Interfollicular epidermal homeostasis: dicing with differentiation.

abstract：:The present study assessed the molecular mechanism underlying ultraviolet (UV) B radiation-induced inhibition of the expression of the adhesion molecule ICAM-1 in human antigen-presenting cells (APC). UVB radiation-induced inhibition of ICAM-I expression in human peripheral blood monocytes was associated with the gene...

journal_title：Experimental dermatology

authors： Grewe M,Stege H,Vink A,Klammer M,Ruzicka T,Roza L,Krutmann J

更新日期：2000-12-01 00:00:00

abstract：:In a large-scale ageing study, 30 inbred mouse strains were systematically screened for histologic evidence of lesions in all organ systems. Ten strains were diagnosed with similar nail abnormalities. The highest frequency was noted in NON/ShiLtJ mice. Lesions identified fell into two main categories: acute to chronic...

journal_title：Experimental dermatology

authors： Linn SC,Mustonen AM,Silva KA,Kennedy VE,Sundberg BA,Bechtold LS,Alghamdi S,Hoehndorf R,Schofield PN,Sundberg JP

更新日期：2019-04-01 00:00:00

abstract：:Sunburn cell (SBC) formation in the epidermis is a characteristic consequence of ultraviolet radiation (UVR) exposure at doses around or above the minimum erythema dose. SBC have been identified morphologically and biologically as keratinocytes undergoing apoptosis. There is evidence that SBC formation is a protective...

journal_title：Experimental dermatology

authors： Murphy G,Young AR,Wulf HC,Kulms D,Schwarz T

更新日期：2001-06-01 00:00:00

abstract：:Tissue-invasive T cells are observed in many inflammatory dermatological diseases, but in most cases, it is not known how they were attracted, what they might recognize, and to which extent they are activated. Answering these questions is surely essential for understanding pathogeneses of the diseases. In a recent iss...

journal_title：Experimental dermatology

authors： Dornmair K

更新日期：2014-06-01 00:00:00

abstract：:We aimed to evaluate the effect of small interfering RNA (siRNA) targeting CTGF on extracellular matrices (ECMs) metabolism in normal and SSc fibroblasts. Normal and SSc fibroblasts were transfected with CTGF-specific siRNAs to silence CTGF synthesis. After silencing CTGF, production of type I collagen and matrix meta...

journal_title：Experimental dermatology

authors： Ishibuchi H,Abe M,Yokoyama Y,Ishikawa O

更新日期：2010-08-01 00:00:00

abstract：:There have been several studies on the role of the monocyte chemotactic protein-1/C-C chemokine receptor type 2 (CCR2) signalling pathway in fibrotic diseases, which identified the blockade of this pathway as a potential therapeutic target for treating fibrosis. We examined the efficacy of CCR2 antagonist (RS-504393) ...

journal_title：Experimental dermatology

authors： Ishikawa M,Yamamoto T

更新日期：2021-01-01 00:00:00

abstract：:Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering skin disease and is characterized by the presence of autoantibodies directed against the hemidesmosomal proteins BP180 and BP230 that can be detected in the skin and serum of BP patients. Histologically, the dermal infiltration of eosinophil...

journal_title：Experimental dermatology

authors： Simon D,Borradori L,Simon HU

更新日期：2017-12-01 00:00:00

abstract：:Hair follicles cyclically regenerate throughout adult mammalian life, owing to a resident population of epithelial hair follicle stem cells. Stem cell (SC) activity drives bouts of follicle growth, which are periodically interrupted by follicle regression and rest. These phases and the transitions between them are tig...

journal_title：Experimental dermatology

authors： Martino PA,Heitman N,Rendl M

更新日期：2020-10-02 00:00:00

abstract：:C1 inhibitor (C1INH) plays an important role in the classical pathway of the complement system. Mutations in C1INH gene cause quantitative or qualitative deficiencies in C1INH, which can lead to hereditary angioedema (HAE) type I or II. Here, we identified a novel frame-shift mutation c.1391-1445del55 (p.v464fsx556) i...

journal_title：Experimental dermatology

authors： Qu L,Wei B,Liu M,Zhang L,Xiao T,Chen HD,Zhou L,Mi QS,He C

更新日期：2012-10-01 00:00:00

abstract：:Canine atopic dermatitis (AD), a chronic inflammatory skin disease, shares characteristics with its human counterpart. To get insight into the role of enzymes involved in production of prostaglandin E(2) (PGE2) and leukotriene B(4) (LTB(4)), potent inflammatory mediators originating from membrane-derived arachidonic a...

journal_title：Experimental dermatology

authors： Schlotter YM,Riemers FM,Rutten VP,Knol EF,Willemse T

更新日期：2010-08-01 00:00:00

abstract：:We have recently demonstrated that telomerase activity is increased and telomere length shortened in lymphocytes from peripheral blood of patients with cutaneous T-cell lymphoma. In order to determine which cell type has increased telomerase activity and shortened telomere length, CD4+, CD8+, CLA+ CD3+ and CLA- CD3+ T...

journal_title：Experimental dermatology

authors： Wu KD,Hansen ER

更新日期：2001-10-01 00:00:00

abstract：:Epidermolytic hyperkeratosis (EHK) is a genodermatosis caused by mutations in either the keratin 1 (K1) or keratin 10 (K10) genes, and characterized by erythroderma and blistering at birth, with development of a ribbed, ichthyotic hyperkeratosis and palmoplantar keratoderma. A wide variety of mutations within the high...

journal_title：Experimental dermatology

authors： Michael EJ,Schneiderman P,Grossman ME,Christiano AM

更新日期：1999-12-01 00:00:00

abstract：:Claudins (Cldn) are the major components of tight junctions (TJs) sealing the paracellular cleft in tissue barriers of various organs. Zebrafish Cldnb, the homolog of mammalian Cldn4, is expressed at epithelial cell-cell contacts and is important for regulating epidermal permeability. The bacterial toxin Clostridium p...

journal_title：Experimental dermatology

authors： Zhang J,Ni C,Yang Z,Piontek A,Chen H,Wang S,Fan Y,Qin Z,Piontek J

更新日期：2015-08-01 00:00:00

abstract：:This review focuses on the photoprotection conferred by lycopene, one of the most potent anti-oxidants. Lycopene has been recently proposed to play a critical role on anticarcinogenic action at different levels. The photoprotective properties of lycopene remain contradictory. Some studies point out a positive and othe...

journal_title：Experimental dermatology

authors： Ascenso A,Ribeiro H,Marques HC,Oliveira H,Santos C,Simões S

更新日期：2014-12-01 00:00:00

abstract：:Melanomas and nevi displaying regression features can be difficult to differentiate. To describe reflectance confocal microscopy features in benign and malignant pigmented skin lesions characterized by regression features in dermoscopy. Observational retrospective study. Inclusion criteria were presence of dermoscopic...

journal_title：Experimental dermatology

authors： Moscarella E,Bombonato C,Pampena R,Kyrgidis A,Benati E,Piana S,Borsari S,Lallas A,Pellacani G,Argenziano G,Longo C

更新日期：2019-02-01 00:00:00

abstract：:Congenital melanocytic nevi (CMN) are benign proliferations that may be associated with various consequences depending on their size. They are characterized by a specific molecular signature, namely a postzygotic somatic NRAS or BRAF mutation. We have recently reported that large CMN (lCMN), which are classically asso...

journal_title：Experimental dermatology

authors： Guégan S,Kadlub N,Picard A,Rouillé T,Charbel C,Coulomb-L'Hermine A,How-Kit A,Fraitag S,Aractingi S,Fontaine RH

更新日期：2016-10-01 00:00:00

abstract：:There have been few reports of successful long-term culture of cells established from cutaneous basal cell carcinoma (BCC) tumors. Here, we describe techniques that have enabled us to establish three long-term cultures of BCC cells isolated from BCC tumors that arose in irradiated Patched 1 (Ptch1)(+/-) mice. All thre...

journal_title：Experimental dermatology

authors： So PL,Langston AW,Daniallinia N,Hebert JL,Fujimoto MA,Khaimskiy Y,Aszterbaum M,Epstein EH Jr

更新日期：2006-09-01 00:00:00

abstract：:Lipoid proteinosis (OMIM 247100), also known as Urbach-Wiethe disease or hyalinosis cutis et mucosae, is a rare autosomal recessive disorder characterized by generalized thickening and scarring of the skin and mucosae. In 2002, the disorder was mapped to a locus on chromosome 1q21 and pathogenic mutations were identif...

journal_title：Experimental dermatology

authors： Chan I,Liu L,Hamada T,Sethuraman G,McGrath JA

更新日期：2007-11-01 00:00:00

abstract：:Solar ultraviolet (UV) radiation has hazardous effects on human health that are, in part, associated with its immunosuppressive effects via the induction of interleukin (IL)-10 production. Although IL-10 is produced by both T helper type 2 (Th2) cells and T-regulatory type 1 (Tr1) cells, the relative contribution of e...

journal_title：Experimental dermatology

authors： Stoebner PE,Rahmoun M,Ferrand C,Meunier L,Yssel H,Pène J

更新日期：2006-08-01 00:00:00

abstract：:Contact allergens induce several accessory signals which promote the activation of antigen-specific T cells. One of these signals is the increased expression of adhesion molecules on antigen-presenting cells and endothelial cells. Epicutaneous application of non-toxic doses of 2,4-dinitrofluorobenzene (DNFB) onto the ...

journal_title：Experimental dermatology

authors： Wildner O,Lipkow T,Knop J

更新日期：1992-11-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a complex autoimmune connective tissue disease combining inflammatory, vasculopathic and fibrotic manifestations. Skin features, which give their name to the disease and are considered as diagnostic as well as prognostic markers, have not been thoroughly investigated in terms of therapeutic...

journal_title：Experimental dermatology

authors： Henrot P,Truchetet ME,Fisher G,Taïeb A,Cario M

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:In vivo reflectance confocal microscopy (RCM) represents a promising imaging tool that allows a non-invasive examination of skin morphology in real time at nearly histological resolution, showing microanatomical structures and individual cells. OBJECTIVES:The aim of our study was to evaluate the diagnostic ...

journal_title：Experimental dermatology

authors： Koller S,Gerger A,Ahlgrimm-Siess V,Weger W,Smolle J,Hofmann-Wellenhof R

更新日期：2009-06-01 00:00:00

abstract：:The molecular nature of the hair cycle clock (HCC), the intrinsic oscillator system that drives hair follicle (HF) cycling, remains incompletely understood; therefore, all relevant key players need to be identified. Here, we present evidence that implicates myelin protein zero-like 3 (MPZL3), a multifunctional nuclear...

journal_title：Experimental dermatology

authors： Nicu C,Wikramanayake TC,Paus R

更新日期：2020-12-01 00:00:00

abstract：:Exposure of the skin to ultraviolet (UV) irradiation induces photoageing through the up-regulation of matrix metalloproteinases (MMPs) and subsequent breakdown of extracellular matrices. Reactive oxygen species (ROS) and epidermal growth factor receptor (EGFR) activation play central roles in UV-induced MMP expression...

journal_title：Experimental dermatology

authors： Park M,Han J,Lee CS,Soo BH,Lim KM,Ha H

更新日期：2013-05-01 00:00:00

abstract：:DECORIN is a prototypical member of the small leucine-rich proteoglycan (SLRP) family that plays important roles in numerous biological processes and cellular biological pathways. We previously showed that Decorin expression was highly enhanced in mouse dorsal hair follicles (HFs) during the anagen phase and was reduc...

journal_title：Experimental dermatology

authors： Zhou L,Jing J,Wang H,Wu X,Lu Z

更新日期：2018-11-01 00:00:00

abstract：:Mast cells (MCs) have been intensely investigated over the past two decades, e.g. the numbers of PubMed-listed reports on MCs have steadily increased and doubled over the past twenty years. Surprisingly, many recent findings that have fundamentally changed our understanding of MC biology and functions have yet to be s...

journal_title：Experimental dermatology

authors： Maurer M,Metz M

更新日期：2005-12-01 00:00:00

abstract：:The process of skin wound healing involves the following three steps: inflammation, tissue formation and tissue remodelling. These optimal steps are required for the development of normal wound healing. Recent reports demonstrated that inflammasomes are involved in the innate immune response. In the present study, we ...

journal_title：Experimental dermatology

authors： Ito H,Kanbe A,Sakai H,Seishima M

更新日期：2018-01-01 00:00:00

abstract：:Nitric oxide (NO) is a potent intercellular mediator of melanogenesis, whereas metallothionein (MT) is an inducible intracellular antioxidant that has been reported to scavenge NO. We investigated the existence and induction of MT in melanocytes, and its inhibitory effect on NO-induced melanogenesis. The expression of...

journal_title：Experimental dermatology

authors： Sasaki M,Kizawa K,Igarashi S,Horikoshi T,Uchiwa H,Miyachi Y

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Methylenetetrahydrofolate reductase (MTHFR) is involved in the formation of methyl donors, which contribute to DNA methylation. DNA methylation is an essential epigenetic feature playing a critical role in gene regulation and cellular differentiation. In addition, MTHFR activity affects plasma homocysteine l...

journal_title：Experimental dermatology

authors： Weger W,Hofer A,Stanger O,Wolf P,El-Shabrawi Y,Renner W,Kerl H,Salmhofer W

更新日期：2008-09-01 00:00:00

abstract：:We analysed the correlation between the expression of HIF-1α (hypoxia-inducible factor 1 alpha), the nuclear receptors: VDR (vitamin D receptor), RORα (retinoic acid receptor-related orphan receptor alpha), and RORγ and CYP24A1 (cytochrome P450 family 24 subfamily A member 1) and CYP27B1 (cytochrome P450 family 27 sub...

journal_title：Experimental dermatology

authors： Brożyna AA,Jóźwicki W,Jetten AM,Slominski AT

更新日期：2019-09-01 00:00:00