Involvement of changes in stratum corneum keratin in wrinkle formation by chronic ultraviolet irradiation in hairless mice.

abstract：:Inflammation is a crucial step in the development of allergic contact dermatitis. The primary contact with chemical allergens, called sensitization, and the secondary contact, called elicitation, result in an inflammatory response in the skin. The ability of contact allergens to induce allergic contact dermatitis corr...

journal_title：Experimental dermatology

authors： Lass C,Merfort I,Martin SF

更新日期：2010-11-01 00:00:00

abstract：:Mast cells (MCs) have been intensely investigated over the past two decades, e.g. the numbers of PubMed-listed reports on MCs have steadily increased and doubled over the past twenty years. Surprisingly, many recent findings that have fundamentally changed our understanding of MC biology and functions have yet to be s...

journal_title：Experimental dermatology

authors： Maurer M,Metz M

更新日期：2005-12-01 00:00:00

abstract：:Seasonal variations can be found in almost any parameter of an organism's biochemistry, physiology, endocrinology, and behaviour. This phenomenon, generally called photoperiodism, results from one of the major functions of the circadian system, i.e. the translation of environmental information into rhythmic intraorgan...

journal_title：Experimental dermatology

authors： Lang R,Hintner H,Hermann A,Brandstaetter R

更新日期：2003-08-01 00:00:00

abstract：:Irradiation with ultraviolet (UV) B light results in the formation of apoptotic keratinocytes called sunburn cells (SC). Although generation of SC appears to be one of the most characteristic features of UV-induced skin damage and has been a well-known phenomenon for a long time, the mechanisms involved are not quite ...

journal_title：Experimental dermatology

authors： Schwarz A,Mahnke K,Luger TA,Schwarz T

更新日期：1997-02-01 00:00:00

abstract：:Type XVII collagen (COL17) is a transmembrane protein expressed in the basal epidermis. COL17 serves as a niche for epidermal stem cells, and although its reduction has been implicated in altering cell polarity and ageing of the epidermis, it is unknown how COL17 affects epidermal cell polarity. Here, we uncovered COL...

journal_title：Experimental dermatology

authors： Watanabe M,Kosumi H,Osada SI,Takashima S,Wang Y,Nishie W,Oikawa T,Hirose T,Shimizu H,Natsuga K

更新日期：2021-01-01 00:00:00

abstract：:Keratinocytes (KCs) play a critical role in maintaining the cutaneous structure and are involved in various physiological and pathologic processes of the skin. Many inflammatory skin diseases and skin cancers result from excessive proliferation and insufficient apoptosis of KCs. Recent data suggested that the sonic he...

journal_title：Experimental dermatology

authors： Liu H,Jian Q,Xue K,Ma C,Xie F,Wang R,Liao W,Liu Y,Chi S,Li C

更新日期：2014-12-01 00:00:00

abstract：:A causative link between emotional stress and acne has long been postulated. There is mounting evidence that the molecular mechanism underlying this observation is related to the expression of receptors for several neuroendocrine mediators by the sebaceous gland. Recent and ongoing studies have indicated that human se...

journal_title：Experimental dermatology

authors： Zouboulis CC,Böhm M

更新日期：2004-01-01 00:00:00

abstract：:Delayed wound healing is one of the major complications in diabetes and is characterized by chronic proinflammatory response, and abnormalities in angiogenesis and collagen deposition. Sirtuin family proteins regulate numerous pathophysiological processes, including those involved in promotion of longevity, DNA repair...

journal_title：Experimental dermatology

authors： Thandavarayan RA,Garikipati VN,Joladarashi D,Suresh Babu S,Jeyabal P,Verma SK,Mackie AR,Khan M,Arumugam S,Watanabe K,Kishore R,Krishnamurthy P

更新日期：2015-10-01 00:00:00

abstract：:The outcome of a cutaneous immune response is critically dependent upon the ability of dendritic cells (DC) to migrate from skin to the draining lymph nodes - a process that is influenced by the cutaneous tissue microenvironment. Here, the role of fibroblasts - a major component of the dermal microenvironment - on the...

journal_title：Experimental dermatology

authors： Saalbach A,Janik T,Busch M,Herbert D,Anderegg U,Simon JC

更新日期：2015-08-01 00:00:00

abstract：:We previously reported that mesenchymal cells (dermal fibroblasts and dermal papilla cells) can stimulate dopa oxidase activity in the skin melanocytes. This study extends the investigation of the influence of the fibroblast in a comparative study of melanogenesis in melanocytes from the hair, the skin and the eye. Cu...

journal_title：Experimental dermatology

authors： Balafa C,Smith-Thomas L,Phillips J,Moustafa M,George E,Blount M,Nicol S,Westgate G,MacNeil S

更新日期：2005-05-01 00:00:00

abstract：:Flavonoids belong to a large group of polyphenolic compounds that are widely present in plants. Certain flavonoids, including naringenin, have cytoprotective properties. Although the antioxidant effect has long been thought to be a crucial factor accounting for the cellular effects of flavonoids, mitochondrial channel...

journal_title：Experimental dermatology

authors： Kampa RP,Kicinska A,Jarmuszkiewicz W,Pasikowska-Piwko M,Dolegowska B,Debowska R,Szewczyk A,Bednarczyk P

更新日期：2019-05-01 00:00:00

abstract：:Corticotropin releasing factor, adrenocorticotropic hormone (ACTH) and alpha-melanocyte stimulating hormone either inhibit or enhance in a dose-dependent fashion an interleukin-4 (IL-4) driven human IgE synthesis in vitro. Here, we show that culture conditions strongly influence the earlier observed dose- and donor-de...

journal_title：Experimental dermatology

authors： Aebischer I,Stämpfli MR,Miescher S,Horn M,Zürcher AW,Stadler BM

更新日期：1996-02-01 00:00:00

abstract：:Keloid is a dermal proliferative disorder characterized by the excessive proliferation and migration of keratinocytes and fibroblasts. Over-activation of the serine/threonine protein kinase, mammalian target of rapamycin (mTOR), plays a pivotal role in the process. Here, we show that both mTOR complex 1 (mTORC1) and m...

journal_title：Experimental dermatology

authors： Chen J,Liu K,Liu Y,Wang X,Zhang Z

更新日期：2019-03-01 00:00:00

abstract：:Unpredictable hypertrophic scarring (HS) occurs after approximately 35% of all surgical procedures and causes significant physical and psychological complaints. Parallel to the need to understanding the mechanisms underlying HS formation, a prognostic tool is needed. The objective was to determine whether (systemic) i...

journal_title：Experimental dermatology

authors： de Bakker E,van der Putten MAM,Heymans MW,Spiekstra SW,Waaijman T,Butzelaar L,Negenborn VL,Beekman VK,Akpinar EO,Rustemeyer T,Niessen FB,Gibbs S

更新日期：2021-01-01 00:00:00

abstract：:The expansive use of immunosuppressive medications in fields such as transplantational medicine and oncology, the higher frequency of invasive procedures in an ageing population and the HIV/AIDS pandemic have increased the frequency of systemic fungal infections. At the same time, increased resistance of pathogenic fu...

journal_title：Experimental dermatology

authors： Mehra T,Köberle M,Braunsdorf C,Mailänder-Sanchez D,Borelli C,Schaller M

更新日期：2012-10-01 00:00:00

abstract：:Even though anthralin is a well-established topical therapeutic agent for psoriasis, little is known about its effects and biochemical mechanisms of signal transduction. In contrast to a previous report, we found that anthralin induced time- and concentration-dependent phosphorylation of epidermal growth factor recept...

journal_title：Experimental dermatology

authors： Peus D,Beyerle A,Vasa M,Pott M,Meves A,Pittelkow MR

更新日期：2004-02-01 00:00:00

abstract：:There is likely general consensus within the skin research community that cell cycle control is critical to epidermal homeostasis and disease. The current predominant model proposes that keratinocytes switch off DNA replication and undergo cell cycle and cell growth arrest as they initiate terminal differentiation. Ho...

journal_title：Experimental dermatology

authors： Gandarillas A,Freije A

更新日期：2014-02-01 00:00:00

abstract：:Type VII collagen is the major component of anchoring fibrils in the epidermal basement membrane. Its expression has been analyzed by immunostaining or Northern blotting, but rarely at the protein level. In this study, we have quantitatively examined the effects of ascorbic acid and various cytokines/growth factors on...

journal_title：Experimental dermatology

authors： Amano S,Ogura Y,Akutsu N,Nishiyama T

更新日期：2007-02-01 00:00:00

abstract：:Chimeric antigen receptor (CAR)-T cells are one of the impressive recent success stories of anti-cancer immunotherapy. Especially in haematological malignancies, this treatment strategy has shown promising results leading to the recent approval of two CAR-T cell constructs targeting CD19 in the United States and the E...

journal_title：Experimental dermatology

authors： Simon B,Uslu U

更新日期：2018-12-01 00:00:00

abstract：:Responses to acetylcholine (ACh) and vasoactive intestinal polypeptide (VIP) were investigated in atopic eczema (AE) patients. To elucidate the involvement of histamine to ACh-provoked vasoreactions and sensations, we applied a selective H1-antagonist (cetirizine) 3 h prior to the ACh-administration. Solutions of acet...

journal_title：Experimental dermatology

authors： Rukwied R,Heyer G

更新日期：1999-02-01 00:00:00

abstract：:The early growth response (Egr)-1 is a transcriptional factor which plays an important role in the regulation of cell growth, differentiation, cell survival and immune responses. Emerging evidences including our data demonstrate that the Egr-1 expression is up-regulated in the psoriatic skin lesions. The purpose of th...

journal_title：Experimental dermatology

authors： Jeong SH,Kim HJ,Jang Y,Ryu WI,Lee H,Kim JH,Bae HC,Choi JE,Kye YC,Son SW

更新日期：2014-12-01 00:00:00

abstract：:In this study, we analysed the modulation of keratinocyte growth factor (KGF) mRNA expression in human dermal fibroblasts cultured either in monolayer or within a collagen matrix (dermal equivalent). In monolayer cultures, KGF expression by quiescent fibroblasts was stimulated by different growth substances such as se...

journal_title：Experimental dermatology

authors： Le Panse R,Bouchard B,Lebreton C,Coulomb B

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:The circadian rhythm is an endogenous clock that governs a wide range of physiological functions. In the skin, rhythmic changes in skin barrier function have been investigated at the physiological level; however, few studies at the molecular level have been reported. Additionally, there is no study on lipido...

journal_title：Experimental dermatology

authors： Jia Y,Zhou M,Huang H,Gan Y,Yang M,Ding R

更新日期：2019-07-01 00:00:00

abstract：:In the inherited blistering skin disease, recessive dystrophic epidermolysis bullosa (RDEB), there is clinical heterogeneity with variable scarring and susceptibility to malignancy. Currently, however, there are few biochemical markers of tissue inflammation or disease progression. We assessed whether the non-histone ...

journal_title：Experimental dermatology

authors： Petrof G,Abdul-Wahab A,Proudfoot L,Pramanik R,Mellerio JE,McGrath JA

更新日期：2013-06-01 00:00:00

abstract：:Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have i...

journal_title：Experimental dermatology

authors： Niyonsaba F,Kiatsurayanon C,Chieosilapatham P,Ogawa H

更新日期：2017-11-01 00:00:00

abstract：:Recently, 3% diclofenacnatrium gel (diclofenac) was introduced for the treatment of actinic keratoses. Data on photocarcinogenesis of topical diclofenac are limited, and we wished to investigate whether topical diclofenac can accelerate photocarcinogenesis using simulated solar radiation (SSR). Diclofenac was applied ...

journal_title：Experimental dermatology

authors： Lerche CM,Philipsen PA,Poulsen T,Wulf HC

更新日期：2011-04-01 00:00:00

abstract：:Keratinocyte apoptosis mediated by Fas/Fas ligand molecular interactions and subsequent caspase activation is believed to play an important role in the pathogenesis of atopic dermatitis (AD), in particular for the formation of spongiosis. To estimate epidermal caspase activation in normal and AD skin under in vivo con...

journal_title：Experimental dermatology

authors： Simon D,Lindberg RL,Kozlowski E,Braathen LR,Simon HU

更新日期：2006-06-01 00:00:00

abstract：:Optimized delivery of antigens combined with sustainable maturation of dendritic cells (DCs) is crucial for generation of effective antitumoral immune responses. Multiple approaches for ex vivo antigen loading and improvement in immunogenicity have been described. We have recently established a single-step protocol co...

journal_title：Experimental dermatology

authors： Buhl T,Braun A,Forkel S,Möbius W,van Werven L,Jahn O,Rezaei-Ghaleh N,Zweckstetter M,Mempel M,Schön MP,Haenssle HA

更新日期：2014-01-01 00:00:00

abstract：:In the last decade, significant progress has been made in understanding skin cancer cell death resistance mechanisms, and a number of new treatment strategies have been developed. Systematic approach genomic studies of various cancer types have opened new possibilities for the development of anticancer therapies. Howe...

journal_title：Experimental dermatology

authors： Feoktistova M,Panayotova-Dimitrova D

更新日期：2017-10-01 00:00:00

abstract：:Congenital melanocytic nevi (CMN) are benign proliferations that may be associated with various consequences depending on their size. They are characterized by a specific molecular signature, namely a postzygotic somatic NRAS or BRAF mutation. We have recently reported that large CMN (lCMN), which are classically asso...

journal_title：Experimental dermatology

authors： Guégan S,Kadlub N,Picard A,Rouillé T,Charbel C,Coulomb-L'Hermine A,How-Kit A,Fraitag S,Aractingi S,Fontaine RH

更新日期：2016-10-01 00:00:00