Immunoreactivity of corticotropin-releasing hormone, adrenocorticotropic hormone and alpha-melanocyte-stimulating hormone in alopecia areata.


:Psychological factors are believed to play a role in the pathogenesis of alopecia areata (AA), a frequently encountered hair disorder. In our study, statistically significant elevation of psychological stress was felt by AA patients prior hair loss compared with control, which was strongly believed contributory to hair loss (t-test, P < 0.01). The corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) mRNA have been identified in the basal layer of the epidermis and pilosebaceous units of the normal scalp. And with the recent discovery of melanocytes and dermal fibroblasts capable of corticosterone production, the presence of a local stress response system resembling the hypothalamic-pituitary-adrenal (HPA) axis has been suggested. The local stress response system is involved in regulation of the normal hair cycle, but its precise role in AA is unknown. The influence of a local HPA axis or rather, CRH-POMC axis in AA was investigated by analysing immunohistochemically the expression levels of CRH and POMC peptides, including the adrenocorticotropic hormone (ACTH) and alpha-melanocyte-stimulating hormone (alpha-MSH), in a number of AA lesions and normal scalp (as control). The epidermis and pilosebaceous units of normal scalp stained weakly with CRH, ACTH and alpha-MSH, whereas those from the affected sites of the AA group showed intense expression of the peptides (chi-square test, P < 0.01). The meaning of this enhanced expression and their role in the pathogenesis of AA should be further evaluated in future.


Exp Dermatol


Experimental dermatology


Kim HS,Cho DH,Kim HJ,Lee JY,Cho BK,Park HJ




Has Abstract


2006-07-01 00:00:00














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    abstract::The immune system is called into action by alarm signals generated from injured tissues. We examined the nature of these alarm signals after exposure of skin residential cells to contact allergens (nickel sulfate and potassium dichromate) and a contact irritant [sodium dodecyl sulfate (SDS)]. Nickel sulfate, potassium...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Spiekstra SW,Toebak MJ,Sampat-Sardjoepersad S,van Beek PJ,Boorsma DM,Stoof TJ,von Blomberg BM,Scheper RJ,Bruynzeel DP,Rustemeyer T,Gibbs S

    更新日期:2005-02-01 00:00:00

  • Apoptosis pathways and oncolytic adenoviral vectors: promising targets and tools to overcome therapy resistance of malignant melanoma.

    abstract::In the last decades melanoma incidence has been increasing worldwide, while mortality remained on a high level. Until now, there is no suitable therapy for metastasized melanoma, which could lead to a significant increase in overall survival. Apoptosis deficiency is supposed to be a critical factor for therapy resista...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Eberle J,Fecker LF,Hossini AM,Kurbanov BM,Fechner H

    更新日期:2008-01-01 00:00:00

  • Chemiluminescent restriction fragment length polymorphism analysis (DNA fingerprinting) to identify keratinocytes from two donors in co-culture.

    abstract::The transplantation of allogeneic cells such as pancreatic islet cells, bone marrow, and keratinocytes for skin replacement is in growing use clinically. Present techniques which are used to distinguish transplanted allogeneic cells from phenotypically identical host cells in chimeric tissue have serious limitations. ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Young DM,Summers WC,Cuono CB

    更新日期:1993-02-01 00:00:00

  • Neuroendocrine regulation of sebocytes -- a pathogenetic link between stress and acne.

    abstract::A causative link between emotional stress and acne has long been postulated. There is mounting evidence that the molecular mechanism underlying this observation is related to the expression of receptors for several neuroendocrine mediators by the sebaceous gland. Recent and ongoing studies have indicated that human se...

    journal_title:Experimental dermatology

    pub_type: 杂志文章,评审


    authors: Zouboulis CC,Böhm M

    更新日期:2004-01-01 00:00:00

  • Leptin of dermal adipose tissue is differentially expressed during the hair cycle and contributes to adipocyte-mediated growth inhibition of anagen-phase vibrissa hair.

    abstract::Adipose tissue encircles the lower portion of anagen hair follicles and may regulate hair cycle progression. As leptin is a major adipokine, its level of expression from the dermal white adipose tissue during hair cycle progression was studied. The result shows that leptin level is differentially expressed during hair...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Yang CC,Sheu HM,Chung PL,Chang CH,Tsai YS,Hughes MW,Tuan TL,Huang LL

    更新日期:2015-01-01 00:00:00

  • The potential role of c-Jun activation in patients with cutaneous lichen planus.

    abstract::c-Jun, a component of the activating protein-1 transcription factor family, has been known to play an important role in the control of cell proliferation. It is also suspected to be a critical mediator of tumor promotion. However, investigations of c-Jun activation patterns in inflammatory and inflammatory transformin...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Marceková Z,Flaig MJ,Kekus M,Ruzicka T,Rupec RA

    更新日期:2010-01-01 00:00:00

  • Identification of a novel mutation in keratin 1 in a family with epidermolytic hyperkeratosis.

    abstract::Epidermolytic hyperkeratosis (EHK) is a hereditary skin disorder typified by blistering due to cytolysis. One in 100,000 individuals is affected by this autosomal-dominant disease. The onset of the disease phenotype is typically at birth. Histological and ultrastructural examination of the epidermis shows a thickened ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Arin MJ,Longley MA,Epstein EH Jr,Rothnagel JA,Roop DR

    更新日期:2000-02-01 00:00:00

  • p53 gene mutations in human skin cancers.

    abstract::The p53 gene is mutated in numerous human cancers. We used it as a molecular target to characterize and try to understand the induction of mutations in human skin cancers. About 40-50% of all skin cancers in normal individuals and 60-80% of the DNA-repair-deficient xeroderma pigmentosum patients exhibit p53 mutations....

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Sarasin A,Giglia-Mari G

    更新日期:2002-01-01 00:00:00

  • Increased expression of ICAM-1, E-selectin, and VCAM-1 by cultured human endothelial cells upon exposure to haptens.

    abstract::Contact allergens induce several accessory signals which promote the activation of antigen-specific T cells. One of these signals is the increased expression of adhesion molecules on antigen-presenting cells and endothelial cells. Epicutaneous application of non-toxic doses of 2,4-dinitrofluorobenzene (DNFB) onto the ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Wildner O,Lipkow T,Knop J

    更新日期:1992-11-01 00:00:00

  • The continued use of sunscreen prevents the development of actinic keratosis in aged Japanese subjects.

    abstract::It is well known that the trigger for actinic keratosis (AK) mainly depends on UV exposure. We evaluated the effects of long-term use of sunscreen on the histopathological and dermoscopic changes of AK in aged patients. Eighteen months use of sunscreen produced no change in the number of actinic keratoses or the advan...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Kunimoto K,Furukawa F,Uede M,Mizuno M,Yamamoto Y

    更新日期:2016-08-01 00:00:00

  • Angiotensin II activates connective tissue growth factor and induces extracellular matrix changes involving Smad/activation and p38 mitogen-activated protein kinase signalling pathways in human dermal fibroblasts.

    abstract::Angiotensin II (Ang II) stimulation has been shown to regulate proliferation of skin fibroblasts and the production of extracellular matrix, which are very important processes in skin wound healing and fibrosis; however, there is little knowledge about the mechanisms involved in this process. We investigated the molec...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Zhang GY,Li X,Yi CG,Pan H,He GD,Yu Q,Jiang LF,Xu WH,Li ZJ,Ding J,Lin DS,Gao WY

    更新日期:2009-11-01 00:00:00

  • Tiled array-based sequencing identifies enrichment of loss-of-function variants in the highly homologous filaggrin gene in African-American children with severe atopic dermatitis.

    abstract::Filaggrin (FLG) loss-of-function (LOF) variants are a major risk factor for the common inflammatory skin disease, atopic dermatitis (AD) and are often population-specific. African-American (AA) children are disproportionately affected with AD, often later developing asthma and/or allergic rhinitis and comprise an atop...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Mathyer ME,Quiggle AM,Wong XFCC,Denil SLIJ,Kumar MG,Ciliberto HM,Bayliss SJ,Common JE,de Guzman Strong C

    更新日期:2018-09-01 00:00:00

  • Correlation of psoriasis activity with abundance of CD25+CD8+ T cells: conditions for cloning T cells from psoriatic plaques.

    abstract::The role of T cells in the pathogenesis of psoriasis is widely acknowledged. However, key aspects of their precise function in the disease as well as the relative pathogenic contribution of T-cell subsets are still unknown. T-cell clones have been isolated from psoriatic plaques but a study of conditions affecting the...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Kohlmann WM,Urban W,Sterry W,Foerster J

    更新日期:2004-10-01 00:00:00

  • What is new in the psychology of chronic itch?

    abstract::Itch is often regarded as unpleasant or bothersome and is accompanied by symptoms of distress and impairments in daily life. The biopsychosocial model of chronic itch describes how psychological factors can contribute to the improvement or exacerbation of chronic itch and related scratching behaviour. Recent research ...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Evers AWM,Peerdeman KJ,van Laarhoven AIM

    更新日期:2019-12-01 00:00:00

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    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Tang L,Wang J,Zhu J,Liang Y

    更新日期:2018-12-01 00:00:00

  • Melanoma risk alleles are associated with downregulation of the MTAP gene and hypermethylation of a CpG island upstream of the gene in dermal fibroblasts.

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    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Sangalli A,Malerba G,Tessari G,Rodolfo M,Gomez-Lira M

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  • Balance of Treg versus T-effector cells during systemic treatment with adalimumab and topical treatment with calcipotriol-betamethasone dipropionate ointment.

    abstract::Diminished suppressive capacity of regulatory T cells (Treg) has been demonstrated in blood and in lesional skin of psoriatic patients. Treatment with anti-TNFα restored the number and function of circulating Treg in psoriasis. We aimed to study Treg in the skin of psoriatic patients undergoing topical treatment with ...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Keijsers RR,Joosten I,Hendriks AG,Koenen HJ,van Erp PE,van de Kerkhof PC

    更新日期:2015-01-01 00:00:00

  • Fluorescence induction of protoporphyrin IX by a new 5-aminolevulinic acid nanoemulsion used for photodynamic therapy in a full-thickness ex vivo skin model.

    abstract::An ex vivo porcine skin model was utilized to analyse the penetration of 5-aminolevulinic acid (5-ALA) contained in a nanoemulsion-based formulation BF-200 ALA (10% 5-ALA-hydrochloride) versus 16% aminolevulinate methyl ester-hydrochloride in a commercially cream (MAL cream) by fluorescence microscopy of their common ...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Maisch T,Santarelli F,Schreml S,Babilas P,Szeimies RM

    更新日期:2010-08-01 00:00:00

  • Vitiligo therapy: restoring immune privilege?

    abstract::The therapeutic hypothesis proposed by Speeckaert and van Geel in this issue (1) is based on the dramatic effects of the new drugs targeting immune privilege checkpoints (PD1/PDL, CTLA4) in current advanced melanoma therapy as major inductors of vitiligo changes in the skin. Such striking clinical manifestations canno...

    journal_title:Experimental dermatology

    pub_type: 评论,杂志文章


    authors: Boniface K,Seneschal J,Taïeb A,Merched A

    更新日期:2017-07-01 00:00:00

  • Enzymes involved in the conversion of arachidonic acid to eicosanoids in the skin of atopic dogs.

    abstract::Canine atopic dermatitis (AD), a chronic inflammatory skin disease, shares characteristics with its human counterpart. To get insight into the role of enzymes involved in production of prostaglandin E(2) (PGE2) and leukotriene B(4) (LTB(4)), potent inflammatory mediators originating from membrane-derived arachidonic a...

    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Schlotter YM,Riemers FM,Rutten VP,Knol EF,Willemse T

    更新日期:2010-08-01 00:00:00

  • Combining a chimeric antigen receptor and a conventional T-cell receptor to generate T cells expressing two additional receptors (TETARs) for a multi-hit immunotherapy of melanoma.

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    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Uslu U,Schuler G,Dörrie J,Schaft N

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  • A single dose of interleukin-31 (IL-31) causes continuous itch-associated scratching behaviour in mice.

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    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Arai I,Tsuji M,Takeda H,Akiyama N,Saito S

    更新日期:2013-10-01 00:00:00

  • TCR Vbeta expression in the small bowel of patients with dermatitis herpetiformis and gluten sensitive enteropathy. Limited expression in dermatitis herpetiformis and treated asymptomatic gluten sensitive enteropathy.

    abstract::Dermatitis herpetiformis (DH) is a blistering skin disease characterized by cutaneous deposits of IgA and an associated, most often asymptomatic, gluten sensitive enteropathy (GSE). Gluten sensitive enteropathy is also seen in patients that do not have skin disease or cutaneous IgA deposits, but do have significant ga...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Hall RP 3rd,Owen S,Smith A,Keough M,Bagheri B,Church P,Streilein R

    更新日期:2000-08-01 00:00:00

  • Lack of expression of an alternative CD20 transcript variant in circulating B cells from patients with pemphigus.

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    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Gamonet C,Ferrand C,Colliou N,Musette P,Joly P,Girardin M,Humbert P,Aubin F

    更新日期:2014-01-01 00:00:00

  • Type XVII collagen interacts with the aPKC-PAR complex and maintains epidermal cell polarity.

    abstract::Type XVII collagen (COL17) is a transmembrane protein expressed in the basal epidermis. COL17 serves as a niche for epidermal stem cells, and although its reduction has been implicated in altering cell polarity and ageing of the epidermis, it is unknown how COL17 affects epidermal cell polarity. Here, we uncovered COL...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Watanabe M,Kosumi H,Osada SI,Takashima S,Wang Y,Nishie W,Oikawa T,Hirose T,Shimizu H,Natsuga K

    更新日期:2021-01-01 00:00:00

  • S100B as a potential biomarker for the detection of cytotoxicity of melanocytes.

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    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Cheong KA,Noh M,Kim CH,Lee AY

    更新日期:2014-03-01 00:00:00

  • Nucleofection is a highly effective gene transfer technique for human melanoma cell lines.

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    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Han SY,Gai W,Yancovitz M,Osman I,Di Como CJ,Polsky D

    更新日期:2008-05-01 00:00:00

  • Production of multiple cytokines by cultured human melanomas.

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    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Bennicelli JL,Guerry D 4th

    更新日期:1993-08-01 00:00:00

  • Intercellular pathway through hyaluronic acid in UVB-induced inflammation.

    abstract::Ultraviolet B (UVB) radiation induces inflammation in the skin specifically at the site of exposure. We unexpectedly found that UVB-induced inflammation was not induced in gp91phox-depleted mice. To test whether gp91phox is directly involved in UVB-induced inflammation, neutrophil- and hyaluronic acid-depleted mice we...

    journal_title:Experimental dermatology

    pub_type: 杂志文章


    authors: Hiramoto K,Kobayashi H,Yamate Y,Ishii M,Sato EF

    更新日期:2012-12-01 00:00:00

  • Cystatin M/E knockdown by lentiviral delivery of shRNA impairs epidermal morphogenesis of human skin equivalents.

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    journal_title:Experimental dermatology

    pub_type: 信件


    authors: Jansen PA,van den Bogaard EH,Kersten FF,Oostendorp C,van Vlijmen-Willems IM,Oji V,Traupe H,Hennies HC,Schalkwijk J,Zeeuwen PL

    更新日期:2012-11-01 00:00:00