Inhibition of intercellular adhesio nmolecule-1 (ICAM-1) expression in ultraviolet B-irradiated human antigen-presenting cells is restored after repair of cyclobutane pyrimidine dimers.

abstract：:Tissue-invasive T cells are observed in many inflammatory dermatological diseases, but in most cases, it is not known how they were attracted, what they might recognize, and to which extent they are activated. Answering these questions is surely essential for understanding pathogeneses of the diseases. In a recent iss...

journal_title：Experimental dermatology

authors： Dornmair K

更新日期：2014-06-01 00:00:00

abstract：:The pathogenesis of lichen sclerosus remains unknown. However, it has been frequently associated clinically with autoimmunity. The MHC haplotype A1, B8, DR3 is associated with many autoimmune conditions and has also been associated with the uncommon allele of the tumour necrosis factor (TNF-alpha) promoter polymorphis...

journal_title：Experimental dermatology

authors： Clay FE,Cork MJ,Wilson AG,Crane AM,Lewis F,Harrington CI,Duff GW

更新日期：1996-08-01 00:00:00

abstract：:Activation of peroxisome proliferator-activated receptors (PPARs) has been shown to have an important role in skin barrier function by regulating differentiation and lipid synthesis in keratinocytes. Oat (Avena sativa) has long been used as a soothing agent to relieve skin irritations, and the clinical benefits of top...

journal_title：Experimental dermatology

authors： Chon SH,Tannahill R,Yao X,Southall MD,Pappas A

更新日期：2015-04-01 00:00:00

abstract：:Given that metastasized melanoma is a fatal disease in most cases, it is tempting to develop strategies to a priori prevent metastasis. We have stimulated the pulmonary innate immune system by macrophage-activating lipopeptide-2 (MALP-2), a specific agonist at Toll-like receptor (TLR) 2/6, and investigated its impact ...

journal_title：Experimental dermatology

authors： Schill T,Schön MP,Pletz N,Emmert S,Schön M

更新日期：2012-02-01 00:00:00

abstract：:A feature of black African hair is an apparent increased fragility of the hair shaft compared to other ethnic groups (as measured by the tensile force needed to break the hair fibre). This has certain similarities to that reported for trichorrhexis nodosa (weathering secondary to physical damage) and trichothiodystrop...

journal_title：Experimental dermatology

authors： Khumalo NP,Dawber RP,Ferguson DJ

更新日期：2005-04-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) gene amplification and protein overexpression are common in several cancers. EGFR status has seldom been studied in cutaneous squamous carcinomas (SCCs), or their precursors, actinic keratoses (AKs). We evaluated the presence of EGFR genomic aberrations and EGFR protein overexpr...

journal_title：Experimental dermatology

authors： Toll A,Salgado R,Yébenes M,Martín-Ezquerra G,Gilaberte M,Baró T,Solé F,Alameda F,Espinet B,Pujol RM

更新日期：2010-02-01 00:00:00

abstract：:Intraepithelial gammadelta T cells are increased in the inflamed small bowel and are also found in increased numbers in cutaneous lesions from patients with dermatitis herpetiformis (DH). Thus, these cells might play an important role in the pathogenesis of the disease. We investigated the T-cell receptor (TCR) delta ...

journal_title：Experimental dermatology

authors： Holtmeier W,Pfänder M,Zollner TM,Kaufmann R,Caspary WF

更新日期：2002-12-01 00:00:00

abstract：:Patients belonging to xeroderma pigmentosum (XP) complementation group C comprise one-third of all XP patients. Only four major reports compiled larger groups of XP-C patients from southern Europe (12 pts), North America (16 pts) and Africa (14 and 56 pts) as well as their genetic background (46 XPC mutations). We ide...

journal_title：Experimental dermatology

authors： Schäfer A,Hofmann L,Gratchev A,Laspe P,Schubert S,Schürer A,Ohlenbusch A,Tzvetkov M,Hallermann C,Reichrath J,Schön MP,Emmert S

更新日期：2013-01-01 00:00:00

abstract：:The miRNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C-ALCL) patients were analysed with miRNA microarrays using the same control group of 12 benign inflammatory dermatoses (BID) as previously used to study the miRNA expression profile of tumor-stage mycosis fungoide...

journal_title：Experimental dermatology

authors： Benner MF,Ballabio E,van Kester MS,Saunders NJ,Vermeer MH,Willemze R,Lawrie CH,Tensen CP

更新日期：2012-08-01 00:00:00

abstract：:Rosacea is one of the most common dermatoses of adults. Although the detailed pathophysiology remains unknown, it is thought that rosacea is caused by a consistently aberrant, innate immune response, and that LL-37 plays an important role. However, involvement of the inflammatory cytokine IL-33 has not yet been studie...

journal_title：Experimental dermatology

authors： Suhng E,Kim BH,Choi YW,Choi HY,Cho H,Byun JY

更新日期：2018-09-01 00:00:00

abstract：:Second-harmonic-generation (SHG) microscopy is a powerful tool for in vivo visualisation of collagen fibres in human skin because of its specific collagen selectivity without the need for staining, non-invasiveness and high-resolution three-dimensional imaging. Although texture analysis of SHG images is a promising me...

journal_title：Experimental dermatology

authors： Ogura Y,Tanaka Y,Hase E,Yamashita T,Yasui T

更新日期：2019-08-01 00:00:00

abstract：:We have previously reported that lymph node cells generated chemotactic factors for Langerhans cells (LCs) in the induction phase of contact dermatitis. In order to clarify the chemotactic factors involved in migration to the regional lymph nodes, we investigated the migratory activity of murine LCs toward several cyt...

journal_title：Experimental dermatology

authors： Yamazaki S,Yokozeki H,Satoh T,Katayama I,Nishioka K

更新日期：1998-02-01 00:00:00

abstract：:The process of skin wound healing involves the following three steps: inflammation, tissue formation and tissue remodelling. These optimal steps are required for the development of normal wound healing. Recent reports demonstrated that inflammasomes are involved in the innate immune response. In the present study, we ...

journal_title：Experimental dermatology

authors： Ito H,Kanbe A,Sakai H,Seishima M

更新日期：2018-01-01 00:00:00

abstract：:Even though anthralin is a well-established topical therapeutic agent for psoriasis, little is known about its effects and biochemical mechanisms of signal transduction. In contrast to a previous report, we found that anthralin induced time- and concentration-dependent phosphorylation of epidermal growth factor recept...

journal_title：Experimental dermatology

authors： Peus D,Beyerle A,Vasa M,Pott M,Meves A,Pittelkow MR

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Recently, germline variants of the melanocortin-1 receptor (MC1R) have been shown to be associated with an increased risk for BRAF mutant but not BRAF wild-type cutaneous melanoma. Similar to melanoma, BRAF mutations are also commonly found in papillary thyroid carcinomas. Furthermore, patients with melanoma...

journal_title：Experimental dermatology

authors： Bauer J,Weng J,Kebebew E,Soares P,Trovisco V,Bastian BC

更新日期：2009-06-01 00:00:00

abstract：:Despite the increasing use of gene transfer strategies in the study of cellular and molecular biology, melanoma cells have remained difficult to transfect in a safe, efficient, and reproducible manner. In the present study, we report the successful use of nucleofector technology to transfect human melanoma cell lines....

journal_title：Experimental dermatology

authors： Han SY,Gai W,Yancovitz M,Osman I,Di Como CJ,Polsky D

更新日期：2008-05-01 00:00:00

abstract：:It is widely recognized that tobacco smoke causes skin pigmentation. No studies, however, have directly evaluated the mechanisms of the changes in smoker's skin pigmentation. In this study, when cultured with water-soluble tobacco smoke extract, the human epidermal melanocytes grew to a large size and produced more me...

journal_title：Experimental dermatology

authors： Nakamura M,Ueda Y,Hayashi M,Kato H,Furuhashi T,Morita A

更新日期：2013-08-01 00:00:00

abstract：:c-Jun, a component of the activating protein-1 transcription factor family, has been known to play an important role in the control of cell proliferation. It is also suspected to be a critical mediator of tumor promotion. However, investigations of c-Jun activation patterns in inflammatory and inflammatory transformin...

journal_title：Experimental dermatology

authors： Marceková Z,Flaig MJ,Kekus M,Ruzicka T,Rupec RA

更新日期：2010-01-01 00:00:00

abstract：:Current gold standard lower extremity cutaneous wound management is not always effective. Cutaneous wounds generate a "current of injury" which is directly involved in wound healing processes. Application of exogenous electrical stimulation has been hypothesised to imitate the natural electric current that occurs in c...

journal_title：Experimental dermatology

authors： Ashrafi M,Alonso-Rasgado T,Baguneid M,Bayat A

更新日期：2017-02-01 00:00:00

abstract：:The expansive use of immunosuppressive medications in fields such as transplantational medicine and oncology, the higher frequency of invasive procedures in an ageing population and the HIV/AIDS pandemic have increased the frequency of systemic fungal infections. At the same time, increased resistance of pathogenic fu...

journal_title：Experimental dermatology

authors： Mehra T,Köberle M,Braunsdorf C,Mailänder-Sanchez D,Borelli C,Schaller M

更新日期：2012-10-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play a critical role in various pathological conditions including cutaneous inflammation. Thus far, serial assessment of MMP activity in ongoing inflammation is hampered due to technical limitations. Here, we present an innovative method for longitudinal detection of MMP activity by in...

journal_title：Experimental dermatology

authors： Steingräber AK,Schelhaas S,Faust A,Jacobs AH,Schäfers M,Goerge T

更新日期：2013-11-01 00:00:00

abstract：:Contact allergens induce several accessory signals which promote the activation of antigen-specific T cells. One of these signals is the increased expression of adhesion molecules on antigen-presenting cells and endothelial cells. Epicutaneous application of non-toxic doses of 2,4-dinitrofluorobenzene (DNFB) onto the ...

journal_title：Experimental dermatology

authors： Wildner O,Lipkow T,Knop J

更新日期：1992-11-01 00:00:00

abstract：:Murine model systems are critically required tools for the investigation of unknown mechanisms of melanoma development and metastasis and for developing more efficient therapies. The Tg(Grm1)EPv melanoma mouse model is characterized by spontaneous development of pigmented cutaneous melanomas at hairless skin regions, ...

journal_title：Experimental dermatology

authors： Schiffner S,Chen S,Becker JC,Bosserhoff AK

更新日期：2012-10-01 00:00:00

abstract：:Wounds close by keratinocytes migrating from the edge of the wound and re-epithelializing the epidermis. It has been proposed that the major stimuli for wound closure are blood-derived growth factors, chemokines and cytokines. The small GTPase R-Ras, a known integrin activator, also regulates vascular permeability dur...

journal_title：Experimental dermatology

authors： Ketomäki T,Vähätupa M,May U,Pemmari T,Ruikka E,Hietamo J,Kaipiainen P,Barker H,Parkkila S,Uusitalo-Järvinen H,Järvinen TAH

更新日期：2019-02-01 00:00:00

abstract：:The contribution of immune checkpoint receptors in the immunopathogenesis of various autoimmune diseases has been addressed in previous reports. In this study,  the expression profile of T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) and programmed cell death-1 (PD-1) checkpoint molecules was investigated...

journal_title：Experimental dermatology

authors： Rahimi A,Hossein-Nataj H,Hajheydari Z,Aryanian Z,Shayannia A,Ajami A,Asgarian-Omran H

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Basal cell carcinoma (BCC) is the most common form of skin cancer with increasing incidence rates worldwide. METHODS:To assess the association of BCC with epidemiologic risk factors in a Southern European population from Greece, we conducted a hospital-based case-control study of 199 patients with BCC and 2...

journal_title：Experimental dermatology

authors： Dessinioti C,Tzannis K,Sypsa V,Nikolaou V,Kypreou K,Antoniou C,Katsambas A,Stratigos AJ

更新日期：2011-08-01 00:00:00

abstract：:Chromatin-IgG complexes appear as electron dense structures (EDS) in glomerular basement membranes in lupus nephritis. Here, we present results of comparative analyses of the composition of EDS in murine lupus dermatitis and nephritis. One focus was to perform an analytical approach to understand why such complex stru...

journal_title：Experimental dermatology

authors： Hedberg A,Fismen S,Fenton KA,Mortensen ES,Rekvig OP

更新日期：2010-08-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are non-haematopoietic cells that reside in most tissues including adult bone marrow. MSCs have recently been extensively studied and used for clinical therapies, including skin wound healing. However, there are still many questions to be answered. In the viewpoint entitled 'Mesenchymal s...

journal_title：Experimental dermatology

authors： Li X,Hamada T,Ohata C,Furumura M,Hashimoto T

更新日期：2013-08-01 00:00:00

abstract：:Alopecia areata (AA) is an autoimmune disease that results in spot baldness in humans. Adequate animal models for AA are currently lacking. The objective of this study was to elucidate the mechanism of autoimmune-like alopecia (ALA) in C57BL/6.CD80CD86-deficient (B6.CD80CD86-/- ) mice. Incidence and severity of alopec...

journal_title：Experimental dermatology

authors： Bae JH,Hwang WS,Jang YJ,Lee YH,Jang DE,Kim JS,Yeom SC

更新日期：2017-11-01 00:00:00

abstract：:Rosacea is a skin inflammatory condition accompanied by cutaneous signs such as oedema, flushing, erythema, telangiectasia and pustules. Generally, rosacea is triggered by ultraviolet B (UVB) exposure. When exposed to UVB, skin epidermis thickens and produces elevated levels of pro-inflammatory cytokines, especially k...

journal_title：Experimental dermatology

authors： Son M,Park J,Oh S,Choi J,Shim M,Kang D,Byun K

更新日期：2020-05-20 00:00:00