understood roles in skin fibrosis and systemic scleroderma (SSc). We examined the role of protease-activated receptors (PAR(1) and PAR(2) ) in the pathophysiology of human SSc and skin fibrosis. Immunohistochemistry showed that PAR(1) immunoreactivity was positive in fibroblas...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Cevikbas F,Seeliger S,Fastrich M,Hinte H,Metze D,Kempkes C,Homey B,Steinhoff M

    更新日期:2011-01-01 00:00:00

  • Tumor-educated myeloid cells: impact the micro- and macroenvironment.

    abstract::Immune escape mechanisms of cancers include some of the mechanisms normally used for immune homeostasis, particular those preventing autoimmunity; one of these is the polarisation of myeloid cells. Thereby, tumors, i.e. the cancerous and stromal cells, also condition distant sites like spleen and bone marrow via solub...

    journal_title:Experimental dermatology

    pub_type: 评论,杂志文章


    authors: Becker JC

    更新日期:2014-03-01 00:00:00

  • The molecular determinants of sunburn cell formation.

    abstract::Sunburn cell (SBC) formation in the epidermis is a characteristic consequence of ultraviolet radiation (UVR) exposure at doses around or above the minimum erythema dose. SBC have been identified morphologically and biologically as keratinocytes undergoing apoptosis. There is evidence that SBC formation is a protective...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Murphy G,Young AR,Wulf HC,Kulms D,Schwarz T

    更新日期:2001-06-01 00:00:00

  • Accelerated differentiation of melanocyte stem cells contributes to the formation of hyperpigmented maculae.

    abstract::It has been reported that the abnormal regulation of melanocyte stem cells (McSCs) causes hair greying; however, little is known about the role of McSCs in skin hyperpigmentation such as solar lentigines (SLs). To investigate the involvement of McSCs in SLs, the canonical Wnt signalling pathway that triggers the diffe...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Yamada T,Hasegawa S,Inoue Y,Date Y,Arima M,Yagami A,Iwata Y,Takahashi M,Yamamoto N,Mizutani H,Nakata S,Matsunaga K,Akamatsu H

    更新日期:2014-09-01 00:00:00

  • E- and P-cadherin expression during murine hair follicle morphogenesis and cycling.

    abstract::The role of adhesion molecules in the control of hair follicle (HF) morphogenesis, regression and cycling is still rather enigmatic. Since the adhesion molecules E- and P-cadherin (Ecad and Pcad) are functionally important, e.g. during embryonic pattern formation, we have studied their expression patterns during neona...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Müller-Röver S,Tokura Y,Welker P,Furukawa F,Wakita H,Takigawa M,Paus R

    更新日期:1999-08-01 00:00:00

  • Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation.

    abstract::The bioactive lysophospholipid sphingosine-1-phosphate (S1P) is best known for its activity as T-cell-active chemoattractant regulating the egress of T cells from the lymph node and, consequently, the availability of T cells for migration into peripheral tissues. This physiological role of S1P is exploited by the drug...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Thieme M,Zillikens D,Sadik CD

    更新日期:2017-03-01 00:00:00

  • Commentary on the practical guide for the study of sebaceous glands.

    abstract::For many years, the function of the sebaceous gland (SG) was underestimated and suggested by Albert M. Kligman as a remnant of human development, a 'living fossil with a past but no future'. However, the last two decades of studies and the discovery of neuro-endocrine pathways in skin have determined the importance of...

    journal_title:Experimental dermatology

    pub_type: 评论,杂志文章


    authors: Nejati R,Skobowiat C,Slominski AT

    更新日期:2013-10-01 00:00:00

  • Suppression of UV-induced damage by a liposomal sunscreen: a prospective, open-label study in patients with cutaneous lupus erythematosus and healthy controls.

    abstract::This study aimed to determine whether a broad-spectrum liposomal sunscreen with a very high sun protection factor (Daylong actinica) can prevent damage induced by ultraviolet (UV) irradiation in patients with cutaneous lupus erythematosus (CLE) and healthy controls (HCs) under standardised conditions. In 20 patients w...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Patsinakidis N,Wenzel J,Landmann A,Koch R,Gerß J,Luger TA,Metze D,Surber C,Kuhn A

    更新日期:2012-12-01 00:00:00

  • Inflammatory skin is associated with changes in the skin microbiota composition on the back of severe acne patients.

    abstract::Acne is the most common inflammatory skin disease, affecting up to 85% of the 11-30 years old world population. Skin microbiota appears as a key player involved in several skin dermatoses physiopathology. Here, we show that inflammatory skin is associated with changes in the skin microbiota composition on the back of ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Dagnelie MA,Montassier E,Khammari A,Mounier C,Corvec S,Dréno B

    更新日期:2019-08-01 00:00:00

  • T-cell receptor gene rearrangement studies as a diagnostic tool in lymphoproliferative skin diseases.

    abstract::The growth of our knowledge in T-cell biology, in particular the molecular biology of the T-cell receptor (TCR), has provided a means to molecularly characterize lymphoproliferative diseases of the skin based on the presence or absence of a clonal population of T lymphocytes. TCR gene rearrangement studies, by Souther...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Lessin SR,Rook AH

    更新日期:1993-03-01 00:00:00

  • Melanoma risk alleles are associated with downregulation of the MTAP gene and hypermethylation of a CpG island upstream of the gene in dermal fibroblasts.

    abstract::Several association studies and GWAS on melanoma skin cancer risk have reported statistically significant signals on 9p21.3 region, where MTAP gene maps. None of the associated SNPs identified in these studies lie in the coding region of the gene and the causative relation of risk alleles with melanoma predisposition ...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Sangalli A,Malerba G,Tessari G,Rodolfo M,Gomez-Lira M

    更新日期:2017-08-01 00:00:00

  • Methods of hair loss evaluation: a comparison of TrichoScan(®) with the modified wash test.

    abstract::The reliability of the methods currently used for diagnosing hair loss is ill defined. We studied 41 subjects complaining of hair loss, including androgenetic alopecia and telogen effluvium, and compared the results obtained with the modified wash test (MWT) and TrichoScan(®) . Data were analysed statistically with th...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Guarrera M,Fiorucci MC,Rebora A

    更新日期:2013-07-01 00:00:00

  • Enzyme-linked immunosorbent assay using multimers of the 16th non-collagenous domain of the BP180 antigen for sensitive and specific detection of pemphigoid autoantibodies.

    abstract::Bullous pemphigoid (BP) and pemphigoid gestationis (PG) are acquired autoimmune subepidermal blistering diseases characterized by autoantibodies against the hemidesmosomal proteins BP180/type XVII collagen and BP230. In the vast majority of BP and PG patients, these autoantibodies bind to epitopes clustered within the...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Sitaru C,Dähnrich C,Probst C,Komorowski L,Blöcker I,Schmidt E,Schlumberger W,Rose C,Stöcker W,Zillikens D

    更新日期:2007-09-01 00:00:00

  • Long non-coding RNA TSIX is upregulated in scleroderma dermal fibroblasts and controls collagen mRNA stabilization.

    abstract::Long non-coding RNAs (lncRNAs) are thought to have various functions other than RNA silencing. We tried to evaluate the expression of lncRNAs in patients with systemic sclerosis (SSc) and determined whether lncRNAs controls collagen expression in dermal fibroblasts. lncRNA expression was determined by real-time PCR an...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Wang Z,Jinnin M,Nakamura K,Harada M,Kudo H,Nakayama W,Inoue K,Nakashima T,Honda N,Fukushima S,Ihn H

    更新日期:2016-02-01 00:00:00

  • How to define chronic pruritus: Symptom or disease?

    abstract::Chronic pruritus (CP) is defined by itching lasting 6 weeks or more and is known to be both a highly prevalent and burdensome symptom of many pruritogenic diseases. Its status as a symptom has many implications mainly that the symptom should evolve and subside with the disease. However, according to the clinical exper...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Ständer S

    更新日期:2019-12-01 00:00:00

  • Curcumin nanoparticles as a photoprotective adjuvant.

    abstract::With rising skin cancer rates and interest in preventing photoaging, adjuvants for sunscreens are in high demand. The potential of curcumin has been posited due to its anti-inflammatory, antioxidant and wound healing properties. In prior studies, curcumin decreased UV-induced inflammation, apoptotic changes in human k...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Adusumilli NC,Mordorski B,Nosanchuk J,Friedman JM,Friedman AJ

    更新日期:2021-01-15 00:00:00

  • Molecular genetics of pseudoxanthoma elasticum.

    abstract::Pseudoxanthoma elasticum (PXE), a systemic heritable connective tissue disorder, is characterized by progressive calcification of elastic structures in the skin, the eyes and the cardiovascular system, with considerable intra- and interfamilial phenotypic variability. Recently, underlying genetic defects have been ide...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Ringpfeil F,Pulkkinen L,Uitto J

    更新日期:2001-08-01 00:00:00

  • The continued use of sunscreen prevents the development of actinic keratosis in aged Japanese subjects.

    abstract::It is well known that the trigger for actinic keratosis (AK) mainly depends on UV exposure. We evaluated the effects of long-term use of sunscreen on the histopathological and dermoscopic changes of AK in aged patients. Eighteen months use of sunscreen produced no change in the number of actinic keratoses or the advan...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Kunimoto K,Furukawa F,Uede M,Mizuno M,Yamamoto Y

    更新日期:2016-08-01 00:00:00

  • Expression of the C-C chemokine MIP-3 alpha/CCL20 in human epidermis with impaired permeability barrier function.

    abstract::External assault to the skin is followed by an epidermal response including synthesis of DNA, lipids, cytokines and migration of antigen presenting cells. MIP-3 alpha (CCL20, LARC, Exodus-1, Scya20) is a recently described C-C chemokine, predominantly expressed in extralymphoid tissue, which is known to direct migrati...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Schmuth M,Neyer S,Rainer C,Grassegger A,Fritsch P,Romani N,Heufler C

    更新日期:2002-04-01 00:00:00

  • Melanoma never says die.

    abstract::Drug resistance in melanoma is commonly attributed to ineffective apoptotic pathways. Targeting apoptosis regulators is thus considered a promising approach to sensitizing melanoma to therapy. In the previous issue of Experimental Dermatology, Plötz and Eberle discuss the role that apoptosis plays in melanoma progress...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Haass NK,Schumacher U

    更新日期:2014-07-01 00:00:00