Abstract:
:Pheomelanin is supposed to be the first type of melanin found in vertebrates, in contrast to the main type - eumelanin. Our study aimed at detecting pheomelanin in the skin of Hymenochirus boettgerii. We employed electron paramagnetic resonance (EPR) spectroscopy, and transmission electron microscopy (TEM), supplemented with standard histology and immunochemistry. We identified pheomelanin in the dorsal skin of adult frogs (not only in the dermis, but also in the epidermis) and in the dorsal tadpole. Our work identifies Hymenochirus boettgerii as a model in the basic study on the mechanism, evolution and role of melanogenesis in animals, including human.
journal_name
Exp Dermatoljournal_title
Experimental dermatologyauthors
Wolnicka-Glubisz A,Pecio A,Podkowa D,Kolodziejczyk LM,Plonka PMdoi
10.1111/j.1600-0625.2012.01511.xsubject
Has Abstractpub_date
2012-07-01 00:00:00pages
537-40issue
7eissn
0906-6705issn
1600-0625journal_volume
21pub_type
信件abstract::Activation of peroxisome proliferator-activated receptors (PPARs) has been shown to have an important role in skin barrier function by regulating differentiation and lipid synthesis in keratinocytes. Oat (Avena sativa) has long been used as a soothing agent to relieve skin irritations, and the clinical benefits of top...
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abstract::Type-1 cytokine-producing T cells are important in the pathogenesis of psoriasis vulgaris, for which efficient therapy is provided by means of narrow-band ultraviolet-B (NB-UVB). The expression of the type-1 cytokine interferon-gamma (IFN-gamma) is regulated by interleukin-12 (IL-12), IL-15, IL-18 and IL-23; however, ...
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journal_title:Experimental dermatology
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journal_title:Experimental dermatology
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pub_type: 杂志文章,评审
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