Increased expression of ICAM-1, E-selectin, and VCAM-1 by cultured human endothelial cells upon exposure to haptens.

abstract：:SHARPIN is an important component of the linear ubiquitin chain assembly complex (LUBAC). Loss of function of SHARPIN results in eosinophilic inflammation in multiple organs including skin with Th2 -dominant cytokines and dysregulated development of lymphoid tissues in mice. The clinicopathological features are simila...

journal_title：Experimental dermatology

authors： Tang L,Wang J,Zhu J,Liang Y

更新日期：2018-12-01 00:00:00

abstract：:Skin irritation is one of the most common adverse reactions in hydroquinone (HQ) and retinoic acid (RA). Although melanocytes have rarely been considered to be involved in skin irritation, RA and particularly HQ could induce melanocyte toxicity, resulting in depigmentation. We chose S100B as a candidate gene for melan...

journal_title：Experimental dermatology

authors： Cheong KA,Noh M,Kim CH,Lee AY

更新日期：2014-03-01 00:00:00

abstract：:Opioids exert major effects not only in the central nervous system but also in immune responses. We investigated the effects of μ-opioid peptides, secreted by tumor cells, on anti-tumor immune responses. For this purpose, tumor growth was studied in wild-type and μ-opioid receptor-deficient (MOR-/-) mice injected with...

journal_title：Experimental dermatology

authors： Boehncke S,Hardt K,Schadendorf D,Henschler R,Boehncke WH,Duthey B

更新日期：2011-01-01 00:00:00

abstract：:Portulaca oleracea extracts, known as Ma Chi Hyun in the traditional Korean medicine, show a variety of biomedical efficacies including those in anti-inflammation and anti-allergy. In this study, we investigate the protective activity of the P. oleracea extracts against UVB-induced damage in human epithelial keratinoc...

journal_title：Experimental dermatology

authors： Lee S,Kim KH,Park C,Lee JS,Kim YH

更新日期：2014-10-01 00:00:00

abstract：:A feature of black African hair is an apparent increased fragility of the hair shaft compared to other ethnic groups (as measured by the tensile force needed to break the hair fibre). This has certain similarities to that reported for trichorrhexis nodosa (weathering secondary to physical damage) and trichothiodystrop...

journal_title：Experimental dermatology

authors： Khumalo NP,Dawber RP,Ferguson DJ

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Methylenetetrahydrofolate reductase (MTHFR) is involved in the formation of methyl donors, which contribute to DNA methylation. DNA methylation is an essential epigenetic feature playing a critical role in gene regulation and cellular differentiation. In addition, MTHFR activity affects plasma homocysteine l...

journal_title：Experimental dermatology

authors： Weger W,Hofer A,Stanger O,Wolf P,El-Shabrawi Y,Renner W,Kerl H,Salmhofer W

更新日期：2008-09-01 00:00:00

abstract：:Nitric oxide (NO) is a reactive endogenous molecule with multiple functions including inflammation and immunity. NO stimulates melanogenesis by activating soluble guanylyl cyclase (sGC) resulting in increases in intracellular guanosine 3',5'-cyclic monophosphate (cGMP). In vitro experiments showed that NO could inhibi...

journal_title：Experimental dermatology

authors： Ivanova K,van den Wijngaard R,Gerzer R,Lamers WH,Das PK

更新日期：2005-06-01 00:00:00

abstract：:To determine the therapeutic mechanism of PUVA in psoriasis vulgaris, the effects of PUVA on activated T lymphocytes were investigated in vitro. Peripheral blood mononuclear cells (PBMC) obtained from healthy volunteers were activated with Con A stimulation (Con A blasts). Both untreated PBMC and Con A blasts were irr...

journal_title：Experimental dermatology

authors： Urano K,Matsuyama T,Urano R,Matsuo I,Habu S

更新日期：1995-02-01 00:00:00

abstract：:We investigated the effects of a single dose of mouse interleukin-31 (IL-31) on scratching behaviour in comparison with spontaneous skin-lesion- or serotonin (5-HT)- induced scratching behaviour in NC/Nga and BALB/c mice. Intradermal (i.d.) injection of IL-31 caused a gradual increase in long-lasting scratching (LLS, ...

journal_title：Experimental dermatology

authors： Arai I,Tsuji M,Takeda H,Akiyama N,Saito S

更新日期：2013-10-01 00:00:00

abstract：:Immune escape mechanisms of cancers include some of the mechanisms normally used for immune homeostasis, particular those preventing autoimmunity; one of these is the polarisation of myeloid cells. Thereby, tumors, i.e. the cancerous and stromal cells, also condition distant sites like spleen and bone marrow via solub...

journal_title：Experimental dermatology

authors： Becker JC

更新日期：2014-03-01 00:00:00

abstract：:It is not clear whether TNF-α antagonists used in the treatment of psoriasis need to act systemically, or whether local inhibition of skin-produced TNF-α would be sufficient to silence skin inflammation. To answer this question, we conducted two multicentre, double-blinded, randomized, placebo-controlled clinical tria...

journal_title：Experimental dermatology

authors： Tsianakas A,Brunner PM,Ghoreschi K,Berger C,Loser K,Röcken M,Stingl G,Luger T,Jung T

更新日期：2016-06-01 00:00:00

abstract：:Pro- and anti-apoptotic members of the Bcl-2 family are fundamental in the control of apoptosis. Among them, Bax plays a key role in apoptosis induction by mediating the release of apoptogenic factors from mitochondria to the cytosol. In this report, we investigated, by immunohistofluorescence, the in vivo distributio...

journal_title：Experimental dermatology

authors： Zuliani T,Obriot H,Tual M,Lachman-Weber N,Dumas M,Formstecher P,Polakowska R,Ratinaud MH

更新日期：2008-02-01 00:00:00

abstract：:Vitiligo is a chronic skin disease characterized by the appearance of zones of depigmentation. It is mostly described as an autoimmune disease in which the immune system destroys the melanocytes. Consistent with this origin, genetic studies have implicated genes encoding proteins mediating the immune response targetin...

journal_title：Experimental dermatology

authors： Delmas V,Larue L

更新日期：2019-06-01 00:00:00

abstract：:We applied atomic force microscopy (AFM) to visualize ultrastructural changes of the keratinocyte morphology after narrow-band ultraviolet B (NB-UVB) irradiation. Immortalized human keratinocytes were cultured under standard conditions, irradiated with NB-UVB light at doses ranging from 50 to 800 mJ/cm2 and imaged by ...

journal_title：Experimental dermatology

authors： Reich A,Lehmann B,Meurer M,Muller DJ

更新日期：2007-12-01 00:00:00

abstract：:Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well-known corticosteroid treatments, H1 receptor (H1R) antagonists also have been used. This study observed effects of histamine H4 receptor (H4R) antagonist usage with H1R antagonist in a murine chronic...

journal_title：Experimental dermatology

authors： Matsushita A,Seike M,Okawa H,Kadawaki Y,Ohtsu H

更新日期：2012-09-01 00:00:00

abstract：:A number of single gene mutations in laboratory mice produce hair follicle defects resulting in deformed hair shafts. The radiation-induced (SB/LeJ-Foxq1(sa)) satin mutant mice have a satin-like sheen to their hair and dilute colouration. This sheen is due to failure of the hair shafts to develop normal medullas, whil...

journal_title：Experimental dermatology

authors： Wu B,Herbert Pratt C,Potter CS,Silva KA,Kennedy V,Sundberg JP

更新日期：2013-03-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play a critical role in various pathological conditions including cutaneous inflammation. Thus far, serial assessment of MMP activity in ongoing inflammation is hampered due to technical limitations. Here, we present an innovative method for longitudinal detection of MMP activity by in...

journal_title：Experimental dermatology

authors： Steingräber AK,Schelhaas S,Faust A,Jacobs AH,Schäfers M,Goerge T

更新日期：2013-11-01 00:00:00

abstract：:The bioactive lysophospholipid sphingosine-1-phosphate (S1P) is best known for its activity as T-cell-active chemoattractant regulating the egress of T cells from the lymph node and, consequently, the availability of T cells for migration into peripheral tissues. This physiological role of S1P is exploited by the drug...

journal_title：Experimental dermatology

authors： Thieme M,Zillikens D,Sadik CD

更新日期：2017-03-01 00:00:00

abstract：:It is widely recognized that tobacco smoke causes skin pigmentation. No studies, however, have directly evaluated the mechanisms of the changes in smoker's skin pigmentation. In this study, when cultured with water-soluble tobacco smoke extract, the human epidermal melanocytes grew to a large size and produced more me...

journal_title：Experimental dermatology

authors： Nakamura M,Ueda Y,Hayashi M,Kato H,Furuhashi T,Morita A

更新日期：2013-08-01 00:00:00

abstract：:Dermatitis herpetiformis (DH) is a blistering skin disease characterized by cutaneous deposits of IgA and an associated, most often asymptomatic, gluten sensitive enteropathy (GSE). Gluten sensitive enteropathy is also seen in patients that do not have skin disease or cutaneous IgA deposits, but do have significant ga...

journal_title：Experimental dermatology

authors： Hall RP 3rd,Owen S,Smith A,Keough M,Bagheri B,Church P,Streilein R

更新日期：2000-08-01 00:00:00

abstract：:Although several cytokines and chemokines have been investigated as possible mediators of fibrosis in systemic sclerosis (SSc), specific correlation between cytokines and organ involvement have not been found yet, and a cytokine profile characteristic of SSc is far to be identified. We studied the profile of antifibro...

journal_title：Experimental dermatology

authors： Gonçalves RSG,Pereira MC,Dantas AT,Almeida AR,Rego MJBM,Lima EA,Pitta IDR,Duarte ALBP,Pitta MGDR

更新日期：2019-10-01 00:00:00

abstract：:Using the indirect immunohistochemical approach, the occurrence of gamma-melanocyte stimulating hormone (gamma-MSH)-like immunoreactivity in human normal keratinocytes is described. The positive cells were observed in each layer of the epidermis (except stratum corneum) and often, at the level of the stratum spinosum,...

journal_title：Experimental dermatology

authors： Johansson O,Liu PY

更新日期：1993-10-01 00:00:00

abstract：:We previously reported that sphingosine-1-phosphate (S1P) decreases melanin synthesis via extracellular signal-regulated protein kinase (ERK) activation and microphthalmia-associated transcription factor (MITF) degradation. Although FTY720 is an S1P structural analogue, the effects of FTY720 on melanogenesis are not c...

journal_title：Experimental dermatology

authors： Lee JE,Kim SY,Jeong YM,Yun HY,Baek KJ,Kwon NS,Park KC,Kim DS

更新日期：2011-03-01 00:00:00

abstract：:Topical photodynamic therapy with 5-aminolevulinic acid (5-ALA) is a newly established treatment modality for epithelial skin cancer. Skin distribution of different 20% 5-ALA formulations was investigated by detection of protoporphyrin IX (PpIX) using an ex vivo porcine skin model. Fluorescence of PpIX was first detec...

journal_title：Experimental dermatology

authors： Maisch T,Worlicek C,Babilas P,Landthaler M,Szeimies RM

更新日期：2008-10-01 00:00:00

abstract：:5-methoxypsoralen (5-MOP) is considered an alternative to 8-methoxypsoralen (8-MOP) for photochemotherapy of psoriasis. We have compared the clinical efficacy and tolerability of 5-MOP (1.2 mg/kg)-UVA versus 8-MOP (0.6 mg/kg)-UVA therapy in 25 patients of skin type III and IV, affected by relapsing plaque-type psorias...

journal_title：Experimental dermatology

authors： Calzavara-Pinton P,Ortel B,Carlino A,Honigsmann H,De Panfilis G

更新日期：1992-07-01 00:00:00

abstract：:Infiltration of eosinophils in atopic dermatitis (AD), which contains inflammatory molecules and cytokines, recruits more inflammatory cells and causes further skin damage. Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine that induces the proinflammatory Th2 immune response and plays an important role in ...

journal_title：Experimental dermatology

authors： Noh JY,Shin JU,Park CO,Lee N,Jin S,Kim SH,Kim JH,Min A,Shin MH,Lee KH

更新日期：2016-11-01 00:00:00

abstract：:Newborn foreskin and adult skin keratinocytes (KTs) were cultured in 24-well plates using keratinocyte basal medium (KBM) either alone or supplemented with epidermal growth factor (EGF) or nerve growth factor (NGF), plus one of the following: insulin (INS), insulin-like growth factors (IGF)-1 or -2, transforming growt...

journal_title：Experimental dermatology

authors： Wilkinson DI,Theeuwes MJ,Farber EM

更新日期：1994-10-01 00:00:00

abstract：:Somatostatin (SST) is a regulatory peptide hormone that acts through five different G protein-coupled receptors (SSTR1-5). Whereas expression of all five SSTR subtypes in epidermis has been shown, the biological relevance of the SST/SSTR system in the skin is completely unknown. We show here that SST is expressed in h...

journal_title：Experimental dermatology

authors： Vockel M,Breitenbach U,Kreienkamp HJ,Brandner JM

更新日期：2010-10-01 00:00:00

abstract：:Ultraviolet (UV) radiation contained in sunlight is considered a major risk in the induction of skin cancer. While mast cells are best known for their role in allergic responses, they have also been shown to play a crucial role in suppressing the anti-tumour immune response following UV exposure. Evidence is now emerg...

journal_title：Experimental dermatology

authors： Sarchio SN,Kok LF,O'Sullivan C,Halliday GM,Byrne SN

更新日期：2012-04-01 00:00:00

abstract：:There have been several studies on the role of the monocyte chemotactic protein-1/C-C chemokine receptor type 2 (CCR2) signalling pathway in fibrotic diseases, which identified the blockade of this pathway as a potential therapeutic target for treating fibrosis. We examined the efficacy of CCR2 antagonist (RS-504393) ...

journal_title：Experimental dermatology

authors： Ishikawa M,Yamamoto T

更新日期：2021-01-01 00:00:00