Overcoming cell death resistance in skin cancer therapy: Novel translational perspectives.

abstract：:The expression of amphiregulin (AR) in the basal epidermis of transgenic mice [keratin 14 promoter AR gene (K14-ARGE)] has been previously shown to induce an early-onset and severe skin pathology, with many similarities to psoriasis. In this study, it is demonstrated that involucrin enhancer/promoter-dependent express...

journal_title：Experimental dermatology

authors： Cook PW,Brown JR,Cornell KA,Pittelkow MR

更新日期：2004-06-01 00:00:00

abstract：:Psoriasis is a chronic immune-mediated skin disease in which the balance in the interplay of immune cells and keratinocytes is disturbed. MicroRNAs (miRNAs) are endogenous small regulatory RNAs that stabilize cellular phenotypes and fine-tune signal transduction feedback loops through the regulation of gene networks. ...

journal_title：Experimental dermatology

authors： Pivarcsi A,Ståhle M,Sonkoly E

更新日期：2014-09-01 00:00:00

abstract：:C1 inhibitor (C1INH) plays an important role in the classical pathway of the complement system. Mutations in C1INH gene cause quantitative or qualitative deficiencies in C1INH, which can lead to hereditary angioedema (HAE) type I or II. Here, we identified a novel frame-shift mutation c.1391-1445del55 (p.v464fsx556) i...

journal_title：Experimental dermatology

authors： Qu L,Wei B,Liu M,Zhang L,Xiao T,Chen HD,Zhou L,Mi QS,He C

更新日期：2012-10-01 00:00:00

abstract：:Human follicle dermal papilla cells (FDPC) are a specialized population of mesenchymal cells located in the skin. They regulate hair follicle (HF) development and growth, and represent a reservoir of multipotent stem cells. Growing evidence supports the hypothesis that HF cycling is associated with vascular remodeling...

journal_title：Experimental dermatology

authors： Bassino E,Gasparri F,Giannini V,Munaron L

更新日期：2015-05-01 00:00:00

abstract：:It is widely recognized that tobacco smoke causes skin pigmentation. No studies, however, have directly evaluated the mechanisms of the changes in smoker's skin pigmentation. In this study, when cultured with water-soluble tobacco smoke extract, the human epidermal melanocytes grew to a large size and produced more me...

journal_title：Experimental dermatology

authors： Nakamura M,Ueda Y,Hayashi M,Kato H,Furuhashi T,Morita A

更新日期：2013-08-01 00:00:00

abstract：:This study demonstrates an innovative application of atomic force microscopy (AFM). The combination of high-resolution AFM technology and tape stripping is presented as a tool for the structure analysis of human stratum corneum (SC) at a nanometer scale. Topographic images with a vertical resolution of about 10 nm of ...

journal_title：Experimental dermatology

authors： Gorzelanny C,Goerge T,Schnaeker EM,Thomas K,Luger TA,Schneider SW

更新日期：2006-05-01 00:00:00

abstract：:Lipoid proteinosis (OMIM 247100), also known as Urbach-Wiethe disease or hyalinosis cutis et mucosae, is a rare autosomal recessive disorder characterized by generalized thickening and scarring of the skin and mucosae. In 2002, the disorder was mapped to a locus on chromosome 1q21 and pathogenic mutations were identif...

journal_title：Experimental dermatology

authors： Chan I,Liu L,Hamada T,Sethuraman G,McGrath JA

更新日期：2007-11-01 00:00:00

abstract：:Keratinocytes (KCs) play a critical role in maintaining the cutaneous structure and are involved in various physiological and pathologic processes of the skin. Many inflammatory skin diseases and skin cancers result from excessive proliferation and insufficient apoptosis of KCs. Recent data suggested that the sonic he...

journal_title：Experimental dermatology

authors： Liu H,Jian Q,Xue K,Ma C,Xie F,Wang R,Liao W,Liu Y,Chi S,Li C

更新日期：2014-12-01 00:00:00

abstract：:The present study assessed the molecular mechanism underlying ultraviolet (UV) B radiation-induced inhibition of the expression of the adhesion molecule ICAM-1 in human antigen-presenting cells (APC). UVB radiation-induced inhibition of ICAM-I expression in human peripheral blood monocytes was associated with the gene...

journal_title：Experimental dermatology

authors： Grewe M,Stege H,Vink A,Klammer M,Ruzicka T,Roza L,Krutmann J

更新日期：2000-12-01 00:00:00

abstract：:Atopic dermatitis (AD) is related to immunoglobulin E (IgE) production, and a type-1 and type-2 helper T cell (Th1/Th2) imbalance has been hypothesized as the aetiology. While itching and scratching are important factors in the development of dermatitis, the mechanisms underlying these phenomena are poorly understood....

journal_title：Experimental dermatology

authors： Hashimoto Y,Takaoka A,Sugimoto M,Honma Y,Sakurai T,Futaki N,Arai I

更新日期：2011-10-01 00:00:00

abstract：:Psoriasis is a chronic inflammatory disease, and microRNAs have been reported to regulate the pathogenesis of psoriasis. Up-regulated miR-744-3p level was identified to associate with psoriasis while the precise functions of miR-744-3p in psoriasis were not well-elucidated. We first confirmed the up-regulation of miR-...

journal_title：Experimental dermatology

authors： Wang C,Zong J,Li Y,Wang X,Du W,Li L

更新日期：2019-03-01 00:00:00

abstract：:Reverse transcriptase qPCR is the most common method to determine and compare mRNA expression levels and relies on normalization using reference genes. The expression levels of the latter, however, are themselves often variable between experimental conditions, thus compromising the results. Using the geNorm algorithm,...

journal_title：Experimental dermatology

authors： Braun A,Sezin T,Bezdek S,Doxastaki I,Zillikens D,Busch HS,Sadik CD

更新日期：2019-08-01 00:00:00

abstract：:Tetracyclines (TCN) have powerful anti-inflammatory properties in addition to their anti-microbial effects. These anti-inflammatory effects are thought to play a role in inhibiting cutaneous inflammation in patients with rosacea and acne; however, the mechanism(s) of this action remains poorly understood. We have prev...

journal_title：Experimental dermatology

authors： Bender A,Zapolanski T,Watkins S,Khosraviani A,Seiffert K,Ding W,Wagner JA,Granstein RD

更新日期：2008-09-01 00:00:00

abstract：:In this study, we determined the adiponectin expression in the serum and lesional skin of patients with scleroderma (SSc). Serum adiponectin concentrations were measured in 32 patients with SSc, 10 patients with SLE, 12 patients with dermatomyositis patients and 13 healthy subjects with specific enzyme-linked immunoso...

journal_title：Experimental dermatology

authors： Arakawa H,Jinnin M,Muchemwa FC,Makino T,Kajihara I,Makino K,Honda N,Sakai K,Fukushima S,Ihn H

更新日期：2011-09-01 00:00:00

abstract：:Newborn foreskin and adult skin keratinocytes (KTs) were cultured in 24-well plates using keratinocyte basal medium (KBM) either alone or supplemented with epidermal growth factor (EGF) or nerve growth factor (NGF), plus one of the following: insulin (INS), insulin-like growth factors (IGF)-1 or -2, transforming growt...

journal_title：Experimental dermatology

authors： Wilkinson DI,Theeuwes MJ,Farber EM

更新日期：1994-10-01 00:00:00

abstract：:Formation of a stratified epidermis is required for the performance of the essential functions of the skin; to act as an outside-in barrier against the access of microorganisms and other external factors, to prevent loss of water and solutes via inside-out barrier functions and to withstand mechanical stresses. Epider...

journal_title：Experimental dermatology

authors： Rogerson C,O'Shaughnessy RFL

更新日期：2018-08-01 00:00:00

abstract：:c-Jun, a component of the activating protein-1 transcription factor family, has been known to play an important role in the control of cell proliferation. It is also suspected to be a critical mediator of tumor promotion. However, investigations of c-Jun activation patterns in inflammatory and inflammatory transformin...

journal_title：Experimental dermatology

authors： Marceková Z,Flaig MJ,Kekus M,Ruzicka T,Rupec RA

更新日期：2010-01-01 00:00:00

abstract：:The miRNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C-ALCL) patients were analysed with miRNA microarrays using the same control group of 12 benign inflammatory dermatoses (BID) as previously used to study the miRNA expression profile of tumor-stage mycosis fungoide...

journal_title：Experimental dermatology

authors： Benner MF,Ballabio E,van Kester MS,Saunders NJ,Vermeer MH,Willemze R,Lawrie CH,Tensen CP

更新日期：2012-08-01 00:00:00

abstract：:There are few contradictory studies investigating the involvement of HPV in melanoma. We designed a controlled study to evaluate the HPV DNA prevalence in melanoma. One hundred patients with cutaneous malignant melanoma diagnosed between 2002 and 2006 were included. Complementary wide excision (healthy skin) was perfo...

journal_title：Experimental dermatology

authors： Ruer JB,Pépin L,Gheit T,Vidal C,Kantelip B,Tommasino M,Prétet JL,Mougin C,Aubin F

更新日期：2009-10-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are thought to have various functions other than RNA silencing. We tried to evaluate the expression of lncRNAs in patients with systemic sclerosis (SSc) and determined whether lncRNAs controls collagen expression in dermal fibroblasts. lncRNA expression was determined by real-time PCR an...

journal_title：Experimental dermatology

authors： Wang Z,Jinnin M,Nakamura K,Harada M,Kudo H,Nakayama W,Inoue K,Nakashima T,Honda N,Fukushima S,Ihn H

更新日期：2016-02-01 00:00:00

abstract：:Antimicrobial peptides and proteins (AMP) are highly active molecules with a broad-spectrum of microbicidal activity. Human beta-defensins (hBD)-2 and hBD-3 were initially isolated from psoriatic-scale extracts, and other AMP have been identified in high concentrations in psoriatic skin explaining the uncommonness of ...

journal_title：Experimental dermatology

authors： Steinz K,Schubert S,Harder J,Gerdes S,Mrowietz U,Gläser R

更新日期：2014-11-01 00:00:00

abstract：:In this study, we analysed the modulation of keratinocyte growth factor (KGF) mRNA expression in human dermal fibroblasts cultured either in monolayer or within a collagen matrix (dermal equivalent). In monolayer cultures, KGF expression by quiescent fibroblasts was stimulated by different growth substances such as se...

journal_title：Experimental dermatology

authors： Le Panse R,Bouchard B,Lebreton C,Coulomb B

更新日期：1996-04-01 00:00:00

abstract：:Sunburn cell (SBC) formation in the epidermis is a characteristic consequence of ultraviolet radiation (UVR) exposure at doses around or above the minimum erythema dose. SBC have been identified morphologically and biologically as keratinocytes undergoing apoptosis. There is evidence that SBC formation is a protective...

journal_title：Experimental dermatology

authors： Murphy G,Young AR,Wulf HC,Kulms D,Schwarz T

更新日期：2001-06-01 00:00:00

abstract：:Irradiation of human keratinocytes with UVB (280-320 nm) in vitro and in vivo activates the metabolism of 7-dehydrocholesterol to hormonally active calcitriol. The production of calcitriol in the skin strongly depends on the photosynthesis of vitamin D(3) which is biologically inactive in the first instance. Vitamin D...

journal_title：Experimental dermatology

authors： Lehmann B

更新日期：2009-02-01 00:00:00

abstract：:The skin forms a barrier that prevents dehydration and keeps us safe from pathogens. To ensure proper function, the skin possesses a myriad of stem cell populations that are essential for maintenance and repair upon damage. In order to protect, the skin is also an active immunological site, with abundant resident immu...

journal_title：Experimental dermatology

authors： Agudo J

更新日期：2020-10-26 00:00:00

abstract：BACKGROUND:The accuracy of diagnosis of skin cancer and especially of early malignant melanoma is most important to reduce its morbidity and mortality. Previous pilot studies using electrical impedance measurements indicate statistically significant accuracies for the detection of skin cancer. OBJECTIVES:The aim of th...

journal_title：Experimental dermatology

authors： Aberg P,Birgersson U,Elsner P,Mohr P,Ollmar S

更新日期：2011-08-01 00:00:00

abstract：:Plasmatic proteasome (p-proteasome) also called circulating proteasome has recently been described as a tumor marker. We investigated the diagnostic and prognostic accuracies of p-proteasome levels in a melanoma population classified according to the American Joint Committee on Cancer staging system. Using an ELISA te...

journal_title：Experimental dermatology

authors： Henry L,Lavabre-Bertrand T,Douche T,Uttenweiler-Joseph S,Fabbro-Peray P,Monsarrat B,Martinez J,Meunier L,Stoebner PE

更新日期：2010-12-01 00:00:00

abstract：:Keloids are fibrous overgrowth induced by cutaneous injury. The pathogenesis of keloids is poorly understood, and no convincing animal model exists. Current hypotheses of the pathogenesis classify keloids as an entity of aberrant fibrosis. Hyperactivation of the MCP-1/CCR2 axis reportedly causes fibrosis in liver cirr...

journal_title：Experimental dermatology

authors： Liao WT,Yu HS,Arbiser JL,Hong CH,Govindarajan B,Chai CY,Shan WJ,Lin YF,Chen GS,Lee CH

更新日期：2010-08-01 00:00:00

abstract：:Activating transcription factor 3 (ATF3) expression is increased in erythema multiforme and is regulated by IFN-gamma in human keratinocytes. Experimental Dermatology 2010; 19: e310-e313. Abstract: Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP responsive element-binding protein (CREB) fami...

journal_title：Experimental dermatology

authors： Pollack BP,Sapkota B,Haun PL

更新日期：2010-08-01 00:00:00

abstract：:Skin barrier damage induces various harmful or even protective reactions in the skin, as represented by enhancement of keratinocyte cytokine production. To investigate whether acute removal of stratum corneum modulates the production of chemokines by epidermal cells, we treated ears of BALB/c and C57BL/6 mice by tape-...

journal_title：Experimental dermatology

authors： Onoue A,Kabashima K,Kobayashi M,Mori T,Tokura Y

更新日期：2009-12-01 00:00:00