Abstract:
:Primary hyperhidrosis is characterized by excessive sweating in palmar, plantar and axillary body regions. Gland hypertrophy and the existence of a third type of sweat gland, the apoeccrine gland, with high fluid transporting capabilities have been suggested as possible causes. This study investigated whether sweat glands were hypertrophied in axillary hyperhidrotic patients and if mechanisms associated with fluid transport were found in all types of axillary sweat glands. The occurrence of apoeccrine sweat glands was also investigated. Axillary skin biopsies from control and hyperhidrosis patients were examined using immunohistochemistry, image analysis and immunofluorescence microscopy. Results showed that glands were not hypertrophied and that only the clear cells in the eccrine glands expressed proteins associated with fluid transport. There was no evidence of the presence of apoeccrine glands in the tissues investigated. Preliminary findings suggest the eccrine gland secretory clear cell as the main source of fluid transport in hyperhidrosis.
journal_name
Exp Dermatoljournal_title
Experimental dermatologyauthors
Bovell DL,MacDonald A,Meyer BA,Corbett AD,MacLaren WM,Holmes SL,Harker Mdoi
10.1111/j.1600-0625.2011.01361.xsubject
Has Abstractpub_date
2011-12-01 00:00:00pages
1017-20issue
12eissn
0906-6705issn
1600-0625journal_volume
20pub_type
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